Allele Dmel\dpp^hr4

General Information
Symbol	Dmel\dpp^hr4	Species	D. melanogaster
Name		FlyBase ID	FBal0003066
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\dpp

Allele class	loss of function, hypomorph
Mutagen	ethyl methanesulfonate
Nature of the Allele
Allele class	loss of function (Arora and Nusslein-Volhard, 1992, Ferguson and Anderson, 1992, Frasch, 1995) hypomorph (St. Johnston et al., 1990, Rushlow et al., 2001, Kenyon et al., 2003)
Mutagen	ethyl methanesulfonate (Spencer et al., 1982, St. Johnston et al., 1990, Terracol and Lengyel, 1994, Wharton et al., 1996)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Point mutation. (Sekelsky et al., 1995) Nucleotide substitution: G2392A. Amino acid replacement: G402E. Amino acid 402 falls in the N-terminal pro region of the dpp protein. (Wharton et al., 1996)
Assay mode
Cytology	Polytene chromosomes normal. Polytene chromosomes normal. (Spencer et al., 1982) Polytene chromosomes normal. (Segal and Gelbart, 1985) Polytene chromosomes normal. (Gelbart, 1982)
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Gelbart, 1982, Raftery et al., 1995) lethal \| recessive \| conditional - heat sensitive (Chanut and Heberlein, 1997) lethal \| embryonic stage (Spencer et al., 1982, Wharton et al., 1996) lethal \| embryonic stage \| recessive (George and Terracol, 1997, Segal and Gelbart, 1985, Nicholls and Gelbart, 1998, Chanut and Heberlein, 1997, Hoffmann and Goodman, 1987) visible (with dpp^d5) (Bangi and Wharton, 2006) visible \| recessive (Spencer et al., 1982) visible \| dominant (Gelbart, 1982)
Phenotype Manifest In
	wing (with dpp^d6) (George and Terracol, 1997, Crickmore and Mann, 2006) wing vein L2 (with dpp^d6) (Bangi and Wharton, 2006) wing vein L4 (with dpp^d6) (Bangi and Wharton, 2006) cytoneme & dorsal mesothoracic disc \| somatic clone (with dpp^hr56) (Hsiung et al., 2005) wing (Gelbart, 1982, Spencer et al., 1982) embryonic epidermis \| dorsal (Arora and Nusslein-Volhard, 1992) dorsal hair & embryo (Arora and Nusslein-Volhard, 1992) antennal sensillum (Arora and Nusslein-Volhard, 1992) maxillary palp sense organ (Arora and Nusslein-Volhard, 1992) amnioserosa (Arora and Nusslein-Volhard, 1992, Mason et al., 1997) germarium (Xie and Spradling, 1998) female germline stem cell (Xie and Spradling, 1998) crossvein (Spencer et al., 1982) male terminalia (Spencer et al., 1982) female analia (Spencer et al., 1982) wing vein (Spencer et al., 1982, Brummel et al., 1994) sex comb (Spencer et al., 1982) scutellar bristle (Spencer et al., 1982) antennal segment 3 (Spencer et al., 1982) capitellum (Spencer et al., 1982) eye (Spencer et al., 1982) embryonic dorsal epidermis (Wharton et al., 1996) cephalopharyngeal skeleton (Wharton et al., 1996) abdominal segment 7 (Wharton et al., 1996) abdominal segment 8 (Wharton et al., 1996) filzkorper (Wharton et al., 1996) embryonic thorax (Wharton et al., 1996) denticle belt & thorax (Wharton et al., 1996) retina \| conditional - heat sensitive (Chanut and Heberlein, 1997) ommatidium \| conditional - heat sensitive (Chanut and Heberlein, 1997) morphogenetic furrow (Chanut and Heberlein, 1997) dorsal appendage (Dequier et al., 2001) wing vein \| ectopic (Brummel et al., 1994) anterior crossvein (Brummel et al., 1994) wing vein L2 (with dpp^d5) (Bangi and Wharton, 2006) wing vein L4 (with dpp^d5) (Bangi and Wharton, 2006) wing vein (with dpp^s6) (Takaesu et al., 2005) wing vein L5 (with dpp^s6) (Takaesu et al., 2005) wing vein L4 (with dpp^s6) (Takaesu et al., 2005) wing vein (with dpp^s6), with Df(2L)C28 (Takaesu