FlyBase Allele Report: Dmel\da[2]

General Information

Symbol

Dmel\da²

Species

D. melanogaster

Name

FlyBase ID

FBal0002215

Feature type

allele

Associated gene

Dmel\da

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

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Help me choose

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Cummings and Cronmiller, 1994)

loss of function allele

(Grammont et al., 1997)

Mutagen

ethyl methanesulfonate

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point_mutation

2L:10,390,920..10,390,920 [+]

Nucleotide change:

C10390920T

Reported nucleotide change:

C1085T

Amino acid change:

Q287term | da-PA; Q287term | da-PB; Q287term | da-PC; Q287term | da-PD

Reported amino acid change:

Q287term

(Baker and Cronmiller, 2001)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Amino acid replacement: Q287term.

(Baker and Cronmiller, 2001)

Nucleotide substitution: C1085T.

(Baker and Cronmiller, 2001)

normal Southern

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with da¹)

(Cummings and Cronmiller, 1994)

lethal (with da⁷)

(Cummings and Cronmiller, 1994)

lethal | recessive

(Baker and Cronmiller, 2001, Cummings and Cronmiller, 1994)

Phenotype Manifest In

egg chamber (with da^lyh)

(Smith and Cronmiller, 2001)

ovary

(Cummings and Cronmiller, 1994)

stalk follicle cell (with da^lyh)

(Smith et al., 2002, Smith and Cronmiller, 2001)

Detailed Description

Statement

Reference

Most ovarioles have no distinct interfollicle stalks in newly eclosed da²/da^lyh females.

(Smith et al., 2002)

da^lyh/da² ovaries show multiple follicular defects, such as missing stalks, multicyst follicles and degeneration of late-stage cysts.

(Smith and Cronmiller, 2001)

Homozygotes have no cpo expressed in PNS at any stage of development, though cpo continues to be expressed in the CNS and a cluster of cells round the posterior spiracle.

(Bellen et al., 1992)

Interacts with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

apparent amorph; recessive lethal; lethal with da¹, Df, or other lethal alleles

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sxl^f1, da[+]/da² has partially lethal - majority die | dominant phenotype, enhanceable by Df(3R)pps¹/+

(Johnson et al., 2010)

Sxl^f1, da[+]/da² has partially lethal - majority die | dominant phenotype, enhanceable by pps^+tJa/Df(3R)pps¹/+

(Johnson et al., 2010)

Enhancer of

Statement

Reference

da[+]/da² is an enhancer | maternal effect of partially lethal | female | maternal effect phenotype of Sxl[+]/Sxl^fP7B0, snf^J210

(Stitzinger et al., 1999)

Suppressor of

Statement

Reference

da[+]/da² is a suppressor of lethal | female phenotype of Sxl^fP7B0

(Stitzinger et al., 1999)

NOT Suppressor of

Statement

Reference

snf[+], da[+], snf^J210, da² is a non-suppressor of lethal | female phenotype of Sxl^fP7B0

(Stitzinger et al., 1999)

Other

Statement

Reference

Sxl[+]/Sxl^fP7B0, da² has partially lethal | female | parental effect phenotype

(Guo et al., 2018)

Sxl^f1, da[+]/da² has partially lethal - majority die | dominant phenotype

(Johnson et al., 2010)

Sxl^fP7B0, da[+]/da² has viable | female phenotype

(Stitzinger et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

da[+]/da² is an enhancer of follicle cell phenotype of Egfr^f3/Egfr^t1

(Smith et al., 2002)

da[+]/da² is an enhancer of follicle cell phenotype of brn^fs.107/brn^l.6P6

(Smith et al., 2002)

da[+]/da² is an enhancer of follicle cell phenotype of brn^fs.107

(Smith et al., 2002)

Other

Statement

Reference

Stat92E⁰⁶³⁴⁶, da² has follicle cell phenotype

(Smith et al., 2002)

da², dx¹ has follicle cell phenotype

(Smith et al., 2002)

da², dx^S1M has follicle cell phenotype

(Smith et al., 2002)

Dsor1[+]/Dsor1^S-1221, da² has follicle cell phenotype

(Smith et al., 2002)

Ras85D^e1B/Ras85D[+], da² has follicle cell phenotype

(Smith et al., 2002)

Sos^e4G/Sos[+], da² has follicle cell phenotype

(Smith et al., 2002)

Stat92E[+]/Stat92E⁰⁶³⁴⁶, da² has follicle cell phenotype

(Smith et al., 2002)

