A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\Dfd1

General Information
SymbolDmel\Dfd1SpeciesD. melanogaster
NameFlyBase IDFBal0002374
Feature typealleleCreated / Updated2006-05-15/2006-05-15
Associated geneDmel\Dfd
Allele classgain of function
Mutagenspontaneous
hide Nature of the Allele
Allele class
gain of function
(Chadwick et al., 1990)
Mutagen
spontaneous
 
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      Large transposon flanked insertion downstream of the Dfd transcription unit.
      (McGinnis et al., 1990)
      50kb insertion within 1kb of the 3' end of the Dfd transcription unit that is flanked by multiple copies of roo elements. Also a duplication of the fourth and fifth Dfd exons on the distal side of the transposon flanked insertion.
      (Chadwick et al., 1990)
      Assay mode
      Caused by insertion
      ?{}Dfd1
      (McGinnis et al., 1990)
      Carried on aberration
      Payne-DS
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 1998.8.25)
      Payne-Dc
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 1998.8.25)
      Payne-D
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 1998.8.25)
      Cytology
      Polytene chromosomes normal.
       
      hide Phenotypic Data
      hide Phenotypic Class
      viable
      (McGinnis and Kaufman, 2002.2.18)
      visible | dominant
      (McGinnis et al., 1990, McGinnis et al., 1990, Chadwick et al., 1990, Regulski et al., 1987, Saget et al., 1998)
      hide Phenotype Manifest In
      ocellus & adult
      (McGinnis et al., 1990)
      head bristle | ectopic
      (Saget et al., 1998)
      adult head
      (Saget et al., 1998)
      head bristle
      (Saget et al., 1998)
      hide Detailed Description
      Statement
      Reference
      dominant Eyes reduced ventrally and anteriorly, or furrowed. Vibrissae tufted. Extremely variable, often overlapping wild type, but usually excellent character with Ly or at 19oC. Classifiable in single dose in triploids (Schultz, 1934). Muller reported an occasional homozygote as extreme dwarf with flimsy wings. RK2.
       
      Adult head defects.
      (Regulski et al., 1987)
      Adults have ventral eye and orbital tissue missing.
      (McGinnis et al., 1990)
      Loss of ventral eye and orbital regions in the adult head. Head defects phenocopied by Dfdhs.PK constructs and heat-shock constructs of the human Hox4.2 in cells of the eye disc during third larval instar development.
      (McGinnis et al., 1990)
      Adult head deformations: lower eye and orbital structures are absent. Homozygotes have bulbous growths in the place of missing eye tissue, these may be duplications of the second antennal segment.
      (Chadwick et al., 1990)
      Heterozygous males have ectopic antero-ventral bristles on the head.
      (Saget et al., 1998)
      hide Interactions
      hide Phenotypic Class
      hideEnhanced by
      Statement
      Reference
      Dfd1 has visible phenotype, enhanceable by M(3)65F1
      (Sinclair et al., 1981)
      hideOther
      Statement
      Reference
      Dfd[+]/Dfd1, M(3)801 has lethal | pharate adult stage | dominant | conditional - heat sensitive phenotype
      (Sinclair et al., 1981)
      Dfd1, mxcG46 has visible | recessive phenotype
      (Saget et al., 1998)
      Dfd1, mxcG46 has visible | dominant phenotype
      (Saget et al., 1998)
      Dfd1, M(3)80[+]/M(3)801 has lethal | pharate adult stage | dominant | conditional - heat sensitive phenotype
      (Sinclair et al., 1981)
      Dfd[+]/Dfd1, mxcM1 has visible | recessive phenotype
      (Saget et al., 1998)
      Dfd1, mxcG43 has visible | dominant phenotype
      (Saget et al., 1998)
      Dfd1, mxcM1 has visible | dominant phenotype
      (Saget et al., 1998)
      hide Phenotype Manifest In
      hideEnhanced by
      Statement
      Reference
      Dfd1 has eye phenotype, enhanceable by M(3)65F1
      (Sinclair et al., 1981)
      Dfd1 has adult head phenotype, enhanceable by M(3)65F1
      (Sinclair et al., 1981)
      Dfd1 has phenotype, enhanceable by apt09049
       