et al., 2005, Takaesu et al., 2005, Takaesu et al., 2005) wing vein L5 (with dpp^s6), with Df(2L)C28 (Takaesu et al., 2005, Takaesu et al., 2005, Takaesu et al., 2005) wing vein L4 (with dpp^s6), with Df(2L)C28 (Takaesu et al., 2005, Takaesu et al., 2005, Takaesu et al., 2005) wing vein L2 (with dpp^s6), with Df(2L)C28 (Takaesu et al., 2005, Takaesu et al., 2005, Takaesu et al., 2005) posterior crossvein (with dpp^s6), with Df(2L)C28 (Takaesu et al., 2005, Takaesu et al., 2005, Takaesu et al., 2005) wing vein L5 (with dpp^s6), with Df(3R)E40 (Takaesu et al., 2005, Takaesu et al., 2005, Takaesu et al., 2005)
Detailed Description
	Statement Reference Heterozygotes with class I dpp alleles have a wild type wing phenotype. Heterozygotes with class II allele dpp^d5 exhibit wings with a deletion of the anterior crossvein. Heterozygotes with class II allele dpp^d28 exhibit held out wings that are missing longitudinal and cross veins, deletion of tarsal claws, male terminalia and female analia. Heterozygotes with class III dpp alleles display reduced held out wings that are missing longitudinal and cross veins, capitella-less halteres, reduced eyes, legs missing claws and missing or rotated male terminalia or female analia. Heterozygotes with class IV dpp alleles display the same phenotype as class III heterozygotes with duplication of scutellar bristles, medial cleft of the dorsal notum, duplication of sex combs and partial duplication of the third antennal segment. Heterozygotes with class V dpp alleles rarely eclose, the surviors exhibit the wing, haltere, eye and terminalia defects. At 18^oC the heterozygotes have less severe phenotypes. (Spencer et al., 1982) Abnormal development begins after germ band extension. (Segal and Gelbart, 1985) Heterozygotes exhibit wings that are stumps. The wings are held out laterally instead of in line with the longitudinal axis of the body. Transheterozygotes with dpp^d-ho exhibit normally oriented wings. (Gelbart, 1982) Fully rescued to adulthood by two wild type copies of dpp. (Hoffmann and Goodman, 1987) z¹ product subliminally inhibits the complementation of dpp^hr4 and dpp^d-ho. The effect is only seen when compounded by the particular effects of rearrangements on synapsis. (Smolik-Utlaut and Gelbart, 1987) Weak ventralised phenotype. Rings of ventral denticle belts differentiate around the entire dorsoventral axis, almost no dorsal hairs are seen and the antennal and maxillary sense organs are missing. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded. (Arora and Nusslein-Volhard, 1992) Dominant lethality less than 50%. Homozygous and transheterozygous embryos were examined with respect to 25 cuticular markers, results demonstrate a graded requirement for dpp along the dorso-ventral axis. (Wharton et al., 1993) Clonal analysis in the developing eye (using the FLP/FRT system) revealed nonautonomous phenotypes with large clones showing posterior-lateral eye parts missing. (Heberlein et al., 1993) dpp^d6/dpp^hr4 individuals have a nearly full size wing, except for the absence of the anterior crossvein, a reduction in the distance between L4 and L5 and a small amount of ectopic vein between L2 and L3. If the flies are also heterozygous for (paternally contributed) sax¹ or sax², L2 is lost and L4 and L5 fused. (Brummel et al., 1994) Survival of heterozygotes is reduced if also heterozygous for certain alleles of tld. (Finelli et al., 1994) Embryos display a moderately ventralised phenotype, maternally contributed tkv alleles cause lethality. (Terracol and Lengyel, 1994) Homozygous