Allele Dmel\Dl^9P

General Information
Symbol	Dmel\Dl^9P	Species	D. melanogaster
Name		FlyBase ID	FBal0002474
Feature type	allele	Associated gene	Dmel\Dl
Also Known As	Dl^9p39

Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Campos-Ortega, 1983, de la Concha et al., 1988, Xu et al., 1990, Brand and Campos-Ortega, 1990, Hukriede and Fleming, 1997)
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Point mutation. (Brand and Campos-Ortega, 1990)
Cytology
Phenotypic Data
Phenotypic Class
	cell lethal \| somatic clone (Dietrich and Campos-Ortega, 1984) lethal \| embryonic stage \| neurogenic phenotype \| recessive (Lehmann et al., 1983) lethal \| recessive (de Celis et al., 1993) neuroanatomy defective \| somatic clone (Udolph et al., 2009) visible (Lai and Rubin, 2001, Vassin et al., 1985, Simpson et al., 1992) visible (with Dl^RF) (Barolo et al., 2000) visible \| dominant (Armstrong et al., 2005, Acar et al., 2008, Christoforou et al., 2008, Xie et al., 2012)
Phenotype Manifest In
	adult thoracic sensillum (Simpson et al., 1992) dMP2 neuron \| somatic clone (Udolph et al., 2009) ectoderm (Bodmer et al., 1993) embryonic cardioblast (Grigorian et al., 2011) embryonic epidermis (Lehmann et al., 1983, Doherty et al., 1997) embryonic pericardial cell (Grigorian et al., 2011) embryonic proventriculus (Fuss et al., 2004) eye (Vassin et al., 1985, Dietrich and Campos-Ortega, 1984) keyhole structure (Fuss et al., 2004) macrochaeta (Armstrong et al., 2005) microchaeta \| cell non-autonomous \| somatic clone (Heitzler and Simpson, 1991) microchaeta \| ectopic \| somatic clone (Renaud and Simpson, 2001) photoreceptor cell R8 (Baker and Zitron, 1995) presumptive embryonic/larval central nervous system (Dietrich and Campos-Ortega, 1984) proventriculus inner layer primordium (Fuss et al., 2004) proventriculus intermediate layer primordium (Fuss et al., 2004) proventriculus outer layer primordium (Fuss et al., 2004) RP2 motor neuron \| somatic clone (Udolph et al., 2009) RP2sib neuron \| somatic clone (Udolph et al., 2009) scutum \| cell non-autonomous \| somatic clone (Heitzler and Simpson, 1991) stomatogastric nervous system primordium (Gonzalez-Gaitan and Jaeckle, 1995) thorax & macrochaeta (Vassin et al., 1985) tormogen cell (with Dl^RF) (Barolo et al., 2000) trichogen cell \| ectopic (with Dl^RF) (Barolo et al., 2000) vMP2 neuron \| somatic clone (Udolph et al., 2009) wing (Dietrich and Campos-Ortega, 1984, Hukriede and Fleming, 1997, Klein and Campos-Ortega, 1992) wing vein (Marenda et al., 2004, Lai and Rubin, 2001, Vassin et al., 1985, Sturtevant and Bier, 1995, Acar et al., 2008, Christoforou et al., 2008) wing vein \| ectopic (Tsuda et al., 2002) wing vein L2 (Xie et al., 2012)
Detailed Description
	Statement Reference Dl[9P]/+ flies display thickened wing veins (typically for veins L2 and L5). (Xie et al., 2012) Mutant embryos show a complete loss of pericardial cells and hematopoietic precursors, while cardioblast numbers are dramatically increased compared to wild type. (Grigorian et al., 2011) Dl[9P] mutant neuroectodermal cells transplanted into wild-type hosts do not affect cell fate changes in NB1-1, MP2 and NB7-1 lineages. RP2/RP2sib and vMP2/dMP2 cell fates are not correctly resolved in Dl[9P] mutants. (Udolph et al., 2009) The accumulation of hemocytes is normal in the wings of heterozygous pupae, both at 22 and 26 hours after puparium formation. Heterozygotes show wing vein thickening. (Christoforou et al., 2008) 20% of heterozygotes have ectopic or duplicated macrochaetae. (Armstrong et al., 2005) In Dl^9P homozygous embryos, the early steps