Allele Dmel\Doa⁶

General Information
Symbol	Dmel\Doa⁶	Species	D. melanogaster
Name		FlyBase ID	FBal0002724
Feature type	allele	Associated gene	Dmel\Doa
Also Known As	Doa^CC

Allele class
Mutagen	gamma ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Genes Doa
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	gamma ray (Rabinow and Birchler, 1989)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by aberration	Tp(3;2)Doa^CC (Rabinow and Birchler, 1989)
Cytology	Polytene chromosomes normal. (Yun et al., 1994)
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Rabinow et al., 1993, Rabinow and Birchler, 1989) visible \| dominant (Rabinow and Birchler, 1990)
Phenotype Manifest In

Detailed Description
	Statement Reference In Doa[6]/Doa[E786] mutants where the Doa[6] allele is from the mother only females are recovered. The flies have rough eyes, duplicated postalar bristles, missing scutellar bristles and disorganisation of the vaginal bristles. When the Doa[E786] allele comes from the mother there are no survivors. (Kpebe and Rabinow, 2008) Rare Doa^HD/Doa⁶ escapers of lethality are found at a frequency of approximately 0.5%. Escapers are more frequently female than male (ratio 4:1). Male escapers are sterile despite having motile sperm. (Rabinow and Birchler, 1989) Heterozygotes with Doa^HD survive rarely and when they do, w^a is darkened to nearly wild-type color; w^sp55 reacts in the opposite manner, becoming nearly white; eyes of escapers have disarranged facets. Males of these heteroallelic combinations involving Doa⁶ are sterile despite having motile sperm; females weakly fertile.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement Reference Doa⁶ is an enhancer of phenotype of w^sp55 (Rabinow and Birchler, 1989)
NOT Enhancer of
Statement Reference Doa⁶ is a non-enhancer of phenotype of w^a2 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^a3 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^a4 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^a57i11 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^a58l (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^a59k1 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^apl (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^bf2 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^bf (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^bl (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^Bwx (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^co (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^col (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^e2 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^E (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^e (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^ec3 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^h (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of wⁱ (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^IR1 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^IR2 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^IR3 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^IR4 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^IR5 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^IR6 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^mo (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^r (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^sat (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^sp2 (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^sp81d (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of w^zm (Rabinow and Birchler, 1989) Doa⁶ is a non-enhancer of phenotype of y² (Rabinow and Birchler, 1989)
Suppressor of
Statement Reference Doa⁶ is a suppressor of phenotype of w^a (Rabinow and Birchler, 1989) Doa⁶ is a suppressor of phenotype of w^aM (Rabinow and Birchler, 1989) Doa⁶ is a suppressor of phenotype of w^aR84h (Rabinow and Birchler, 1989)
NOT Suppressor of
Statement Reference Doa⁶ is a non-suppressor of phenotype of w^a2 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^a3 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^a4 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^a57i11 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^a58l (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^a59k1 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^apl (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^bf2 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^bf (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^bl (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^Bwx (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^co (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^col (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^e2 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^E (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^e (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^ec3 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^h (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of wⁱ (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^IR1 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^IR2 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^IR3 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^IR4 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^IR5 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^IR6 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^mo (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^r (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^sat (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^sp2 (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^sp81d (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of w^zm (Rabinow and Birchler, 1989) Doa⁶ is a non-suppressor of phenotype of y² (Rabinow and Birchler, 1989)
Additional Comments
Genetic Interactions
Statement Reference Rare Doa^HD/Doa⁶ escapers show extreme suppression of the w^a phenotype, such that eyes, Malpighian tubules, ocelli and testes are essentially wild-type in colour. They have disordered eye facets and scutellar bristles are often missing or abnormal. Male escapers carrying w^sp55 have bleach-white eyes. (Rabinow and Birchler, 1989)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Does not interact with gypsy induced alleles at several loci (f¹, y² and ct⁶). (Rabinow and Birchler, 1989)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Doa⁶ Doa^CC (Yun et al., 1994, Rabinow et al., 1993, Rabinow and Birchler, 1990, Rabinow and Birchler, 1989, Kpebe and Rabinow, 2008)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Kpebe and Rabinow, 2008, Genetics 179(4): 1973--1987 Dissection of darkener of apricot kinase isoform functions in Drosophila. [FBrf0205853] Yun et al., 1994, Genes Dev. 8(10): 1160--1173 The Doa locus encodes a member of a new protein kinase family and is essential for eye and embryonic development in Drosophila melanogaster. [FBrf0074875] Rabinow et al., 1993, Genetics 134(4): 1175--1185 Mutations at the darkener of apricot locus modulate transcript levels of copia and copia-induced mutations in Drosophila melanogaster. [FBrf0058584] Rabinow and Birchler, 1990, Genet. Res. (Camb.) 55: 141--151 Interactions among modifiers of retrotransposon-induced alleles of the white locus of Drosophila melanogaster. [FBrf0051869] Rabinow and Birchler, 1989, EMBO J. 8: 879--889 A dosage-sensitive modifier of retrotransposon-induced alleles of the Drosophila white locus. [FBrf0049635]

Allele Dmel\Doa6

Allele Dmel\Doa⁶