FlyBase Allele Report: Dmel\dpp[hr4]

7-day old dpp^hr4/+ germaria have normal numbers of germline stem cells (GSCs), but at 63-days old, these germaria have significantly lower GSC numbers compared to controls - most have only one or no GSCs. 35-day old and 63-day old heterozygous germaria also contain significantly fewer cysts than controls, although cap cells are maintained at normal numbers.

(Pan et al., 2007)

dpp^d5/dpp^hr4 flies show reductions in wing vein spacing and loss of wing veins.

(Zeng et al., 2007)

dpp^d5/dpp^hr4 wings show a truncation of both the L2 and L4 veins, while dpp^d6/dpp^hr4 wings have only two veins, L3 and L5 and are missing L2 and L4 completely.

(Bangi and Wharton, 2006)

Wing size is reduced in dpp^hr4/dpp^d6 flies.

(Crickmore and Mann, 2006)

When single cell dpp^hr4/dpp^hr56 clones are made in the wing imaginal disc, cytonemes in the wing primordium are affected. At the non-permissive temperature (29^oC) cytonemes emanating from cells at the lateral flanks of discs do not orient themselves towards the anterior posterior organiser (as those see in wild-type do). Cytonemes in these discs are also more numerous than in wild-type, and unlike in the wild-type, are sometimes seen to be bent, curved or crossing over each other. These effects are not observed if mutant larvae are heatshocked and returned to permissive temperatures.

(Hsiung et al., 2005)

dpp^s6/dpp^hr4 transheterozygotes are adult viable and exhibit occasional wing vein defects. Truncation of longitudinal vein 5 (L5) is observed in approximately 11% of adults, while 2% display truncations of L4 and L5.

dpp^s6/dpp^hr4 Df(2L)C28 flies exhibit an increased frequency of L5 wing vein defects (95% compared to 11% in dpp^s6/dpp^hr4 flies). Approximately 20% show defects in L4 and L5 wing veins, and 5% exhibit defects in L5 and L2, or L5 and the posterior crossvein, indicating an enhancement of the dpp^s6/dpp^hr4 wing vein phenotype.

No lethality is associated with either the dpp^s6/dpp^hr4 or dpp^s6/dpp^hr4 Df(2L)C28 genotypes.

dpp^s6/dpp^hr4 Df(3R)E40 flies exhibit an increased frequency of L5 wing vein defects (28% compared to 11% in dpp^s6/dpp^hr4 flies).

(Takaesu et al., 2005)

dpp^hr4/dpp^hr56 males raised at 18^oC to eclosion and then shifted to 29^oC, show no significant loss of germline stem cells after 1 week.

(Kawase et al., 2004)

Approximately 50% of eggs laid by heterozygous females have shortened and abnormally shaped respiratory appendages.

(Dequier et al., 2001)

dpp^hr4/dpp^s6 causes relatively few wings to have abnormal venation.

(Nicholls and Gelbart, 1998)

Females carrying temperature sensitive combinations dpp^e90/dpp^hr56 or dpp^hr4/dpp^hr56 after shifting to the restrictive temperature for one week show 40-50% of germaria that are significantly smaller than wild type. The effect is more pronounced in older females. Stem cell number is reduced, stem cells have differentiated into cysts. Some effect on egg chamber budding is seen.

(Xie and Spradling, 1998)

Eye discs from dpp^hr4/dpp^hr56 larvae grown at 29^oC for 48 hrs show several phenotypes including failure of retinal differentiation or partial ommatidial differentiation, ommatidia are retricted to the posterior part of the disc and absent from the lateral margins. Occasionally eye discs show normal size and morphology. These eye discs show anterior-most ommatidia that are abnormal mature in comparison to wild type ommatidia at similar positions. Also, cell death is observed ahead of the differentiated region. Surviving adults show slightly roughened eyes that are reduced along the anterior-posterior axis, consistent with a failure of normal morphgenetic progression.

(Chanut and Heberlein, 1997)

Embryos are ventralised. dpp^hr4/dpp^d6 transheterozygotes exhibit reduced wings to approximately half wild type size and no defects in eyes or legs.

(George and Terracol, 1997)

Homozygotes produce approximately 30 amnioserosa cells. This phenotype is not altered if the embryos are also carrying 2 copies of tsg^twi.PM.

(Mason et al., 1997)

Embryos show cuticular holes, disorganization of the head skeleton, internalization of the seventh and eighth abdominal segments and the filzkorper and a thoracic constriction. The first and second ventral denticle belts are expanded. A significant percentage of surviving transheterozygotes between dpp^hr56 and dpp^hr4 or dpp^hr27 have a split notum.

(Wharton et al., 1996)

Homozygous embryos have 6 +/- 10 amnioserosa cells (compare to 164 +/- 23 cells in wild type embryos), many embryos lack amnioserosa entirely. Heterozygotes have 124 +/- 9 amnioserosa cells, a fraction of embryos die.

(Raftery et al., 1995)

dpp^hr4/dpp^d-ho transheterozygotes show a wild type wing phenotype in an otherwise normal genetic background.

