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General Information
Symbol
Dmel\dlg15
Species
D. melanogaster
Name
FlyBase ID
FBal0002674
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dlglv55, v55
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In dlg12/dlg15 flies the border follicle cells have much reduced polarity. Delamination of these cells is delayed, but their migration is accelerated.

dlg12/dlg15 animals are viable and have completely normal egg chambers at 18oC. After 6 hours at 25oC, follicle cells exit the follicular epithelium and intermingle with germ cells at the anterior and posterior poles of the egg chamber. Cells that remain in the epithelium retain their polarised characteristics, whereas those that have exited the epithelium have an apolar morphology. Nurse cells extend processes to meet the invasive follicle cells, and the oocyte elongates to contact the cells. Follicle cells at the anterior and posterior ends of the egg chambers preferentially incorporate BrdU. Follicle cells do not have an invasive phenotype in females with homozygous dlg15 clones in the germ cells and follicle cells.

The lethal period is during the late pupal phase.

late pupal lethal

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Hemizygous males are partially rescued by one copy of Rnor\SAP97Scer\UAS.cTa expressed using Scer\GAL4da.G32, resulting in viable adults which are sterile and unable to fly.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Geer.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (9)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (10)