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General Information
Symbol
Dmel\Dl9P
Species
D. melanogaster
Name
FlyBase ID
FBal0002474
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Dl9p39
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

thorax & macrochaeta

Detailed Description
Statement
Reference

Dl9P heterozygotes show a fully penetrant wing vein thickening phenotype and extra wing vein material phenotypes, as compared to controls.

Dl9P/+ flies display thickened wing veins (typically for veins L2 and L5).

Mutant embryos show a complete loss of pericardial cells and hematopoietic precursors, while cardioblast numbers are dramatically increased compared to wild type.

Dl9P mutant neuroectodermal cells transplanted into wild-type hosts do not affect cell fate changes in NB1-1, MP2 and NB7-1 lineages.

RP2/RP2sib and vMP2/dMP2 cell fates are not correctly resolved in Dl9P mutants.

The accumulation of hemocytes is normal in the wings of heterozygous pupae, both at 22 and 26 hours after puparium formation.

Heterozygotes show wing vein thickening.

20% of heterozygotes have ectopic or duplicated macrochaetae.

In Dl9P homozygous embryos, the early steps of proventricular development including the formation of the ball-like evagination at the ectoderm/endoderm boundary occur normally. However, at stage 14, the anterior boundary cells of the keyhole region fail to invaginate into the endodermal cell layer, but arrest anteriorly and do not move inwards until the final stages of embryonic development (16 and 17). In addition, the posterior boundary cells of the endodermal component of the proventriculus rim collapses in these animals.

Heterozygotes display extra vein material particularly at the distal tip of veins.

Homozygous mutant somatic clones in the notum give a phenotype of adjacent bristles with no intervening epidermal cells. A band of mutant epidermis, that averages about 4.2 cells wide around the clone, have a wild-type phenotype.

Dl9P/DlRF animals shifted to the nonpermissive temperature during the early pupal stage develop double shaft bristles.

Homozygous clones in the scutum produce a similar phenotype to homozygous DlRevF10 clones.

Heterozygotes with SerBd-3 are viable and exhibit a severe wing phenotype.

Small effect on the Brd1 and Brd3 bristle multiplication phenotype.

Clusters of R8 cells develop in DlRF/Dl9P flies raised at the restrictive temperature. The clusters are not randomly arranged, but are based on the original R8 array.

Instead of forming distinct invagination folds, the Dl mutant stomodeal nervous system anlage invaginates en masse.

Thickened vein mutant.

Hyperplasia of replicating sensory precursors: due to an increased number of ectodermal cells being recruited as sensory precursor cells.

In double mutant clones with Nl1N-ts1, both wild type and mutant bristles are formed along the mosaic borders, and occasionally a mutant and a wild type bristle are found adjacent to each other (which never happens in either single mutant). Homozygous NAx-59b mutant clones develop as epidermis, and this requires Dl function.

Dl9P/+ flies carrying one or two copies of EgfrE1 or EgfrE3 often have blistered wings.

Clones in the thorax have an abnormal distribution of microchaetae and macrochaetae.

Increase in SMCs per cluster in embryos lacking the maternal product.

Mutant clones cause the differentiation of masses of adjacent microchaetae not separated by epidermal hairs. On the scutum cells adopt a neural fate. Mutant cells behave nonautonomously: cells produce epidermis only along the mosaic border where they are in contact with wild type cells.

Severe "abruptex" phenotype. Capable of rescuing the lethality conferred by all negatively complementing Ax heteroallelic combinations, individuals display an Ax, not wild type, phenotype.

Wing phenotype: wing vein 2 and the distal part of wing vein 5 are irregularly broadened. Other veins often form knots. All veins have pronounced deltas at the wing margin. Rough eye phenotype. Number of bristles in the thoracic segments is frequently increased.

Homozygous clones in the eye and the cuticle are cell lethal.

Double mutants Dl9P and dl2 had neuralization of additional ectodermal cells in the thoracic and abdominal segments. Double mutants Dl9P and Tl had neuralization of the entire ectoderm, a huge CNS and no epidermis as it had been substituted for by neural tissue.

