Allele Dmel\da³

General Information
Symbol	Dmel\da³	Species	D. melanogaster
Name		FlyBase ID	FBal0002216
Feature type	allele	Associated gene	Dmel\da

Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference normal Southern
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive
Phenotype Manifest In
	dorsal row \| somatic clone (Jafar-Nejad et al., 2006) intestinal stem cell \| somatic clone (Bardin et al., 2010) trichome of the posterior wing margin \| somatic clone (Jafar-Nejad et al., 2006) ventral row \| somatic clone (Jafar-Nejad et al., 2006)
Detailed Description
	Statement Reference Homozygous intestinal stem cell clones fail to grow and are composed of single or pairs of differentiated enterocyte cells. (Bardin et al., 2010) da³ clones in the wing result in the loss of both anterior and posterior wing margin bristles. (Jafar-Nejad et al., 2006)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference da³ is a suppressor of lethal \| somatic clone phenotype of emc^AP6 (Bhattacharya and Baker, 2011)
Phenotype Manifest In
Enhancer of
Statement Reference da[+]/da³ is an enhancer of interommatidial bristle \| cold sensitive phenotype of wg^ts.sev (Cadigan et al., 2002)
Suppressor of
Statement Reference da³ is a suppressor of eye disc \| somatic clone phenotype of emc^AP6 (Bhattacharya and Baker, 2011) da³ is a suppressor of eye disc anterior to the morphogenetic furrow \| somatic clone phenotype of emc^AP6 (Bhattacharya and Baker, 2011) da³ is a suppressor of morphogenetic furrow \| somatic clone phenotype of emc^AP6 (Bhattacharya and Baker, 2011)
Other
Statement Reference Scer\GAL4^tub.PU, da³, sens^Scer\UAS.cNa has adult thorax & microchaeta \| somatic clone phenotype (Jafar-Nejad et al., 2006) Scer\GAL4^tub.PU, da³, sens^Scer\UAS.cNa has eo neuron \| somatic clone phenotype (Jafar-Nejad et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference da[3]/emc[AP6] double mutant eye disc clones survive in a non-minute background but lack neuronal differentiation. Neither ectopic neuronal differentiation ahead of the furrow nor ectopic morphogenetic furrow initiation from the eye margins is observed. (Bhattacharya and Baker, 2011) Thoracic clones that express sens^Scer\UAS.cNa, under the control of Scer\GAL4^tub, in a da³ background results in clones that lack microchaetae. No neurons are observed in these clones. (Jafar-Nejad et al., 2006) da³ dominantly enhances the loss of eye bristles seen in flies carrying wg^ts.sev at 17.6^oC. (Cadigan et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	da¹
Rescued by	da³ is rescued by da^+t8.8 (Bhattacharya and Baker, 2011)
Comments	Fails to complement deficiencies for da and other lethal da alleles.
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	da³ (Jafar-Nejad et al., 2006, Bardin et al., 2010, Bhattacharya and Baker, 2011)
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Bhattacharya and Baker, 2011, Cell 147(4): 881--892 A Network of Broadly Expressed HLH Genes Regulates Tissue-Specific Cell Fates. [FBrf0216641] Bardin et al., 2010, Development 137(5): 705--714 Transcriptional control of stem cell maintenance in the Drosophila intestine. [FBrf0209974] Jafar-Nejad et al., 2006, Development 133(9): 1683--1692 Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. [FBrf0190299] Jafar-Nejad et al., 2003, Genes Dev. 17(23): 2966--2978 Senseless acts as a binary switch during sensory organ precursor selection. [FBrf0167609] Cadigan et al., 2002, Development 129(14): 3393--3402 Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless. [FBrf0151912] Cronmiller and Cummings, 1993, Mech. Dev. 42(3): 159--169 The daughterless gene product in Drosophila is a nuclear protein that is broadly expressed throughout the organism during development. [FBrf0058994] Cronmiller and Cline, 1987, Cell 48: 479--487 The Drosophila sex determination gene daughterless has different functions in the germ line versus the soma. [FBrf0045764]

Allele Dmel\da3

Allele Dmel\da³