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General Information
Symbol
Dmel\CycA5
Species
D. melanogaster
Name
FlyBase ID
FBal0002203
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cycAneo114, l(3)neo114
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P element insertion

Insertion components
P{hsneo}CycA5
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

CycA5 and CycA5/CycA3 embryos show a failure of epidermal cells to undergo mitosis 16.

Tracheal branches in many CycA5/Df(3L)vin3 embryos form with half the normal number of cells, yet have normal diameters and lengths.

In mutant embryos, the ganglion mother cells, GMC1-1a and GMC4-2a fail to divide into their normal progeny. The non-dividing GMC1-1a and GMC4-2a cells are larger than normal and sit where its offspring should normally be and appear to adopt aCC and RP2 neuron fates respectively. A loss of approximately 20% of EL neurons is also seen.

Expression of dapGMR.PdN transgene in CycA5 flies has no effect on the eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

CycA[+]/CycA5 is a suppressor of increased cell death phenotype of shtd1

CycA[+]/CycA5 is a suppressor | partially of partially lethal phenotype of dally06464

CycA[+]/CycA5 is a suppressor | partially of visible phenotype of dally06464

CycA5 is a suppressor of hyperplasia phenotype of wtse26-1

CycA5 is a suppressor of large body | pupal stage phenotype of wtse26-1

CycA5 is a suppressor of hyperplasia phenotype of wtsP8

CycA5 is a suppressor of visible phenotype of rux3

NOT Suppressor of
Statement
Reference

CycA5 is a non-suppressor of visible phenotype of DpGMR.PD, E2f1GMR.PD

Other
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

CycA[+]/CycA5 is a suppressor of eye phenotype of shtd1

CycA[+]/CycA5 is a suppressor of ommatidium phenotype of shtd1

CycA[+]/CycA5 is a suppressor of aster | embryonic cycle 5 phenotype of CycB+t10

CycA[+]/CycA5 is a suppressor of aster | embryonic cycle 6 phenotype of CycB+t10

CycA[+]/CycA5 is a suppressor of aster | embryonic cycle 7 phenotype of CycB+t10

CycA[+]/CycA5 is a suppressor of mitotic domain 1 | embryonic cycle 14 phenotype of CycB+t10

CycA[+]/CycA5 is a suppressor of ommatidium phenotype of dally06464

CycA[+]/CycA5 is a suppressor | partially of wing vein L5 phenotype of dally06464

CycA[+]/CycA5 is a suppressor | partially of antenna phenotype of dally06464

CycA5 is a suppressor of pupa phenotype of wtse26-1

CycA5 is a suppressor of eye phenotype of wtsP8

CycA5 is a suppressor of phenotype of ruxunspecified

CycA5 is a suppressor of phenotype of rux9

CycA5 is a suppressor of eye phenotype of rux3

Other
Additional Comments
Genetic Interactions
Statement
Reference

Cells in the dorsolateral epidermis arrest prematurely in G2 of cycle 15 in CycA5/CycBunspecified embryos. The nuclear density in these embryos is also halved.

The lethality seen in dally06464 homozygotes is reduced if they are also heterozygous for CycA5. The penetrance of the eye, antenna and wing defects seen in dally06464 homozygotes is reduced if they are also heterozygous for CycA5.

Dominantly suppresses the phenotype of wtsP8 or wtse26-1 homozygotes.

Dominantly enhances the rough eye phenotype of CycEJP homozygotes. One copy of CycA5 has no effect on the reduction in the number of cells entering S phase posterior to the morphogenetic furrow seen in CycEJP homozygotes. One copy of CycA5 enhances the reduction in the number of mitotic cells posterior to the morphogenetic furrow seen in CycEJP homozygotes.

Lowering the dose of CycA rescues the rux germline phenotype.

Dominantly restores 81% of ommatidia of rux3 to wild type.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

A. Spradling.

Cooley et al.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (14)
References (35)