FlyBase Allele Report: Dmel\dpp[d6]

General Information

Symbol

Dmel\dpp^d6

Species

D. melanogaster

Name

FlyBase ID

FBal0003003

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Also Known As

dpp^d-6, dpp⁶

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Brook and Cohen, 1996, Goto et al., 1995)

Mutagen

X ray

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Caused by aberration

In(2L)dpp^d6

Cytology

Nature of the lesion

Statement

Reference

Deletion of control elements.

(Brook and Cohen, 1996)

Inversion breakpoint within the regulatory disk region, effectively deleting some of the regulatory sequences that direct expression in imaginal discs.

(Sekelsky et al., 1995)

Breakpoint allele.

(St. Johnston et al., 1990)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | conditional | third instar larval stage

(Frandsen et al., 2008)

abnormal size

(Kaphingst and Kunes, 1994)

abnormal size (with dpp^d14)

(Künnapuu et al., 2009)

decreased occurrence of cell division | third instar larval stage

(Kaphingst and Kunes, 1994)

increased cell number | embryonic stage

(Frandsen et al., 2008)

increased cell number | third instar larval stage

(Frandsen et al., 2008)

partially lethal (with dpp^d12)

(Mandal and Lakhotia, 1999)

viable (with dpp^s-hc1)

(Stultz et al., 2005)

viable (with dpp^TgR46.1)

(Stultz et al., 2005)

visible

(Maves and Schubiger, 1998, Sekelsky et al., 1995, Staehling-Hampton et al., 1994, St. Johnston et al., 1990)

visible (with dpp^d5)

(Bangi and Wharton, 2006)

visible (with dpp^d12)

(Mandal and Lakhotia, 1999)

visible (with dpp^d14)

(Künnapuu et al., 2009)

visible (with dpp^d14), with Scer\GAL4^dpp.blk1, dpp^{MFSI.III.UAS.Tag:HA}

(Künnapuu et al., 2009)

visible (with dpp^d14), with Scer\GAL4^dpp.blk1, dpp^{MFSI.UAS.Tag:HA}

(Künnapuu et al., 2009)

visible (with dpp^d14), with Scer\GAL4^dpp.blk1, dpp^{UAS.cSa.Tag:HA}

(Künnapuu et al., 2009)

visible | recessive

(Yu et al., 2000, Emerald and Roy, 1998, Khalsa et al., 1998, Saget et al., 1998)

Phenotype Manifest In

antenna (with dpp^d12)

(Mandal and Lakhotia, 1999)

antenna | ectopic

(Saget et al., 1998)

antennal disc (with dpp^d12)

(Mandal and Lakhotia, 1999)

anterior crossvein

(Khalsa et al., 1998, Brummel et al., 1994)

arista (with dpp^d12)

(Mandal and Lakhotia, 1999)

dorsal appendage

(Dequier et al., 2001)

embryonic/larval heart

(Johnson et al., 2007)

embryonic/larval lymph gland | embryonic stage

(Frandsen et al., 2008)

embryonic/larval lymph gland | third instar larval stage

(Frandsen et al., 2008)

embryonic/larval pericardial cell | increased number

(Johnson et al., 2007)

embryonic/larval plasmatocyte | conditional | third instar larval stage

(Frandsen et al., 2008)

embryonic/larval plasmatocyte | third instar larval stage

(Frandsen et al., 2008)

eye

(Horsfield et al., 1998, Saget et al., 1998, Sekelsky et al., 1995)

femur (with dpp^d12)

(Mandal and Lakhotia, 1999)

fifth segment of antenna (with dpp^d12)

(Mandal and Lakhotia, 1999)

fourth segment of antenna (with dpp^d12)

(Mandal and Lakhotia, 1999)

hemocyte | embryonic stage

(Frandsen et al., 2008)

hypogynial long bristle

(Emerald and Roy, 1998)

hypogynial tooth

(Emerald and Roy, 1998)

lamellocyte | conditional | third instar larval stage

(Frandsen et al., 2008)

leg

(Maves and Schubiger, 1998, St. Johnston et al., 1990)

leg (with dpp^d12)

(Mandal and Lakhotia, 1999)

leg | ectopic

(Saget et al., 1998)

male genitalia

(Emerald and Roy, 1998)

male genitalia (with dpp^d12)