(Sanicola et al., 1995)

Heterozygotes are viable, heterozygotes derived from Mad^-/Mad⁺ mothers frequently die. Transheterozygotes with dpp^d6 have wings approximately half normal size and normal legs and eyes (less severe than dpp^d6 homozygous phenotype). When in combination with Df(2L)C28/Mad⁺ the transheterozygotes exhibit more severe phenotype, further reduction in wing blade, slight reduction in the eye and loss of tarsal claws. Trisomy for Mad (Dp(2;3)JS20) partially ameliorates transheterozygote phenotype, wings are of normal size and show residual vein fusions.

(Sekelsky et al., 1995)

dpp^d6/dpp^hr4 individuals have a nearly full size wing, except for the absence of the anterior crossvein, a reduction in the distance between L4 and L5 and a small amount of ectopic vein between L2 and L3. If the flies are also heterozygous for (paternally contributed) sax¹ or sax², L2 is lost and L4 and L5 fused.

(Brummel et al., 1994)

Survival of heterozygotes is reduced if also heterozygous for certain alleles of tld.

(Finelli et al., 1994)

Embryos display a moderately ventralised phenotype, maternally contributed tkv alleles cause lethality.

(Terracol and Lengyel, 1994)

Clonal analysis in the developing eye (using the FLP/FRT system) revealed nonautonomous phenotypes with large clones showing posterior-lateral eye parts missing.

(Heberlein et al., 1993)

Dominant lethality less than 50%. Homozygous and transheterozygous embryos were examined with respect to 25 cuticular markers, results demonstrate a graded requirement for dpp along the dorso-ventral axis.

(Wharton et al., 1993)

Weak ventralised phenotype. Rings of ventral denticle belts differentiate around the entire dorsoventral axis, almost no dorsal hairs are seen and the antennal and maxillary sense organs are missing. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.

(Arora and Nusslein-Volhard, 1992)

Fully rescued to adulthood by two wild type copies of dpp.

(Hoffmann and Goodman, 1987)

z¹ product subliminally inhibits the complementation of dpp^hr4 and dpp^d-ho. The effect is only seen when compounded by the particular effects of rearrangements on synapsis.

(Smolik-Utlaut and Gelbart, 1987)

Abnormal development begins after germ band extension.

(Segal and Gelbart, 1985)

Heterozygotes exhibit wings that are stumps. The wings are held out laterally instead of in line with the longitudinal axis of the body. Transheterozygotes with dpp^d-ho exhibit normally oriented wings.

(Gelbart, 1982)

Heterozygotes with class I dpp alleles have a wild type wing phenotype. Heterozygotes with class II allele dpp^d5 exhibit wings with a deletion of the anterior crossvein. Heterozygotes with class II allele dpp^d28 exhibit held out wings that are missing longitudinal and cross veins, deletion of tarsal claws, male terminalia and female analia. Heterozygotes with class III dpp alleles display reduced held out wings that are missing longitudinal and cross veins, capitella-less halteres, reduced eyes, legs missing claws and missing or rotated male terminalia or female analia. Heterozygotes with class IV dpp alleles display the same phenotype as class III heterozygotes with duplication of scutellar bristles, medial cleft of the dorsal notum, duplication of sex combs and partial duplication of the third antennal segment. Heterozygotes with class V dpp alleles rarely eclose, the surviors exhibit the wing, haltere, eye and terminalia defects. At 18^oC the heterozygotes have less severe phenotypes.

(Spencer et al., 1982)

External Data

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Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dpp^hr4 has lethal | recessive | embryonic stage phenotype, enhanceable | maternal effect by Df(2L)C144/+

(Su et al., 2001)

dpp^hr4 has lethal | recessive | embryonic stage phenotype, enhanceable | maternal effect by Df(2L)DTD52-D51/+

(Su et al., 2001)

dpp^hr4 has lethal | recessive | embryonic stage phenotype, enhanceable | maternal effect by T(2;3)DTD46.4/+

(Su et al., 2001)

dpp^hr4 has lethal | recessive | embryonic stage phenotype, enhanceable | maternal effect by lilli^a16/lilli[+]

(Su et al., 2001)

Suppressed by

Statement

Reference

Df(2R)Pcl11B/+, dpp^hr4 has partially lethal - majority die | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa/Scer\GAL4^VP16.nos.UTR

(Quijano et al., 2016)

Df(2R)Pcl11B/+, dpp^hr4 has partially lethal - majority die | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa

(Quijano et al., 2016)

Df(2R)Pcl11B/+, dpp^hr4 has partially lethal - majority die | maternal effect phenotype, suppressible | partially by Scer\GAL4^VP16.nos.UTR/lolal^UASp.Tag:HA

(Quijano et al., 2016)

Df(2R)Pcl11B/+, dpp^hr4 has partially lethal - majority die | maternal effect phenotype, suppressible | partially by lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa/Scer\GAL4^VP16.nos.UTR

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by Scer\GAL4^VP16.nos.UTR/lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by tkv^Q253D.UASp/Scer\GAL4^VP16.nos.UTR

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by tkv^Q253D.UASp

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by sax^{Q263D.UAS.cDa}/Scer\GAL4^VP16.nos.UTR

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by sax^{Q263D.UAS.cDa}

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by Scer\GAL4^VP16.nos.UTR/Med^UASp.cSa

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by Med^UASp.cSa

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by Scer\GAL4^VP16.nos.UTR/Med^K738R.UASp

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by Med^K738R.UASp

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by Scer\GAL4^VP16.nos.UTR/Trl^EY04024

