Allele Dmel\disco³

General Information
Symbol	Dmel\disco³	Species	D. melanogaster
Name		FlyBase ID	FBal0002450
Feature type	allele	Associated gene	Dmel\disco

Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Steller et al., 1987)
Mutagen	ethyl methanesulfonate (Steller et al., 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	behavior defective (Sakai and Ishida, 2001) mating rhythm defective \| female limited (Sakai and Ishida, 2001) viable (Steller et al., 1987) visual behavior defective \| recessive (Steller et al., 1987)
Phenotype Manifest In

Detailed Description
	Statement Reference When wild-type flies are moved from a LD cycle to a DD cycle, at CT12 (circadian time) there is a reduction in mating activity seen. This reduction is abolished in per⁰¹ mutants. This effect is seen if mutant females are mated with either wild-type or mutant males. If mutant males are crossed with wild-type females, no phenotype is seen. (Sakai and Ishida, 2001) Viable. Adult eye and optic lobes have defects. The unconnected phenotype exhibits photoreceptors that degenerate with age, disorganized muscle tissue fills the space normally occupied by optic ganglia: flies are blind. The connected phenotype exhibits photoreceptor axons that innervate the optic ganglia, structure is disorganized and distinguishable from wild type. Extensive degeneration of photoreceptor cells becomes apparent in the form of dark spots on the compound eye. (Steller et al., 1987) reduced viability.
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Steller.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	disco³
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Sakai and Ishida, 2001, Proc. Natl. Acad. Sci. U.S.A. 98(16): 9221--9225 Circadian rhythms of female mating activity governed by clock genes in Drosophila. [FBrf0137348] Dowse et al., 1989, Behav. Genet. 19(4): 529--542 High-resolution analysis of locomotor activity rhythms in disconnected, a visual system mutant of Drosophila melanogaster. [FBrf0049221] Steller et al., 1987, Cell 50: 1139--1153 Disconnected: a locus required for neuronal pathway formation in the visual system of Drosophila. [FBrf0045748]

Allele Dmel\disco3

Allele Dmel\disco³