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General Information
Symbol
Dmel\DuoxCy
Species
D. melanogaster
Name
Curly
FlyBase ID
FBal0002196
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G2816443T

Amino acid change:

G1505C | Duox-PB; G1505C | Duox-PC

Reported amino acid change:

G1505C

Reported_genomic_loc:

2L_r6:2816443..2816443

Comment:

The nucleotide change is correct and the amino acid change is reversed between Duox[Cy] and Duox[K] in Figure 1B.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

(Amino acid change is revision of data in FBrf0230212).

Amino acid replacement: G1505C.

Nucleotide substitution: C?A.

Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Wing phenotype is additive with that of U1 and U2.

Wings curled upward; rarely overlaps wild type at 25oC, but frequently overlaps at 19oC. Curvature caused by the unequal contraction of the upper and lower epithelia during the drying period following emergence from the pupa case (Waddington, 1940). Flightless but thoracic innervation normal (Chiarodo, Reing and Saranchak, 1971). Expression decreased by larval crowding, increased by increased temperature during pupal development (Nozawa, 1956). Classifiable in single dose in triploids. Usually homozygous lethal but may emerge as dwarf with more extreme wing character. Effective lethal phase late embryo-early larva (Kidwell, 1972). Cy is readily revertable by both EMS and irradiation. In addition some balanced Cy chromosomes pick up suppressors of Cy in stock. RK1A.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

DuoxCy has phenotype, suppressible by Su(Cy)1

DuoxCy has phenotype, suppressible by Bl1

NOT suppressed by
Statement
Reference

DuoxCy has phenotype, non-suppressible by su(Hw)2

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Complementation test based on lethal phenotype.

Images (1)
Stocks (365)
Notes on Origin
Discoverer
Comments
Comments

The curly winged mutant phenotype can be suppressed by exposure to fluorescent light.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Curly
Secondary FlyBase IDs
    References (23)