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General Information
Symbol
Dmel\Dlvi1
Species
D. melanogaster
Name
viable
FlyBase ID
FBal0002635
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Dlvia1
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygous adults have wild-type wings.

The temperature sensitive heterozygous combination, Dlvi1/Dl6B leads to animals that exhibit a ISNb axon bypass phenotype. These axons reach their targets via an aberrant trajectory, in which ISNb axons remain associated with the ISN. About 23% of hemisegments are affected. The formation of neuromuscular synapses to ventral longitudinal muscles occur as efficiently in mutant animals than in controls. Other kinds of ISNb misrouting phenotypes are seen at a low frequency. However gross stalling of ISNb axons is not seen, nor are defects in muscle development.

Abnormal microtubule organisation is seen in Dlvi1/Dl6B oocytes.

Dl6B/Dlvi1 embryos show a great reduction in egg laying at the restrictive temperature (32oC). Mislocalization of bcd to the posterior pole of the oocyte and excess of polar cells were evident.

Heterozygotes have extreme extra microchaetae phenotypes.

Homozygous adults exhibit a high penetrance of tarsal segments 3 and 4 fusion.

Homozygous viable. Slight δ-like thickenings at posterior tips of wing veins 2, 3, 4 and 5; roughening of eye. Dlvi1 homozygotes also show shortening and frequent fusion of tarsal segments. A few homozygous embryos fail to hatch, showing patchy neuralization in cephalic and ventral territories. Dlvi1/+ normal. Trans heterozygotes with dominant alleles show extreme wing, eye and tarsal abnormalities.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Dlvi1/Dl[+] is an enhancer of visible phenotype of edm1/edts

Phenotype Manifest In
Enhancer of
Statement
Reference

Dlvi1/Dl[+] is an enhancer of wing vein L2 phenotype of edm1/edts

Other
Additional Comments
Genetic Interactions
Statement
Reference

The thickening of wing vein L2 seen in edm1/edts flies grown at 25oC is enhanced by Dlvi1/+, and in addition, extra wing vein material is seen in the posterior cell of the wing.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Vassin.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (10)