Allele Dmel\Dfd^rv1

General Information
Symbol	Dmel\Dfd^rv1	Species	D. melanogaster
Name		FlyBase ID	FBal0002390
Feature type	allele	Associated gene	Dmel\Dfd
Also Known As	Dfd^RX1

Allele class	amorphic allele - genetic evidence
Mutagen	X ray
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Jack et al., 1988, Zeng et al., 1994)
Mutagen	X ray (Chadwick et al., 1990)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Dfd¹ (Regulski et al., 1987, Chadwick et al., 1990)
Nature of the lesion	Statement Reference Transposition of the first two exons from the full length Dfd transcription unit to 98F. Transposon flanked insertion and duplicated Dfd exons remain unchanged. (Chadwick et al., 1990)
Caused by aberration	Tp(3;3)Dfd^rv1 (Regulski et al., 1987, Yun et al., 1994)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Regulski et al., 1987) lethal \| recessive (Chadwick et al., 1990)
Phenotype Manifest In

Detailed Description
	Statement Reference No change in the spatial distribution of ae mRNA. (Roder et al., 1992) Phenotypic reversion of the dominant phenotype. (Chadwick et al., 1990) Loss of mouth hooks and cirri, ventral plates are partially duplicated in the anterior atrium replacing the H piece and lateral graten. (McGinnis et al., 1990) Larval atrium is transformed to pharynx. (Jack et al., 1988) Dfd^rv1/Df(3R)Scr individuals exhibit variable head defects: loss of pattern elements derived from the maxillary and mandibular segments, but no developmental defects in the thorax or abdomen. The head displays a duplication of a cuticular element of the larval head skeleton. (Regulski et al., 1987)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 10 )
Bloomington	1975 Df(3R)M86D, Dp(3;3)Dfd^rv1, Dfd^rv1 p^p Doa¹⁰/TM3, Sb¹ 1982 Df(3R)Tpl3, Dp(3;3)Dfd^rv1, kni^ri-1 Dfd^rv1 p^p Doa¹⁰/TM3, Sb¹ 1986 Df(3R)Tpl9, Dp(3;3)Dfd^rv1, kni^ri-1 Dfd^rv1 p^p Doa¹⁰/TM3, Sb¹ 1984 Df(3R)Tpl6, Dp(3;3)Dfd^rv1, kni^ri-1 Dfd^rv1 p^p Doa¹⁰/TM6B, Tb¹ 1990 Df(3R)Tpl10, Dp(3;3)Dfd^rv1, kni^ri-1 Dfd^rv1 p^p Doa¹⁰/TM3, Sb¹
Kyoto	106610 Df(3R)M86D, Dp(3;3)Dfd^rv1, Dfd^rv1 p^p Doa¹⁰/TM3, Sb¹ 106617 Df(3R)Tpl9, Dp(3;3)Dfd^rv1, kni^ri-1 Dfd^rv1 p^p Doa¹⁰/TM3, Sb¹ 106616 Df(3R)Tpl6, Dp(3;3)Dfd^rv1, kni^ri-1 Dfd^rv1 p^p Doa¹⁰/TM6B, Tb¹ 106729 Df(3R)Tpl10, Dp(3;3)Dfd^rv1, kni^ri-1 Dfd^rv1 p^p Doa¹⁰/TM3, Sb¹ 106614 Df(3R)Tpl3, Tp(3;3)Dfd^rv1, kni^ri-1 Dfd^rv1 p^p Doa¹⁰/TM3, Sb¹ Ser¹
Notes on Origin
Discoverer	Hazelrigg.
	Revertant.
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Dfd^+RX1 Dfd^rv1 Dfd^RX1 (Gould et al., 1997, Haerry and Gehring, 1997, Yun et al., 1994, Roder et al., 1992, Bergson and McGinnis, 1990, Chadwick et al., 1990, McGinnis et al., 1990, Jack et al., 1988, Regulski et al., 1987) Dfd^Rx1 (Lou et al., 1995, Zeng et al., 1994)
Name Synonym
Secondary FlyBase IDs

References ( 11 )
Research paper	Gould et al., 1997, Genes Dev. 11(7): 900--913 Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns. [FBrf0098982] Haerry and Gehring, 1997, Dev. Biol. 186(1): 1--15 A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax. [FBrf0093491] Lou et al., 1995, Nucleic Acids Res. 23(17): 3481--3487 Deformed expression in the Drosophila central nervous system is controlled by an autoactivated intronic enhancer. [FBrf0084148] Yun et al., 1994, Genes Dev. 8(10): 1160--1173 The Doa locus encodes a member of a new protein kinase family and is essential for eye and embryonic development in Drosophila melanogaster. [FBrf0074875] Zeng et al., 1994, EMBO J. 13(10): 2362--2377 Deformed protein binding sites and cofactor binding sites are required for the function of a small segment-specific regulatory element in Drosophila embryos. [FBrf0074891] Roder et al., 1992, Development 115(4): 1017--1033 The role of the teashirt gene in trunk segmental identity in Drosophila. [FBrf0055836] Bergson and McGinnis, 1990, EMBO J. 9(4): 4287--4297 An autoregulatory enhancer element of the Drosophila homeotic gene Deformed. [FBrf0051666] Chadwick et al., 1990, Dev. Biol. 141(10): 130--140 Ectopic expression from the Deformed gene triggers a dominant defect in Drosophila adult head development. [FBrf0051503] Jack et al., 1988, Genes Dev. 2: 635--651 Pair-rule segmentation genes regulate the expression of the homeotic selector gene, Deformed. [FBrf0048119] Regulski et al., 1987, EMBO J. 6: 767--777 Developmental and molecular analysis of Deformed; a homeotic gene controlling Drosophila head development. [FBrf0046135]
Review	McGinnis et al., 1990, Adv. Genet. 27: 363--402 Establishment and maintenance of position-specific expression of the Drosophila homeotic selector gene Deformed. [FBrf0051116]

Allele Dmel\Dfdrv1

Allele Dmel\Dfd^rv1