Open Close
General Information
Symbol
Dmel\Dfd3
Species
D. melanogaster
Name
FlyBase ID
FBal0002376
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
DfdrC11
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T6801152A

Reported nucleotide change:

T?A

Amino acid change:

F414I | Dfd-PA

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Nucleotide substitution: T?A. Amino acid replacement: I?F. Amino acid subsitution occurs at position 49 of the homeodomain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Dfd13/Dfd3 flies reared at 29oC reach adulthood at a rate of approximately 50% that of wild type.

Dfd3/Dfd13 transheterozygotes have reduced viability of about 50%.

Homozygous embryos exhibit truncated lateralgraten and medially split T-ribs. Heterozygotes with Dfd13 have reduced viability and adults exhibit an intermediate phenotype.

Individuals raised at the restrictive temperature during postembryonic development display failure of suboesophageal ganglion (SEG) and thoracic ganglion (TG) to separate. There is not a discrete temperature sensitive period for SEG-TG separation. Salivary glans are found located tangled in the midthorax and in the neck. Heterozygotes with Dfd9 display a range of maxillary palp defects. Mild defects shpw a decrease in the palp size, are immobile and have reduced numbers of mechanosensory bristles. Moderate defects include missing one palp and severe defects include having both palps missing.

Mouth hook material is not in wild type position: defects in structures derived from the maxillary, mandibular and premandibular regions of the embryonic head.

temperature-sensitive

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference

Dfd3 has phenotype, enhanceable by LanA3A1

Dfd3 has phenotype, enhanceable by LanA4A8

Dfd3 has phenotype, enhanceable by LanA6A1

Dfd3 has phenotype, enhanceable by LanA6A52

Dfd3 has phenotype, enhanceable by cncVL110

Dfd3 has phenotype, enhanceable by dfc5A54

Dfd3 has phenotype, enhanceable by dfcC1

Dfd3 has phenotype, enhanceable by hh5A7

Dfd3 has phenotype, enhanceable by mor4A3

Dfd3 has phenotype, enhanceable by slsC138

Additional Comments
Genetic Interactions
Statement
Reference

The survival of Dfd13/Dfd3 hypomorphs is reduced if they are also carrying Ser5A29, SerRX106 or Serrev6-1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Cain.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)