Open Close
General Information
Symbol
Dmel\dppd-ho
Species
D. melanogaster
Name
FlyBase ID
FBal0002997
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dppho2, dppho, dppdho
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

3kb deletion of sequences 23kb 3' of the dpp transcription unit.

2.7kb deletion.

Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies homozygous for both dpps1 and dppd-ho display shortened L4, and occasionally, L2 and posterior crossveins.

Held out wings, no noticeable eye roughening.

dpps1 dppd-ho double mutant chromosome partially suppresses the penetrance of the hhMrt phenotype.

dpphr4/dppd-ho transheterozygotes show a wild type wing phenotype in an otherwise normal genetic background.

Held out wing, defects in sensilla campaniforma on the wing blade.

Complete wings, reduction of sensilla on the dorsal radius from 25 to 8 and an additional fold.

Held out wing phenotype.

z1 product subliminally inhibits the complementation of dpphr4 and dppd-ho. The effect is only seen when compounded by the particular effects of rearrangements on synapsis.

Held-out wings. The wings are held out laterally instead of in line with the longitudinal axis of the body. Transheterozygotes with dpphr4 exhibit normally oriented wings.

Wings are held out laterally to the long axis of the body.

Wings extended at right angles to body. RK1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

dppd-ho/dpps1 has visible phenotype, enhanceable by Lpt1/Lpt[+]

Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

dppd-ho/dpp[+] is a suppressor of visible phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

dppd-ho is a suppressor of visible phenotype of upd1GMR.PB

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

dppd-ho/dpps1 has posterior crossvein phenotype, enhanceable by Lpt1/Lpt[+]

dppd-ho has phenotype, enhanceable by tld14

NOT suppressed by
Statement
Reference

dppd-ho has phenotype, non-suppressible by su(Hw)2

Enhancer of
Statement
Reference

dppd-ho/dppd-ho is an enhancer of genital disc phenotype of ix1

Suppressor of
Statement
Reference

dppd-ho/dpp[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

dppd-ho is a suppressor of eye phenotype of upd1GMR.PB

dppd-ho is a suppressor of eye phenotype of CycEJP

dppd-ho/dppd12 is a suppressor of eye phenotype of CycEJP

dppd-ho/dpphr4 is a suppressor of eye phenotype of CycEJP

dppd-ho/tkvunspecified is a suppressor of phenotype of CycEJP

dppd-ho/putunspecified is a suppressor of phenotype of CycEJP

dppd-ho/Madunspecified is a suppressor of phenotype of CycEJP

Medunspecified/dppd-ho is a suppressor of phenotype of CycEJP

dppd-ho/shnunspecified is a suppressor of phenotype of CycEJP

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

A high frequency of tumour growth occurs below the anal plates of the terminalia in chromosomally female flies homozygous for ix5 and dppd-ho. In contrast, no major abnormalities are detected in the terminalia of XY ix1 dppd-ho double homozygotes.

A high frequency of tumour growth occurs below the anal plates of the terminalia in chromosomally female flies homozygous for ix1 and dppd-ho, or homozygous for ix1 and trans-heterozygous for dppd5/dppd-ho or dppd6/dppd-ho.

Homozygosity for dppd-ho significantly enhances the number of cell deaths in ix1 homozygous genital discs.

Approximately 6% of flies trans-heterozygous for Lpt1/dpps1 dppd-ho display a shortened posterior crossvein.

Lpt1/+ flies homozygous for both dpps1 and dppd-ho show enhancement of the posterior crossvein phenotype relative to trans-heterozygotes, and shortened L2 and L4 veins.

In(2LR)DTD52, dppd-ho/In(2LR)DTD11, dpphr4 flies have wild-type wing posture. Df(2L)DTD52-D51, dppd-ho/In(2LR)DTD11, dpphr4 flies have a heldout wing posture.

The dpphr4/dppd-ho phenotype is dominantly enhanced by en96 (In(2R)DTD96), to cause heldout wings.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Allele class: d-ho

Images (0)
Mutant
Wild-type
Stocks (29)
Notes on Origin
Discoverer

Novitski, July 1935.

Comments
Comments

Class I dpp allele.

dpp class I allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (39)