A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\Dfd1

General Information
SymbolDmel\Dfd1SpeciesD. melanogaster
NameFlyBase IDFBal0002374
Feature typealleleAssociated geneDmel\Dfd
Also Known AsDfdD
Map ( GBrowse ) GBrowse View Helpdetailed view FBal0002374
Allele classgain of function allele
Mutagenspontaneous
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Description
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FB2013_03
FB2013_02
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hide Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
insertion site
evidence=experimental
comment=Dfd1 is a 50kb insertion flanked by multiple roo elements that falls within 1kb of the 3' end of the Dfd transcription unit.
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
50kb insertion within 1kb of the 3' end of the Dfd transcription unit that is flanked by multiple copies of roo elements. Also a duplication of the fourth and fifth Dfd exons on the distal side of the transposon flanked insertion.
Large transposon flanked insertion downstream of the Dfd transcription unit.
Caused by insertion
Carried on aberration
Cytology
Polytene chromosomes normal.
 
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Statement
Reference
Heterozygous males have ectopic antero-ventral bristles on the head.
Adult head deformations: lower eye and orbital structures are absent. Homozygotes have bulbous growths in the place of missing eye tissue, these may be duplications of the second antennal segment.
Adults have ventral eye and orbital tissue missing.
Loss of ventral eye and orbital regions in the adult head. Head defects phenocopied by Dfdhs.PK constructs and heat-shock constructs of the human Hox4.2 in cells of the eye disc during third larval instar development.
Adult head defects.
dominant Eyes reduced ventrally and anteriorly, or furrowed. Vibrissae tufted. Extremely variable, often overlapping wild type, but usually excellent character with Ly or at 19oC. Classifiable in single dose in triploids (Schultz, 1934). Muller reported an occasional homozygote as extreme dwarf with flimsy wings. RK2.
 
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Linkouts
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hideEnhanced by
Statement
Reference
Dfd1 has visible phenotype, enhanceable by M(3)65F1
hideOther
Statement
Reference
Dfd[+]/Dfd1, M(3)801 has lethal | dominant | pharate adult stage | heat sensitive phenotype
Dfd[+]/Dfd1, mxcM1 has visible | recessive phenotype
Dfd1, M(3)80[+]/M(3)801 has lethal | dominant | pharate adult stage | heat sensitive phenotype
hide Phenotype Manifest In
hideEnhanced by
Statement
Reference
Dfd1 has adult head phenotype, enhanceable by M(3)65F1
Dfd1 has eye phenotype, enhanceable by M(3)65F1
Dfd1 has phenotype, enhanceable by apt09049
 
hideOther
Statement
Reference
Dfd[+]/Dfd1, mxcM1 has arista phenotype
Dfd[+]/Dfd1, mxcM1 has eye phenotype
Dfd1, M(3)80[+]/M(3)801 has head phenotype
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hide Genetic Interactions
Statement
Reference
Hemizygous mxcM1 males have normal eyes. mxcM1/Y Dfd1/+ males have no aristae, and the maxillary palps and eyes are extremely reduced. mxcG46/Y Dfd1/+ and mxcG43/Y Dfd1/+ males have head defects.
The Dfd1 eye phenotype is enhanced by M(3)65F1. Dfd1/M(3)801 double heterozygotes survive at 22oC but not at 29oC. At 29oC, the double heterozygotes pupate, but die as pharate adults that fail to eclose and lack most head structures.
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Statement
Reference
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Comments
hide Stocks ( 18 )
Bloomington
Kyoto
hide Notes on Origin
Discoverer
Cattell, July 1913.
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Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym
Dfd1
 
Name Synonym
Secondary FlyBase IDs
  • FBal0029316
  • FBal0038714
hide References ( 16 )
Research paper
Saget et al., 1998, Genetics 149(4): 1823--1838
Needs and targets for the multi sex combs gene product in Drosophila melanogaster. [FBrf0103357]
McCarron et al., 1994, Genetics 136(3): 1013--1023
Drosophila P element transposase induces male recombination additively and without a requirement for P element excision or insertion. [FBrf0073864]
Chadwick et al., 1990, Dev. Biol. 141(10): 130--140
Ectopic expression from the Deformed gene triggers a dominant defect in Drosophila adult head development. [FBrf0051503]
McGinnis et al., 1990, Cell 63: 969--976
Human Hox-4.2 and Drosophila Deformed encode similar regulatory specificities in Drosophila embryos and larvae. [FBrf0051400]
Regulski et al., 1987, EMBO J. 6: 767--777
Developmental and molecular analysis of Deformed; a homeotic gene controlling Drosophila head development. [FBrf0046135]
Hazelrigg and Kaufman, 1983, Genetics 105: 581--600
Revertants of dominant mutations associated with the Antennapedia gene complex of Drosophila melanogaster: Cytology and genetics. [FBrf0039462]
Scott et al., 1983, Cell 35: 763--776
The molecular organization of the Antennapedia locus of Drosophila. [FBrf0039012]
Sinclair et al., 1981, Genetics 97(34): 581--606
Genetic and developmental analysis of a temperature-sensitive Minute mutation of Drosophila melanogaster. [FBrf0036530]
Schultz, 1934, D. I. S. 1: 55--56
The manifestation of dominants in the triploid. [FBrf0002742]
Bridges and Morgan, 1923, Publs Carnegie Instn 327: 1--251
The third-chromosome group of mutant characters of Drosophila melanogaster. [FBrf0001261]
Review
McGinnis et al., 1990, Adv. Genet. 27: 363--402
Establishment and maintenance of position-specific expression of the Drosophila homeotic selector gene Deformed. [FBrf0051116]
Personal communication to FlyBase
McGinnis and Kaufman, 2002.2.18, Dfd<up>1</up> is homozygous viable.
Dfd1 is homozygous viable. [FBrf0145638]
Florence, 1999.7.22, Notes from Brian Florence.
Notes from Brian Florence. [FBrf0109188]
Bloomington Drosophila Stock Center, 1998.8.25, Variants of Payne.
Variants of Payne. [FBrf0104711]
FlyBase analysis
FlyBase Curators, 2006-, Balancer summary information.
Balancer summary information. [FBrf0189689]
Book
Morgan et al., 1925, Biblphia Genet. 2: 262pp
The genetics of Drosophila melanogaster. [FBrf0001379]