Allele Dmel\dpp^d-blk

General Information
Symbol	Dmel\dpp^d-blk	Species	D. melanogaster
Name		FlyBase ID	FBal0002996
Feature type	allele	Associated gene	Dmel\dpp
Also Known As	dpp^blk

Allele class
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	spontaneous (Blackman et al., 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Deletion from position 106 to 111.4 on the molecular map (FBrf0051824). (Bergstrom et al., 1995) 5kb deletion of sequences 17kb 3' of the dpp transcribed region. (Masucci et al., 1990) Deletion spanning the disc region II and III, insertion of 1.9kb hobo element at the deletion site. (Blackman et al., 1987) hobo
Caused by insertion	H{}dpp^d-blk (Sedkov et al., 2003, Blackman et al., 1987)
Cytology	Polytene chromosomes normal.
Phenotypic Data
Phenotypic Class
	visible (Staehling-Hampton et al., 1994, Treisman et al., 1997, Lin et al., 2003, Blackman et al., 1987, Bach et al., 2003, Masucci et al., 1990, Jones et al., 2006) visible \| recessive (Royet and Finkelstein, 1997, Curtiss and Mlodzik, 2000)
Phenotype Manifest In
	eye (Royet and Finkelstein, 1997, Horsfield et al., 1998, Treisman et al., 1997, Curtiss and Mlodzik, 2000, Lin et al., 2003, Blackman et al., 1987, Bach et al., 2003, Sedkov et al., 2003, Jones et al., 2006) eye-antennal disc (Wiersdorff et al., 1996) frons \| ectopic (Royet and Finkelstein, 1997) morphogenetic furrow (Curtiss and Mlodzik, 2000, Lin et al., 2003, Treisman and Rubin, 1995, Wiersdorff et al., 1996) ommatidium (Royet and Finkelstein, 1997, Staehling-Hampton et al., 1994, Chanut and Heberlein, 1997, Masucci et al., 1990, Jones et al., 2006) photoreceptor cell (Lin et al., 2003) retina (Chanut and Heberlein, 1997)
Detailed Description
	Statement Reference Mutants have a very small, rough eye with few facets. (Jones et al., 2006) Homozygotes have small eyes. (Bach et al., 2003) Mutant show partial inhibition of the morphogenetic furrow, and reduced photoreceptor differentiation, resulting in a small eye phenotype in adults. (Lin et al., 2003) A morphogenetic furrow initiates only in the centre of mutant eye discs. Although it progresses anteriorly in a normal fashion, it fails to spread laterally. Homozygous flies have small eyes. (Curtiss and Mlodzik, 2000) Small, rough eyes. (Horsfield et al., 1998) Ommatidial array is slightly disorganised but an equator is still discernible separating 10 or more rows of dorsal ommatidia from 2-3 rows of ventral ommatidia. Head cuticle replaces portions of the retinal field near the dorsal and ventral margins (the effect is more pronounced ventrally). Rotational polarity is maintained in dorsal and ventral portions. Asymmetric retinal differentiation occurs with retinal development (failure of ommatidial differentiation in the ventral eye disc), it is not a consequence of cell death. Anterior-dorsal ptc^S2 clone in dpp^d-blk eye disc causes ectopic differentiation ahead of the morphogenetic furrow, this wave of ectopic differentiation propogates into neighbouring ptc⁺ tissue. A ventral margin clone in dpp^d-blk eye disc causes ectopic differentiation that propogates into ventral ptc⁺ tissue. Clone spanning a large portion of ventral epithelium and ventral posterior margin rescues ventral differentiation to a relatively normal pattern. (Chanut and Heberlein, 1997) dally⁰⁶⁴⁶⁴ homozygotes show a slight reduction in the eye which is more severe when they are also heterozygous for dpp^d-blk. (Jackson et al., 1997) Homozygotes have greatly reduced compound eyes consisting of only a few ommatidia. The eye is largely replaced by frons cuticle, with ectopic frons cuticle lying between the orbital cuticle and the remaining ommatidia, and also between the shingle cuticle and ommatidia. (Royet and Finkelstein, 1997) Eye discs have a similar appearance to those of hypomorphic Mad alleles. The furrow initiates in a restricted area at the posterior edge and dpp expression is not maintained along the posterior margin. (Wiersdorff et