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by Trl^EY04024

(Quijano et al., 2016)

dpp^hr4/dpp[+], faf^FO8 has lethal | dominant | maternal effect | embryonic stage phenotype, suppressible by Scer\GAL4^VP16.nos.UTR/Med^UASp.cSa

(Stinchfield et al., 2012)

dpp^hr4/dpp[+], faf^FO8 has lethal | dominant | maternal effect | embryonic stage phenotype, suppressible by Scer\GAL4^VP16.nos.UTR/Med^K738R.UASp

(Stinchfield et al., 2012)

dpp^hr4/dpp[+], sax¹ has lethal | dominant | maternal effect phenotype, suppressible by Dp(2;2)DTD48/+

(Twombly et al., 2009)

dpp^hr4/dpp[+], sax¹ has lethal | dominant | maternal effect phenotype, suppressible by Dp(2;2)B16/+

(Twombly et al., 2009)

dpp^hr4/dpp[+], sax² has lethal | dominant | maternal effect phenotype, suppressible by Dp(2;2)DTD48/+

(Twombly et al., 2009)

dpp^hr4/dpp[+], sax² has lethal | dominant | maternal effect phenotype, suppressible by Dp(2;2)B16/+

(Twombly et al., 2009)

NOT Enhancer of

Statement

Reference

dpp^hr4/dpp[+] is a non-enhancer of visible phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

NOT Suppressor of

Statement

Reference

dpp^hr4/dpp[+] is a non-suppressor of visible phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

Other

Statement

Reference

Df(2R)Pcl11B/+, dpp^hr4 has partially lethal - majority die | maternal effect phenotype

(Quijano et al., 2016)

Med[+]/Med¹⁵, dpp^hr4 has partially lethal - majority die phenotype

(Quijano et al., 2016)

Mad¹²/Mad[+], dpp^hr4 has partially lethal - majority die phenotype

(Quijano et al., 2016)

dpp^hr4, lolal^k02512/lolal[+] has partially lethal - majority die | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹⁷²² has partially lethal - majority live | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4, lolal^G9603/lolal[+] has partially lethal - majority live | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4/dpp[+], faf^FO8 has lethal | dominant | maternal effect | embryonic stage phenotype

(Stinchfield et al., 2012)

dpp^hr4/dpp[+], faf^EP381 has lethal | maternal effect phenotype

(Stinchfield et al., 2012)

Med¹⁵, dpp^hr4/dpp[+] has lethal | maternal effect phenotype

(Stinchfield et al., 2012)

Med¹⁷, dpp^hr4/dpp[+] has lethal | maternal effect phenotype

(Stinchfield et al., 2012)

Med⁸, dpp^hr4/dpp[+] has lethal | dominant | maternal effect phenotype

(Stinchfield et al., 2012)

dpp^hr4, mEFG1^GA1/l(2)27Ea[+] has lethal | embryonic stage phenotype

(Trivigno and Haerry, 2011)

dpp^hr4, mEFG1^GA25/ico[+] has lethal | embryonic stage phenotype

(Trivigno and Haerry, 2011)

dpp^hr4/dpp[+], sax¹ has lethal | dominant | maternal effect phenotype

(Twombly et al., 2009)

dpp^hr4/dpp[+], sax² has lethal | dominant | maternal effect phenotype

(Twombly et al., 2009)

dpp^hr4/dpp[+], sax⁶ has partially lethal - majority live | dominant | maternal effect phenotype

(Twombly et al., 2009)

dpp^hr4/dpp[+], sax^P has lethal | dominant | maternal effect phenotype

(Twombly et al., 2009)

dpp^hr4/dpp[+], sax^1rv1 has partially lethal - majority live | dominant | maternal effect phenotype

(Twombly et al., 2009)

Mad¹, dpp^s6/dpp^hr4 has lethal phenotype

(Takaesu et al., 2005)

Df(2L)DTD52-D51, In(2LR)DTD11, dpp^d-ho/dpp^hr4 has visible phenotype

(Gelbart, 2001.4.19)

DTD45.10^45.10, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD45.5, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD45.9, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD46.4, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD46.7, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;4)DTD43.1, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

In(2L)DTD42.0, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

dpp^d-ho/dpp^hr4, lilli^a16 has visible phenotype

(Su et al., 2001)

DTD46.5^46.5, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD45.1^45.1, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD46.8^46.8, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD44.4^44.4, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

Ab(?)DTD44.2, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

Ab(?)DTD45.2, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD44.3^44.3, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD44.5^44.5, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD45.11^45.11, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD45.7^45.7, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD46.6^46.6, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD45.8^45.8, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

Df(2L)C144, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

Dp(2;2)DTD45.12, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

In(2L)DTD46.3, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

In(2LR)DTD45.6, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

In(2LR)DTD46.2, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

In(2LR)DTD46.9, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD43.3, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD43.4, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD43.5, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD44.1, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD45.3, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD45.4, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^d5/dpp^hr4 has wing vein L2 phenotype, enhanceable by gbb¹/gbb[+]

