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General Information
Symbol
Dmel\dncML
Species
D. melanogaster
Name
FlyBase ID
FBal0002718
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
dnc1/dncML adults show a significant reduction in performance index in an aversive olfactory learning assay compared to control flies.
dncML homozygous and dncM14/dncML heterozygous mutants exhibit an increase in the number of naturally occurring synaptopods at the type II endings. This increase is eliminated in a Dp(1;2)51b background.
Mutant flies show a significant reduction in the number of rest hours per 24 hours compared to controls.
Some dncML flies are arrhythmic with respect to locomotor activity (only 63.16% are rhythmic).
Flies have a low learning score (0.15) in an olfactory classical conditioning paradigm. Homozygous females are sterile. Fertility is restored to approximately 50% if dnchs.PD is expressed using heat shock.
The point of maximal phase delay of the light induced phase response curve (PRC) differs significantly from that of wild type and the circadian period is significantly shorter.
Flies transformed with the P{dnchs.P} or P{rat\dnchs.P} construct display increased learning scores. Reduced learning and memory.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Suppressor of
Statement
Reference
dncML/dnc[+] is a suppressor of small body | pupal stage phenotype of Nf1E2
dncML/dnc[+] is a suppressor of learning defective | dominant | adult stage phenotype of Fmr13
dncML is a suppressor of size defective phenotype of Nf1unspecified
NOT Suppressor of
Statement
Reference
dncML is a non-suppressor of locomotor rhythm defective phenotype of Nf1P2
dncML is a non-suppressor of locomotor rhythm defective phenotype of Nf1P1
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Trans-heterozygotes of Fmr13 and dncML do not exhibit learning deficits.
The low learning score phenotype is completely rescued by Rat\RD1hs.PD expressed using heat shock.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
dncML is partially rescued by dnchs.P
Comments
Expression of dncScer\UAS.cCa exclusively in octopaminergic neurons under the control of Scer\GAL4Tdc2.PC rescues the increase in synaptopods at neuromuscular junction type II endings seen in dncML homozygous and dncM14/dncML heterozygous mutants.
The low learning score phenotype is partially rescued by dnchs.PD expressed using heat shock. Fertility is restored to approximately 50% if dnchs.PD is expressed using heat shock.
A partial rescue is seen after induction of dnchs.P. A significant increase in the initial learning score is seen. Heat shock pulses four days after hatching partly rescues female fertility.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
Enzyme activity is 3% of wild-type.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (14)