Allele Dmel\CycA⁵

General Information
Symbol	Dmel\CycA⁵	Species	D. melanogaster
Name		FlyBase ID	FBal0002203
Feature type	allele	Created / Updated	2006-05-14/2006-05-14
Associated gene	Dmel\CycA

Allele class
Mutagen	P-element activity, PM hybrid dysgenesis
Nature of the Allele
Allele class
Mutagen	P-element activity (Cooley et al., 1988, Lehner and O'Farrell, 1989, Berg and Spradling, 1991) PM hybrid dysgenesis (Smith et al., 1993)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P element insertion
Assay mode
Caused by insertion	P{hsneo}CycA⁵ (Cooley et al., 1988, Lehner and O'Farrell, 1989, Smith et al., 1993, de Nooij et al., 2000, Berg and Spradling, 1991, Lehner et al., 1991)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Lehner and O'Farrell, 1989, Cooley et al., 1988, Berg and Spradling, 1991) mitotic cell cycle defective \| embryonic stage (Reber et al., 2006) mitotic cell cycle defective \| embryonic stage (with CycA³) (Reber et al., 2006)
Phenotype Manifest In
	embryonic/larval dorsal trunk (with Df(3L)vin3) (Beitel and Krasnow, 2000) embryonic/larval transverse connective (with Df(3L)vin3) (Beitel and Krasnow, 2000) ganglion mother cell GMC1-1a (Lear et al., 1999) ganglion mother cell GMC4-2a (Lear et al., 1999) EL neuron (Lear et al., 1999) embryonic epidermis (Reber et al., 2006) embryonic epidermis (with CycA³) (Reber et al., 2006)
Detailed Description
	Statement Reference Expression of dap^GMR.PdN transgene in CycA⁵ flies has no effect on the eye phenotype. (de Nooij et al., 1996) In mutant embryos, the ganglion mother cells, GMC1-1a and GMC4-2a fail to divide into their normal progeny. The non-dividing GMC1-1a and GMC4-2a cells are larger than normal and sit where its offspring should normally be and appear to adopt aCC and RP2 neuron fates respectively. A loss of approximately 20% of EL neurons is also seen. (Lear et al., 1999) Tracheal branches in many CycA⁵/Df(3L)vin3 embryos form with half the normal number of cells, yet have normal diameters and lengths. (Beitel and Krasnow, 2000) CycA[5] and CycA[5]/CycA[3] embryos show a failure of epidermal cells to undergo mitosis 16. (Reber et al., 2006)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference CycA⁵ is an enhancer of visible \| recessive phenotype of CycE^JP (Secombe et al., 1998)
NOT Enhancer of
Statement Reference CycA⁵ is a non-enhancer of visible phenotype of Dp^GMR.PD, E2f^GMR.PD (Staehling-Hampton et al., 1999) CycA⁵ is a non-enhancer of mitotic cell cycle defective \| maternal effect phenotype of png¹⁰⁵⁸/png³³¹⁸ (Lee et al., 2001) CycA⁵ is a non-enhancer of mitotic cell cycle defective \| maternal effect phenotype of png¹⁰⁵⁸ (Lee et al., 2001)
Suppressor of
Statement Reference CycA⁵ is a suppressor of visible phenotype of rux³ (Thomas et al., 1994) CycA[+]/CycA⁵ is a suppressor \| partially of visible phenotype of dally⁰⁶⁴⁶⁴ (Nakato et al., 2002) CycA[+]/CycA⁵ is a suppressor \| partially of lethal \| partially phenotype of dally⁰⁶⁴⁶⁴ (Nakato et al., 2002) CycA⁵ is a suppressor of hyperplastic phenotype of wts^e26-1 (Tao et al., 1999) CycA⁵ is a suppressor of hyperplastic phenotype of wts^P8 (Tao et al., 1999)
NOT Suppressor of
Statement Reference CycA⁵ is a non-suppressor of visible phenotype of Dp^GMR.PD, E2f^GMR.PD (Staehling-Hampton et al., 1999)
Other
Statement Reference CycA⁵, CycB^unspecified has mitotic cell cycle defective phenotype (Meyer et al., 2002, Meyer et al., 2002)
Phenotype Manifest In
Enhancer of
Statement Reference CycA⁵ is an enhancer of eye phenotype of CycE^JP (Secombe et al., 1998)
Suppressor of
Statement Reference CycA[+]/CycA⁵ is a suppressor of aster & cycle 5 embryo phenotype of CycB^+t10 (Ji et al., 2002) CycA[+]/CycA⁵ is a suppressor of aster & cycle 6 embryo phenotype of CycB^+t10 (Ji et al., 2002) CycA[+]/CycA⁵ is a suppressor of aster & cycle 7 embryo phenotype of CycB^+t10 (Ji et al., 2002) CycA[+]/CycA⁵ is a suppressor of cycle 14 embryo phenotype of CycB^+t10 (Ji et al., 2002) CycA⁵ is a suppressor of eye phenotype of rux³ (Thomas et al., 1994) CycA⁵ is a suppressor of phenotype of rux⁹ (Gonczy et al., 1994) CycA[+]/CycA⁵ is a suppressor \| partially of antenna phenotype of dally⁰⁶⁴⁶⁴ (Nakato et al., 2002) CycA[+]/CycA⁵ is a suppressor of ommatidium phenotype of dally⁰⁶⁴⁶⁴ (Nakato et al., 2002) CycA[+]/CycA⁵ is a suppressor \| partially of wing vein L5 phenotype of dally⁰⁶⁴⁶⁴ (Nakato et al., 2002) CycA⁵ is a suppressor of phenotype of rux^unspecified (Gonczy et al., 1994) CycA⁵ is a suppressor of eye phenotype of wts^P8 (Tao et al., 1999)
Other
Statement Reference CycA⁵, CycB^unspecified has cell cycle phenotype (Meyer et al., 2002, Meyer et al., 2002) CycA⁵, CycB^unspecified has embryonic dorsal epidermis \| lateral phenotype (Meyer et al., 2002, Meyer et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference Lowering the dose of CycA rescues the rux germline phenotype. (Gonczy et al., 1994) Dominantly restores 81% of ommatidia of rux³ to wild type. (Thomas et al., 1994) Dominantly enhances the rough eye phenotype of CycE^JP homozygotes. One copy of CycA⁵ has no effect on the reduction in the number of cells entering S phase posterior to the morphogenetic furrow seen in CycE^JP homozygotes. One copy of CycA⁵ enhances the reduction in the number of mitotic cells posterior to the morphogenetic furrow seen in CycE^JP homozygotes. (Secombe et al., 1998) Dominantly suppresses the phenotype of wts^P8 or wts^e26-1 homozygotes. (Tao et al., 1999) Cells in the dorsolateral epidermis arrest prematurely in G2 of cycle 15 in CycA⁵/CycB^unspecified embryos. The nuclear density in these embryos is also halved. (Meyer et al., 2002) The lethality seen in dally⁰⁶⁴⁶⁴ homozygotes is reduced if they are also heterozygous for CycA⁵. The penetrance of the eye, antenna and wing defects seen in dally⁰⁶⁴⁶⁴ homozygotes is reduced if they are also heterozygous for CycA⁵. (Nakato et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	CycA^j3C8 (BDGP Project Members, 1994-1999)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	A. Spradling. Cooley et al.

Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	cycA⁵ (Nakato et al., 2002, Lear et al., 1999) CycA⁵ cycA^ne0114 (Beitel and Krasnow, 2000) CycA^neo17 cycA^neo114 (Ji et al., 2002, de Nooij et al., 2000, Salzberg et al., 1994, Thomas et al., 1994) CycA^neo114 (Meyer et al., 2002, Pritchard and Schubiger, 1996, Edgar et al., 1994, Corbin et al., 1991, Reber et al., 2006) cycA^neo114e (de Nooij et al., 1996) CycA^neo (Zraly et al., 2004) cyclin A^neo114 (Tao et al., 1999) cyclinA^neo114e (Staehling-Hampton et al., 1999) l(3)neo17 (Lee et al., 2001, Beaton, 1999.12.12, ) l(3)neo114 (Smith et al., 1993, Lehner et al., 1991) neo17 (Berg and Spradling, 1991) neo114 (Lehner and O'Farrell, 1989, )
Name Synonym
Secondary FlyBase IDs
	FBal0002205
References ( 32 )

Generate a list of	All references relating to this allele ( 32 )

List References by type	Research paper ( 29 ) Personal communication to FlyBase ( 2 ) Computer file ( 1 )
Recent research papers ( 1 )
	Reber et al., 2006, Development 133(16): 3201--3211 Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25. [FBrf0195204] Show all research papers ...

Allele Dmel\CycA5

Allele Dmel\CycA⁵