(Bangi and Wharton, 2006)

dpp^hr4/dpp^d6 has wing phenotype, enhanceable by tkv^UAS.cNa/Scer\GAL4^Tub.PU

(Crickmore and Mann, 2006)

dpp^s6/dpp^hr4 has wing vein phenotype, enhanceable by Mad¹

(Takaesu et al., 2005)

dpp^s6/dpp^hr4 has wing vein phenotype, enhanceable by Med⁷

(Takaesu et al., 2005)

dpp^s6/dpp^hr4 has wing vein L5 phenotype, enhanceable by Med⁷

(Takaesu et al., 2005)

dpp^s6/dpp^hr4 has wing vein L4 phenotype, enhanceable by Med⁷

(Takaesu et al., 2005)

dpp^hr4 has embryonic epidermis phenotype, enhanceable by cype[+]/cype⁰³⁷⁷¹/cype⁰³⁷⁷¹

(Szuplewski and Terracol, 2001)

dpp^hr4 has embryonic/first instar larval cuticle phenotype, enhanceable by cype[+]/cype⁰³⁷⁷¹/cype⁰³⁷⁷¹

(Szuplewski and Terracol, 2001)

dpp^hr4 has phenotype, enhanceable by Med¹¹/Med[+]

(Hudson et al., 1998)

dpp^hr4 has phenotype, enhanceable by Med[+]/Med¹²

(Hudson et al., 1998)

dpp^hr4 has phenotype, enhanceable by Med¹³/Med[+]

(Hudson et al., 1998)

dpp^hr4 has phenotype, enhanceable by Med¹⁴/Med[+]

(Hudson et al., 1998)

dpp^hr4 has phenotype, enhanceable by Med[+]/Med¹⁵

(Hudson et al., 1998)

dpp^hr4 has phenotype, enhanceable by Med¹⁶/Med[+]

(Hudson et al., 1998)

dpp^hr4 has phenotype, enhanceable by Med¹⁷/Med[+]

(Hudson et al., 1998)

dpp^hr4 has phenotype, enhanceable by Med[+]/Med¹⁸

(Hudson et al., 1998)

dpp^hr4 has phenotype, enhanceable by Df(3L)66C-G28/+

(Nicholls and Gelbart, 1998)

dpp^hr4 has cephalopharyngeal skeleton phenotype, enhanceable by Df(2R)Pcl11B/+

(Nicholls and Gelbart, 1998)

dpp^hr4 has wing vein phenotype, enhanceable by Df(2R)Pcl11B/+

(Nicholls and Gelbart, 1998)

dpp^hr4 has wing vein phenotype, enhanceable by Df(2R)Pcl7B/+

(Nicholls and Gelbart, 1998)

dpp^hr4/dpp^d6 has wing phenotype, enhanceable by vri[+]/vri¹

(George and Terracol, 1997)

dpp^hr4/dpp^d6 has wing phenotype, enhanceable by vri²/vri[+]

(George and Terracol, 1997)

dpp^hr4 has phenotype, enhanceable by vri^5R4.11

(George and Terracol, 1997)

dpp^hr4 has phenotype, enhanceable by vri^5R5.24

(George and Terracol, 1997)

dpp^hr4 has phenotype, enhanceable by vri^5R5.7

(George and Terracol, 1997)

dpp^hr4 has phenotype, enhanceable by vri^5R7.2

(George and Terracol, 1997)

dpp^hr4 has phenotype, enhanceable by vri^5R8.4

(George and Terracol, 1997)

dpp^hr4 has phenotype, enhanceable by vri^k03801

(George and Terracol, 1997)

dpp^hr4 has phenotype, enhanceable by vri^k05901

(George and Terracol, 1997)

dpp^hr4 has phenotype, enhanceable by vri^k09602

(George and Terracol, 1997)

dpp^hr4 has phenotype, enhanceable by vri^k09713

(George and Terracol, 1997)

dpp^hr4 has phenotype, enhanceable by vri^k11805

(George and Terracol, 1997)

dpp^hr4 has phenotype, enhanceable by Mad²

(Raftery et al., 1995)

dpp^hr4 has phenotype, enhanceable by Mad³

(Raftery et al., 1995)

dpp^hr4 has phenotype, enhanceable by Mad⁴

(Raftery et al., 1995)

dpp^hr4 has phenotype, enhanceable by Med¹

(Raftery et al., 1995)

dpp^hr4 has phenotype, enhanceable by Med²

(Raftery et al., 1995)

dpp^hr4 has phenotype, enhanceable by Med³

(Raftery et al., 1995)

dpp^hr4 has phenotype, enhanceable by Med⁴

(Raftery et al., 1995)

dpp^hr4 has phenotype, enhanceable by scw^E1

(Raftery et al., 1995)

dpp^hr4 has phenotype, enhanceable by scw^E2

(Raftery et al., 1995)

dpp^hr4 has phenotype, enhanceable by tld¹⁴

(Raftery et al., 1995)

dpp^hr4 has phenotype, enhanceable by tld^E1

(Raftery et al., 1995)

NOT Enhanced by

Statement

Reference

dpp^Sal20, dpp^hr4 has phenotype, non-enhanceable by Df(3L)66C-G28/+

(Nicholls and Gelbart, 1998)

Suppressed by

Statement

Reference

Df(2R)Pcl11B/+, dpp^hr4 has embryo phenotype, suppressible | partially by lolal^UASp.cQa/Scer\GAL4^VP16.nos.UTR

(Quijano et al., 2016)

Df(2R)Pcl11B/+, dpp^hr4 has embryo phenotype, suppressible | partially by lolal^UASp.cQa

