Point mutation.
Dl9P heterozygotes show a fully penetrant wing vein thickening phenotype and extra wing vein material phenotypes, as compared to controls.
Dl9P/+ flies display thickened wing veins (typically for veins L2 and L5).
Mutant embryos show a complete loss of pericardial cells and hematopoietic precursors, while cardioblast numbers are dramatically increased compared to wild type.
The accumulation of hemocytes is normal in the wings of heterozygous pupae, both at 22 and 26 hours after puparium formation.
Heterozygotes show wing vein thickening.
20% of heterozygotes have ectopic or duplicated macrochaetae.
In Dl9P homozygous embryos, the early steps of proventricular development including the formation of the ball-like evagination at the ectoderm/endoderm boundary occur normally. However, at stage 14, the anterior boundary cells of the keyhole region fail to invaginate into the endodermal cell layer, but arrest anteriorly and do not move inwards until the final stages of embryonic development (16 and 17). In addition, the posterior boundary cells of the endodermal component of the proventriculus rim collapses in these animals.
Heterozygotes display extra vein material particularly at the distal tip of veins.
Homozygous mutant somatic clones in the notum give a phenotype of adjacent bristles with no intervening epidermal cells. A band of mutant epidermis, that averages about 4.2 cells wide around the clone, have a wild-type phenotype.
Homozygous clones in the scutum produce a similar phenotype to homozygous DlRevF10 clones.
Heterozygotes with SerBd-3 are viable and exhibit a severe wing phenotype.
Instead of forming distinct invagination folds, the Dl mutant stomodeal nervous system anlage invaginates en masse.
Thickened vein mutant.
Hyperplasia of replicating sensory precursors: due to an increased number of ectodermal cells being recruited as sensory precursor cells.
In double mutant clones with Nl1N-ts1, both wild type and mutant bristles are formed along the mosaic borders, and occasionally a mutant and a wild type bristle are found adjacent to each other (which never happens in either single mutant). Homozygous NAx-59b mutant clones develop as epidermis, and this requires Dl function.
Clones in the thorax have an abnormal distribution of microchaetae and macrochaetae.
Increase in SMCs per cluster in embryos lacking the maternal product.
Mutant clones cause the differentiation of masses of adjacent microchaetae not separated by epidermal hairs. On the scutum cells adopt a neural fate. Mutant cells behave nonautonomously: cells produce epidermis only along the mosaic border where they are in contact with wild type cells.
Severe "abruptex" phenotype. Capable of rescuing the lethality conferred by all negatively complementing Ax heteroallelic combinations, individuals display an Ax, not wild type, phenotype.
Wing phenotype: wing vein 2 and the distal part of wing vein 5 are irregularly broadened. Other veins often form knots. All veins have pronounced deltas at the wing margin. Rough eye phenotype. Number of bristles in the thoracic segments is frequently increased.
Homozygous clones in the eye and the cuticle are cell lethal.
Extreme embryonic neurogenic phenotype.