of proventricular development including the formation of the ball-like evagination at the ectoderm/endoderm boundary occur normally. However, at stage 14, the anterior boundary cells of the keyhole region fail to invaginate into the endodermal cell layer, but arrest anteriorly and do not move inwards until the final stages of embryonic development (16 and 17). In addition, the posterior boundary cells of the endodermal component of the proventriculus rim collapses in these animals. (Fuss et al., 2004) Heterozygotes display extra vein material particularly at the distal tip of veins. (Lai and Rubin, 2001) Homozygous mutant somatic clones in the notum give a phenotype of adjacent bristles with no intervening epidermal cells. A band of mutant epidermis, that averages about 4.2 cells wide around the clone, have a wild-type phenotype. (Renaud and Simpson, 2001) Dl^9P/Dl^RF animals shifted to the nonpermissive temperature during the early pupal stage develop double shaft bristles. (Barolo et al., 2000) Homozygous clones in the scutum produce a similar phenotype to homozygous Dl^RevF10 clones. (Zeng et al., 1998) Heterozygotes with Ser^Bd-3 are viable and exhibit a severe wing phenotype. (Hukriede and Fleming, 1997) Small effect on the Brd¹ and Brd³ bristle multiplication phenotype. (Leviten and Posakony, 1996) Clusters of R8 cells develop in Dl^RF/Dl^9P flies raised at the restrictive temperature. The clusters are not randomly arranged, but are based on the original R8 array. (Baker and Zitron, 1995) Instead of forming distinct invagination folds, the Dl mutant stomodeal nervous system anlage invaginates en masse. (Gonzalez-Gaitan and Jaeckle, 1995) Thickened vein mutant. (Sturtevant and Bier, 1995) Hyperplasia of replicating sensory precursors: due to an increased number of ectodermal cells being recruited as sensory precursor cells. (Bodmer et al., 1993) In double mutant clones with N^l1N-ts1, both wild type and mutant bristles are formed along the mosaic borders, and occasionally a mutant and a wild type bristle are found adjacent to each other (which never happens in either single mutant). Homozygous N^Ax-59b mutant clones develop as epidermis, and this requires Dl function. (Heitzler and Simpson, 1993) Dl^9P/+ flies carrying one or two copies of Egfr^E1 or Egfr^E3 often have blistered wings. (Baker and Rubin, 1992) Clones in the thorax have an abnormal distribution of microchaetae and macrochaetae. (Simpson et al., 1992) Increase in SMCs per cluster in embryos lacking the maternal product. (Goriely et al., 1991) Mutant clones cause the differentiation of masses of adjacent microchaetae not separated by epidermal hairs. On the scutum cells adopt a neural fate. Mutant cells behave nonautonomously: cells produce epidermis only along the mosaic border where they are in contact with wild type cells. (Heitzler and Simpson, 1991) Severe "abruptex" phenotype. Capable of rescuing the lethality conferred by all negatively complementing Ax heteroallelic combinations, individuals display an Ax, not wild type, phenotype. (Xu et al., 1990) Wing phenotype: wing vein 2 and the distal part of wing vein 5 are irregularly broadened. Other veins often form knots. All veins have pronounced deltas at the wing margin. Rough eye phenotype. Number of bristles in the thoracic segments is frequently increased. (Vassin et al., 1985) Homozygous clones in the eye and the cuticle are cell lethal. (Dietrich and Campos-Ortega, 1984) Double mutants Dl^9P and dl² had neuralization of additional ectodermal cells in the thoracic and abdominal segments. Double mutants Dl^9P and Tl had neuralization of the entire ectoderm, a huge CNS and no epidermis as it had been substituted for by neural tissue. (Campos-Ortega, 1983) Extreme embryonic neurogenic phenotype. (Lehmann et al., 1983) extreme allele
