FlyBase Allele Report: Dmel\dpy[olvR]

General Information

Symbol

Dmel\dpy^olvR

Species

D. melanogaster

Name

oblique lethal vortex Ruffled

FlyBase ID

FBal0002971

Feature type

allele

Associated gene

Dmel\dpy

Associated Insertion(s)

Carried in Construct

Also Known As

dp^olvR

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

Progenitor genotype

Caused by aberration

In(2L)dp^olvR

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with dpy^2f1-olv)

(Coelho et al., 2005)

lethal (with dpy^2f2-lv)

(Coelho et al., 2005)

lethal (with dpy^2f3-olv)

(Coelho et al., 2005)

lethal | recessive

visible | dominant

Phenotype Manifest In

Detailed Description

Statement

Reference

The wings of dpy^olvR mutant heterozygotes appear wild type.

(Ray et al., 2015)

A dp^olvR heterozygous background markedly increases the penetrance of wing blisters causes by expression of Eogt^NIG.9867R under the control of Scer\GAL4^en-e16E.

(Sakaidani et al., 2011)

Homozygous dp^olvR embryos have a tracheal disintegration phenotype similar to Df(2R)Px2 homozygotes. All tracheal branches except the dorsal trunk and the dorsal branch of the first tracheal metamere undergo disintegration. The branches that undergo disintegration include the cerebral branch, ventral cephalic, pharyngeal branch, dorsal branch, visceral branch, transverse connective, lateral trunk anterior, lateral trunk posterior and ganglionic branch. Instead of fine tracheal tubes, in homozygous dp^olvR embryos these are transformed into hollow cysts. However, the dorsal trunk is not affected, indicating that dp^olvR embryos exhibit an absence of tubes with autocellular adherens junctions. The subsequent differentiation of the dorsal branches does not seem to be affected in dp^olvR homozygous embryos. Terminal branch formation or integrity is not detectably affected in dp^olvR homozygous embryos. In addition, the formation of fusion tubes between the bilateral dorsal branches along the dorsal midline occurs normally in dp^olvR homozygous embryos.

(Jazwinska et al., 2003)

Oblique wing phenotype (o). Thoracic vortex phenotype (v). Similar to dp^olv, but heterozygous dp^olvR has slightly spread wings with uneven surface and ruffled margin. Ruffling effect overlaps wild type at 25^oC. RK2A.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

dpy[+]/dpy^olvR is an enhancer of visible | dominant phenotype of nw^D

(Ray et al., 2015)

dpy[+]/dpy^olvR is an enhancer of visible | dominant phenotype of nw^B

(Ray et al., 2015)

dpy^olvR/dp[+] is an enhancer of visible | heat sensitive phenotype of Dcr-2^UAS.cDa, Eogt^GD5084, Scer\GAL4^en.PU

(Müller et al., 2013)

Other

Statement

Reference

Yif1^doc-1, dpy[+]/dpy^olvR has visible | adult stage phenotype

(Kandasamy et al., 2021)

Yif1^doc-1, dpy[+]/dpy^olvR has decreased size | adult stage phenotype

(Kandasamy et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

dpy[+]/dpy^olvR is an enhancer of wing phenotype of nw^D

(Ray et al., 2015)

dpy[+]/dpy^olvR is an enhancer of wing phenotype of nw^B

(Ray et al., 2015)

dpy[+]/dpy^olvR is an enhancer of wing blade posterior compartment | heat sensitive phenotype of Dcr-2^UAS.cDa, Eogt^GD5084, Scer\GAL4^en.PU

(Müller et al., 2013)

dpy^olvR is an enhancer of epidermis phenotype of Eogt^NIG.9867R, Scer\GAL4^en-e16E

(Sakaidani et al., 2011)

Other

Statement

Reference

Yif1^doc-1, dpy[+]/dpy^olvR has wing phenotype

(Kandasamy et al., 2021)

dpy^olvR, pio^2R-16 has visceral tracheal branch primordium phenotype

(Jazwinska et al., 2003)

dpy^olvR, pio^2R-16 has tracheal lateral trunk anterior branch primordium phenotype

(Jazwinska et al., 2003)

dpy^olvR, pio^2R-16 has cerebral tracheal branch phenotype

(Jazwinska et al., 2003)

dpy^olvR, pio^2R-16 has tracheal lateral trunk posterior branch primordium phenotype

(Jazwinska et al., 2003)

dpy^olvR, pio^2R-16 has adult dorsal tracheal branch phenotype

(Jazwinska et al., 2003)

dpy^olvR, pio^2R-16 has pharyngeal tracheal branch phenotype

(Jazwinska et al., 2003)

dpy^olvR, pio^2R-16 has ventral cephalic tracheal branch phenotype

(Jazwinska et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

dpy^olvR, Yif1^doc-1 double heterozygotes show a small, oblique wing phenotype.

(Kandasamy et al., 2021)

dpy^olvR enhances the wing phenotypes seen in nw^D heterozygotes alone. A spectrum of phenotypes is seen, ranging from a sharply tapered wing blade to complete retraction of the wing blade.

dpy^olvR enhances the wing phenotypes seen in nw^B heterozygotes alone. A spectrum of phenotypes is seen, ranging from a sharply tapered wing blade to complete retraction of the wing blade.

(Ray et al., 2015)

dp^olvR dominantly enhances the wing blistering phenotype seen in the posterior compartment of wings in flies expressing Eogt^GD5084 under the control of Scer\GAL4^en.PU in the presence of Dcr-2^Scer\UAS.cDa, such that the phenotype is seen at 22.5[o]C.

(Müller et al., 2013)

The tracheal disintegration phenotype of dp^olvR;pio^2R-16 double mutant embryos appear very similar to those observed in dp^olvR and pio^2R-16 single-mutant embryos.

(Jazwinska et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

dpy^2f3-olv

(Coelho et al., 2005)

dpy^2f1-olv

(Coelho et al., 2005)

dpy^2f2-lv

(Coelho et al., 2005)