(Quijano et al., 2016)

Df(2R)Pcl11B/+, dpp^hr4 has embryo phenotype, suppressible | partially by Scer\GAL4^VP16.nos.UTR/lolal^UASp.Tag:HA

(Quijano et al., 2016)

Df(2R)Pcl11B/+, dpp^hr4 has embryo phenotype, suppressible | partially by lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa/Scer\GAL4^VP16.nos.UTR

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by Scer\GAL4^VP16.nos.UTR/lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible by tkv^Q253D.UASp/Scer\GAL4^VP16.nos.UTR

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by tkv^Q253D.UASp

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by sax^{Q263D.UAS.cDa}/Scer\GAL4^VP16.nos.UTR

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by sax^{Q263D.UAS.cDa}

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by Scer\GAL4^VP16.nos.UTR/Med^UASp.cSa

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by Med^UASp.cSa

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo phenotype, suppressible | partially by Scer\GAL4^VP16.nos.UTR/Med^K738R.UASp

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo phenotype, suppressible | partially by Med^K738R.UASp

(Quijano et al., 2016)

dpp^hr4/dpp[+], faf^FO8 has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by Scer\GAL4^VP16.nos.UTR/Med^K738R.UASp

(Stinchfield et al., 2012)

dpp^hr4/dpp[+], faf^FO8 has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible | partially by Med^K738R.UASp

(Stinchfield et al., 2012)

dpp^hr4/dpp[+], faf^FO8 has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by Scer\GAL4^VP16.nos.UTR/Med^UASp.cSa

(Stinchfield et al., 2012)

NOT suppressed by

Statement

Reference

dpp^hr4/dpp[+], faf^FO8 has embryonic/first instar larval cuticle | maternal effect phenotype, non-suppressible by Med^UASp.cSa

(Stinchfield et al., 2012)

Enhancer of

Statement

Reference

dpp^hr4/dpp^d6 is an enhancer of wing phenotype of Scer\GAL4^Tub.PU, tkv^UAS.cNa

(Crickmore and Mann, 2006)

dpp^hr4 is an enhancer of embryonic/first instar larval cuticle phenotype of tor^13D

(Strecker et al., 1991)

NOT Enhancer of

Statement

Reference

dpp^hr4/dpp[+] is a non-enhancer of wing phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

Suppressor of

Statement

Reference

dpp^hr4/dpp[+] is a suppressor | partially of embryonic/first instar larval cuticle phenotype of sog^Y506

(Stinchfield et al., 2012)

dpp^hr4/dpp[+] is a suppressor | partially of denticle phenotype of sog^Y506

(Stinchfield et al., 2012)

dpp^d-ho/dpp^hr4 is a suppressor of eye phenotype of CycE^JP

(Horsfield et al., 1998)

NOT Suppressor of

Statement

Reference

dpp^hr4/dpp[+] is a non-suppressor of wing phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

Other

Statement

Reference

Df(2R)Pcl11B/+, dpp^hr4 has embryo | maternal effect phenotype

(Quijano et al., 2016)

Med[+]/Med¹⁵, dpp^hr4 has embryo | maternal effect phenotype

(Quijano et al., 2016)

Mad¹²/Mad[+], dpp^hr4 has embryo | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4, lolal^k02512/lolal[+] has embryo | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹⁷²² has embryo | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4, lolal^G9603/lolal[+] has embryo | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4, msk[+]/msk⁵ has embryo | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4, msk^B185/msk[+] has embryo | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4/dpp[+], faf^FO8 has embryonic/first instar larval cuticle | maternal effect phenotype

(Stinchfield et al., 2012)

dpp^hr4/dpp[+], faf^EP381 has embryonic/first instar larval cuticle | maternal effect phenotype

(Stinchfield et al., 2012)

Med⁸, dpp^hr4/dpp[+] has embryonic/first instar larval cuticle | maternal effect phenotype

(Stinchfield et al., 2012)

dpp^hr56/dpp^hr4, gbb[+]/gbb^D4 has male germline stem cell phenotype

(Kawase et al., 2004)

dpp^hr56/dpp^hr4, gbb^D4 has male germline stem cell phenotype

(Kawase et al., 2004)

Df(2L)DTD52-D51, In(2LR)DTD11, dpp^d-ho/dpp^hr4 has wing phenotype

(Gelbart, 2001.4.19)

DTD45.10^45.10, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD45.5, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD45.9, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD46.4, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD46.7, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;4)DTD43.1, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

In(2L)DTD42.0, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

dpp^d-ho/dpp^hr4, lilli^a16 has wing phenotype

(Su et al., 2001)

DTD46.5^46.5, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD45.1^45.1, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD46.8^46.8, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD44.4^44.4, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

Ab(?)DTD44.2, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

Ab(?)DTD45.2, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD44.3^44.3, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD44.5^44.5, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD45.11^45.11, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD45.7^45.7, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD45.8^45.8, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

Df(2L)C144, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

Dp(2;2)DTD45.12, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD46.6^46.6, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