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Dl^9P has visible \| dominant phenotype, enhanceable by brm[+]/brm² (Armstrong et al., 2005) Dl^9P has visible \| dominant phenotype, enhanceable by rumi⁴⁴/rumi⁴⁴ (Acar et al., 2008) Dl^9P has visible phenotype, enhanceable by neur^Scer\UAS.cLa/Scer\GAL4^VMQ (Lai and Rubin, 2001)
NOT Enhanced by
Statement Reference Dl^9P has visible phenotype, non-enhanceable by Scer\GAL4^VMQ/neur^{αRING.Scer\UAS} (Lai and Rubin, 2001)
Suppressed by
Statement Reference Dl^9P has cell lethal \| somatic clone phenotype, suppressible by H² (Dietrich and Campos-Ortega, 1984)
Enhancer of
Statement Reference Dl^9P/Dl[+] is an enhancer of visible \| dominant phenotype of brm² (Armstrong et al., 2005) Dl^9P/Dl[+] is an enhancer of visible \| heat sensitive phenotype of peb¹ (Wilk et al., 2004) Dl^9P/Dl[+] is an enhancer of visible phenotype of Rala^EE1 (Cho and Fischer, 2011) Dl^9P/Dl[+] is an enhancer of visible phenotype of rumi⁴⁴ (Acar et al., 2008) Dl^9P/Dl[+] is an enhancer of visible phenotype of Scer\GAL4^A9, uif^{asterisk.Scer\UAS} (Xie et al., 2012) Dl^9P/Dl[+] is an enhancer of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.Scer\UAS.T:Ivir\HA1} (Armstrong et al., 2005) Dl^9P/Dl[+] is an enhancer of visible phenotype of Scer\GAL4^lz-gal4, sens^Scer\UAS.cNa (Pepple et al., 2007) Dl^9P/Dl[+] is an enhancer of visible phenotype of Scer\GAL4^tub.PU, csw^{N308D.Scer\UAS.P\T} (Oishi et al., 2006) Dl^9P is an enhancer of visible phenotype of Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa (White and Jarman, 2000)
Suppressor of
Statement Reference Dl^9P is a suppressor of lethal phenotype of N^Ax-9/N^Ax-E2 (Xu et al., 1990) Dl^9P is a suppressor of visible phenotype of os^GMR.PB (Mukherjee et al., 2006) Dl^9P is a suppressor of visible phenotype of Ret^MEN2A.GMR (Read et al., 2005) Dl^9P is a suppressor of visible phenotype of Ret^MEN2B.GMR (Read et al., 2005)
Phenotype Manifest In
Enhanced by
Statement Reference Dl^9P has macrochaeta phenotype, enhanceable by brm[+]/brm² (Armstrong et al., 2005) Dl^9P has phenotype, enhanceable by Su(H)² (Fortini and Artavanis-Tsakonas, 1994) Dl^9P has wing phenotype, enhanceable by bs^F31/bs[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by cic[+]/cic^D49 (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)9P39.3¹/E(Dl)9P39.3[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)9P39.8[+]/E(Dl)9P39.8¹ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)D72¹/E(Dl)D72[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)D165¹/E(Dl)D165[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)F10¹/E(Dl)F10[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)F14[+]/E(Dl)F14² (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)F14[+]/E(Dl)F14³ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)F14[+]/E(Dl)F14^KP77 (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)F14¹/E(Dl)F14[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)F14⁴/E(Dl)F14[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)F14^P/E(Dl)F14[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)F25[+]/E(Dl)F25¹ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)F42[+]/E(Dl)F42¹ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)F167[+]/E(Dl)F167¹ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)KP254^P/E(Dl)KP254[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by