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General Information
Symbol
Dmel\dppH61
Species
D. melanogaster
Name
FlyBase ID
FBal0003063
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dppHin61
Mutagen
Nature of the Allele
Mutagen
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Small deletion that removes most of the 3' coding exon of dpp (St. Johnston, EMBO J. 6: 2785--2791).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous embryos have a fully ventralised cuticle with a herniated head, ectopic denticle belt replacing the Filzkorper and ventral denticle belts encircling the body.

dppH61/dppH48 embryos show loss of dorsal tissue and expansion of the lateral denticle bands into dorsal regions. Head involution defects result in extruded globular structures at the anterior of the embryo.

Clones in the eye imaginal disc cause a reduction in the size of the eye. Clones in the anterior of the eye completely devoid of dpp (haploinsufficiency is circumvented by using an FRT chromosome containing on the left arm dppH61 and on the right arm dppSal20) display normal ommatidia throughout the entire clone.

Denticle belts extend around the entire circumference of homozygous embryos.

Fail to complete germ band extension, die with strong ventralized phenotype and no dorsal derived epidermis.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

dppH61 is a suppressor of visible | recessive phenotype of Pka-C1E95

Phenotype Manifest In
Suppressed by
Statement
Reference
Suppressor of
Statement
Reference

dppH61 is a suppressor of wing | somatic clone phenotype of Pka-C1H2

dppH61 is a suppressor of scutum | somatic clone phenotype of Pka-C1H2

dppH61 is a suppressor of haltere | somatic clone phenotype of Pka-C1H2

dppH61 is a suppressor of antenna | somatic clone phenotype of Pka-C1H2

dppH61 is a suppressor | partially of leg | somatic clone phenotype of Pka-C1H2

Additional Comments
Genetic Interactions
Statement
Reference

The non-autonomous extra macrochaetae phenotype of Pka-C1E95 homozygous clones is suppressed if the clones are also homozygous for dppH61.

Clones double mutant for dppH61 Pka-C1E95 do not cause supernumerary structures in the leg and wing. Clones positioned at the compartment boundary exhibit long range effects causing a marked reduction in wing size and loss of vein pattern in anterior and posterior compartments. Short range effects include inducing immediate neighbours to form ectopic veins and margin bristles, the clones fail to differentiate wing veins in a cell autonomous fashion.

Suppresses the majority of pattern defects caused by Pka-C1H2 clones in the wing, notum, halteres and antennae and partially suppresses defects in the ventral regions of the leg.

Xenogenetic Interactions
Statement
Reference

Three copies of dpp::Hsap\BMP4fl.cPa fully rescues the embryonic phenotype of dppH61/Df(2L)DTD48.

Complementation and Rescue Data
Rescued by
Comments

Two copies of dppP23 completely rescues the embryonic dorsal-ventral patterning defect of null dppH61/Df(2L)DTD48 genotype.

Mutant phenotype rescued by P element mediated transformation of a wild type copy of dpp.

Allele class: Hin

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (21)