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General Information
Symbol
Dmel\DlX
Species
D. melanogaster
Name
extreme
FlyBase ID
FBal0002638
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Extra EPCs (eve-positive heart associated or pericardial cells) and DA1 founders (and subsequently muscles) are seen in most hemisegments of mutant embryos.

    Heterozygotes show wing vein thickenings of L2 and terminal deltas.

    The number of ftz expressing MP2 neurons increases compared to wild-type (About 15 on each side of the midline, as compared to 2 in wild-type) in homozygous embryos derived from homozygous female germ-line clones (lacking both maternal and zygotic function). In homozygous embryos derived from homozygous female germ-line clones (lacking both maternal and zygotic function), RP2sib neurons become eve expressing RP2 neurons. Occasionally a third RP2-like cell is observed. Usib neurons also appear to become U neurons.

    The number of cells in the nau-expressing muscle precursor clusters is increased compared to wild-type in homozygous embryos and in homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic function).

    Homozygotes exhibit ommatidia containing an increased number of rhabdomere-bearing cells.

    Extreme neurogenic phenotype.

    DlX shows severe neural hypertrophy, a 6--9 fold increase in nau expressing cells per cluster relative to wild type. Clusters of βTub85D producing cells also enlarge and merge together but they cannot assume correct morphology as they don't fuse properly, they are also displaced. In addition Mhc protein is highly expressed and the Mhc expressing cells are arranged in irregular clusters.

    extreme allele

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    DlX has visible | dominant phenotype, enhanceable by CG6194[+]/Atg4bP0997

    Enhancer of
    Statement
    Reference

    Dl[+]/DlX is an enhancer of visible | heat sensitive phenotype of peb1

    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    DlX has pericardial cell | ectopic phenotype, enhanceable by aosΔ7

    DlX has dorsal acute muscle | ectopic phenotype, enhanceable by aosΔ7

    DlX has wing vein L2 phenotype, enhanceable by CG6194[+]/Atg4bP0997

    DlX has wing vein phenotype, enhanceable by CG6194[+]/Atg4bP0997

    Enhancer of
    Statement
    Reference

    Dl[+]/DlX is an enhancer of eye phenotype of Scer\GAL4ey.PH, fngUAS.cKa

    Dl[+]/DlX is an enhancer of eye | heat sensitive phenotype of peb1

    DlX is an enhancer of pericardial cell | ectopic phenotype of aosΔ7

    DlX is an enhancer of pericardial cell | precursor | ectopic phenotype of aosΔ7

    DlX is an enhancer of dorsal acute muscle | ectopic phenotype of aosΔ7

    Suppressor of
    NOT Suppressor of
    Other
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    58.3% of stl4/+ ; DlX/+ ovarioles have compound or morphologically disrupted follicles.

    One copy of DlX enhances the small eye phenotype of flies in which fngScer\UAS.cKa is expressed under the control of Scer\GAL4ey.PH.

    The EPC and DA1 phenotype seen in argosΔ7 and DlX exhibit a synergistic effect on each other when combined. An increase in the number of DO2 muscles is also seen.

    The wing vein thickenings of L2 and terminal deltas seen in DlX/+ flies is enhanced by CG6194P0997/+.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (3)
    Notes on Origin
    Discoverer

    Stern, 1932.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    References (28)