Polytene chromosomes normal.
adult thorax & adult epidermis
denticle belt & thorax
The progeny from dpphr27/+ fathers exhibit lethality when mothers are either Med15/+, Df(2R)Pcl11B/+, lolalk02512/+ or lolal1122/+, exhibit near lethality when mothers are either lolalG9603/+ or Df(2R)12/+, and exhibit semi-lethality when mothers are either Mad12/+ or lolal1722/+, as compared to controls; the lethality of the progeny from dpphr27/+ fathers and lolal1122/+ mothers is partially rescued by the maternal expression of either lolalScer\UAS.P\T.cQa, lolalScer\UAS.P\T.T:Ivir\HA1, tkvQ253D.Scer\UAS.P\T, saxQ263D.Scer\UAS.cDa, MedScer\UAS.P\T.cSa or MedK738R.Scer\UAS.P\T, either under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 or, to a lower extent, in the absence of the Gal4 driver.
dpphr27/+ ; Ack86/Ack86 embryos show dorsal closure defects at a relatively low frequency, but which is significantly higher than the frequency seen in either dpphr27/+ or Ack86/Ack86 single mutant embryos.
100% of the expected cype03771/dpphr27 adult progeny are recovered from a cross of dpphr27/+ females to cype03771/+ males. Only 4% of the expected cype03771/dpphr27 adult progeny are recovered from a cross of cype03771/+ females to dpphr27/+ males. The lethality is embryonic and the embryos are weakly to moderately ventralised.
The wing phenotype of dppd5/dpphr27 flies is strongly enhanced by two copies of p38bDN.Scer\UAS expressed under the control of one copy of Scer\GAL432B; veins L4 and L5 are partially fused and the distance between veins L2 and L3 is reduced.
Med1 shows a dominant maternal effect interaction with dpp; when Med1/+ females are crossed to dpphr27/+ males, all progeny carrying dpphr27 die. This lethality is rescued by MedUbi-p63E.PD also partly by MadUbi-p63E.T:Hsap\MYC. Mad12 shows a dominant maternal effect interaction with dpp; when Mad12/+ females are crossed to dpphr27/+ males, all progeny carrying dpphr27 die. This lethality is rescued by MadUbi-p63E.T:Hsap\MYC also partly by MedUbi-p63E.PD.
When in combination with vri mutations, vrik05901 lethal revertant lines or Df(2L)tkv2 lethality is greatly increased and embryos are more strongly ventralised. Escaper vri3 dpphr27 flies exhibit wings with extra vein material between L2 and L3, atrophic wings and a split thorax.
Allele class: hin-r