E(Dl)KP420^P (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by net[+]/net^9P39.6 (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by net[+]/net^F170 (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by net^D90/net[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by net^KP92/net[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by Ni[+]/Ni^D115 (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by Ni^F200/Ni[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by Px[+]/Px⁹ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by Px[+]/Px¹⁰ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by Px[+]/Px¹¹ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by px[+]/px¹⁹ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by Px[+]/Px^D123 (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by Px[+]/Px^F5 (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by Px[+]/Px^F7 (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by Px^D10/Px[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by RpL19[+]/RpL19^P (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, enhanceable by RpS3² (Dietrich and Campos-Ortega, 1984) Dl^9P has wing vein \| ectopic phenotype, enhanceable by ebi^E4 (Tsuda et al., 2002) Dl^9P has wing vein phenotype, enhanceable by neur^Scer\UAS.cLa/Scer\GAL4^VMQ (Lai and Rubin, 2001) Dl^9P has wing vein phenotype, enhanceable by rumi⁴⁴/rumi⁴⁴ (Acar et al., 2008) Dl^9P has wing vein phenotype, enhanceable by Snr1^E1 (Marenda et al., 2004) Dl^9P has wing vein phenotype, enhanceable by Snr1^R3/Snr1^E1 (Marenda et al., 2004)
NOT Enhanced by
Statement Reference Dl^9P has wing vein phenotype, non-enhanceable by Scer\GAL4^VMQ/neur^{αRING.Scer\UAS} (Lai and Rubin, 2001)
Suppressed by
Statement Reference Dl^9P has eye \| somatic clone phenotype, suppressible by H² (Dietrich and Campos-Ortega, 1984) Dl^9P has presumptive embryonic/larval central nervous system phenotype, suppressible by H² (Dietrich and Campos-Ortega, 1984) Dl^9P has wing phenotype, suppressible by S[+]/S⁵⁵ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S[+]/S⁵⁶ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S[+]/S⁵⁷ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S[+]/S⁵⁸ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S[+]/S⁵⁹ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S[+]/S⁶¹ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S[+]/S⁶⁴ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S[+]/S⁶⁵ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S[+]/S⁶⁷ (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S⁶⁰/S[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S⁶²/S[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S⁶³/S[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S⁶⁶/S[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by S^KP347/S[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by Su(Dl)D107¹/Su(Dl)D107[+] (Klein and Campos-Ortega, 1992) Dl^9P has wing phenotype, suppressible by Su(Dl)F116¹/Su(Dl)F116[+] (Klein and Campos-Ortega, 1992)
NOT suppressed by
Statement Reference Dl^9P has embryonic epidermis phenotype, non-suppressible by bib^Scer\UAS.cDa/Scer\GAL4^h-1J3 (Doherty et al., 1997)
Enhancer of