In(2L)DTD46.3, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

In(2LR)DTD45.6, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

In(2LR)DTD46.2, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

In(2LR)DTD46.9, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD43.3, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD43.4, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD43.5, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD44.1, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD45.3, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD45.4, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

dpp^hr4/dpp^d6, vri¹ has wing vein phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri¹ has eye phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri¹ has leg phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri[+]/vri¹ has wing vein phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri[+]/vri¹ has eye phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri[+]/vri¹ has leg phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri²/vri[+] has wing vein phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri²/vri[+] has eye phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri²/vri[+] has leg phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri² has wing vein phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri² has eye phenotype

(George and Terracol, 1997)

dpp^hr4/dpp^d6, vri² has leg phenotype

(George and Terracol, 1997)

dpp^hr4/dpp[+], tld^E1 has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

dpp^hr4/dpp[+], tld^E1 has embryo | embryonic stage 14 phenotype

(Raftery et al., 1995)

Med⁴, dpp^hr4/dpp[+] has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

Med³, dpp^hr4/dpp[+] has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

dpp^hr4, tld^E1/tld[+] has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

dpp^hr4, tld^E1/tld[+] has embryo | embryonic stage 14 phenotype

(Raftery et al., 1995)

Med²/Med[+], dpp^hr4 has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

Med[+]/Med³, dpp^hr4 has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

Med⁴/Med[+], dpp^hr4 has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

Med², dpp^hr4/dpp[+] has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

dpp^d-ho/dpp^hr4, en⁹⁶ has wing phenotype

(Sanicola et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

The progeny from dpp^hr4/+ fathers exhibit near lethality when mothers are either Df(2R)Pcl11B/+, lolal^k02512/+ or lolal¹¹²²/+, and exhibit increased lethality when mothers are either lolal¹⁷²²/+ or lolal^G9603/+, as compared to controls mothers; there is no obvious increased lethality as compared to controls if these parental genders are reversed. The progeny from dpp^hr4/+ fathers exhibit near lethality when mothers are Med¹⁵/+, and semi-lethality when mothers are Mad¹²/+, but not when mothers are Df(2R)12/+, as compared to controls mothers.

The near lethality of the progeny from Df(2R)Pcl11B/+ mothers and dpp^hr4/+ fathers is weakly rescued by the maternal expression of either lolal^{Scer\UAS.P\T.cQa} or lolal^{Scer\UAS.P\T.T:Ivir\HA1}, either under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} or in the absence of the Gal4 driver.

The near lethality of the progeny from lolal¹¹²²/+ mothers and dpp^hr4/+ fathers is fully rescued by the maternal expression of either tkv^{Q253D.Scer\UAS.P\T} or Med^{K738R.Scer\UAS.P\T}, either under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} or in the absence of the Gal4 driver, is fully rescued by the maternal expression of either Med^{Scer\UAS.P\T.cSa} or Trl^EY04024, under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} but only partially rescued in the absence of the Gal4 driver, and is partially rescued by the maternal expression of either lolal^{Scer\UAS.P\T.cQa}, lolal^{Scer\UAS.P\T.T:Ivir\HA1} or sax^{Q263D.Scer\UAS.cDa}, either under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} or in the absence of the Gal4 driver.

The progeny from dpp^hr4/+ fathers present embryo ventralization in most cases if mothers are Med¹⁵/+, and present embryo ventralization in less than half of cases if mothers are either Mad¹²/+, Df(2R)Pcl11B/+, lolal^k02512/+, lolal¹¹²²/+, lolal¹⁷²²/+, lolal^G9603/+, msk⁵/+ or msk^B185/+, as compared to controls; the embryo ventralization of the progeny from dpp^hr4/+ fathers and lolal¹¹²²/+ mothers is fully rescued by the maternal expression of tkv^{Q253D.Scer\UAS.P\T} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}, but only partially in the absence of the Gal4 driver, and is partially rescued by the maternal expression of either lolal^{Scer\UAS.P\T.cQa}, lolal^{Scer\UAS.P\T.T:Ivir\HA1}, sax^{Q263D.Scer\UAS.cDa}, Med^{Scer\UAS.P\T.cSa} or Med^{K738R.Scer\UAS.P\T}, either under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} or in the absence of the Gal4 driver.

(Quijano et al., 2016)

Embryos derived from faf^FO8/+ females mated to dpp^hr4/+ males show strong lethality (only 10% of the expected number survive). The embryos have a ventralised cuticle phenotype.

Animals derived from homozygous faf^EP381 females mated to dpp^hr4/+ males show strong lethality (only 26% of the expected number survive). The embryos have a ventralised cuticle phenotype.

Animals derived from Med⁸/+ females mated to dpp^hr4/+ males show strong lethality (5% of the expected number survive). The embryos have a ventralised cuticle phenotype.

Animals derived from homozygous Med¹⁵ or Med¹⁷ females mated to dpp^hr4/+ males show strong lethality (less than 5% of the expected number survive).

dpp^hr4/+ partially suppresses the cuticle phenotype of sog^Y506 hemizygous embryos, partially restoring denticles and producing a curved body.

The survival of the progeny of faf^FO8/+ females mated to dpp^hr4/+ males is increased 1.6-fold by basal expression of Med^{Scer\UAS.P\T.cSa} (in the absence of a Scer\GAL4 driver) in the females, while basal expression of Med^{K738R.Scer\UAS.P\T} in the females increases survival of the progeny 4.2-fold. Expression of either Med^{Scer\UAS.P\T.cSa} or Med^{K738R.Scer\UAS.P\T} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} in the females increases survival of the progeny to approximately 80% in both cases.

