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General Information
Symbol
Dmel\Dfd1
Species
D. melanogaster
Name
FlyBase ID
FBal0002374
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
DfdD
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
insertion site
Comment:

Dfd1 is a 50kb insertion flanked by multiple roo elements that falls within 1kb of the 3' end of the Dfd transcription unit.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

50kb insertion within 1kb of the 3' end of the Dfd transcription unit that is flanked by multiple copies of roo elements. Also a duplication of the fourth and fifth Dfd exons on the distal side of the transposon flanked insertion.

Large transposon flanked insertion downstream of the Dfd transcription unit.

Insertion components
?{}Dfd1
Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes have head defects, including reduced eyes and ectopic maxillary palps behind the antenna (20% penetrance for the ectopic maxillary palp phenotype).

Heterozygous males have ectopic antero-ventral bristles on the head.

Adult head deformations: lower eye and orbital structures are absent. Homozygotes have bulbous growths in the place of missing eye tissue, these may be duplications of the second antennal segment.

Adults have ventral eye and orbital tissue missing.

Loss of ventral eye and orbital regions in the adult head. Head defects phenocopied by Dfdhs.PK constructs and heat-shock constructs of the human Hox4.2 in cells of the eye disc during third larval instar development.

Adult head defects.

dominant Eyes reduced ventrally and anteriorly, or furrowed. Vibrissae tufted. Extremely variable, often overlapping wild type, but usually excellent character with Ly or at 19oC. Classifiable in single dose in triploids (Schultz, 1934). Muller reported an occasional homozygote as extreme dwarf with flimsy wings. RK2.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Dfd1 has visible phenotype, enhanceable by M(3)65F1

Suppressed by
Statement
Reference

Dfd1 has visible | dominant phenotype, suppressible by MED192/MED19[+]

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

Dfd1 has eye phenotype, enhanceable by M(3)65F1

Dfd1 has adult head phenotype, enhanceable by M(3)65F1

Dfd1 has phenotype, enhanceable by apt09049

Suppressed by
Statement
Reference

Dfd1 has maxillary palpus | ectopic phenotype, suppressible by MED192/MED19[+]

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The ectopic maxillary palp phenotype seen in Dfd1/+ flies is fully suppressed by MED192/+.

Hemizygous mxcM1 males have normal eyes. mxcM1/Y Dfd1/+ males have no aristae, and the maxillary palps and eyes are extremely reduced. mxcG46/Y Dfd1/+ and mxcG43/Y Dfd1/+ males have head defects.

The Dfd1 eye phenotype is enhanced by M(3)65F1. Dfd1/M(3)801 double heterozygotes survive at 22oC but not at 29oC. At 29oC, the double heterozygotes pupate, but die as pharate adults that fail to eclose and lack most head structures.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (16)
Notes on Origin
Discoverer

Cattell, July 1913.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0029316
  • FBal0038714
References (17)