al., 1996) Allows furrow movement only in the central region of the eye disc, loss of one copy of wg is sufficient to increase the size of the eye. (Treisman and Rubin, 1995) Small eye phenotype. (Staehling-Hampton et al., 1994, Treisman et al., 1997) Reduction in number of eye facets. Mutant phenotype can be rescued by P{TnJMB7}. (Masucci et al., 1990) Eye reduced in size. (Blackman et al., 1987)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference dpp^d-blk has visible \| recessive phenotype, enhanceable by ey^Scer\UAS.cHa/Scer\GAL4^ey.PH (Curtiss and Mlodzik, 2000) dpp^d-blk has visible \| recessive phenotype, enhanceable by Scer\GAL4^ey.PH/dac^Scer\UAS.cSa (Curtiss and Mlodzik, 2000) dpp^d-blk has visible \| recessive phenotype, enhanceable by so^Scer\UAS.cPa/Scer\GAL4^dpp.blk1 (Curtiss and Mlodzik, 2000) dpp^d-blk has visible \| recessive phenotype, enhanceable by so^Scer\UAS.cPa/Scer\GAL4^ey.PH (Curtiss and Mlodzik, 2000)
Suppressed by
Statement Reference dpp^d-blk has visible \| recessive phenotype, suppressible \| partially by Scer\GAL4^dpp.blk1/eya^Scer\UAS.cBa (Curtiss and Mlodzik, 2000) dpp^d-blk has visible phenotype, suppressible \| partially by spen^k13624/spen^k07721 (Lin et al., 2003) dpp^d-blk has visible phenotype, suppressible by l(2)rQ313[+]/snama^rQ313 (Jones et al., 2006) dpp^d-blk has visible phenotype, suppressible by snama^PX1/mnm[+] (Jones et al., 2006)
Enhancer of
Statement Reference dpp^d-blk/dpp[+] is an enhancer of visible \| recessive phenotype of dally⁰⁶⁴⁶⁴ (Jackson et al., 1997)
Other
Statement Reference dally[+]/dally⁰⁶⁴⁶⁴, dpp^d-blk has visible \| dominant phenotype (Jackson et al., 1997) dally⁰⁶⁴⁶⁴, dpp^d-blk/dpp[+] has visible \| dominant phenotype (Jackson et al., 1997)
Phenotype Manifest In
Enhanced by
Statement Reference dpp^d-blk has eye phenotype, enhanceable by B[+]/B¹ (Sedkov et al., 2003) dpp^d-blk has eye phenotype, enhanceable by ey^Scer\UAS.cHa/Scer\GAL4^ey.PH (Curtiss and Mlodzik, 2000) dpp^d-blk has eye phenotype, enhanceable by osa³⁰⁸ (Treisman et al., 1997) dpp^d-blk has eye phenotype, enhanceable by Scer\GAL4^ey.PH/dac^Scer\UAS.cSa (Curtiss and Mlodzik, 2000) dpp^d-blk has eye phenotype, enhanceable by so^Scer\UAS.cPa/Scer\GAL4^dpp.blk1 (Curtiss and Mlodzik, 2000) dpp^d-blk has eye phenotype, enhanceable by so^Scer\UAS.cPa/Scer\GAL4^ey.PH (Curtiss and Mlodzik, 2000) dpp^d-blk has eye phenotype, enhanceable by trr¹/trr[+] (Sedkov et al., 2003)
Suppressed by
Statement Reference dpp^d-blk has eye-antennal disc phenotype, suppressible \| partially by Mad^{Ubi-p63E.T:Hsap\MYC} (Wiersdorff et al., 1996) dpp^d-blk has eye disc phenotype, suppressible \| partially by Scer\GAL4^dpp.blk1/eya^Scer\UAS.cBa (Curtiss and Mlodzik, 2000) dpp^d-blk has eye phenotype, suppressible \| partially by Scer\GAL4^dpp.blk1/eya^Scer\UAS.cBa (Curtiss and Mlodzik, 2000) dpp^d-blk has eye phenotype, suppressible \| partially by spen^k13624/spen^k07721 (Lin et al., 2003) dpp^d-blk has eye phenotype, suppressible by l(2)rQ313[+]/snama^rQ313 (Jones et al., 2006) dpp^d-blk has eye phenotype, suppressible by snama^PX1/mnm[+] (Jones et al., 2006) dpp^d-blk has morphogenetic furrow phenotype, suppressible \| partially by Scer\GAL4^dpp.blk1/eya^Scer\UAS.cBa (Curtiss and Mlodzik, 2000) dpp^d-blk has ommatidium phenotype, suppressible \| partially by Scer\GAL4^dpp.blk1/eya^Scer\UAS.cBa (Curtiss and Mlodzik, 2000) dpp^d-blk has ommatidium phenotype, suppressible by l(2)rQ313[+]/snama^rQ313 (Jones et al., 2006) dpp^d-blk has ommatidium phenotype, suppressible by snama^PX1/mnm[+] (Jones et al., 2006) dpp^d-blk has photoreceptor cell phenotype, suppressible \| partially by spen^k13624/spen^k07721 (Lin et al., 2003)
NOT suppressed by
Statement Reference dpp^d-blk has eye phenotype, non-suppressible by gbb^Scer\UAS.cSa/Scer\GAL4^dpp.blk1 (Staehling-Hampton et al., 1994) dpp^d-blk has eye phenotype, non-suppressible by gbb^Scer\UAS.cSb/Scer\GAL4^dpp.blk1 (Staehling-Hampton et al., 1994)
Enhancer of