extreme allele
Delta9P has visible phenotype, enhanceable by neurUAS.cLa/Scer\GAL4VMQ
Delta9P has visible phenotype, non-enhanceable by Scer\GAL4VMQ/neurαRING.UAS
Delta9P has FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone phenotype, suppressible by H2
Delta9P/Dl[+] is an enhancer of visible phenotype of Scer\GAL4A9, uifasterisk.UAS
Delta9P/Dl[+] is an enhancer of visible phenotype of Scer\GAL4lz-gal4, sensUAS.cNa
Delta9P/Dl[+] is an enhancer of visible phenotype of Scer\GAL4Tub.PU, cswN308D.UASp
Delta9P/Dl[+] is an enhancer of visible phenotype of Scer\GAL4ey.PH, brmK804R.UAS.Tag:HA
Delta9P is an enhancer of visible phenotype of Scer\GAL4sca-109-68, atoUAS.cJa
Delta9P is a suppressor of visible phenotype of upd1GMR.PB
Delta9P is a suppressor of visible phenotype of RetMEN2B.GMR
Delta9P is a suppressor of visible phenotype of RetMEN2A.GMR
Delta9P has macrochaeta phenotype, enhanceable by brm[+]/brm2
Delta9P has wing vein phenotype, enhanceable by neurUAS.cLa/Scer\GAL4VMQ
Delta9P has wing phenotype, enhanceable by E(Dl)F14[+]/E(Delta)F142
Delta9P has wing phenotype, enhanceable by E(Dl)F14[+]/E(Delta)F143
Delta9P has wing phenotype, enhanceable by E(Delta)F144/E(Dl)F14[+]
Delta9P has wing phenotype, enhanceable by E(Dl)F14[+]/E(Delta)F14KP77
Delta9P has wing phenotype, enhanceable by E(Delta)F14P/E(Dl)F14[+]
Delta9P has wing phenotype, enhanceable by E(Dl)F167[+]/E(Delta)F1671
Delta9P has wing phenotype, enhanceable by E(Dl)F25[+]/E(Delta)F251
Delta9P has wing phenotype, enhanceable by E(Dl)F42[+]/E(Delta)F421
Delta9P has wing phenotype, enhanceable by E(Delta)KP254P/E(Dl)KP254[+]
Delta9P has wing phenotype, enhanceable by E(Delta)KP420P
Delta9P has wing phenotype, enhanceable by PlexateD10/Px[+]
Delta9P has wing phenotype, enhanceable by Px[+]/PlexateD123
Delta9P has wing phenotype, enhanceable by E(Delta)9P39.31/E(Dl)9P39.3[+]
Delta9P has wing phenotype, enhanceable by E(Dl)9P39.8[+]/E(Delta)9P39.81
Delta9P has wing phenotype, enhanceable by E(Delta)D1651/E(Dl)D165[+]
Delta9P has wing phenotype, enhanceable by E(Delta)D721/E(Dl)D72[+]
Delta9P has wing phenotype, enhanceable by E(Delta)F101/E(Dl)F10[+]
Delta9P has wing phenotype, enhanceable by E(Delta)F141/E(Dl)F14[+]
Delta9P has wing vein phenotype, non-enhanceable by Scer\GAL4VMQ/neurαRING.UAS
Delta9P has wing phenotype, suppressible by Su(Delta)D1071/Su(Dl)D107[+]
Delta9P has wing phenotype, suppressible by Su(Delta)F1161/Su(Dl)F116[+]
Delta9P has eye | somatic clone phenotype, suppressible by H2
Delta9P has presumptive embryonic/larval central nervous system phenotype, suppressible by H2
Delta9P has embryonic epidermis phenotype, non-suppressible by bibUAS.cDa/Scer\GAL4h-1J3
Delta9P/Dl[+] is an enhancer of wing vein phenotype of Scer\GAL4A9, uifasterisk.UAS
Delta9P/Dl[+] is an enhancer of interommatidial bristle | ectopic phenotype of Scer\GAL4lz-gal4, sensUAS.cNa
Delta9P/Dl[+] is an enhancer of ommatidium phenotype of Scer\GAL4lz-gal4, sensUAS.cNa
Delta9P/Dl[+] is an enhancer of wing vein | ectopic phenotype of Scer\GAL4Tub.PU, cswN308D.UASp
Delta9P/Dl[+] is an enhancer of eye phenotype of Scer\GAL4ey.PH, brmK804R.UAS.Tag:HA
Delta9P/Dl[+] is an enhancer of ommatidium phenotype of Scer\GAL4ey.PH, brmK804R.UAS.Tag:HA
Delta9P/Dl[+] is an enhancer of macrochaeta phenotype of brm2
Delta9P is an enhancer of ommatidium phenotype of Gp150k11120b/Gp150P8
Delta9P is an enhancer of ommatidium phenotype of Gp150k11120b
Delta9P/Dl[+] is an enhancer of eye phenotype of ebi1-334.GMR
Delta9P is an enhancer of eye phenotype of Scer\GAL4sca-109-68, atoUAS.cJa
Delta9P is an enhancer of ommatidium phenotype of Scer\GAL4sca-109-68, atoUAS.cJa
Delta9P/Dl[+] is a suppressor of posterior crossvein phenotype of DgO86
Delta9P is a suppressor of eye phenotype of upd1GMR.PB
Delta9P is a suppressor of eye phenotype of RetMEN2B.GMR
Delta9P is a suppressor of eye phenotype of RetMEN2A.GMR
Delta9P/Dl[+], brm2 has ommatidium phenotype
Delta9P, brm2 has ommatidium phenotype
Delta9P, bru1QB/bru1PD has egg chamber phenotype
Delta9P, bru1QB/bru1PD has stalk follicle cell phenotype
Delta9P, frcNP0297 has anterior scutellar bristle phenotype
Delta9P, Scer\GAL4VMQ, neurUAS.cLa has wing phenotype
Delta9P, Df(1)sc-B57 has interstitial cell precursor phenotype
Delta9P, Df(1)sc-B57 has adult midgut progenitor cell phenotype
The wing vein phenotype resulting from the expression of uifasterisk.Scer\UAS under the control of Scer\GAL4A9 is enhanced by Dl9P.