Extreme embryonic neurogenic phenotype.

extreme allele

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Dl9P has visible | dominant phenotype, enhanceable by rumi44/rumi44

Dl9P has visible | dominant phenotype, enhanceable by brm[+]/brm2

NOT Enhanced by
Statement
Reference

Dl9P has visible phenotype, non-enhanceable by Scer\GAL4VMQ/neurαRING.UAS

Suppressed by
Enhancer of
Statement
Reference

Dl9P/Dl[+] is an enhancer of visible phenotype of Scer\GAL4A9, uifasterisk.UAS

Dl9P/Dl[+] is an enhancer of visible phenotype of RalaEE1

Dl9P/Dl[+] is an enhancer of visible phenotype of rumi44

Dl9P/Dl[+] is an enhancer of visible phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

Dl9P/Dl[+] is an enhancer of visible phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

Dl9P/Dl[+] is an enhancer of visible | dominant phenotype of brm2

Dl9P/Dl[+] is an enhancer of visible | heat sensitive phenotype of peb1

Suppressor of
Statement
Reference

Dl9P is a suppressor of visible phenotype of upd1GMR.PB

Dl9P is a suppressor of visible phenotype of RetMEN2B.GMR

Dl9P is a suppressor of visible phenotype of RetMEN2A.GMR

Dl9P is a suppressor of lethal phenotype of NAx-9/NAx-E2

Phenotype Manifest In
Enhanced by
Statement
Reference

Dl9P has wing vein phenotype, enhanceable by rumi44/rumi44

Dl9P has macrochaeta phenotype, enhanceable by brm[+]/brm2

Dl9P has wing vein phenotype, enhanceable by Snr1R3/Snr1E1

Dl9P has wing vein phenotype, enhanceable by Snr1E1

Dl9P has wing vein | ectopic phenotype, enhanceable by ebiE4

Dl9P has phenotype, enhanceable by Su(H)2

Dl9P has wing phenotype, enhanceable by E(Dl)F14[+]/E(Dl)F142

Dl9P has wing phenotype, enhanceable by E(Dl)F14[+]/E(Dl)F143

Dl9P has wing phenotype, enhanceable by E(Dl)F144/E(Dl)F14[+]

Dl9P has wing phenotype, enhanceable by E(Dl)F14[+]/E(Dl)F14KP77

Dl9P has wing phenotype, enhanceable by E(Dl)F14P/E(Dl)F14[+]

Dl9P has wing phenotype, enhanceable by E(Dl)F167[+]/E(Dl)F1671

Dl9P has wing phenotype, enhanceable by E(Dl)F25[+]/E(Dl)F251

Dl9P has wing phenotype, enhanceable by E(Dl)F42[+]/E(Dl)F421

Dl9P has wing phenotype, enhanceable by RpL19[+]/RpL19P

Dl9P has wing phenotype, enhanceable by E(Dl)KP254P/E(Dl)KP254[+]

Dl9P has wing phenotype, enhanceable by E(Dl)KP420P

Dl9P has wing phenotype, enhanceable by Ni[+]/Ni-KD115

Dl9P has wing phenotype, enhanceable by Ni-KF200/Ni[+]

Dl9P has wing phenotype, enhanceable by Px[+]/Plexate10

Dl9P has wing phenotype, enhanceable by Px[+]/Plexate11

Dl9P has wing phenotype, enhanceable by Px[+]/Plexate9

Dl9P has wing phenotype, enhanceable by PlexateD10/Px[+]

Dl9P has wing phenotype, enhanceable by Px[+]/PlexateD123

Dl9P has wing phenotype, enhanceable by Px[+]/PlexateF5

Dl9P has wing phenotype, enhanceable by Px[+]/PlexateF7

Dl9P has wing phenotype, enhanceable by E(Dl)9P39.31/E(Dl)9P39.3[+]

Dl9P has wing phenotype, enhanceable by bsF31/bs[+]

Dl9P has wing phenotype, enhanceable by net[+]/net9P39.6

Dl9P has wing phenotype, enhanceable by netD90/net[+]