Su(dx)[+]/Su(dx)², da² has follicle cell phenotype

(Smith et al., 2002)

da², drk[+], drk^e0A, drk^e0A has follicle cell phenotype

(Smith et al., 2002)

da², grk⁶/grk⁶ has follicle cell phenotype

(Smith et al., 2002)

da², dx¹/dx[+] has follicle cell phenotype

(Smith et al., 2002)

da², dx^S1M/dx[+] has follicle cell phenotype

(Smith et al., 2002)

da², grk³, grk³, grk[+] has follicle cell phenotype

(Smith et al., 2002)

da², grk⁶, grk⁶, grk[+] has follicle cell phenotype

(Smith et al., 2002)

da², hop²/hop[+] has follicle cell phenotype

(Smith et al., 2002)

da², Raf⁷/phl[+] has follicle cell phenotype

(Smith et al., 2002)

da², pnt[+]/pnt⁰⁷⁸²⁵ has follicle cell phenotype

(Smith et al., 2002)

da², rl[+]/rl^S-135 has follicle cell phenotype

(Smith et al., 2002)

da², rl[+]/rl^Sem has follicle cell phenotype

(Smith et al., 2002)

da², spi¹/spi[+] has follicle cell phenotype

(Smith et al., 2002)

Su(dx)², da² has follicle cell phenotype

(Smith et al., 2002)

da², spi³/spi[+] has follicle cell phenotype

(Smith et al., 2002)

Su(H)[+]/Su(H)¹, da² has follicle cell phenotype

(Smith et al., 2002)

da², rl^Sem has follicle cell phenotype

(Smith et al., 2002)

da², spi¹ has follicle cell phenotype

(Smith et al., 2002)

da², hop² has follicle cell phenotype

(Smith et al., 2002)

da², pnt⁰⁷⁸²⁵ has follicle cell phenotype

(Smith et al., 2002)

da², drk^e0A/drk^e0A has follicle cell phenotype

(Smith et al., 2002)

da², spi³ has follicle cell phenotype

(Smith et al., 2002)

da², rl^S-135 has follicle cell phenotype

(Smith et al., 2002)

da², Raf⁷ has follicle cell phenotype

(Smith et al., 2002)

Dsor1^S-1221, da² has follicle cell phenotype

(Smith et al., 2002)

Ras85D^e1B, da² has follicle cell phenotype

(Smith et al., 2002)

Su(H)¹, da² has follicle cell phenotype

(Smith et al., 2002)

Sos^e4G, da² has follicle cell phenotype

(Smith et al., 2002)

da², grk³/grk³ has follicle cell phenotype

(Smith et al., 2002)

da[+]/da², stl^8-1204 has ovariole phenotype

(Smith and Cronmiller, 2001)

da², stl^8-1204 has ovariole phenotype

(Smith and Cronmiller, 2001)

da², toc[-] has ovary phenotype

(Grammont et al., 1997)

N^l1N-ts1, da² has ovary phenotype

(Cummings and Cronmiller, 1994)

Dl⁹, da² has ovary phenotype

(Cummings and Cronmiller, 1994)

da², mam^IL113 has ovary phenotype

(Cummings and Cronmiller, 1994)

Additional Comments

Genetic Interactions

Statement

Reference

When da² heterozygous mothers are crossed to Sxl^fP7B0/Y fathers only 53% of the expected Sxl^fP7B0/+ female progeny survive to adulthood.

(Guo et al., 2018)

Only 57% of the expected Sxl^f1/+ daughters from da²/+ mothers survive to adulthood.

When mothers are heterozygous for both Df(3R)pps[1] and da², there is a significant reduction in viability.

(Johnson et al., 2010)

sev¹⁴/da² double heterozygous females do not have follicular defects in the ovary.

(Smith et al., 2002)

da² stl^8-1204 double heterozygotes show severe morphological defects in all ovarioles.

(Smith and Cronmiller, 2001)

Female Sxl^fP7B0/+ embryos are fully viable if their mothers are heterozygous for da², but only 7% viable if their mothers are heterozygous for both da² and snf^J210.

(Stitzinger et al., 1999)

Transheterozygotes with toc alleles exhibit ovary defects.

(Grammont et al., 1997)

Double heterozygotes of N^l1N-ts1 or Dl⁹ with da² show ovarian defects as for mutant da genotypes: stalkless ovaries, compound egg chambers and no distinction between germarium and vitellarium. Double heterozygotes of mam^IL113 with da² show ovarian defects as for mutant da genotypes and doubly heterozygous N and Dl mutants.

(Cummings and Cronmiller, 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

da^lyh

(Smith and Cronmiller, 2001)

Comments

da^lyh fails to complement da² for follicle cell formation.

(Smith and Cronmiller, 2001)

Lethality of da²/da⁷ or da¹/da² can be rescued by da^hs.PSP, and females show same follicular phenotype as da^s22/da⁷.

(Cummings and Cronmiller, 1994)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

da²

(Guo et al., 2018, Johnson et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (16)

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