Allele Dmel\cv-c¹

General Information
Symbol	Dmel\cv-c¹	Species	D. melanogaster
Name		FlyBase ID	FBal0002188
Feature type	allele	Associated gene	Dmel\cv-c

Allele class
Mutagen	spontaneous
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	spontaneous
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (Pilgram et al., 2011) neurophysiology defective (Pilgram et al., 2011) neurophysiology defective, with Scer\GAL4^OK6, cv-c^Scer\UAS.cDa (Pilgram et al., 2011) neurophysiology defective (with cv-c^C524) (Pilgram et al., 2011) neurophysiology defective (with cv-c^M62) (Pilgram et al., 2011) neurophysiology defective \| dominant (Pilgram et al., 2011) viable (Denholm et al., 2005) visible \| recessive (Pilgram et al., 2011)
Phenotype Manifest In
	anterior crossvein (Denholm et al., 2005, ) eye leg neuromuscular junction (Pilgram et al., 2011) neuromuscular junction, with Scer\GAL4^OK6, cv-c^Scer\UAS.cDa (Pilgram et al., 2011) neuromuscular junction (with cv-c^C524) (Pilgram et al., 2011) neuromuscular junction (with cv-c^M62) (Pilgram et al., 2011) posterior crossvein (Denholm et al., 2005, Pilgram et al., 2011) posterior crossvein (with cv-c^M62) (Denholm et al., 2005) t-bar (Pilgram et al., 2011)
Detailed Description
	Statement Reference Most of the posterior crossvein is missing in homozygous cv-c[1] mutants. The remnant of the posterior crossvein is detached, it does not reach the fourth and fifth longitudinal wing veins. The posterior crossvein appears normal in cv-c[1] heterozygotes. Miniature excitatory junction potentials (mEJPs) recorded at third instar larval neuromuscular junctions of homozygous cv-c[1] mutants are not significantly different from that of wild-type larvae. The amplitudes of excitatory junction potentials (EJPs) evoked by stimulation at 0.3 Hz and recorded at third instar larval neuromuscular junctions of homozygous cv-c[1] and heterozygous cv-c[1]/+ or trans-heterozygous cv-c[1]/cv-c[C524] and cv-c[1]/cv-c[M62] mutants are significantly increased above control levels. As a result, quantal content (QC) is about 70% higher than the QC in the wild-type control. Expression of cv-c[Scer\UAS.cDa] in motoneurons under the control of Scer\GAL4[OK6] fails to rescue the abnormal quantal content (QC) phenotype of cv-c[1]/+ larvae. Expression of cv-c[Scer\UAS.cDa] in muscle under the control of Scer\GAL4[G14] rescues the abnormal quantal content (QC) phenotype of cv-c[1]/+ larvae. There is an increase in the number of T-bars at cv-c[1] mutant neuromuscular junctions relative to controls. (Pilgram et al., 2011) In the wings of cv-c¹ flies the posterior crossvein is completely absent and the anterior crossvein is detached from the fourth longitudinal vein. cv-c¹/cv-c^M62 wings display the same posterior crossvein phenotype. (Denholm et al., 2005) Posterior crossvein usually absent or greatly reduced. Anterior crossvein usually present but often detached. Eye flattened or with vertical shallow furrow. Legs weak, especially tarsal joints. Occasionally overlaps wild type. RK2.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference cv-c¹ has neurophysiology defective \| dominant phenotype, suppressible \| partially by Scer\GAL4^G14/Dys^GS12472 (Pilgram et al., 2011)
Other
Statement Reference Dys^E6, cv-c¹ has visible \| dominant phenotype (Pilgram et al., 2011)
Phenotype Manifest In
Suppressed by
Statement Reference cv-c¹ has neuromuscular junction phenotype, suppressible \| partially by Scer\GAL4^G14/Dys^GS12472 (Pilgram et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference Most of the posterior crossvein is missing in Dys[E6]/+, cv-c[1]/+ double heterozygotes. The remnant of the posterior crossvein is detached, it does not reach the fourth and fifth longitudinal wing veins. The increased quantal content (QC) measured at the neuromuscular junction of cv-c[1]/+ mutants is reduced as a result of expression of Dys[GS12472] under the control of Scer\GAL4[G14]. Heterozygosity for Cdc42[4] in a cv-c[1]/+ mutant background restores quantal content (QC) to wild-type levels. (Pilgram et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	cv-c¹ is rescued by Scer\GAL4^G14/cv-c^Scer\UAS.cDa (Pilgram et al., 2011)
Not rescued by	cv-c¹ is not rescued by Scer\GAL4^OK6/cv-c^Scer\UAS.cDa (Pilgram et al., 2011)
Comments	Expression of cv-c[Scer\UAS.cDa] in motoneurons under the control of Scer\GAL4[OK6] fails to rescue the abnormal quantal content (QC) phenotype of cv-c[1]/+ larvae. Expression of cv-c[Scer\UAS.cDa] in muscle under the control of Scer\GAL4[G14] rescues the abnormal quantal content (QC) phenotype of cv-c[1]/+ larvae. (Pilgram et al., 2011)
Stocks ( 24 )
Bloomington	473 cv-c¹ Sb^sbd-2 680 y¹; TM1, red¹ cv-c¹/TM2 472 w¹¹¹⁸; cv-c¹/TM3, Sb¹ Ser¹ 3524 y¹; Df(3R)Po2, cv-c¹/TM2; sv^spa-pol 3525 y¹; Df(3R)Po3, cv-c¹/TM2; sv^spa-pol 3526 y¹; Df(3R)Po4, cv-c¹/TM2; sv^spa-pol 3527 y¹; Df(3R)c(3)G-2, cv-c¹/TM2; sv^spa-pol
Kyoto	105929 cv-c¹ 108938 y¹; TM1, red¹ cv-c¹/TM2 107082 y¹; Df(3R)Po2, cv-c¹/TM2; sv^spa-pol 107083 y¹; Df(3R)Po3, cv-c¹/TM2; sv^spa-pol 107084 y¹; Df(3R)Po4, cv-c¹/TM2; sv^spa-pol
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Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	cv-c¹ (Pilgram et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Denholm et al., 2005, Development 132(10): 2389--2400 crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis. [FBrf0187455] Johannes and Preiss, 2002, Mech. Dev. 115(1-2): 3--14 Wing vein formation in Drosophila melanogaster: hairless is involved in the cross-talk between Notch and EGF signaling pathways. [FBrf0149093] Nelson and Szauter, 1992, Molec. gen. Genet. 235: 11--21 Cytogenetic analysis of chromosome region 89A of Drosophila melanogaster: isolation of deficiencies and mapping of Po, Aldox-1 and transposon insertions. [FBrf0057262]

Allele Dmel\cv-c1

Allele Dmel\cv-c¹