(Mandal and Lakhotia, 1999)

medulla anlage

(Kaphingst and Kunes, 1994)

mesoderm

(Johnson et al., 2007)

ommatidium

(Kaphingst and Kunes, 1994, Staehling-Hampton et al., 1994)

ommatidium (with dpp^d12)

(Mandal and Lakhotia, 1999)

sex comb | increased number (with dpp^d12)

(Mandal and Lakhotia, 1999)

tarsal segment

(Saget et al., 1998)

tarsal segment (with dpp^d12)

(Mandal and Lakhotia, 1999)

taste bristle (with dpp^d12)

(Yasunaga et al., 2006)

tibia (with dpp^d12)

(Mandal and Lakhotia, 1999)

unguis

(Saget et al., 1998, Sekelsky et al., 1995)

unguis (with dpp^d12)

(Mandal and Lakhotia, 1999)

ventral thoracic disc (with dpp^d12)

(Mandal and Lakhotia, 1999)

wing

(Yu et al., 2000, Maves and Schubiger, 1998, Saget et al., 1998, Sekelsky et al., 1995, Staehling-Hampton et al., 1994, Posakony et al., 1990)

wing (with dpp^d5)

(Bangi and Wharton, 2006)

wing (with dpp^d12)

(Mandal and Lakhotia, 1999)

wing (with dpp^d14)

(Künnapuu et al., 2009)

wing (with dpp^hr4)

(Crickmore and Mann, 2006, George and Terracol, 1997)

wing (with dpp^hr27)

(Bangi and Wharton, 2006)

wing vein

(Brummel et al., 1994)

wing vein | ectopic

(Brummel et al., 1994)

wing vein L2

(Yu et al., 2000)

wing vein L2 (with dpp^hr4)

(Bangi and Wharton, 2006)

wing vein L2 (with dpp^hr27)

(Bangi and Wharton, 2006)

wing vein L3

(Yu et al., 2000)

wing vein L3 (with dpp^d14), with Scer\GAL4^dpp.blk1, dpp^{MFSI.III.UAS.Tag:HA}

(Künnapuu et al., 2009)

wing vein L3 (with dpp^d14), with Scer\GAL4^dpp.blk1, dpp^{MFSI.UAS.Tag:HA}

(Künnapuu et al., 2009)

wing vein L3 (with dpp^d14), with Scer\GAL4^dpp.blk1, dpp^{UAS.cSa.Tag:HA}

(Künnapuu et al., 2009)

wing vein L4

(Yu et al., 2000)

wing vein L4 (with dpp^hr4)

(Bangi and Wharton, 2006)

wing vein L4 (with dpp^hr27)

(Bangi and Wharton, 2006)

wing vein L5

(Yu et al., 2000)

Detailed Description

Statement

Reference

No wing phenotypes are seen in dpp^d6 heterozygotes.

(Layalle et al., 2011)

dpp^d6/dpp^d14 flies are viable and have small wings.

dpp^d6/dpp^d14 wings are rescued by the expression of dpp^{Scer\UAS.cSa.T:Ivir\HA1} under the control of Scer\GAL4^dpp.blk1 except for ectopic vein materials around longitudinal vein L3.

The size and morphology of dpp^d6/dpp^d14 mutant wings are almost completely rescued by the expression of dpp^{MFSI.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^dpp.blk1 except for ectopic vein material around L3.

The size and morphology of dpp^d6/dpp^d14 mutant wings are almost completely rescued by the expression of dpp^{MFSI.III.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^dpp.blk1 except for ectopic vein material around L3.