embryos have 6 +/- 10 amnioserosa cells (compare to 164 +/- 23 cells in wild type embryos), many embryos lack amnioserosa entirely. Heterozygotes have 124 +/- 9 amnioserosa cells, a fraction of embryos die. (Raftery et al., 1995) dpp^hr4/dpp^d-ho transheterozygotes show a wild type wing phenotype in an otherwise normal genetic background. (Sanicola et al., 1995) Heterozygotes are viable, heterozygotes derived from Mad^-/Mad⁺ mothers frequently die. Transheterozygotes with dpp^d6 have wings approximately half normal size and normal legs and eyes (less severe than dpp^d6 homozygous phenotype). When in combination with Df(2L)C28/Mad⁺ the transheterozygotes exhibit more severe phenotype, further reduction in wing blade, slight reduction in the eye and loss of tarsal claws. Trisomy for Mad (Dp(2;3)JS20) partially ameliorates transheterozygote phenotype, wings are of normal size and show residual vein fusions. (Sekelsky et al., 1995) Embryos show cuticular holes, disorganization of the head skeleton, internalization of the seventh and eighth abdominal segments and the filzkorper and a thoracic constriction. The first and second ventral denticle belts are expanded. A significant percentage of surviving transheterozygotes between dpp^hr56 and dpp^hr4 or dpp^hr27 have a split notum. (Wharton et al., 1996) Eye discs from dpp^hr4/dpp^hr56 larvae grown at 29^oC for 48 hrs show several phenotypes including failure of retinal differentiation or partial ommatidial differentiation, ommatidia are retricted to the posterior part of the disc and absent from the lateral margins. Occasionally eye discs show normal size and morphology. These eye discs show anterior-most ommatidia that are abnormal mature in comparison to wild type ommatidia at similar positions. Also, cell death is observed ahead of the differentiated region. Surviving adults show slightly roughened eyes that are reduced along the anterior-posterior axis, consistent with a failure of normal morphgenetic progression. (Chanut and Heberlein, 1997) Embryos are ventralised. dpp^hr4/dpp^d6 transheterozygotes exhibit reduced wings to approximately half wild type size and no defects in eyes or legs. (George and Terracol, 1997) Homozygotes produce approximately 30 amnioserosa cells. This phenotype is not altered if the embryos are also carrying 2 copies of tsg^twi.PM. (Mason et al., 1997) dpp^hr4/dpp^s6 causes relatively few wings to have abnormal venation. (Nicholls and Gelbart, 1998) Females carrying temperature sensitive combinations dpp^e90/dpp^hr56 or dpp^hr4/dpp^hr56 after shifting to the restrictive temperature for one week show 40-50% of germaria that are significantly smaller than wild type. The effect is more pronounced in older females. Stem cell number is reduced, stem cells have differentiated into cysts. Some effect on egg chamber budding is seen. (Xie and Spradling, 1998) Approximately 50% of eggs laid by heterozygous females have shortened and abnormally shaped respiratory appendages. (Dequier et al., 2001) dpp^hr4/dpp^hr56 males raised at 18^oC to eclosion and then shifted to 29^oC, show no significant loss of germline stem cells after 1 week. (Kawase et al., 2004) When single cell dpp^hr4/dpp^hr56 clones are made in the wing imaginal disc, cytonemes in the wing primordium are affected. At the non-permissive temperature (29^oC) cytonemes emanating from cells at the lateral flanks of discs do not orient themselves towards the anterior posterior organiser (as those see in wild-type do). Cytonemes in these discs are also more numerous than in wild-type, and