      hideOther
      Statement
      Reference
      Dfd1, mxcG46 has adult head phenotype
      (Saget et al., 1998, Saget et al., 1998)
      Dfd1, M(3)80[+]/M(3)801 has head phenotype
      (Sinclair et al., 1981)
      Dfd[+]/Dfd1, mxcM1 has arista phenotype
      (Saget et al., 1998)
      Dfd[+]/Dfd1, mxcM1 has eye phenotype
      (Saget et al., 1998)
      Dfd[+]/Dfd1, mxcM1 has maxillary palpus phenotype
      (Saget et al., 1998)
      Dfd1, mxcG43 has adult head phenotype
      (Saget et al., 1998)
      Dfd1, mxcM1 has arista phenotype
      (Saget et al., 1998)
      Dfd1, mxcM1 has eye phenotype
      (Saget et al., 1998)
      Dfd1, mxcM1 has maxillary palpus phenotype
      (Saget et al., 1998)
      Dfd1, qedS140V has vibrissae phenotype
      (Florence, 1999.7.22)
      Dfd1, qed1 has vibrissae phenotype
      (Florence, 1999.7.22)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      The Dfd1 eye phenotype is enhanced by M(3)65F1. Dfd1/M(3)801 double heterozygotes survive at 22oC but not at 29oC. At 29oC, the double heterozygotes pupate, but die as pharate adults that fail to eclose and lack most head structures.
      (Sinclair et al., 1981)
      Hemizygous mxcM1 males have normal eyes. mxcM1/Y Dfd1/+ males have no aristae, and the maxillary palps and eyes are extremely reduced. mxcG46/Y Dfd1/+ and mxcG43/Y Dfd1/+ males have head defects.
      (Saget et al., 1998)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 24 )
      Bloomington
      800
      Dfd1 pp
      2341
      Dfd1/TM3, Sb1
      4071
      T(3;4)Dubinin/In(3R)P, Dfd1
      891
      T(3;4)c/In(3R)P, Dfd1 ca1
      632
      wk1/In(3R)P, Dfd1 ca1
      487
      Dl11/In(3R)P, Dfd1 ca1
      488
      Dl12/In(3R)P, Dfd1 ca1
      495
      dwh1/In(3R)P, Dfd1 ca1
      1714
      Df(3R)M86D, Dfd1 pp/TM3, Ser1
      2213
      ftz6 Dfd1 pp/TM3, Sb1
      Kyoto
      105937
      Dl12/In(3R)P, Dfd1 ca1
      106467
      Df(3R)M86D, Dfd1 pp/TM3, Ser1
      hide Notes on Origin
      Discoverer
      Cattell, July 1913.
      hide Synonyms & Secondary IDs ( 4 )
      Reported As
      Symbol Synonym
      Dfd
      (Sinclair et al., 1981)
      Dfd1
       
      DfdD
      (Saget et al., 1998, Chadwick et al., 1990, McGinnis et al., 1990, McGinnis et al., 1990, Regulski et al., 1987)
      unnamed
      (Hazelrigg and Kaufman, 1983)
      Name Synonym
      Secondary FlyBase IDs
      • FBal0029316
      • FBal0038714
      hide References ( 16 )
      Research paper
      Saget et al., 1998, Genetics 149(4): 1823--1838
      Needs and targets for the multi sex combs gene product in Drosophila melanogaster. [FBrf0103357]
      McCarron et al., 1994, Genetics 136(3): 1013--1023
      Drosophila P element transposase induces male recombination additively and without a requirement for P element excision or insertion. [FBrf0073864]
      Chadwick et al., 1990, Dev. Biol. 141(10): 130--140
      Ectopic expression from the Deformed gene triggers a dominant defect in Drosophila adult head development. [FBrf0051503]
      McGinnis et al., 1990, Cell 63: 969--976
      Human Hox-4.2 and Drosophila Deformed encode similar regulatory specificities in Drosophila embryos and larvae. [FBrf0051400]
      Regulski et al., 1987, EMBO J. 6: 767--777
      Developmental and molecular analysis of Deformed; a homeotic gene controlling Drosophila head development. [FBrf0046135]
      Hazelrigg and Kaufman, 1983, Genetics 105: 581--600
      Revertants of dominant mutations associated with the Antennapedia gene complex of Drosophila melanogaster: Cytology and genetics. [FBrf0039462]
      Scott et al., 1983, Cell 35: 763--776
      The molecular organization of the Antennapedia locus of Drosophila. [FBrf0039012]
      Sinclair et al., 1981, Genetics 97(34): 581--606
      Genetic and developmental analysis of a temperature-sensitive Minute mutation of Drosophila melanogaster. [FBrf0036530]
      Schultz, 1934, D. I. S. 1: 55--56
      The manifestation of dominants in the triploid. [FBrf0002742]
      Bridges and Morgan, 1923, Publs Carnegie Instn 327: 1--251
      The third-chromosome group of mutant characters of Drosophila melanogaster. [FBrf0001261]
      Review
      McGinnis et al., 1990, Adv. Genet. 27: 363--402
      Establishment and maintenance of position-specific expression of the Drosophila homeotic selector gene Deformed. [FBrf0051116]
      Personal communication to FlyBase
      McGinnis and Kaufman, 2002.2.18, Dfd<up>1</up> is homozygous viable.
      Dfd<up>1</up> is homozygous viable. [FBrf0145638]
      Florence, 1999.7.22, Notes from Brian Florence.
      Notes from Brian Florence. [FBrf0109188]
      Bloomington Drosophila Stock Center, 1998.8.25, Variants of Payne.
      Variants of Payne. [FBrf0104711]
      FlyBase analysis
      FlyBase Curators, 2006-, Balancer summary information.
      Balancer summary information. [FBrf0189689]
      Book
      Morgan et al., 1925, Biblphia Genet. 2: 262pp
      The genetics of Drosophila melanogaster. [FBrf0001379]