(Künnapuu et al., 2009)

dpp^d6 mutant embryos display an increased number of hematopoietic cells in the lymph gland of embryos compared to wild-type, and the lymph gland is still hypertrophic in third instar larvae and there is an overabundance of plasmatocyte precursors. There is no significant difference in the number of crystal cell precursors in these larvae.

dpp^d6 mutant larvae fed on S. typhimurium experience a developmental delay of 1 full day from hatching to pupation, and infection results in eventual lethality of these animals. Under normal conditions, dpp^d6 mutant larvae generate 38% more blood cells per larvae compared to wild-type. There is significantly more (74%) blood cells observed in 3-day fed infected mutant larvae than in non-infected mutant larvae. There is no significant difference in the number of crystal cells between infected mutant and wild-type larvae. In the absence of infection 48% of blood cells in mutant larve are new plasmatocytes, compared to 31% in controls. Within 1 day of infection, the level of new plasmatocytes decreases to 23% and continues to decrease over subsequent days, reduced compared to levels in wild-type infected larvae. Infected dpp^d6 mutant larvae are significantly impaired in their ability to produce lamellocytes, whereas infected wild-type larvae show >10-fold increase in the percentage of circulating lamellocytes.

(Frandsen et al., 2008)

Stage 15 dpp^d6 embryos contain a significantly greater number of zfh1-expressing pericardial cells than normal, but show no change in the number of Mef2 expressing cardiac cells. Hyperplasia of the zfh1-expressing pericardial cells is still seen in stage 17 mutant embryos.

dpp^d6 embryos show expanded cell proliferation in the dorsal mesoderm during stage 12 compared to wild-type embryos, and cell division in the dorsal mesoderm persists in dpp^d6 embryos throughout stage 13 (in contrast to wild type, where cell division is absent in the dorsal mesoderm in stage 13).

In the anterior region of the heart (the aorta), mutant first instar larvae show no difference in heart rate or pulse distance compared to controls. However, in the posterior region (the heart proper), the mutant larvae show a considerable reduction in the systolic distance (mutant cells do not approach each other as closely as wild-type cells do) and the diastolic distance (mutant cells do not separate from each other as far as wild-type cells do). The mutant larvae have a 44% reduction in the average pulse distance per beat, an indication that the beat volume is significantly reduced. The heart rate in the posterior region of the heart is comparable to wild type.

(Johnson et al., 2007)

Heterozygotes do not have an ectopic wing vein phenotype.

(Ramel et al., 2007)

dpp^d6/dpp^hr4 wings have only two veins, L3 and L5 and are missing L2 and L4 completely. dpp^d6/dpp^hr27 mutants have wings that are significantly reduced in size and that are missing L3 and L5. The wings of dpp^d5/dpp^d6 mutants are so small that the identification of patterning defects is obscured.

(Bangi and Wharton, 2006)

Wing size is reduced in dpp^hr4/dpp^d6 flies.

(Crickmore and Mann, 2006)

dpp^d12/dpp^d6 flies show a considerable loss of taste bristles but do not show a loss of pseudotrachae or a significant change in gross mediproboscis morphology.

(Yasunaga et al., 2006)

Approximately 50% of eggs laid by heterozygous females have shortened and abnormally shaped respiratory appendages.

(Dequier et al., 2001)

dpp^d6/dpp^hr27 flies show partial fusions of the L2 and L3 and the L4 and L5 wing veins. The wing is compressed along the A/P axis compared to wild type.

(Yu et al., 2000)

dpp^d6/dpp^d12 flies have a reduced number of ommatidia. The adults are weak, short-lived (live for 2-3 days) and have abnormalities in the wing, leg, antenna and external genitalia. The tarsal and meta-tarsal segments of all legs are abnormal in dpp^d6/dpp^d12 flies, due to loss of claws and fusion of the tarsal segments. The dorsal parts of the leg are sometimes ventralised. The tibia and femur are progressively less affected, while the trochanter and coxa are almost wild type. The number of sex comb bristles is generally higher than normal. dpp^d6/dpp^d12 flies have defects in the distal segments of the antenna. The arista is usually absent and a conical projection is present on the third segment (which presumably represents the fused 4th, 5th and 6th antennal segments). Most dpp^d6/dpp^d12 males completely lack external genitalia while some have abnormal external genitalia. There is little effect on the female genitalia. The leg and antennal discs of dpp^d6/dpp^d12 larvae are deformed.

(Mandal and Lakhotia, 1999)

The external genitalia of dpp^d6/dpp^d12 males are reduced to a small ring like structure. dpp^d6/dpp^d12 females show duplication of the thorn bristles accompanied by an absence of long bristles.

(Emerald and Roy, 1998)

Small, rough eyes.