Statement Reference Dl^9P/Dl[+] is an enhancer of eye \| heat sensitive phenotype of peb¹ (Wilk et al., 2004) Dl^9P/Dl[+] is an enhancer of eye phenotype of ebi^1-334.GMR (Tsuda et al., 2002) Dl^9P/Dl[+] is an enhancer of eye phenotype of Rala^EE1 (Cho and Fischer, 2011) Dl^9P/Dl[+] is an enhancer of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.Scer\UAS.T:Ivir\HA1} (Armstrong et al., 2005) Dl^9P/Dl[+] is an enhancer of interommatidial bristle \| ectopic phenotype of Scer\GAL4^lz-gal4, sens^Scer\UAS.cNa (Pepple et al., 2007) Dl^9P/Dl[+] is an enhancer of macrochaeta phenotype of brm² (Armstrong et al., 2005) Dl^9P/Dl[+] is an enhancer of ommatidium phenotype of Scer\GAL4^ey.PH, brm^{K804R.Scer\UAS.T:Ivir\HA1} (Armstrong et al., 2005) Dl^9P/Dl[+] is an enhancer of ommatidium phenotype of Scer\GAL4^lz-gal4, sens^Scer\UAS.cNa (Pepple et al., 2007) Dl^9P/Dl[+] is an enhancer of wing vein \| ectopic phenotype of Scer\GAL4^tub.PU, csw^{N308D.Scer\UAS.P\T} (Oishi et al., 2006) Dl^9P/Dl[+] is an enhancer of wing vein phenotype of rumi⁴⁴ (Acar et al., 2008) Dl^9P/Dl[+] is an enhancer of wing vein phenotype of Scer\GAL4^A9, uif^{asterisk.Scer\UAS} (Xie et al., 2012) Dl^9P is an enhancer of eye phenotype of Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa (White and Jarman, 2000) Dl^9P is an enhancer of ommatidium phenotype of Gp150^k11120b (Fetchko et al., 2002) Dl^9P is an enhancer of ommatidium phenotype of Gp150^k11120b/Gp150^P8 (Fetchko et al., 2002) Dl^9P is an enhancer of ommatidium phenotype of Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa (White and Jarman, 2000) Dl^9P is an enhancer of phenotype of sca^MSKF (Hu et al., 1995)
Suppressor of
Statement Reference Dl^9P/Dl[+] is a suppressor of posterior crossvein phenotype of Dg^O86 (Christoforou et al., 2008) Dl^9P is a suppressor of eye phenotype of os^GMR.PB (Mukherjee et al., 2006) Dl^9P is a suppressor of eye phenotype of Ret^MEN2A.GMR (Read et al., 2005) Dl^9P is a suppressor of eye phenotype of Ret^MEN2B.GMR (Read et al., 2005)
Other
Statement Reference Df(1)sc-B57, Dl^9P has adult midgut precursor cell phenotype (Tepass and Hartenstein, 1995) Df(1)sc-B57, Dl^9P has interstitial cell precursor phenotype (Tepass and Hartenstein, 1995) Dl^9P, aret^QB/aret^PD has egg chamber phenotype (Yan and Macdonald, 2004, Yan and Macdonald, 2004) Dl^9P, aret^QB/aret^PD has interfollicle cell phenotype (Yan and Macdonald, 2004, Yan and Macdonald, 2004) Dl^9P, brm² has ommatidium phenotype (Armstrong et al., 2005) Dl^9P, frc^NP0297 has anterior scutellar bristle phenotype (Goto et al., 2001, Goto et al., 2001) Dl^9P, RpS3² has eye phenotype (Dietrich and Campos-Ortega, 1984, Dietrich and Campos-Ortega, 1984) Dl^9P, Scer\GAL4^VMQ, neur^Scer\UAS.cLa has wing phenotype (Lai and Rubin, 2001, Lai and Rubin, 2001) Dl^9P, Su(dx)[+]/Su(dx)¹, dx^ENU has ocellus phenotype (Busseau et al., 1994) Dl^9P, Su(dx)[+]/Su(dx)¹, dx^ENU has wing phenotype (Busseau et al., 1994) Dl^9P/Dl[+], brm² has ommatidium phenotype (Armstrong et al., 2005) Dl^9P/Dl[+], Su(dx)[+]/Su(dx)¹, dx^ENU has ocellus phenotype (Busseau et al., 1994) Dl^9P/Dl[+], Su(dx)[+]/Su(dx)¹, dx^ENU has wing phenotype (Busseau et al., 1994) Dl^9P/Dl[+], Su(dx)¹, dx^ENU has ocellus phenotype (Busseau et al., 1994) Dl^9P/Dl[+], Su(dx)¹, dx^ENU has wing phenotype (Busseau et al., 1994)
Additional Comments
Genetic Interactions
Statement Reference The wing vein phenotype resulting from the expression of uif[asterisk.Scer\UAS] under the control of Scer\GAL4[A9] is enhanced by Dl[9P]. (Xie et al., 2012) The rough eye phenotype of Rala[EE1]/Y adults is dominantly enhanced by Dl[9P]. (Cho and Fischer, 2011) Flies that are homozygous for rumi⁴⁴ and heterozygous for Dl^9P show a synergistic increase in wing vein expansion. (Acar et al., 2008) The "detached" posterior crossvein phenotype seen in Dg^O86 homozygotes is suppressed by Dl^9P/+. (Christoforou et al., 2008) The Dl^9P thick vein phenotype is enhanced by Snr1^E1, especially near the distal tips of veins