FlyBase Allele Report: Dmel\dor[8]

General Information

Symbol

Dmel\dor⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0002736

Feature type

allele

Associated gene

Dmel\dor

Associated Insertion(s)

Carried in Construct

Also Known As

dor^l

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Shestopal et al., 1997)

Progenitor genotype

Cytology

Description

Insertion of DNA at least 4.3kb in length.

(Shestopal et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

insertion

X:1,664,939..1,666,581 [+]

Linked to:

EcoRI-BamHI restriction fragment

Comment:

Insertion of DNA at least 4.3kb in length. Insertion site localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator

(Shestopal et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with Ras85D^V12.UAS

(Chi et al., 2010)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

dor⁸ larval nephrocytes exhibit decreased density of slit diaphragms in the cortical region and abnormal internal accumulation of slit diaphragms, compared to controls.

(Atienza-Manuel et al., 2021)

Homozygous mushroom body gamma neuron clones show normal axon pruning.

(Issman-Zecharya and Schuldiner, 2014)

dor⁸ clones exhibit an endosome clustering phenotype.

(Gailite et al., 2012)

Homozygous clones in the eye lack almost all pigmentation.

(Akbar et al., 2009)

Late larval lethal.

(Schwartz, 1999.1.18)

Homozygous clones in the eye lack pigmentation. Only minor defects are seen in the composition of the ommatidia. The majority of rhabdomeres are normal. Giant multivesicular bodies (MVBs) with diameters up to 3μm are seen in mutant pigment cells. Many of the internal vesicles in these structures appear coated (this is not seen in wild-type rhabdomeres). Smaller MVBs are seen in mutant photoreceptor cells (these are not seen in wild-type cells).

(Sevrioukov et al., 1999)

Homozygous larvae die 90-100 hours after hatching. Heterozygotes with Df(1)RA19 die in the middle of the third instar.

(Belyaeva et al., 1982)

Malpighian tubule colour: nearly colourless except at base.

(Oftedal, 1953)

A gut abnormality appears at 65 hr that results in obliteration of gut lumen and loss of all food material.

(Russell, 1940)

Melanotic tumors develop.

(Stark, 1919, Stark, 1918)

RK2. Male larvae die 90-100 hr after hatching. dor⁸/dor¹ has orange eyes like dor¹/dor¹, as well as the sterility effects (Clancy; Redfeld and Schultz).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

dor[+]/dor⁸ is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

Suppressor of

Statement