FB2020_01, released Feb 12, 2020

Allele: Dmel\da3

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General Information
Symbol
Dmel\da3
Species
D. melanogaster
Name
FlyBase ID
FBal0002216
Feature type
allele
Associated gene
Dmel\da
Associated Insertion(s)
Carried in Construct
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

Mutagen
ethyl methanesulfonate
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      normal Southern

      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous intestinal stem cell clones fail to grow and are composed of single or pairs of differentiated enterocyte cells.

      (Bardin et al., 2010)

      da3 clones in the wing result in the loss of both anterior and posterior wing margin bristles.

      (Jafar-Nejad et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      da3 is a suppressor of lethal | somatic clone phenotype of emcAP6

      (Bhattacharya and Baker, 2011)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      da[+]/da3 is an enhancer of interommatidial bristle | cold sensitive phenotype of wgts.sev

      (Cadigan et al., 2002)
      Suppressor of
      Other
      Statement
      Reference

      Scer\GAL4Tub.PU, da3, sensUAS.cNa has adult thorax & microchaeta | somatic clone phenotype

      (Jafar-Nejad et al., 2006)

      Scer\GAL4Tub.PU, da3, sensUAS.cNa has eo neuron | somatic clone phenotype

      (Jafar-Nejad et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      da3/emcAP6 double mutant eye disc clones survive in a non-minute background but lack neuronal differentiation. Neither ectopic neuronal differentiation ahead of the furrow nor ectopic morphogenetic furrow initiation from the eye margins is observed.

      (Bhattacharya and Baker, 2011)

      Thoracic clones that express sensScer\UAS.cNa, under the control of Scer\GAL4tub, in a da3 background results in clones that lack microchaetae. No neurons are observed in these clones.

      (Jafar-Nejad et al., 2006)

      da3 dominantly enhances the loss of eye bristles seen in flies carrying wgts.sev at 17.6oC.

      (Cadigan et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      da1

      Rescued by

      da3 is rescued by da+t8.8

      (Bhattacharya and Baker, 2011)
      Comments

      Fails to complement deficiencies for da and other lethal da alleles.

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      da3
      (Li and Baker, 2018, Bhattacharya and Baker, 2011, Bardin et al., 2010, Jafar-Nejad et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)