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General Information
Symbol
Dmel\CycA3
Species
D. melanogaster
Name
FlyBase ID
FBal0002201
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(3)183, cycA183
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
A large deletion that removes the complete CycA locus and extends into flanking genes.
Deletion of CycA coding sequence.
Small deletion that removes cyclin sequences.
molecular deletion
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
CycA5/CycA3 embryos show a failure of epidermal cells to undergo mitosis 16.
In CycA3 mutant embryos, division of the NB6-4t lineage is arrested afer the first or second division. However, the first division of this lineage produces one glial cell and one neuronal cell as in wild-type.
Only one, two or three cells are found in the position of the NB7-3 clusters (8%, 75% and 17% respectively) compared to the four seen in wild-type.
In mutant embryos, two to four progeny cells of NB6-4T appear in each hemisegment, as opposed to the 5 to 6 cells seen in wild-type. In the abdominal segment of this mutant, more than half of NB6-4A divided once into 2 cells. The first cell division. the onset of glial differentiation and cell fate bifurcation occur normally in these embryos.
Mitosis is arrested during the 16th cell cycle. Cells are stillable to differentiate and dorsal medial cells carrying bilateral cytoplasmic extensions are clearly identifiable in late embryos. Scer\GAL4sim.PS-mediated expression of spis.Scer\UAS increases the number of dorsal medial cells, the implantation of one or two midline cells from these donors into CycA mutant embryos fails to induce additional dorsal medial cells.
In embryos double mutant for CycA3, no mitotic figures are observed at mitosis 15. BrdU incorporations reveal that the block is in the preceding G2.
CycAhari/CycA3 heterozygotes exhibit a 'hari' phenotype.
Entry into mitosis 16 does not occur in the mutant cells of the epidermis. Cells do not exhibit complete cell cycle arrest.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
CycA3/CycA[+] is a suppressor of partially lethal phenotype of dally06464
CycA3/CycA[+] is a suppressor | partially of partially lethal phenotype of dallyΔP-305
CycA3/CycA[+] is a suppressor | partially of visible phenotype of dally06464
CycA3 is a suppressor of visible phenotype of rux3
NOT Suppressor of
Statement
Reference
CycA3/CycA[+] is a non-suppressor of increased cell death phenotype of shtd1
Phenotype Manifest In
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference
CycA3 is an enhancer of wing phenotype of Scer\GAL4en-e16E, armUAS.cWa
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
CycA3/CycA[+] is a suppressor | partially of antenna phenotype of dally06464
CycA3/CycA[+] is a suppressor | partially of lamina anlage & mitotic cell cycle phenotype of dally06464
CycA3/CycA[+] is a suppressor of ommatidium phenotype of dally06464
CycA3/CycA[+] is a suppressor | partially of wing vein L5 phenotype of dally06464
CycA3 is a suppressor of eye phenotype of rux3
NOT Suppressor of
Statement
Reference
CycA3/CycA[+] is a non-suppressor of eye phenotype of shtd1
CycA3/CycA[+] is a non-suppressor of ommatidium phenotype of shtd1
Additional Comments
Genetic Interactions
Statement
Reference
The lethality seen in dally06464 homozygotes is completely suppressed if they are also heterozygous for CycA3. The penetrance of the eye, antenna and wing defects seen in dally06464 homozygotes is reduced if they are also heterozygous for CycA3. The severity of the dally06464 eye defects are also reduced in the double mutants. The lethality seen in dallyΔP-305 homozygotes is reduced if they are also heterozygous for CycA3. The ability of dally06464 lamina precursor neurons to enter a second division cycle is largely restored if they are also carrying CycA3.
No effect on the faf eye phenotype.
Dominantly restores 81% of ommatidia of rux3 to wild type.
The mitotic cycle phenotype can be rescued by heat shock induced expression of CycBhs.PK.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
This phenotype can be rescued by heat shock induced expression of CycAhs.PK.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
References (18)