L3, L4 and L5. The Dl^9P thick vein phenotype is enhanced by Snr1^E1/Snr1^R3. (Marenda et al., 2004) Ovarioles in aret^QB/aret^QB ; Dl^9P/+ females form a single large egg chambers with many germline cells. The fusome appears as dots. Most egg chambers have more than 16 germline cells in aret^QB/aret^PD ; Dl^9P/+ ovaries. Three classes of abnormal egg chambers are seen, which are present in roughly equal numbers. In the first class, a large number of germline cells of roughly equal size are enveloped by a single epithelium of follicle cells. The remaining two classes arise from partial fusion of separate cysts; no stalk cells can be detected and the follicle cell layers of different egg chambers remain in contact with each other. In the "anterior/posterior fusion" class, a well-defined linear organisation within individual ovarioles is maintained, and adjacent egg chambers are fused with each other at their anterior and posterior boundaries. In the "random fusion" class, egg chambers are positioned irregularly and can be closely apposed to multiple different egg chambers on lateral as well as on anterior and posterior surfaces. In both the partial fusion classes, each egg chamber contains an oocyte. In the anterior/posterior fusion class the oocyte is present at the posterior of the cyst and in the random fusion class the oocyte is either lateral or posterior relative to the overall polarity of the ovariole. (Yan and Macdonald, 2004) The addition of Dl^9P/+ to Gp150^P8/Gp150^k11120b animals increases the proportion of mutant ommatidia from 19.2% to 67.6%. The addition of Dl^9P/+ to Gp150^k11120b/+ animals increases the proportion of mutant ommatidia from 0.19% to 2.7%. (Fetchko et al., 2002) the addition of one copy of ebi^E4 enhances the dominant wing vein phenotype seen in Dl^9P/+ animals. The combination of ebi^1-334.GMR and Dl^9P/+ leads to flies with a significantly rough eye phenotype. (Tsuda et al., 2002) frc^NP0297 in double heterozygous combination with Dl^9P results in duplications of the anterior scutellar bristles. (Goto et al., 2001) The combination of Dl^9P and neur^Scer\UAS.cLa ( when driven by Scer\GAL4^VMQ) produces a blistered wing phenotype. (Lai and Rubin, 2001) The combination of Dl^9P and neur^Scer\UAS.cLa (when driven by Scer\GAL4^VMQ) produces a blistered wing phenotype. (Lai and Rubin, 2001) Enhances the rough eye phenotype caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68. (White and Jarman, 2000) The cuticle defect of homozygous embryos is not rescued by bib^Scer\UAS.cDa expressed under the control of Scer\GAL4^h-1J3. (Doherty et al., 1997) Double mutants with Df(1)sc-B57 have normal midgut epithelium, but the large basophilic midgut cells are missing and the number of adult midgut precursor cells are reduced. (Tepass and Hartenstein, 1995) Flies that are dx^ENU/Y; Su(dx)¹/+; Dl^9P/+ are viable but display clear dx phenotypes in the ocelli and wings. (Busseau et al., 1994) Delta phenotype dominantly enhanced by Su(H)². (Fortini and Artavanis-Tsakonas, 1994) Dl^9P flies carrying RpS3² in trans have an enhanced Dl wing phenotype and extremely rough eyes. Few flies of this genotype eclose. H² reduces the central nervous system hypertrophy seen in Dl^9P homozygous embryos. Double homozygous Dl^9P H² clones in the eye are viable, and are sometimes indistinguishable from wild-type. (Dietrich and Campos-Ortega, 1984)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	4220 ru¹ h¹ th¹ st¹ cu¹ sr¹ Dl^9P e^s ca¹/TM3, Sb¹ Ser¹
Kyoto	107640 ru¹ h¹ th¹ st¹ cu¹ sr¹ Dl^9P e^s ca¹/TM3, Sb¹
Notes on Origin
Discoverer	Nusslein-Volhard.