Dl9P has wing phenotype, enhanceable by net[+]/netF170

Dl9P has wing phenotype, enhanceable by netKP92/net[+]

Dl9P has wing phenotype, enhanceable by px[+]/px19

Dl9P has wing phenotype, enhanceable by E(Dl)9P39.8[+]/E(Dl)9P39.81

Dl9P has wing phenotype, enhanceable by E(Dl)D1651/E(Dl)D165[+]

Dl9P has wing phenotype, enhanceable by cic[+]/cicD49

Dl9P has wing phenotype, enhanceable by E(Dl)D721/E(Dl)D72[+]

Dl9P has wing phenotype, enhanceable by E(Dl)F101/E(Dl)F10[+]

Dl9P has wing phenotype, enhanceable by E(Dl)F141/E(Dl)F14[+]

Dl9P has wing phenotype, enhanceable by RpS32

NOT Enhanced by
Statement
Reference

Dl9P has wing vein phenotype, non-enhanceable by Scer\GAL4VMQ/neurαRING.UAS

Suppressed by
Statement
Reference

Dl9P has wing phenotype, suppressible by S[+]/S55

Dl9P has wing phenotype, suppressible by S[+]/S56

Dl9P has wing phenotype, suppressible by S[+]/S65

Dl9P has wing phenotype, suppressible by S66/S[+]

Dl9P has wing phenotype, suppressible by S[+]/S67

Dl9P has wing phenotype, suppressible by SKP347/S[+]

Dl9P has wing phenotype, suppressible by Su(Dl)D1071/Su(Dl)D107[+]

Dl9P has wing phenotype, suppressible by Su(Dl)F1161/Su(Dl)F116[+]

Dl9P has wing phenotype, suppressible by S[+]/S57

Dl9P has wing phenotype, suppressible by S[+]/S58

Dl9P has wing phenotype, suppressible by S[+]/S59

Dl9P has wing phenotype, suppressible by S60/S[+]

Dl9P has wing phenotype, suppressible by S[+]/S61

Dl9P has wing phenotype, suppressible by S62/S[+]

Dl9P has wing phenotype, suppressible by S63/S[+]

Dl9P has wing phenotype, suppressible by S[+]/S64

Dl9P has eye | somatic clone phenotype, suppressible by H2

NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference

Dl9P/Dl[+] is an enhancer of wing vein phenotype of Scer\GAL4A9, uifasterisk.UAS

Dl9P/Dl[+] is an enhancer of eye phenotype of RalaEE1

Dl9P/Dl[+] is an enhancer of wing vein phenotype of rumi44

Dl9P/Dl[+] is an enhancer of ommatidium phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

Dl9P/Dl[+] is an enhancer of wing vein | ectopic phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

Dl9P/Dl[+] is an enhancer of eye phenotype of Scer\GAL4ey.PH, brmK804R.UAS.Tag:HA

Dl9P/Dl[+] is an enhancer of macrochaeta phenotype of brm2

Dl9P/Dl[+] is an enhancer of eye | heat sensitive phenotype of peb1

Dl9P is an enhancer of ommatidium phenotype of Gp150k11120b/Gp150P8

Dl9P is an enhancer of ommatidium phenotype of Gp150k11120b

Dl9P/Dl[+] is an enhancer of eye phenotype of ebi1-334.GMR

Dl9P is an enhancer of phenotype of scaMSKF

Suppressor of
Statement
Reference

Dl9P/Dl[+] is a suppressor of posterior crossvein phenotype of DgO86

Dl9P is a suppressor of eye phenotype of upd1GMR.PB

Dl9P is a suppressor of eye phenotype of RetMEN2B.GMR

Dl9P is a suppressor of eye phenotype of RetMEN2A.GMR

Other
Additional Comments
Genetic Interactions
Statement
Reference

The wing vein phenotype resulting from the expression of uifasterisk.Scer\UAS under the control of Scer\GAL4A9 is enhanced by Dl9P.

