Allele Dmel\Dl³

General Information
Symbol	Dmel\Dl³	Species	D. melanogaster
Name		FlyBase ID	FBal0002460
Feature type	allele	Associated gene	Dmel\Dl

Allele class	loss of function allele
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Long et al., 1996)
Mutagen	spontaneous
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Shepard et al., 1989) visible (Schultz, 1929) visible \| dominant (Tian et al., 2004)
Phenotype Manifest In
	aCC neuron (Skeath and Doe, 1998) crossvein (Schultz, 1929) dMP2 neuron (Skeath and Doe, 1998) neuroblast (Skeath and Doe, 1998) pCC neuron (Skeath and Doe, 1998) posterior crossvein (Tian et al., 2004) RP2 motor neuron (Skeath and Doe, 1998) RP2sib neuron (Skeath and Doe, 1998) U neuron (Skeath and Doe, 1998) Usib neuron (Skeath and Doe, 1998) vMP2 neuron (Skeath and Doe, 1998, Spana and Doe, 1996) wing vein L2 (Tian et al., 2004) wing vein L2 \| distal (Tian et al., 2004) wing vein L4 (Tian et al., 2004) wing vein L5 \| distal (Tian et al., 2004)
Detailed Description
	Statement Reference Heterozygous flies show a mild vein thickening along the length and at the distal tip of wing vein L2, bifurcation of the posterior crossvein at its junction with vein L5, thickening of vein L5 at the distal tip and a thickening of vein L4 at its junction with the anterior crossvein. (Tian et al., 2004) The RP2 motoneuron duplicated at the expense of the RP2sib. The aCC motoneuron is duplicated at the expense of the pCC interneuron. The Usib fates are duplicated at the expense of the U neurons. The dMP2 is duplicated at the expense of the vMP2. No change was observable in EL cell fate. This phenotype is the reciprocal of that shown for numb mutants. Mutant embryos show excess neuroblast formation characteristic of neurogenic mutants. (Skeath and Doe, 1998) Assymetric division of all the MP2 precursors formed is not altered, but the smaller vMP2 is transformed to the dMP2 fate. In numb¹ Dl³ double mutants all MP2 neurons develop as dMP2. (Spana and Doe, 1996) Individuals heterozygous for Bpt¹ and heterozygous for Dl³ exhibit no Bpt¹ phenotype. (Duus et al., 1992) Lethal or semi-lethal when in combination with large deficiency alleles of E(spl) or Df(3R)Espl3. suppressor Extragenic suppressor of the N^spl-1-E(spl)¹ interaction. (Shepard et al., 1989) Dl³ shows similar although less severe phenotypes to Dl¹. In contrast to Dl¹, Dl³ shows a thickening at the crossveins. (Schultz, 1929) Like Dl¹ but deltas at margin are slight; longitudinal veins between anterior and posterior crossveins and crossveins themselves are thickened. Spreading of wing slighter than in Dl¹. Better viability than Dl¹. homozygous lethal. RK1.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Dl³ has visible \| dominant phenotype, enhanceable by lqf[+]/lqf^ARI (Tian et al., 2004)
Enhancer of
Statement Reference Dl³ is an enhancer of visible phenotype of Myt1^GMR.PP (Price et al., 2002)
Suppressor of
Statement Reference Dl³ is a suppressor of visible phenotype of os^GMR.PB (Mukherjee et al., 2006)
Other