Comments
	The genotypes Dl^RF/Dl^RF, Dl^RF/Dl^6B, and Dl^RF/Dl^9P show a hypomorphic series, with Dl^RF/Dl^9P showing the least function at any given restrictive temperature. (Parks and Muskavitch, 1993) dominantly suppressed by alleles of H and S and two Su(Dl) loci, and dominantly enhanced by alleles of Px, px, Ni, bs, net and 13 E(Dl) loci. (Klein and Campos-Ortega, 1992) Strong Dl allele. (Heitzler and Simpson, 1991) Autosomal repressor: suppress phenotypes of all viable "abruptex" alleles but not the lethality of the lethal "abruptex" alleles. (Xu et al., 1990)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	9P39 (Mukherjee et al., 2006) Delta9p (Grigorian et al., 2011) Dl^9p39 (Lai et al., 2001, Zeng et al., 1998) Dl^9P39 (Renaud and Simpson, 2001, Ramain et al., 2001, Lai and Rubin, 2001, Barolo et al., 2000, Lecourtois and Schweisguth, 1998, Doherty et al., 1997, Sun and Artavanis-Tsakonas, 1997, Leviten and Posakony, 1996, Hartenstein et al., 1996, Hu et al., 1995, Baker and Zitron, 1995, Sturtevant and Bier, 1995, Tepass and Hartenstein, 1995, Fortini and Artavanis-Tsakonas, 1994, Simpson et al., 1993, Rhyu et al., 1994, Coyle-Thompson and Banerjee, 1993, Busseau et al., 1994, Simpson et al., 1992, Bodmer et al., 1993, de Celis et al., 1993, Bender et al., 1993, Heitzler and Simpson, 1993, Parks and Muskavitch, 1993, Baker and Rubin, 1992, Rao et al., 1991, Goriely et al., 1991, Heitzler and Simpson, 1991, Brand and Campos-Ortega, 1990, Xu and Artavanis-Tsakonas, 1990, Xu et al., 1990, de la Concha et al., 1988, Vassin and Campos-Ortega, 1987, Vassin et al., 1985, Dietrich and Campos-Ortega, 1984, Lehmann et al., 1983, Campos-Ortega, 1983, ) Dl^9P (Pepple et al., 2007, Acar et al., 2008, Udolph et al., 2009, Christoforou et al., 2008, Brodu et al., 2004, Cho and Fischer, 2011, Park et al., 2011, Xie et al., 2012, Oishi et al., 2006) Dl^9p (Liu et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 71 )

Generate a list of	All references relating to this allele ( 71 )

List References by type	Research paper ( 69 ) Review ( 1 ) Stock list ( 1 )
Recent research papers ( 4 )
	Xie et al., 2012, PLoS ONE 7(4): e36362 Uif, a Large Transmembrane Protein with EGF-Like Repeats, Can Antagonize Notch Signaling in Drosophila. [FBrf0218242] Cho and Fischer, 2011, Development 138(7): 1349--1359 Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation. [FBrf0213208] Grigorian et al., 2011, Dev. Biol. 353(1): 105--118 The convergence of Notch and MAPK signaling specifies the blood progenitor fate in the Drosophila mesoderm. [FBrf0213410] Park et al., 2011, PLoS Genet. 7(8): e1002241 Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. [FBrf0215231] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\Dl9P

Allele Dmel\Dl^9P