(Horsfield et al., 1998)

Heterozygotes are phenotypically wild-type. Wings derived from dpp^d6/dpp^s4 animals lack only the anterior crossvein.

(Khalsa et al., 1998)

dpp^d6/dpp^d8 transheterozygotes have defects in both wing and leg development. Mutants can produce ventral wing hinge structures in transdetermined legs.

(Maves and Schubiger, 1998)

70 to 100% of homozygous males show loss of tarsi and claws and have small wings and eyes. 35 to 70% of homozygous males show duplication of leg structures, and 10 to 35% of homozygous males have duplicated antennal structures.

(Saget et al., 1998)

dpp^hr4/dpp^d6 transheterozygotes exhibit reduced wings to approximately half wild type size and no defects in eyes or legs.

(George and Terracol, 1997)

Homozygotes exhibit greatly reduced wings and eyes and loss of tarsal claws at the tips of the legs. Transheterozygotes with dpp^hr4 have wings approximately half size and normal legs and eyes. When in combination with Df(2L)C28/Mad⁺ the transheterozygotes exhibit more severe phenotype, further reduction in wing blade, slight reduction in the eye and loss of tarsal claws. Trisomy for Mad (Dp(2;3)JS20) partially ameliorates transheterozygote phenotype, wings are of normal size and show residual vein fusions.

(Sekelsky et al., 1995)

dpp^d6/dpp^hr4 individuals have a nearly full size wing, except for the absence of the anterior crossvein, a reduction in the distance between L4 and L5 and a small amount of ectopic vein between L2 and L3.

(Brummel et al., 1994)

The medulla neuropil is reduced to a size similar to that produced by inactivating wg prior to 44hr AEL. The number of ommatidia is correspondingly reduced. The number of outer proliferative center cells incorporating BrdU is markedly decreased in the Fas2 expressing domain of wg and dpp early third instar brains.

(Kaphingst and Kunes, 1994)

dpp^d6/dpp^d14 clones are associated with defects in the wing, but not the notum. dpp^d6/dpp^d14 clones in the posterior compartment are associated with normal venation.

(Posakony et al., 1990)

Adults lack distal portion of appendages.

(St. Johnston et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dpp^d6/dpp^d12 has visible phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6 has visible | recessive phenotype, enhanceable by mxc^G43

(Saget et al., 1998)

NOT Enhancer of

Statement

Reference

dpp^d6/dpp[+] is a non-enhancer of visible phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

dpp^d6/dpp^d6 is a non-enhancer of visible | recessive phenotype of mxc^G43

(Saget et al., 1998)

Suppressor of

Statement

Reference

dpp^d6/dpp[+] is a suppressor of abnormal neuroanatomy phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

dpp^d6/dpp[+] is a suppressor | partially of visible phenotype of Scer\GAL4[-], Snoo^GS-C517T

(Ramel et al., 2007)

dpp^d6/dpp[+] is a suppressor | partially of visible phenotype of Scer\GAL4^Tub.PU, Snoo^GS-C517T

(Ramel et al., 2007)

dpp^d6/dpp[+] is a suppressor of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

dpp^d6 is a suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

dpp^d6/dpp[+] is a non-suppressor of visible phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

Other

Statement

Reference

dpp^d6, ix¹ has neoplasia phenotype

(Chatterjee et al., 2015)

dpp^d5/dpp^d6, ix¹ has neoplasia phenotype

(Chatterjee et al., 2015)

dpp^d-ho/dpp^d6, ix¹ has neoplasia phenotype

(Chatterjee et al., 2015)

Df(2R)en-SFX31/+, dpp^d6 has visible | dominant | adult stage phenotype

(Layalle et al., 2011)

dpp^d6, en[+]/en⁵⁴ has visible | dominant | adult stage phenotype

(Layalle et al., 2011)

dpp^s4/dpp^d6, gbb¹ has visible phenotype

(Khalsa et al., 1998)

dpp^s4/dpp^d6, gbb¹ has partially lethal phenotype

(Khalsa et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^hr4/dpp^d6 has wing phenotype, enhanceable by tkv^UAS.cNa/Scer\GAL4^Tub.PU