unlike in the wild-type, are sometimes seen to be bent, curved or crossing over each other. These effects are not observed if mutant larvae are heatshocked and returned to permissive temperatures. (Hsiung et al., 2005) dpp[d5]/dpp[hr4] wings show a truncation of both the L2 and L4 veins, while dpp[d6]/dpp[hr4] wings have only two veins, L3 and L5 and are missing L2 and L4 completely. (Bangi and Wharton, 2006) Wing size is reduced in dpp[hr4]/dpp[d6] flies. (Crickmore and Mann, 2006) dpp[s6]/dpp[hr4] transheterozygotes are adult viable and exhibit occasional wing vein defects. Truncation of longitudinal vein 5 (L5) is observed in approximately 11% of adults, while 2% display truncations of L4 and L5. dpp[s6]/dpp[hr4] Df(2L)C28 flies exhibit an increased frequency of L5 wing vein defects (95% compared to 11% in dpp[s6]/dpp[hr4] flies). Approximately 20% show defects in L4 and L5 wing veins, and 5% exhibit defects in L5 and L2, or L5 and the posterior crossvein, indicating an enhancement of the dpp[s6]/dpp[hr4] wing vein phenotype. No lethality is associated with either the dpp[s6]/dpp[hr4] or dpp[s6]/dpp[hr4] Df(2L)C28 genotypes. dpp[s6]/dpp[hr4] Df(3R)E40 flies exhibit an increased frequency of L5 wing vein defects (28% compared to 11% in dpp[s6]/dpp[hr4] flies). (Takaesu et al., 2005)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference dpp^hr4 has lethal \| embryonic stage \| recessive phenotype, enhanceable \| maternal effect by Df(2L)C144/+ (Su et al., 2001) dpp^hr4 has lethal \| embryonic stage \| recessive phenotype, enhanceable \| maternal effect by Df(2L)DTD52-D51/+ (Su et al., 2001) dpp^hr4 has lethal \| embryonic stage \| recessive phenotype, enhanceable \| maternal effect by T(2;3)DTD46.4/+ (Su et al., 2001) dpp^hr4 has lethal \| embryonic stage \| recessive phenotype, enhanceable \| maternal effect by lilli^a16/lilli[+] (Su et al., 2001)
NOT Enhancer of
Statement Reference dpp^hr4/dpp[+] is a non-enhancer of visible phenotype of I-2^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC}, Scer\GAL4^vg.PM, put^Scer\UAS.cMa (Bennett et al., 2003)
NOT Suppressor of
Statement Reference dpp^hr4/dpp[+] is a non-suppressor of visible phenotype of I-2^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC}, Scer\GAL4^vg.PM, put^Scer\UAS.cMa (Bennett et al., 2003)
Other
Statement Reference DTD45.10^45.10, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001, Su et al., 2001) DTD46.6^46.6, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001, Su et al., 2001) Df(2L)DTD52-D51, In(2LR)DTD11, dpp^d-ho/dpp^hr4 has visible phenotype (Gelbart, 2001.4.19) dpp^d-ho/dpp^hr4, lilli^a16 has visible phenotype (Su et al., 2001, Su et al., 2001) DTD46.5^46.5, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001, Su et al., 2001) DTD45.1^45.1, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001, Su et al., 2001) DTD46.8^46.8, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001, Su et al., 2001) DTD44.4^44.4, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001, Su et al., 2001) Ab(?)DTD44.2, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) Ab(?)DTD45.2, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) DTD44.3^44.3, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001, Su et al., 2001) DTD44.5^44.5, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001, Su et al., 2001) DTD45.11^45.11, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001, Su et al., 2001) DTD45.7^45.7, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001, Su et al., 