Statement Reference dpp^d-blk/dpp[+] is an enhancer of eye phenotype of dally⁰⁶⁴⁶⁴ (Jackson et al., 1997)
Suppressor of
Statement Reference dpp^d-blk is a suppressor of phenotype of wg^l-12 (Treisman and Rubin, 1995)
Other
Statement Reference dally[+]/dally⁰⁶⁴⁶⁴, dpp^d-blk has eye phenotype (Jackson et al., 1997)
Additional Comments
Genetic Interactions
Statement Reference The dpp^d-blk phenotype is partially rescued by eya^Scer\UAS.cBa expressed under the control of Scer\GAL4^dpp.blk1. Specifically, the morphogenetic furrow spreads in a normal fashion dorsally along the lateral margin to form an almost complete dorsal half of an eye. The morphogenetic furrow does not spread ventrally along the margin. The small size of dpp^d-blk/dpp^d12 eye discs is partially rescued by eya^Scer\UAS.cBa expressed under the control of Scer\GAL4^dpp.blk1 and greater numbers of developing ommatidia are seen. The dpp^d-blk small eye phenotype is enhanced by so^Scer\UAS.cPa expressed under the control of either Scer\GAL4^dpp.blk1 or Scer\GAL4^ey.PH, which often results in a complete lack of eye development. Expression of dac^Scer\UAS.cSa under the control of Scer\GAL4^ey.PH results in a variable decrease in the size of dpp^d-blk eyes. Expression of ey^Scer\UAS.cHa under the control of Scer\GAL4^ey.PH interferes with dpp^d-blk eye development to a variable extent, often resulting in smaller eyes. (Curtiss and Mlodzik, 2000) Flies heterozygous for both dally⁰⁶⁴⁶⁴ and dpp^d-blk show eye abnormalities never observed in flies heterozygous for dally⁰⁶⁴⁶⁴ or dpp^d-blk alone. (Jackson et al., 1997) The eye disc phenotype is partially rescued by Mad^{Ubi-p63E.T:Hsap\MYC}. (Wiersdorff et al., 1996) In wg^l-12, dpp^d-blk eye discs the dpp^d-blk mutation completely abolishes the effects of loss of wg expression (inwardly directed furrow movement is not present). (Treisman and Rubin, 1995) In double mutants of bun^rI043 and the eye specific allele dpp^d-blk the frequency of survivors is decreased relative to the single bun^rI043 mutant and the eye is extremely reduced due to differentiation of a very small number of ommatidia. (Treisman et al., 1995) Scer\GAL4^dpp.blk1 driven expression of gbb^Scer\UAS.cSb or gbb^Scer\UAS.cSa is unable to rescue the mutant phenotype. (Staehling-Hampton et al., 1994) Transheterozygotes with eya⁴ are normal. (Eissenberg and Ryerse, 1991)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	dpp^d-blk is rescued by dpp^Scer\UAS.cSa/Scer\GAL4^dpp.blk1 (Staehling-Hampton et al., 1994)
Comments	Small eye phenotype can be rescued by dpp^TnJMB7 and Scer\GAL4^dpp.blk1 driving the expression of dpp^Scer\UAS.cSa. (Staehling-Hampton et al., 1994) Allele class: d-blk
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	The strain dpp^d-blk is capable of promoting the mobilization of hobos. The strain contains numerous internally deleted hobos and two 3.0kb copies. The ability to promoter mobilisation results from the action of the 3.0kb elements. One of these elements was cloned and used to produce plasmid "pHFL1". (Blackman et al., 1989)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	dpp^blk (Bach et al., 2003, Sedkov et al., 2003, Lin et al., 2003, Chanut et al., 2002, Lin et al., 2001, Curtiss and Mlodzik, 2000, Greenwood and Struhl, 1999, Liu and Reinke, 1997, Jackson et al., 1997, Heldin et al., 1997, Fini et al., 1997, Chanut and Heberlein, 1997, Chanut and Heberlein, 1997, Theisen et al., 1996, Wiersdorff et al., 1996, Eissenberg and Ryerse, 1991, Blackman et al., 1987, Jones et al., 2006) dpp^dblk (Calvi and Gelbart, 1994) dpp^d-blk
Name Synonym	blink (Theisen et al., 1996)
Secondary FlyBase IDs

References ( 32 )

Generate a list of	All references relating to this allele ( 32 )

List References by type	Research paper ( 26 ) Supplementary material ( 1 ) Review ( 2 ) Abstract ( 2 ) Letter ( 1 )
Recent research papers (0)
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Allele Dmel\dppd-blk

Allele Dmel\dpp^d-blk