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General Information
Symbol
Dmel\Dfd13
Species
D. melanogaster
Name
FlyBase ID
FBal0002386
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
DfdrV8
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G6792327A

Amino acid change:

M1I | Dfd-PA

Comment:

Initiator methionine codon mutated. Tranlation thought to start at next available methionine at codon 6.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Nucleotide substitution: G3A. G3 falls in the initiator methionine; initiation is presumed to start at codon 6.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The midline of the adult brain is intact in Dfd13/Df(3R)Scr hemizygotes. The retractor muscles of the rostrum of the proboscis are missing.

Dfd13/Dfd3 flies reared at 29oC reach adulthood at a rate of approximately 50% that of wild type.

Dfd3/Dfd13 transheterozygotes have reduced viability of about 50%.

Heterozygotes with Dfd3 have reduced viability and adults exhibit an intermediate phenotype.

Viable. Failure of suboesophageal ganglion (SEG) and thoracic ganglion (TG) to separate.

Mouth hook material is not in wild type position: defects in structures derived from the maxillary, mandibular and premandibular regions of the embryonic head. Heterozygotes with other Dfd alleles at 29oC give adult survivors with mutant head phenotypes in varying degrees of severity.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference

Dfd13 has phenotype, enhanceable by LanA3A1

Dfd13 has phenotype, enhanceable by LanA4A8

Dfd13 has phenotype, enhanceable by LanA6A1

Dfd13 has phenotype, enhanceable by LanA6A52

Dfd13 has phenotype, enhanceable by cncVL110

Dfd13 has phenotype, enhanceable by dfc5A54

Dfd13 has phenotype, enhanceable by dfcC1

Dfd13 has phenotype, enhanceable by hh5A7

Dfd13 has phenotype, enhanceable by mor4A3

Dfd13 has phenotype, enhanceable by slsC138

Additional Comments
Genetic Interactions
Statement
Reference

The survival of Dfd13/Dfd3 hypomorphs is reduced if they are also carrying Ser5A29, SerRX106 or Serrev6-1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Merrill.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (8)