Allele Dmel\dp^ov1

General Information
Symbol	Dmel\dp^ov1	Species	D. melanogaster
Name	oblique vortex	FlyBase ID	FBal0002834
Feature type	allele	Associated gene	Dmel\dp

Allele class
Mutagen	spontaneous
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	spontaneous
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of a blood element into intron 11. (Carmon et al., 2010)
Caused by insertion	blood{}dp^ov1 (Carmon et al., 2010)
Carried on aberration	C(2L)RM-P2 CyO-dpc (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28) Df(2L)BSC6 (Deal et al., 2001.8.1) Df(2L)BSC41 (Deal et al., 2003.9.17) Df(2L)BSC53 (Deal et al., 2004.7.8) Df(2L)k05007-mr19 (Roote, 2000.6.13) Df(2L)k07245-mr9 (Roote, 2000.6.13) Df(2L)k07245-mr28 (Roote, 2000.6.13) Df(2L)k09033-mr9 (Roote, 2000.6.13) Df(2L)k09033-mr19 (Roote, 2000.6.13) Df(2L)k14608-mr4 (Roote, 2000.6.13) Df(2L)k14608-mr6 (Roote, 2000.6.13) Df(2L)k14608-mr15 (Roote, 2000.6.13) Df(2L)k14608-mr16 (Roote, 2000.6.13) Df(2L)k14608-mr27 (Roote, 2000.6.13) Df(2L)k14608-mr29 (Roote, 2000.6.13) Df(2L)PZ05271-mr15 (Roote, 2000.6.13) Df(2L)PZ05271-mr45 (Roote, 2000.6.13) Df(2L)PZ06430-mr2 (Roote, 2000.6.13) Df(2L)PZ06430-mr11 (Roote, 2000.6.13) Df(2L)PZ06430-mr14 (Roote, 2000.6.13) Df(2L)PZ07130-mr1 (Roote, 2000.6.13) Df(2L)PZ07130-mr9 (Roote, 2000.6.13) Dp(2;2)Cam10 (Roote, 2004.6.24)
Cytology
Phenotypic Data
Phenotypic Class
	immune response defective \| adult stage (Von Ohlen et al., 2012) visible (Olguín et al., 2011) visible (with dp^2f1-olv) (Coelho et al., 2005) visible (with dp^2f2-lv) (Coelho et al., 2005) visible (with dp^2f3-olv) (Coelho et al., 2005) visible \| recessive
Phenotype Manifest In
	adult thorax (Kjaer, 1989) adult thorax (with dp^2f1-olv) (Coelho et al., 2005) adult thorax (with dp^2f2-lv) (Coelho et al., 2005) adult thorax (with dp^2f3-olv) (Coelho et al., 2005) adult thorax (with dp^v2) (Kjaer, 1989) adult thorax & adult epidermis dorsocentral bristle mesothoracic tergum (Olguín et al., 2011) wing (Kjaer, 1989, ) wing (with dp^2f1-olv) (Coelho et al., 2005) wing (with dp^2f3-olv) (Coelho et al., 2005) wing (with dp^o2) (Kjaer, 1989)
Detailed Description
	Statement Reference Mutant flies show significantly increased survival compared to wild-type flies after infection with E. chaffeensis. Bacterial replication is significantly reduced in the mutant flies compared to wild type. (Von Ohlen et al., 2012) Mutant flies have anterior indentations in the notum epidermis. (Olguín et al., 2011) "ov" class allele. (Carmon et al., 2010) dp[ov1] embryos do not show defects in tracheal tube length and do not show breaks in the tracheal branches. (Swanson et al., 2009) dp^TC4/dp^ov1 flies have "lopped" and "vortex" phenotypes. Body and leg size are reduced. (Carlson, 1956) Oblique wing phenotype (o). Thoracic vortex phenotype (v). Wings reduced one-third and have oblique truncation; angle between veins L2 and L3 widened; intercrossvein distances shortened; marginal vein intact; two vortices with whorls of hairs in dorsocentral region; dorsocentral bristles medially displaced; vortex expression in most flies at 26^oC; comma effect in anterior thorax also present in most flies at 26^oC. At lower temperatures, wing effect persists, but thorax appears normal. Body and leg size normal except at temperatures above 28^oC, when they are somewhat reduced. RK1.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference dp^ov1 has planar polarity defective phenotype, enhanceable by chas¹ (Olguín et al., 2011) dp^ov1 has visible phenotype, enhanceable by chas¹ (Olguín et al., 2011)