(Crickmore and Mann, 2006)

dpp^d6/dpp^d12 has sex comb | increased number phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has tarsal segment phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has tibia phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has antenna phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has fourth segment of antenna phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has fifth segment of antenna phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has arista phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has femur phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has leg phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has male genitalia phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has ommatidium phenotype, enhanceable by B¹

(Mandal and Lakhotia, 1999)

dpp^d6 has tarsal segment phenotype, enhanceable by mxc^G43

(Saget et al., 1998)

dpp^d6 has leg | ectopic phenotype, enhanceable by mxc^G43

(Saget et al., 1998)

dpp^d6 has wing phenotype, enhanceable by mxc^G43

(Saget et al., 1998)

dpp^d6 has eye phenotype, enhanceable by mxc^G43

(Saget et al., 1998)

dpp^d6 has antenna | ectopic phenotype, enhanceable by mxc^G43

(Saget et al., 1998)

dpp^hr4/dpp^d6 has wing phenotype, enhanceable by vri[+]/vri¹

(George and Terracol, 1997)

dpp^hr4/dpp^d6 has wing phenotype, enhanceable by vri²/vri[+]

(George and Terracol, 1997)

Suppressed by

Statement

Reference

dpp^s4/dpp^d6 has anterior crossvein phenotype, suppressible by gbb¹

(Khalsa et al., 1998)

NOT suppressed by

Statement

Reference

dpp^d6 has eye phenotype, non-suppressible by gbb^UAS.cSa/Scer\GAL4^dpp.blk1

(Staehling-Hampton et al., 1994)

dpp^d6 has wing phenotype, non-suppressible by gbb^UAS.cSa/Scer\GAL4^dpp.blk1

(Staehling-Hampton et al., 1994)

dpp^d6 has eye phenotype, non-suppressible by gbb^UAS.cSb/Scer\GAL4^dpp.blk1

(Staehling-Hampton et al., 1994)

dpp^d6 has wing phenotype, non-suppressible by gbb^UAS.cSb/Scer\GAL4^dpp.blk1

(Staehling-Hampton et al., 1994)

Enhancer of

Statement

Reference

dpp^hr4/dpp^d6 is an enhancer of wing phenotype of Scer\GAL4^Tub.PU, tkv^UAS.cNa

(Crickmore and Mann, 2006)

dpp^d6 is an enhancer of anterior crossvein phenotype of cv-2^k03511/Df(2R)Pu-D17

(Conley et al., 2000)

NOT Enhancer of

Statement

Reference

dpp^d6/dpp[+] is a non-enhancer of wing phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

Suppressor of

Statement

Reference

dpp^d6/dpp[+] is a suppressor of eye disc phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

dpp^d6/dpp[+] is a suppressor of glial cell phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

dpp^d6/dpp[+] is a suppressor | partially of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, Snoo^GS-C517T

(Ramel et al., 2007)

dpp^d6/dpp[+] is a suppressor | partially of wing vein | ectopic phenotype of Scer\GAL4[-], Snoo^GS-C517T

(Ramel et al., 2007)

dpp^d6/dpp[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

dpp^d6 is a suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

dpp^d6 is a non-suppressor of embryonic/larval lymph gland | embryonic stage phenotype of zfh1²

(Frandsen et al., 2008)

dpp^d6 is a non-suppressor of hemocyte | embryonic stage phenotype of zfh1²

(Frandsen et al., 2008)

dpp^d6/dpp[+] is a non-suppressor of wing phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

Other

Statement

Reference

dpp^d6, ix¹ has terminalia phenotype

(Chatterjee et al., 2015)

dpp^d5/dpp^d6, ix¹ has terminalia phenotype

(Chatterjee et al., 2015)

dpp^d-ho/dpp^d6, ix¹ has terminalia phenotype

(Chatterjee et al., 2015)

Df(2R)en-SFX31/+, dpp^d6 has anterior crossvein phenotype

(Layalle et al., 2011)

dpp^d6, en[+]/en⁵⁴ has anterior crossvein phenotype

(Layalle et al., 2011)

B¹, dpp^d6/dpp^d12 has antennal segment 2 sense organ phenotype

(Mandal and Lakhotia, 1999)

B¹, dpp^d6/dpp^d12 has second segment of antenna phenotype

(Mandal and Lakhotia, 1999)

