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General Information
Symbol
Dmel\da2
Species
D. melanogaster
Name
FlyBase ID
FBal0002215
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C10390920T

Reported nucleotide change:

C1085T

Amino acid change:

Q287term | da-PA; Q287term | da-PB; Q287term | da-PC; Q287term | da-PD

Reported amino acid change:

Q287term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q287term.

Nucleotide substitution: C1085T.

normal Southern

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Most ovarioles have no distinct interfollicle stalks in newly eclosed da2/dalyh females.

dalyh/da2 ovaries show multiple follicular defects, such as missing stalks, multicyst follicles and degeneration of late-stage cysts.

Homozygotes have no cpo expressed in PNS at any stage of development, though cpo continues to be expressed in the CNS and a cluster of cells round the posterior spiracle.

Interacts with RpII140wimp maternal effect.

apparent amorph; recessive lethal; lethal with da1, Df, or other lethal alleles

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

da[+]/da2 is a suppressor of lethal | female phenotype of SxlfP7B0

NOT Suppressor of
Statement
Reference

snf[+], da[+], snfJ210, da2 is a non-suppressor of lethal | female phenotype of SxlfP7B0

Other
Phenotype Manifest In
Enhancer of
Statement
Reference

da[+]/da2 is an enhancer of follicle cell phenotype of Egfrf3/Egfrt1

da[+]/da2 is an enhancer of follicle cell phenotype of brnfs.107/brnl.6P6

da[+]/da2 is an enhancer of follicle cell phenotype of brnfs.107

Other
Statement
Reference

Ras85De1B/Ras85D[+], da2 has follicle cell phenotype

Su(dx)[+]/Su(dx)2, da2 has follicle cell phenotype

da2, dx1/dx[+] has follicle cell phenotype

da2, grk3, grk3, grk[+] has follicle cell phenotype

da2, grk6, grk6, grk[+] has follicle cell phenotype

da2, hop2/hop[+] has follicle cell phenotype

da2, Raf7/phl[+] has follicle cell phenotype

da2, spi1/spi[+] has follicle cell phenotype

da2, spi3/spi[+] has follicle cell phenotype

Su(H)[+]/Su(H)1, da2 has follicle cell phenotype

da2, toc[-] has ovary phenotype

Additional Comments
Genetic Interactions
Statement
Reference

When da2 heterozygous mothers are crossed to SxlfP7B0/Y fathers only 53% of the expected SxlfP7B0/+ female progeny survive to adulthood.

Only 57% of the expected Sxlf1/+ daughters from da2/+ mothers survive to adulthood.

When mothers are heterozygous for both Df(3R)pps[1] and da2, there is a significant reduction in viability.

sev14/da2 double heterozygous females do not have follicular defects in the ovary.

da2 stl8-1204 double heterozygotes show severe morphological defects in all ovarioles.

Female SxlfP7B0/+ embryos are fully viable if their mothers are heterozygous for da2, but only 7% viable if their mothers are heterozygous for both da2 and snfJ210.

Transheterozygotes with toc alleles exhibit ovary defects.

Double heterozygotes of Nl1N-ts1 or Dl9 with da2 show ovarian defects as for mutant da genotypes: stalkless ovaries, compound egg chambers and no distinction between germarium and vitellarium. Double heterozygotes of mamIL113 with da2 show ovarian defects as for mutant da genotypes and doubly heterozygous N and Dl mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments

dalyh fails to complement da2 for follicle cell formation.

Lethality of da2/da7 or da1/da2 can be rescued by dahs.PSP, and females show same follicular phenotype as das22/da7.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (16)