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General Information
Symbol
Dmel\D1
Species
D. melanogaster
Name
FlyBase ID
FBal0002210
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The aberration breakpoint is +2 to +5 kb 5' of the D transcription unit (where 0 indicates the translation start site).

Breakpoint maps 5' to the D transcription unit, within approximately 2-5kb of the transcription start site.

Caused by aberration
Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

D1/+ individuals have posterior alar lobe deletions.

Exhibits a dominant wing hinge phenotype.

D1 is lethal over both "Sai" alleles of mirr but other D alleles are viable, implying that this lethality is due to the 69D3-4 breakpoint of the D1 inversion. Dominant late pupal lethal interaction of D1 with eyD is probably not an integral aspect of the D phenotype as D4 and D5/D+;eyD/ey+ flies are viable. Viable when heterozygous with all lethal D alleles, the phenotype is the sum of the two D alleles.

Wings extended uniformly at 45o from body axis and elevated 30o above (occasionally sharply downcast and dragging). Alulae missing. Dorsocentrals and some other bristles reduced in number (Sturtevant, 1918; Plunkett, 1926). Head often deformed or split in postvertical region. Halteres turned down. Homozygous lethal. Nearly lethal in combination with eyD (Sobels, Kruijt and Spronk, 1951). Partially suppressed by sc alleles that remove postverticals (sc, sc4, sc6, sc7) but not by others (Df(1)ase-1, sc5) (Sturtevant). Classifiable in triploids. RK2A.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

D1 is an enhancer of visible phenotype of upd1GMR.PB

Phenotype Manifest In
NOT suppressed by
Statement
Reference

D1 has phenotype, non-suppressible by su(Hw)2

Enhancer of
Statement
Reference

D1 is an enhancer of eye phenotype of upd1GMR.PB

Additional Comments
Genetic Interactions
Statement
Reference

D1 is epistatic to Mpe1; Mpe1/D1 flies show the D1 phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (1)
Stocks (49)
Notes on Origin
Discoverer

Bridges, 3rd Jan. 1915.

It is possible that the D1 and D3 inversions reflect dominant mutations in the 'Sail' function of mirr (see mirrSaiD1 and mirrSaiD3).

Comments
Comments

There is some uncertainty in the designation of D1, D3 and "D9" as dominant D alleles. The wing phenotype of D3 (a protein null) is similar, if not identical, to D1 when assayed in outcrossed individuals; it is thus possible that the phenotype of D1 itself is not due to changes at the D locus. D protein is ectopically expressed in the wing discs of D1 individuals and reversion of D1 is associated with loss of D expression in the wing disc.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (15)