Ovarioles in aretQB/aretQB ; Dl9P/+ females form a single large egg chambers with many germline cells. The fusome appears as dots. Most egg chambers have more than 16 germline cells in aretQB/aretPD ; Dl9P/+ ovaries. Three classes of abnormal egg chambers are seen, which are present in roughly equal numbers. In the first class, a large number of germline cells of roughly equal size are enveloped by a single epithelium of follicle cells. The remaining two classes arise from partial fusion of separate cysts; no stalk cells can be detected and the follicle cell layers of different egg chambers remain in contact with each other. In the "anterior/posterior fusion" class, a well-defined linear organisation within individual ovarioles is maintained, and adjacent egg chambers are fused with each other at their anterior and posterior boundaries. In the "random fusion" class, egg chambers are positioned irregularly and can be closely apposed to multiple different egg chambers on lateral as well as on anterior and posterior surfaces. In both the partial fusion classes, each egg chamber contains an oocyte. In the anterior/posterior fusion class the oocyte is present at the posterior of the cyst and in the random fusion class the oocyte is either lateral or posterior relative to the overall polarity of the ovariole.
The addition of Dl9P/+ to Gp150P8/Gp150k11120b animals increases the proportion of mutant ommatidia from 19.2% to 67.6%. The addition of Dl9P/+ to Gp150k11120b/+ animals increases the proportion of mutant ommatidia from 0.19% to 2.7%.
the addition of one copy of ebiE4 enhances the dominant wing vein phenotype seen in Dl9P/+ animals. The combination of ebi1-334.GMR and Dl9P/+ leads to flies with a significantly rough eye phenotype.
The combination of Dl9P and neurScer\UAS.cLa (when driven by Scer\GAL4VMQ) produces a blistered wing phenotype.
The combination of Dl9P and neurScer\UAS.cLa ( when driven by Scer\GAL4VMQ) produces a blistered wing phenotype.
Enhances the rough eye phenotype caused by expression of atoScer\UAS.cJa under the control of Scer\GAL4sca-109-68.
The cuticle defect of homozygous embryos is not rescued by bibScer\UAS.cDa expressed under the control of Scer\GAL4h-1J3.
Double mutants with Df(1)sc-B57 have normal midgut epithelium, but the large basophilic midgut cells are missing and the number of adult midgut precursor cells are reduced.
Delta phenotype dominantly enhanced by Su(H)2.
Dl9P flies carrying RpS32 in trans have an enhanced Dl wing phenotype and extremely rough eyes. Few flies of this genotype eclose. H2 reduces the central nervous system hypertrophy seen in Dl9P homozygous embryos. Double homozygous Dl9P H2 clones in the eye are viable, and are sometimes indistinguishable from wild-type.
Nusslein-Volhard.
Autosomal repressor: suppress phenotypes of all viable "abruptex" alleles but not the lethality of the lethal "abruptex" alleles.
Strong Dl allele.
dominantly suppressed by alleles of H and S and two Su(Dl) loci, and dominantly enhanced by alleles of Px, px, Ni, bs, net and 13 E(Dl) loci.
The genotypes DlRF/DlRF, DlRF/Dl6B, and DlRF/Dl9P show a hypomorphic series, with DlRF/Dl9P showing the least function at any given restrictive temperature.