Allele Dmel\cv-2¹

General Information
Symbol	Dmel\cv-2¹	Species	D. melanogaster
Name		FlyBase ID	FBal0002186
Feature type	allele	Associated gene	Dmel\cv-2

Allele class
Mutagen	spontaneous
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	spontaneous
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology	Polytene chromosomes normal.
Phenotypic Data
Phenotypic Class
	visible (Szuperák et al., 2011)
Phenotype Manifest In
	anterior crossvein (Conley et al., 2000, ) anterior crossvein (with Df(2R)Pu-D17) (Conley et al., 2000) crossvein (Amoros et al., 2002) posterior crossvein (Conley et al., 2000, Szuperák et al., 2011) wing vein (with Df(2R)Pu-D17) (Conley et al., 2000)
Detailed Description
	Statement Reference 100% of homozygotes lack the posterior crossveins. (Szuperák et al., 2011) No obvious tergal depressor of trochanter (TDT) muscle fiber defect is observed in homozygous cv-2[1] animals. (Jaramillo et al., 2009) Mutant larvae do not have defects in the establishment or maintenance of dendritic tiling in class IV dendrite arborisation (da) neurons. (Parrish et al., 2007) Mutants lack crossveins. (Amoros et al., 2002) cv-2¹ in combination with Df(2R)Pu-D17 always leads to the loss of the posterior crossvein (PCV) and can lead to the loss of the whole of the anterior crossvein (ACV) and the ends of some longitudinal veins. Homozygotes lack most or all of the PCV and in some cases the posterior of the ACV. (Conley et al., 2000) Anterior and posterior crossveins absent. RK1.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference cv-2¹ has visible phenotype, suppressible \| partially by ltl^Scer\UAS.cSa (Szuperák et al., 2011)
Other
Statement Reference cv-2¹, ltl⁴/ltl² has lethal phenotype (Szuperák et al., 2011, Szuperák et al., 2011)
Phenotype Manifest In
Suppressed by
Statement Reference cv-2¹ has crossvein phenotype, suppressible by ash2^S112411 (Amoros et al., 2002) cv-2¹ has posterior crossvein phenotype, suppressible \| partially by ltl^Scer\UAS.cSa (Szuperák et al., 2011)
NOT Suppressor of
Statement Reference cv-2¹ is a non-suppressor of crossvein \| ectopic phenotype of ash2^S112411 (Amoros et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference Two copies of P{UAS-ltl.S}5 (which allow leaky expression of ltl[Scer\UAS.cSa] in the absence of a Scer\GAL4 driver) fully restore the posterior crossvein in 45% of wings of cv-2[1]/cv-2[1] animals. (Szuperák et al., 2011) cv-2¹/cv-2¹, ash2^S112411/+ flies have normal crossveins. cv-2¹/cv-2¹, ash2^S112411/ash2^S112411 have extra crossveins and reduction in wing size. (Amoros et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	cv-2¹ is rescued by Scer\GAL4^A9/cv-2^Scer\UAS.cSa (Serpe et al., 2008)
Comments	Expression of one copy of cv-2[Scer\UAS.cSa] under the control of Scer\GAL4[A9] rescues the posterior crossvein defects seen in homozygous cv-2[1] mutants. Expression of cv-2[N.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[hh.PU] partially rescues the rescues the posterior crossvein defects seen in homozygous cv-2[1] mutants. (Serpe et al., 2008)
Stocks ( 3 )
Bloomington	6302 cv-2¹ 6521 l(2)57Cb¹ cv-2¹/SM1 6524 l(2)57Ce¹ cv-2¹/SM1
Notes on Origin
Discoverer
	Segregated from: Several natural populations.
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	cv-2¹ (Szuperák et al., 2011, Parrish et al., 2007, Jaramillo et al., 2009, Pilgram et al., 2011, Serpe et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Szuperák et al., 2011, Development 138(4): 715--724 Feedback regulation of Drosophila BMP signaling by the novel extracellular protein Larval Translucida. [FBrf0212881] Jaramillo et al., 2009, Development 136(7): 1105--1113 Crossveinless and the TGF{beta} pathway regulate fiber number in the Drosophila adult jump muscle. [FBrf0207556] Serpe et al., 2008, Dev. Cell 14(6): 940--953 The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila. [FBrf0204848] Parrish et al., 2007, Genes Dev. 21(8): 956--972 Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. [FBrf0201136] Ralston and Blair, 2005, Dev. Biol. 280(1): 187--200 Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone. [FBrf0183863] Amoros et al., 2002, Int. J. Dev. Biol. 46(3): 321--324 The ash2 gene is involved in Drosophila wing development. [FBrf0149044] Conley et al., 2000, Development 127(18): 3947--3959 Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila. [FBrf0129774]

Allele Dmel\cv-21

Allele Dmel\cv-2¹