Enhancer of
Statement Reference dp^ov1 is an enhancer of planar polarity defective phenotype of chas¹ (Olguín et al., 2011) dp^ov1 is an enhancer of visible phenotype of chas¹ (Olguín et al., 2011)
Phenotype Manifest In
Enhanced by
Statement Reference dp^ov1 has mesothoracic tergum phenotype, enhanceable by chas¹ (Olguín et al., 2011)
Suppressed by
Statement Reference dp^ov1/dp^o2 has wing phenotype, suppressible by su(dp^ov)¹ (Kjaer, 1989) dp^ov1/dp^o2 has wing phenotype, suppressible by su(dp^ov)² (Kjaer, 1989) dp^ov1/dp^o2 has wing phenotype, suppressible by su(dp^ov)³ (Kjaer, 1989) dp^ov1 has adult thorax phenotype, suppressible by su(dp^ov)¹ (Kjaer, 1989) dp^ov1 has wing phenotype, suppressible by su(dp^ov)¹ (Kjaer, 1989) dp^ov1 has wing phenotype, suppressible by su(dp^ov)² (Kjaer, 1989) dp^ov1 has wing phenotype, suppressible by su(dp^ov)³ (Kjaer, 1989)
NOT suppressed by
Statement Reference dp^ov1 has adult thorax phenotype, non-suppressible by su(dp^ov)² (Kjaer, 1989) dp^ov1 has adult thorax phenotype, non-suppressible by su(dp^ov)³ (Kjaer, 1989) dp^v2/dp^ov1 has adult thorax phenotype, non-suppressible by su(dp^ov)¹ (Kjaer, 1989) dp^v2/dp^ov1 has adult thorax phenotype, non-suppressible by su(dp^ov)² (Kjaer, 1989) dp^v2/dp^ov1 has adult thorax phenotype, non-suppressible by su(dp^ov)³ (Kjaer, 1989)
Enhancer of
Statement Reference dp^ov1 is an enhancer of mesothoracic tergum phenotype of chas¹ (Olguín et al., 2011) dp^ov1 is an enhancer of presumptive embryonic/larval tracheal system phenotype of vari^f00033 (Swanson et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference chas[1] dp[ov1] double mutants show enhanced indentations of the anterior notum epidermis and enhanced planar polarity defects compared to either single mutant. (Olguín et al., 2011) The tracheal tube length defects caused by vari[f00033] are enhanced if the embryos are also mutant for dp[ov1]. (Swanson et al., 2009) The oblique wing phenotype is suppressed in homozygous su(dp^ov)¹, su(dp^ov)² or su(dp^ov)³ flies. The vortex (thoracic invagination) phenotype is suppressed in homozygous su(dp^ov)¹ flies. The wing phenotype of dp^ov1/dp^o2 flies is totally suppressed by su(dp^ov)¹, su(dp^ov)² or su(dp^ov)³. (Kjaer, 1989)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	dp^2f1-olv (Coelho et al., 2005) dp^2f2-lv (Coelho et al., 2005) dp^2f3-olv (Coelho et al., 2005)
Comments
Stocks ( 166 )
Bloomington	276 dp^ov1 277 dp^ov1 cn¹ bw¹ 3077 Df(2L)spd, al¹ dp^ov1/CyO 5084 Df(2L)pr-M1, dp^ov1 bw¹/CyO 6338 Df(2L)BSC6, dp^ov1 cn¹/SM6a 7147 Df(2L)BSC41, dp^ov1 cn¹/CyO
Kyoto	105826 dp^ov1 105827 dp^ov1 cn¹ bw¹ 105796 ast⁴ dp^ov1 cl¹ 106823 Df(2L)spd, al¹ dp^ov1/CyO 108030 Df(2L)pr-M1, dp^ov1 bw¹/CyO 108739 Df(2L)BSC6, dp^ov1 cn¹/SM6a
	More stocks available...
Notes on Origin
Discoverer	Morgan, 16 Oct. 1918.