B¹, dpp^d6/dpp^d12 has antennal segment 3 sense organ phenotype

(Mandal and Lakhotia, 1999)

B¹, dpp^d6/dpp^d12 has third segment of antenna phenotype

(Mandal and Lakhotia, 1999)

B¹, dpp^d6/dpp^d12 has leg sensillum phenotype

(Mandal and Lakhotia, 1999)

dpp^s4/dpp^d6, gbb¹ has wing phenotype

(Khalsa et al., 1998)

dpp^hr4/dpp^d6, vri² has wing vein phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri² has eye phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri[+]/vri¹ has wing vein phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri² has leg phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri[+]/vri¹ has eye phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri[+]/vri¹ has leg phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri²/vri[+] has wing vein phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri²/vri[+] has eye phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri²/vri[+] has leg phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri¹ has wing vein phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri¹ has eye phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri¹ has leg phenotype

(George and Terracol, 1997)

dpp^d5/dpp^d6, sax¹ has prothoracic unguis phenotype

(Brummel et al., 1994)

dpp^d5/dpp^d6, sax¹ has mesothoracic unguis phenotype

(Brummel et al., 1994)

dpp^d5/dpp^d6, sax¹ has metathoracic unguis phenotype

(Brummel et al., 1994)

dpp^d5/dpp^d6, sax² has prothoracic unguis phenotype

(Brummel et al., 1994)

dpp^d5/dpp^d6, sax² has mesothoracic unguis phenotype

(Brummel et al., 1994)

dpp^d5/dpp^d6, sax² has metathoracic unguis phenotype

(Brummel et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

A high frequency of tumour growth occurs below the anal plates of the terminalia in chromosomally female flies homozygous for ix¹ and dpp^d6, or homozygous for ix¹ and trans-heterozygous for dpp^d5/dpp^d6 or dpp^d6/dpp^d-ho.

(Chatterjee et al., 2015)

Loss of the anterior crossvein is seen in 74% of dpp^d6 Df(2R)en-SFX31 double heterozygous flies.

Loss of the anterior crossvein is seen in dpp^d6 en⁵⁴ double heterozygous flies.

(Layalle et al., 2011)

The glial overmigration phenotype seen in spin¹⁰⁴⁰³ eye discs is significantly suppressed if the animals are also heterozygous for dpp^d6.

(Yuva-Aydemir et al., 2011)

There are no hematopoietic cells in the lymph gland of dpp^d6, zfh1² double mutant embryos.

(Frandsen et al., 2008)

The frequency of the Snoo^GS-C517T/Snoo^GS-C517T ectopic wing vein phenotype is significantly suppressed if the flies are also carrying one copy of dpp^d6.

The frequency of the ectopic wing vein phenotype caused by expression of Snoo^GS-C517T under the control of Scer\GAL4^tub is significantly suppressed if the flies are also carrying one copy of dpp^d6.

(Ramel et al., 2007)

Flies that express tkv^Scer\UAS.cNa, under the control of Scer\GAL4^tub, in a dpp^hr4/dpp^d6 background, have smaller wings than flies expressing the transgene in a wild-type background and than dpp^hr4/dpp^d6 flies that do not express tkv^Scer\UAS.cNa.

(Crickmore and Mann, 2006)

The severity of the leg defects seen in dpp^d6/dpp^d16 flies is enhanced by B¹. There is an overall shortening in length along the proximal-distal axis of the leg and complete or partial fusion or even total loss of tarsal segments. The tibia and femur are deformed, showing shortening, bulging and disorganised bristle patterns. The coxa and trochanter are not so strongly affected. The sex comb of the prothoracic leg, when present, is always duplicated in these flies. The antenna phenotype of dpp^d6/dpp^d16 flies is enhanced by B¹; the arista, 4th and 5th segments are completely absent and the 2nd and 3rd segments are widened and deformed and have defects in the bristle pattern. B¹ ; dpp^d6/dpp^d16 flies completely lack ommatidia. All B¹ ; dpp^d6/dpp^d16 males completely lack external genitalia.