The ventralised cuticle phenotype of embryos derived from faf^FO8/+ females mated to dpp^hr4/+ males is not rescued by basal expression of Med^{Scer\UAS.P\T.cSa} (in the absence of a Scer\GAL4 driver) in the females, while basal expression of Med^{K738R.Scer\UAS.P\T} in the females results in the rescue of the ventralised cuticle phenotype in some embryos. Expression of either Med^{Scer\UAS.P\T.cSa} or Med^{K738R.Scer\UAS.P\T} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} in the females effectively rescues the ventralised cuticle phenotype of the embryos.

(Stinchfield et al., 2012)

ico^GA1/+, dpp^hr4/+ animals die as embryos.

ico^GA25/+, dpp^hr4/+ animals die as embryos.

(Trivigno and Haerry, 2011)

When dpp^hr4/+ males are crossed to sax¹/+ or sax²/+ females, all the resulting dpp^hr4/+ progeny die. Similarly, any one of the paternal dpp^e87/+, dpp^hr56/+, dpp^hr90/+ or dpp^hr27/+ genotypes in combination with either one of the maternal sax¹/+ or sax²/+ genotypes results in increased dpp zygotic haplolethality in the progeny.

The maternal enhancement of the dpp^hr4/+ zygotic haplolethality by sax¹/+ is suppressed by either Dp(2;2)DTD48/+ or Dp(2;2)B16/.

The maternal enhancement of the dpp^hr4/+ zygotic haplolethality by sax²/+ is suppressed by either Dp(2;2)DTD48/+ or Dp(2;2)B16/.

When dpp^hr4/+ males are crossed to females of any one of the Df(2R)ST1/+, Df(2R)P32a/+ or Df(2R)H23/+ genotypes, similarly to wild-type flies, most of the resulting dpp^hr4/+ progeny survive.

When sax^P/+ females are crossed to dpp^hr4/+ males, most of the resulting dpp^hr4/+ progeny die.

When sax^1rv1/+ females are crossed to dpp^hr4/+ males, the resulting dpp^hr4/+ progeny show a moderate drop in viability compared to the dpp^hr4/+ progeny of wild-type mothers in control crosses.

When sax⁶/+ females are crossed to dpp^hr4/+ males, the resulting dpp^hr4/+ progeny show a moderate drop in viability compared to the dpp^hr4/+ progeny of wild-type mothers in control crosses.

When dpp[hr4]/+ males are crossed to females of any one of the genotypes sax^1rv5/+, sax³/+, sax⁴/+ and sax⁵/+, the resulting dpp^hr4/+ progeny do not show any significant drop in viability compared to the dpp^hr4/+ progeny of wild-type mothers in control crosses.

(Twombly et al., 2009)

Flies that express tkv^Scer\UAS.cNa, under the control of Scer\GAL4^tub, in a dpp^hr4/dpp^d6 background, have smaller wings than flies expressing the transgene in a wild-type background and than dpp^hr4/dpp^d6 flies that do not express tkv^Scer\UAS.cNa.

(Crickmore and Mann, 2006)

bam^hs.PO animals cultured at 18^oC and heat shocked as late stage pupae (37^oC, 4 times for 2 hours each with an 8-12 hour interval) produce adult females with agametic germaria. If these animals also carry the temperature sensitive allelic combination dpp^hr56/dpp^e90, and are shifted to 29^oC (the non-permissive temperature) for 10 days, the resulting agametic germaria contain only slightly less follicle cells than controls (bam^hs.PO only).

(Kirilly et al., 2005)

dpp^s6/dpp^hr4 Mad¹ flies exhibit L4 and L5 wing vein defects in almost 100% of cases. Approximately 10% of wings with L4 and L5 defects exhibit missing crossveins (anterior, posterior, or both) and small wing margin notches. This indicates an enhancement of the dpp^s6/dpp^hr4 phenotype by Mad¹.

Only 71% of the expected dpp^s6/dpp^hr4 Mad¹ progeny are recovered, indicating a statistically significant amount of lethality.

dpp^s6/dpp^hr4 Med⁷ flies exhibit L4 and L5 wing vein defects in approximately 42% of cases, with 15% of these wings also exhibiting defects in L2, or the posterior crossvein or margin notches.

(Takaesu et al., 2005)

dpp^hr4/dpp^hr56; gbb^D4/+ males raised at 18^oC to eclosion and then shifted to 29^oC for one week have an average of 3.1 germ-line stem cells per testis, compared to 8.6 in gbb^D4/+.

(Kawase et al., 2004)

In(2LR)DTD52, dpp^d-ho/In(2LR)DTD11, dpp^hr4 flies have wild-type wing posture. Df(2L)DTD52-D51, dpp^d-ho/In(2LR)DTD11, dpp^hr4 flies have a heldout wing posture.