The rough eye phenotype of RalaEE1/Y adults is dominantly enhanced by Dl9P.

Flies that are homozygous for rumi44 and heterozygous for Dl9P show a synergistic increase in wing vein expansion.

The "detached" posterior crossvein phenotype seen in DgO86 homozygotes is suppressed by Dl9P/+.

The Dl9P thick vein phenotype is enhanced by Snr1E1, especially near the distal tips of veins L3, L4 and L5. The Dl9P thick vein phenotype is enhanced by Snr1E1/Snr1R3.

Ovarioles in aretQB/aretQB ; Dl9P/+ females form a single large egg chambers with many germline cells. The fusome appears as dots. Most egg chambers have more than 16 germline cells in aretQB/aretPD ; Dl9P/+ ovaries. Three classes of abnormal egg chambers are seen, which are present in roughly equal numbers. In the first class, a large number of germline cells of roughly equal size are enveloped by a single epithelium of follicle cells. The remaining two classes arise from partial fusion of separate cysts; no stalk cells can be detected and the follicle cell layers of different egg chambers remain in contact with each other. In the "anterior/posterior fusion" class, a well-defined linear organisation within individual ovarioles is maintained, and adjacent egg chambers are fused with each other at their anterior and posterior boundaries. In the "random fusion" class, egg chambers are positioned irregularly and can be closely apposed to multiple different egg chambers on lateral as well as on anterior and posterior surfaces. In both the partial fusion classes, each egg chamber contains an oocyte. In the anterior/posterior fusion class the oocyte is present at the posterior of the cyst and in the random fusion class the oocyte is either lateral or posterior relative to the overall polarity of the ovariole.

The addition of Dl9P/+ to Gp150P8/Gp150k11120b animals increases the proportion of mutant ommatidia from 19.2% to 67.6%. The addition of Dl9P/+ to Gp150k11120b/+ animals increases the proportion of mutant ommatidia from 0.19% to 2.7%.

the addition of one copy of ebiE4 enhances the dominant wing vein phenotype seen in Dl9P/+ animals. The combination of ebi1-334.GMR and Dl9P/+ leads to flies with a significantly rough eye phenotype.

frcNP0297 in double heterozygous combination with Dl9P results in duplications of the anterior scutellar bristles.

The combination of Dl9P and neurScer\UAS.cLa (when driven by Scer\GAL4VMQ) produces a blistered wing phenotype.

The combination of Dl9P and neurScer\UAS.cLa ( when driven by Scer\GAL4VMQ) produces a blistered wing phenotype.

Enhances the rough eye phenotype caused by expression of atoScer\UAS.cJa under the control of Scer\GAL4sca-109-68.

The cuticle defect of homozygous embryos is not rescued by bibScer\UAS.cDa expressed under the control of Scer\GAL4h-1J3.

Double mutants with Df(1)sc-B57 have normal midgut epithelium, but the large basophilic midgut cells are missing and the number of adult midgut precursor cells are reduced.

Flies that are dxENU/Y; Su(dx)1/+; Dl9P/+ are viable but display clear dx phenotypes in the ocelli and wings.

Delta phenotype dominantly enhanced by Su(H)2.

Dl9P flies carrying RpS32 in trans have an enhanced Dl wing phenotype and extremely rough eyes. Few flies of this genotype eclose. H2 reduces the central nervous system hypertrophy seen in Dl9P homozygous embryos. Double homozygous Dl9P H2 clones in the eye are viable, and are sometimes indistinguishable from wild-type.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Nusslein-Volhard.

Comments
Comments

Autosomal repressor: suppress phenotypes of all viable "abruptex" alleles but not the lethality of the lethal "abruptex" alleles.

Strong Dl allele.

dominantly suppressed by alleles of H and S and two Su(Dl) loci, and dominantly enhanced by alleles of Px, px, Ni, bs, net and 13 E(Dl) loci.

The genotypes DlRF/DlRF, DlRF/Dl6B, and DlRF/Dl9P show a hypomorphic series, with DlRF/Dl9P showing the least function at any given restrictive temperature.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (74)