2001) DTD45.8^45.8, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001, Su et al., 2001) Df(2L)C144, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) Dp(2;2)DTD45.12, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) In(2L)DTD46.3, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) In(2LR)DTD45.6, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) In(2LR)DTD46.2, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) In(2LR)DTD46.9, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) T(2;3)DTD43.3, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) T(2;3)DTD43.4, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) T(2;3)DTD43.5, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) T(2;3)DTD44.1, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) T(2;3)DTD45.3, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) T(2;3)DTD45.4, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) T(2;3)DTD45.5, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) T(2;3)DTD45.9, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) T(2;3)DTD46.4, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) T(2;3)DTD46.7, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) T(2;4)DTD43.1, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) In(2L)DTD42.0, dpp^d-ho/dpp^hr4 has visible phenotype (Su et al., 2001) Mad¹, dpp^s6/dpp^hr4 has lethal phenotype (Takaesu et al., 2005)
Phenotype Manifest In
Enhanced by
Statement Reference dpp^hr4 has phenotype, enhanceable by Med¹¹/Med[+] (Hudson et al., 1998) dpp^hr4 has phenotype, enhanceable by Med[+]/Med¹² (Hudson et al., 1998) dpp^hr4 has phenotype, enhanceable by Med¹³/Med[+] (Hudson et al., 1998) dpp^hr4 has phenotype, enhanceable by Med¹⁴/Med[+] (Hudson et al., 1998) dpp^hr4 has phenotype, enhanceable by Med[+]/Med¹⁵ (Hudson et al., 1998) dpp^hr4 has phenotype, enhanceable by Med¹⁶/Med[+] (Hudson et al., 1998) dpp^hr4 has phenotype, enhanceable by Med¹⁷/Med[+] (Hudson et al., 1998) dpp^hr4 has phenotype, enhanceable by Med[+]/Med¹⁸ (Hudson et al., 1998) dpp^hr4/dpp^d6 has wing phenotype, enhanceable by vri[+]/vri¹ (George and Terracol, 1997) dpp^hr4/dpp^d6 has wing phenotype, enhanceable by vri²/vri[+] (George and Terracol, 1997) dpp^hr4 has phenotype, enhanceable by Mad² (Raftery et al., 1995) dpp^hr4 has phenotype, enhanceable by Mad³ (Raftery et al., 1995) dpp^hr4 has phenotype, enhanceable by Mad⁴ (Raftery et al., 1995) dpp^hr4 has phenotype, enhanceable by Med¹ (Raftery et al., 1995) dpp^hr4 has phenotype, enhanceable by Med² (Raftery et al., 1995) dpp^hr4 has phenotype, enhanceable by Med³ (Raftery et al., 1995) dpp^hr4 has phenotype, enhanceable by Med⁴ (Raftery et al., 1995) dpp^hr4 has phenotype, enhanceable by scw^E1 (Raftery et al., 1995) dpp^hr4 has phenotype, enhanceable by scw^E2 (Raftery et al., 1995) dpp^hr4 has phenotype, enhanceable by tld¹⁴ (Raftery et al., 1995) dpp^hr4 has phenotype, enhanceable by tld^E1 (Raftery et al., 1995) dpp^hr4 has embryonic epidermis phenotype, enhanceable by cype[+]/cype⁰³⁷⁷¹ (Szuplewski and Terracol, 2001) dpp^hr4 has embryonic/first instar larval cuticle phenotype, enhanceable by cype[+]/cype⁰³⁷⁷¹ (Szuplewski and Terracol, 2001) dpp^hr4 has phenotype, enhanceable by vri^5R4.11 (George and Terracol, 1997) dpp^hr4 has phenotype, enhanceable by vri^5R5.24 (George and Terracol, 1997) dpp^hr4 has phenotype, enhanceable by vri^5R5.7 (George and Terracol, 1997) dpp^hr4 has phenotype, enhanceable by vri^5R7.2 (George and Terracol, 1997) dpp^hr4 has phenotype, enhanceable by vri^5R8.4 (George and Terracol, 1997) dpp^hr4 has phenotype, enhanceable by