(Gelbart, 2001.4.19)

dpp^d-ho/dpp^hr4 shows heldout wings in combination with In(2L)DTD42.0, T(2;4)DTD43.1, T(2;3)DTD43.3, T(2;3)DTD43.4, T(2;3)DTD43.5, T(2;3)DTD44.1, Ab(?)DTD44.2, DTD44.3^44.3, DTD44.4^44.4, DTD44.5^44.5, DTD45.1^45.1, Ab(?)DTD45.2, T(2;3)DTD45.3, T(2;3)DTD45.4, T(2;3)DTD45.5, In(2LR)DTD45.6, DTD45.7^45.7, DTD45.8^45.8, T(2;3)DTD45.9, DTD45.10^45.10, DTD45.11^45.11, Dp(2;2)DTD45.12, In(2LR)DTD46.2, In(2L)DTD46.3, T(2;3)DTD46.4, DTD46.5^46.5, DTD46.6^46.6, T(2;3)DTD46.7, DTD46.8^46.8, In(2LR)DTD46.9, Df(2L)C144 or lilli^a16.

(Su et al., 2001)

71% of the expected cype⁰³⁷⁷¹/dpp^hr4 adult progeny are recovered from a cross of dpp^hr4/+ females to cype⁰³⁷⁷¹/+ males. Only 38% of the expected cype⁰³⁷⁷¹/dpp^hr4 adult progeny are recovered from a cross of cype⁰³⁷⁷¹/+ females to dpp^hr4/+ males. The lethality is embryonic and the embryos are weakly to moderately ventralised.

(Szuplewski and Terracol, 2001)

Enhanced lethality in heterozygous individuals from crosses involving Df(2R)Pcl11B or Df(3L)66C-G28 acts during embryonic and larval stages, though cuticle preparations from affected embryos reveal no consistent abnormalities. The incidence of head skeleton herniation is increased compared to that seen for singly dpp^hr4 mutant embryos. The incidence of abnormal venation in dpp^hr4/dpp^s6 is increased by Df(2R)Pcl11B or Df(2R)Pcl7B.

(Nicholls and Gelbart, 1998)

When in combination with vri mutations, vri^k05901 lethal revertant lines or Df(2L)tkv2 lethality is greatly increased and embryos are more strongly ventralised. vri¹/+ or vri²/+ causes a further reduction in wing size and wing veins of dpp^hr4/dpp^d6 transheterozygotes. Eyes are smaller and rough and legs are truncated.

(George and Terracol, 1997)

Homozygous lethal phenotype can be enhanced by Med, Mad, tld and scw enhancer mutations.

(Raftery et al., 1995)

The dpp^hr4/dpp^d-ho phenotype is dominantly enhanced by en⁹⁶ (In(2R)DTD96), to cause heldout wings.

(Sanicola et al., 1995)

Increased dose of tld⁺ does not suppress the mutant phenotype.

(Ferguson and Anderson, 1992)

Enhancement of tor^13D embryos: decrease in proportion of embryos that formed cuticle, or cuticle with denticles and increase in proportion of embryos that formed empty sacs.

(Strecker et al., 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

dpp^hr56

(Chanut and Heberlein, 1997)

Rescued by

dpp^hr4/Df(2R)Pcl11B is rescued by dpp^Sal20

(Nicholls and Gelbart, 1998)

Comments

Lethal interaction between dpp^hr4 and Df(2R)Pcl11B, Df(3L)66C-G28 and Mad¹² can be rescued by dpp^Sal20.

(Nicholls and Gelbart, 1998)

The transheterozygous combination dpp^hr4/dpp^hr56 allows development to adult-hood in a temperature-sensitive manner. The permissive temperature is 17^oC and the restrictive temperature is 29^oC.

(Chanut and Heberlein, 1997)

Allele class: hin-r

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

81062

net¹ dpp^hr4/CyO, P{en1}wg^en11

Notes on Origin

Discoverer

Comments

Class EL allele.

(Smolik-Utlaut and Gelbart, 1987)

Based on considerations of degree of dominant lethality, dpp alleles can be placed in an allelic series. Progressing from weakest to most severe the series is: dpp^e87 < dpp^e90 < dpp^hr56 < dpp^hr4 < dpp^hr92 < dpp^hr27 < dpp^hr93 < dpp^H94 < dpp^H95 < dpp^H96 = dpp^H91 = dpp^H46.

(Wharton et al., 1993)

dpp^hr4 shows interallelic complementation at 18^oC with dpp^hr56 and dpp^e90.

(Wharton et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

dpp-hr4

(Haerry, 2011.12.5)

dpp⁴

(Roy et al., 2014, Hsiung et al., 2005, Smolik-Utlaut and Gelbart, 1987, Segal and Gelbart, 1985, Spencer et al., 1982)

dpp^Hin-r4

(Strecker et al., 1991)

dpp^hin-r4

(Ferguson and Anderson, 1992, Schulz and Miksch, 1989, Irish and Gelbart, 1987)

dpp^hinr4

(Hoffmann and Goodman, 1987)

dpp^his4

(Crickmore and Mann, 2006)

dpp^hr4

(Quijano et al., 2016, Inaba et al., 2015, Künnapuu et al., 2014, Stinchfield et al., 2012, Kirilly et al., 2011, Trivigno and Haerry, 2011, Chen et al., 2010, Twombly et al., 2009, Pan et al., 2007, Zeng et al., 2007, Bangi and Wharton, 2006, Lin et al., 2006, Kirilly et al., 2005, Takaesu et al., 2005)

hin-r4

(Arora and Nusslein-Volhard, 1992)

Name Synonyms

Secondary FlyBase IDs

FBal0031053

References (65)

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