Statement Reference Df(2R)M58F, Dl³ has partially lethal - majority die \| dominant phenotype (Schultz, 1929) Dl³, M(2)31A[+]/M(2)31A¹ has viable phenotype (Schultz, 1929) Dl³, M(3)96CF¹ has lethal \| dominant phenotype (Schultz, 1929) Dl³, M(3)99E¹/M(3)99E[+] has viable phenotype (Schultz, 1929) Dl³, RpS3[+]/RpS3¹ has viable phenotype (Schultz, 1929) Dl³/Dl[+], e(r)^27-1 has partially lethal - majority die phenotype (Tsubota et al., 2011) Dl³/Dl[+], M(2)31A¹ has viable phenotype (Schultz, 1929) Dl³/Dl[+], M(3)96CF¹ has lethal \| dominant phenotype (Schultz, 1929) Dl³/Dl[+], M(3)99E¹ has viable phenotype (Schultz, 1929) Dl³/Dl[+], RpS3¹ has viable phenotype (Schultz, 1929)
Phenotype Manifest In
Enhanced by
Statement Reference Dl³ has posterior crossvein phenotype, enhanceable by lqf[+]/lqf^ARI (Tian et al., 2004) Dl³ has wing vein L2 \| distal phenotype, enhanceable by lqf[+]/lqf^ARI (Tian et al., 2004) Dl³ has wing vein L2 phenotype, enhanceable by lqf[+]/lqf^ARI (Tian et al., 2004) Dl³ has wing vein L4 phenotype, enhanceable by lqf[+]/lqf^ARI (Tian et al., 2004) Dl³ has wing vein L5 \| distal phenotype, enhanceable by lqf[+]/lqf^ARI (Tian et al., 2004)
Suppressed by
Statement Reference Dl³ has phenotype, suppressible by S¹ (Schultz, 1929) Dl³ has wing vein phenotype, suppressible by sno^71e3 (Coyle-Thompson and Banerjee, 1993)
NOT suppressed by
Statement Reference Dl³ has phenotype, non-suppressible by Dp(2;3)P (Schultz, 1929)
Enhancer of
Statement Reference Dl³/Dl[+] is an enhancer of cardioblast \| supernumerary phenotype of lqf^ARI (Tian et al., 2004) Dl³ is an enhancer of eye phenotype of Myt1^GMR.PP (Price et al., 2002)
Suppressor of
Statement Reference Dl³ is a suppressor of eye phenotype of os^GMR.PB (Mukherjee et al., 2006)
Other
Statement Reference Dl³, stl[+]/stl⁴ has ovariole phenotype (Ozdowski et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference 96.1% of stl[4]/+ ; Dl[3]/+ ovarioles have compound or morphologically disrupted follicles. (Ozdowski et al., 2009) Heterozygosity for Dl³ increases the frequency of lqf^ARI embryos that show an excess cardioblast phenotype at 18^oC. lqf^ARI dominantly enhances the expressivity and penetrance of all Dl³/+ wing vein phenotypes. (Tian et al., 2004) The confluens phenotype of Dl³ is suppressed by sno^71e3. (Coyle-Thompson and Banerjee, 1993) Dl³ is viable in double heterozygous combination with RpS3¹, M(2)31A¹ or M(3)99E¹. (Schultz, 1929)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Dl^BE21 (Shepard et al., 1989) Dl^BE23 (Shepard et al., 1989) Dl^BE24 (Shepard et al., 1989) Dl^BE26 (Shepard et al., 1989) Dl^BE32 (Shepard et al., 1989) Dl^BE35 (Shepard et al., 1989) Dl^BX40 (Shepard et al., 1989) Dl^BX41 (Shepard et al., 1989) Dl^BX45 (Shepard et al., 1989) Dl^BX46 (Shepard et al., 1989) Dl^CE21 (Shepard et al., 1989) Dl^CE23 (Shepard et al., 1989) Dl^CE33 (Shepard et al., 1989) Dl^CE34 (Shepard et al., 1989) Dl^CE37 (Shepard et al., 1989) Dl^CE43 (Shepard et al., 1989)
Rescued by	Dl³ is rescued by Scer\GAL4^twi.PG/Dl^Scer\UAS.cJa (Lear et al., 1999)
Partially rescued by	Dl³ is partially rescued by Scer\GAL4^W381/Dl^Scer\UAS.cJa (Lear et al., 1999)
Comments
Stocks ( 2 )
Bloomington	483 Dl³/In(3R)C, e¹
Kyoto	105935 Dl³/In(3R)C, sprd¹ e¹
Notes on Origin
Discoverer	Bridges, 10th Dec. 1924.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	3 (Mukherjee et al., 2006) Dl³ (Babaoglan et al., 2009, Ozdowski et al., 2009, Tsubota et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 20 )