vri^k03801 (George and Terracol, 1997) dpp^hr4 has phenotype, enhanceable by vri^k05901 (George and Terracol, 1997) dpp^hr4 has phenotype, enhanceable by vri^k09602 (George and Terracol, 1997) dpp^hr4 has phenotype, enhanceable by vri^k09713 (George and Terracol, 1997) dpp^hr4 has phenotype, enhanceable by vri^k11805 (George and Terracol, 1997) dpp^hr4 has phenotype, enhanceable by Df(3L)66C-G28/+ (Nicholls and Gelbart, 1998) dpp^hr4 has cephalopharyngeal skeleton phenotype, enhanceable by Df(2R)Pcl11B/+ (Nicholls and Gelbart, 1998) dpp^hr4 has wing vein phenotype, enhanceable by Df(2R)Pcl11B/+ (Nicholls and Gelbart, 1998) dpp^hr4 has wing vein phenotype, enhanceable by Df(2R)Pcl7B/+ (Nicholls and Gelbart, 1998) dpp^d5/dpp^hr4 has wing vein L2 phenotype, enhanceable by gbb¹/gbb[+] (Bangi and Wharton, 2006) dpp^hr4/dpp^d6 has wing phenotype, enhanceable by tkv^Scer\UAS.cNa/Scer\GAL4^tub (Crickmore and Mann, 2006) dpp^s6/dpp^hr4 has wing vein phenotype, enhanceable by Mad¹ (Takaesu et al., 2005) dpp^s6/dpp^hr4 has wing vein phenotype, enhanceable by Med⁷ (Takaesu et al., 2005) dpp^s6/dpp^hr4 has wing vein L5 phenotype, enhanceable by Med⁷ (Takaesu et al., 2005) dpp^s6/dpp^hr4 has wing vein L4 phenotype, enhanceable by Med⁷ (Takaesu et al., 2005)
NOT Enhanced by
Statement Reference dpp^Sal20, dpp^hr4 has phenotype, non-enhanceable by Df(3L)66C-G28/+ (Nicholls and Gelbart, 1998)
Enhancer of
Statement Reference dpp^hr4 is an enhancer of embryonic/first instar larval cuticle phenotype of tor^13D (Strecker et al., 1991) dpp^hr4/dpp^d6 is an enhancer of wing phenotype of Scer\GAL4^tub, tkv^Scer\UAS.cNa (Crickmore and Mann, 2006)
NOT Enhancer of
Statement Reference dpp^hr4/dpp[+] is a non-enhancer of wing phenotype of I-2^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC}, Scer\GAL4^vg.PM, put^Scer\UAS.cMa (Bennett et al., 2003)
Suppressor of
Statement Reference dpp^d-ho/dpp^hr4 is a suppressor of eye phenotype of CycE^JP (Horsfield et al., 1998)
NOT Suppressor of
Statement Reference dpp^hr4/dpp[+] is a non-suppressor of wing phenotype of I-2^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC}, Scer\GAL4^vg.PM, put^Scer\UAS.cMa (Bennett et al., 2003)
Other
Statement Reference DTD45.10^45.10, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001, Su et al., 2001) dpp^hr4/dpp^d6, vri² has wing vein phenotype (George and Terracol, 1997) dpp^hr4/dpp^d6, vri² has eye phenotype (George and Terracol, 1997) dpp^hr4/dpp^d6, vri² has leg phenotype (George and Terracol, 1997) DTD46.6^46.6, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001, Su et al., 2001) dpp^hr56/dpp^hr4, gbb[+]/gbb^D4 has male germline stem cell phenotype (Kawase et al., 2004) Med⁴, dpp^hr4/dpp[+] has cephalopharyngeal skeleton phenotype (Raftery et al., 1995) dpp^d-ho/dpp^hr4, en⁹⁶ has wing phenotype (Sanicola et al., 1995, Sanicola et al., 1995) dpp^hr4/dpp^d6, vri[+]/vri¹ has wing vein phenotype (George and Terracol, 1997) dpp^hr4/dpp^d6, vri[+]/vri¹ has eye phenotype (George and Terracol, 1997) dpp^hr4/dpp^d6, vri[+]/vri¹ has leg phenotype (George and Terracol, 1997) dpp^hr4/dpp^d6, vri²/vri[+] has wing vein phenotype (George and Terracol, 1997) dpp^hr4/dpp^d6, vri²/vri[+] has eye phenotype (George and Terracol, 1997) dpp^hr4/dpp^d6, vri²/vri[+] has leg phenotype (George and Terracol, 1997) Med³, dpp^hr4/dpp[+] has cephalopharyngeal skeleton phenotype (Raftery et al., 1995) Df(2L)DTD52-D51, In(2LR)DTD11, dpp^d-ho/dpp^hr4 has wing phenotype (Gelbart, 2001.4.19) dpp^d-ho/dpp^hr4, lilli^a16 has wing phenotype (Su et al., 2001, Su et al., 