(Mandal and Lakhotia, 1999)

The anterior crossvein is restored in dpp^d6/dpp^s4 flies carrying one copy of gbb¹. The wing is reduced in size in these animals and viability is significantly reduced.

(Khalsa et al., 1998)

Very few wg^Act5C.PS; dpp^d6/dpp^d8 flies exhibit wg-induced transdetermination, legs with wing tissue.

(Maves and Schubiger, 1998)

Does not enhance the phenotype of mxc^G43 hemizygotes. The dpp^d6 phenotypes are enhanced if the flies are also hemizygous for mxc^G43.

(Saget et al., 1998)

vri¹/+ or vri²/+ causes a further reduction in wing size and wing veins of dpp^hr4/dpp^d6 transheterozygotes. Eyes are smaller and rough and legs are truncated.

(George and Terracol, 1997)

If dpp^d6/dpp^hr4 flies are also heterozygous for (paternally contributed) sax¹ or sax², L2 is lost and L4 and L5 fused. Whereas dpp^d5/dpp^d6 legs are normal, if the flies are also heterozygous for sax¹ or sax² then legs tend to lack tarsal claws.

(Brummel et al., 1994)

Scer\GAL4^dpp.blk1 driven expression of gbb^Scer\UAS.cSa or gbb^Scer\UAS.cSb is unable to rescue the mutant phenotype.

(Staehling-Hampton et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dpp^d6 is rescued by dpp^UAS.cSa/Scer\GAL4^dpp.blk1

(Staehling-Hampton et al., 1994)

Partially rescued by

dpp^d6/dpp^d14 is partially rescued by Scer\GAL4^dpp.blk1/dpp^{UAS.cSa.Tag:HA}

(Künnapuu et al., 2009)

dpp^d6/dpp^d14 is partially rescued by Scer\GAL4^dpp.blk1/dpp^{MFSI.UAS.Tag:HA}

(Künnapuu et al., 2009)

dpp^d6/dpp^d14 is partially rescued by dpp^{MFSI.III.UAS.Tag:HA}/Scer\GAL4^dpp.blk1

(Künnapuu et al., 2009)

dpp^d6 is partially rescued by dpp^TnJMB7

(Masucci et al., 1990)

Not rescued by

dpp^d6/dpp^d14 is not rescued by dpp^{MFSII.UAS.Tag:HA}

(Künnapuu et al., 2009)

Comments

dpp^d6/dpp^d14 wings are rescued by the expression of dpp^{Scer\UAS.cSa.T:Ivir\HA1} under the control of Scer\GAL4^dpp.blk1 except for ectopic vein materials around longitudinal vein L3.

The expression of dpp^{MFSII.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^dpp.blk1 fails to rescue the wing phenotype of dpp^d6/dpp^d14 mutants.

(Künnapuu et al., 2009)

Eye and wing phenotypes can be rescued by Scer\GAL4^dpp.blk1 driving the expression of dpp^Scer\UAS.cSa.

(Staehling-Hampton et al., 1994)

Belongs to the disk-III class of alleles.

(St. Johnston et al., 1990)

Allele class: d-III

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

2062

dpp^d6/CyO

81064

y¹ w^*; dpp^d6 P{GAL4}LE/CyO, P{en1}wg^en11

Kyoto

106644

dpp^d6/CyO

Notes on Origin

Discoverer

Comments

dpp class III allele.

(Segal and Gelbart, 1985)

Clonal analysis shows a requirement for dpp⁺ function in cells adjacent to the anterior-posterior compartment boundary of the wing primordium.

(Posakony et al., 1990)

Intermediate disk dpp allele.

(Staehling-Hampton et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Dpp⁶

(Yuva-Aydemir et al., 2011)

(Stultz et al., 2005)

dpp⁶

(Segal and Gelbart, 1985)

dpp^D6

(Layalle et al., 2011)

dpp^d-6

(Goto et al., 1995, Staehling-Hampton et al., 1994)

dpp^d6

(Li et al., 2020, Chatterjee et al., 2015, Dolezal et al., 2015, Künnapuu et al., 2009, Frandsen et al., 2008, Johnson et al., 2007, Ramel et al., 2007, Bangi and Wharton, 2006, Crickmore and Mann, 2006, Oishi et al., 2006, Yasunaga et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (46)

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