Research paper	Tsubota et al., 2011, Fly 5(4): 275--284 Interactions between enhancer of rudimentary and Notch and deltex reveal a regulatory function of enhancer of rudimentary in the Notch signaling pathway in Drosophila melanogaster. [FBrf0217950] Babaoglan et al., 2009, Development 136(24): 4089--4098 Sanpodo: a context-dependent activator and inhibitor of Notch signaling during asymmetric divisions. [FBrf0209326] Ozdowski et al., 2009, Genetics 183(3): 1027--1040 stall Encodes an ADAMTS Metalloprotease and Interacts Genetically With Delta in Drosophila Ovarian Follicle Formation. [FBrf0209377] Mukherjee et al., 2006, Genetics 172(3): 1683--1697 Identification of Drosophila genes modulating janus kinase/signal transducer and activator of transcription signal transduction. [FBrf0190752] Desbordes et al., 2005, Genetics 170(2): 749--766 A screen for genes regulating the wingless gradient in Drosophila embryos. [FBrf0187638] Tian et al., 2004, Development 131(23): 5807--5815 Epsin potentiates Notch pathway activity in Drosophila and C. elegans. [FBrf0180177] Price et al., 2002, Genetics 161(2): 721--731 Ectopic expression of the Drosophila Cdk1 inhibitory kinases, wee1 and myt1, interferes with the second mitotic wave and disrupts pattern formation during eye development. [FBrf0149024] Gurganus et al., 1999, Genetics 152(4): 1585--1604 High-resolution mapping of quantitative trait loci for sternopleural bristle number in Drosophila melanogaster. [FBrf0109835] Lear et al., 1999, Mech. Dev. 88(2): 207--219 Neural cell fate in rca1 and cycA mutants: the roles of intrinsic and extrinsic factors in asymmetric division in the Drosophila central nervous system. [FBrf0111940] Lyman and Mackay, 1998, Genetics 149(2): 983--998 Candidate quantitative trait loci and naturally occurring phenotypic variation for bristle number in Drosophila melanogaster. The Delta-Hairless gene region. [FBrf0102969] Skeath and Doe, 1998, Development 125(10): 1857--1865 Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS. [FBrf0102831] Long et al., 1996, Genetics 144(4): 1497--1510 Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster. [FBrf0091115] Spana and Doe, 1996, Neuron 17(1): 21--26 Numb antagonizes Notch signaling to specify sibling neuron cell fates. [FBrf0089976] Coyle-Thompson and Banerjee, 1993, Development 119(2): 377--395 The strawberry notch gene functions with Notch in common developmental pathways. [FBrf0068459] Duus et al., 1992, Dev. Biol. 151: 34--47 Blackpatch, a neural degeneration mutation that interacts with the Notch locus in Drosophila. [FBrf0055810] Alton et al., 1989, Dev. Genet. 10: 261--272 Molecular genetics of Delta, a locus required for ectodermal differentiation in Drosophila. [FBrf0049525] Shepard et al., 1989, Genetics 122: 429--438 A tripartite interaction among alleles of Notch, Delta, and Enhancer of split during imaginal development of Drosophila melanogaster. [FBrf0049904] Schultz, 1929, Genetics 14: 366--419 The Minute reaction in the development of Drosophila melanogaster. [FBrf0001812]
Book	Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044] Bridges and Brehme, 1944, Publs Carnegie Instn 552: vii + 257pp The mutants of Drosophila melanogaster. [FBrf0006100]

Allele Dmel\Dl3

Allele Dmel\Dl³