2001) dpp^hr4, tld^E1/tld[+] has cephalopharyngeal skeleton phenotype (Raftery et al., 1995) dpp^hr4, tld^E1/tld[+] has stage 14 embryo phenotype (Raftery et al., 1995) Med²/Med[+], dpp^hr4 has cephalopharyngeal skeleton phenotype (Raftery et al., 1995) Med[+]/Med³, dpp^hr4 has cephalopharyngeal skeleton phenotype (Raftery et al., 1995) Med⁴/Med[+], dpp^hr4 has cephalopharyngeal skeleton phenotype (Raftery et al., 1995) DTD46.5^46.5, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001, Su et al., 2001) DTD45.1^45.1, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001, Su et al., 2001) DTD46.8^46.8, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001, Su et al., 2001) DTD44.4^44.4, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001, Su et al., 2001) Med², dpp^hr4/dpp[+] has cephalopharyngeal skeleton phenotype (Raftery et al., 1995) Ab(?)DTD44.2, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) Ab(?)DTD45.2, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) DTD44.3^44.3, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001, Su et al., 2001) DTD44.5^44.5, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001, Su et al., 2001) DTD45.11^45.11, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001, Su et al., 2001) DTD45.7^45.7, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001, Su et al., 2001) DTD45.8^45.8, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001, Su et al., 2001) Df(2L)C144, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) Dp(2;2)DTD45.12, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) In(2L)DTD46.3, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) In(2LR)DTD45.6, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) In(2LR)DTD46.2, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) In(2LR)DTD46.9, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) T(2;3)DTD43.3, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) T(2;3)DTD43.4, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) T(2;3)DTD43.5, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) T(2;3)DTD44.1, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) T(2;3)DTD45.3, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) T(2;3)DTD45.4, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) T(2;3)DTD45.5, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) T(2;3)DTD45.9, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) T(2;3)DTD46.4, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) T(2;3)DTD46.7, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) T(2;4)DTD43.1, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) In(2L)DTD42.0, dpp^d-ho/dpp^hr4 has wing phenotype (Su et al., 2001) dpp^hr56/dpp^hr4, gbb^D4 has male germline stem cell phenotype (Kawase et al., 2004) dpp^hr4/dpp[+], tld^E1 has cephalopharyngeal skeleton phenotype (Raftery et al., 1995) dpp^hr4/dpp[+], tld^E1 has stage 14 embryo phenotype (Raftery et al., 1995) dpp^hr4/dpp^d6, vri¹ has wing vein phenotype (George and Terracol, 1997) dpp^hr4/dpp^d6, vri¹ has eye phenotype (George and Terracol, 1997) dpp^hr4/dpp^d6, vri¹ has leg phenotype (George and Terracol, 1997)
Additional Comments
Genetic Interactions
Statement Reference Enhancement of tor^13D embryos: decrease in proportion of embryos that formed cuticle, or cuticle with denticles and increase in proportion of embryos that formed empty sacs. (Strecker et al., 1991) Increased dose of tld⁺ does not suppress the mutant phenotype. (Ferguson and Anderson, 1992) Homozygous lethal phenotype can be enhanced by Med,

Allele Dmel\dpphr4

Allele Dmel\dpp^hr4