Comments
	Aspartate transcarbamylase (ATCase), orotate phosphoribosyltransferase (OPRTase) and orotidine-5'-phosphate decarboxylase (ODCase) activity is elevated in dp^ov1 flies and normalised in su(dp^ov)¹ dp^ov1 flies. (Kjaer, 1989)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	dp (Carlson, 1956, ) dp^ov1 (Swanson et al., 2009, Von Ohlen et al., 2012, Olguín et al., 2011) dp^ov (Kjaer, 1989, ) dp^ovCB1 ov1 (Carmon et al., 2010) unnamed (Roote, 2004.6.24)
Name Synonym	oblique vortex
Secondary FlyBase IDs

References ( 17 )
Research paper	Von Ohlen et al., 2012, Infect. Immun. 80(10): 3576--3586 Identification of Critical Host Mitochondrion-Associated Genes during Ehrlichia chaffeensis Infections. [FBrf0219421] Carmon et al., 2010, PLoS ONE 5(8): e12319 A Molecular Analysis of Mutations at the Complex dumpy Locus in Drosophila melanogaster. [FBrf0211710] Swanson et al., 2009, Genetics 181(4): 1281--1290 Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization. [FBrf0207797] Coelho et al., 2005, Genetics 171(2): 597--614 A genetic screen for dominant modifiers of a small-wing phenotype in Drosophila melanogaster identifies proteins involved in splicing and translation. [FBrf0190712] Kjaer, 1989, Hereditas 110(1): 7--12 A new X-bound suppressor mutation in Drosophila melanogaster suppressor of dumpy. [FBrf0050051] Sederoff, 1967, Nature 216: 1348--1349 Rare pseudoallelic crossover between two phenotypically identical alleles at a restricted sublocus of dumpy in Drosophila melanogaster. [FBrf0018916] Carlson, 1956, D. I. S. 30: 70 [New mutants report.] [FBrf0094323] Morgan, 1929, Publs Carnegie Instn 399: 169--199 Contributions to the genetics of Drosophila simulans and Drosophila melanogaster. [FBrf0001868]
Supplementary material	Olguín et al., 2011, Curr. Biol. 21(3): Supplemental Information. [FBrf0213857]
Personal communication to FlyBase	Deal et al., 2004.7.8, Isolation and characterization of Df(2L)BSC53. Isolation and characterization of Df(2L)BSC53. [FBrf0178896] Roote, 2004.6.24, Cam Dps. Cam Dps. [FBrf0178882] Deal et al., 2003.9.17, Isolation and characterization of Df(2L)BSC41. Isolation and characterization of Df(2L)BSC41. [FBrf0161614] Bloomington Drosophila Stock Center, 2001.8.28, Balancer Variants. Balancer Variants. [FBrf0138610] Deal et al., 2001.8.1, Isolation and Characterization of Df(2L)BSC6. Isolation and Characterization of Df(2L)BSC6. [FBrf0137514] Roote, 2000.6.13, New P derivatives. New P derivatives. [FBrf0129261]
FlyBase analysis	FlyBase Curators, 2006-, Balancer summary information. Balancer summary information. [FBrf0189689]
Book	Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]

Allele Dmel\dpov1

Allele Dmel\dp^ov1