FlyBase Allele Report: Dmel\dpp[hr56]

General Information

Symbol

Dmel\dpp^hr56

Species

D. melanogaster

Name

FlyBase ID

FBal0003068

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Also Known As

dpp⁵⁶

Key Links

Genomic Maps

JBrowse

Allele class

heat sensitive loss of function allele

Mutagen

Nature of the Allele

Allele class

heat sensitive loss of function allele

(Wharton et al., 1996)

Mutagen

gamma ray

(Wharton et al., 1996)

ethyl methanesulfonate

(St. Johnston et al., 1990)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Irish and Gelbart, 1987)

Description

Alteration in amino acids 397 to 400; H replaces QRNY.

(Newfeld et al., 1997)

Deletion of GCA at position 2383 such that CGCAAC becomes CAC. Consequently RN becomes His at amino acid 399. Amino acid 399 falls in the N-terminal pro region of the dpp protein.

(Wharton et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:2,457,989..2,457,991 [+]

Comment:

Deletion of GCA such that CGCAAC becomes CAC. Consequently RN becomes His at amino acid 399.

(Wharton et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | oogenesis (with dpp^d12)

(Liu et al., 2024)

abnormal size | dominant

(McCartney et al., 2000)

decreased cell number | dominant | progressive

(Pan et al., 2007)

increased cell death

(Chang et al., 2003)

lethal

(Wharton et al., 1993)

lethal (with dpp^d12)

(Bangi and Wharton, 2006)

lethal | embryonic stage | recessive

(Chanut and Heberlein, 1997)

lethal | heat sensitive

(Twombly et al., 1996)

lethal | recessive

(Newfeld et al., 1997)

lethal | recessive | heat sensitive

(Chanut and Heberlein, 1997)

lethal - all die during embryonic stage

(Irish and Gelbart, 1987)

lethal - all die during embryonic stage | heat sensitive

(Wharton et al., 1996)

lethal - all die during embryonic stage | recessive

(Hoffmann and Goodman, 1987)

partially lethal - majority die (with dpp^d5)

(Twombly et al., 2009)

partially lethal - majority die (with dpp^FRT-CA)

(Akiyama et al., 2022)

partially lethal - majority die (with dpp^FRT-PSB)

(Akiyama et al., 2022)

some die during embryonic stage

(Irish and Gelbart, 1987)

some die during embryonic stage | heat sensitive

(Wharton et al., 1996)

some die during embryonic stage | recessive

(Hoffmann and Goodman, 1987)

viable (with dpp^FO)

(Akiyama et al., 2022)

visible (with dpp^d5)

(Zeng et al., 2007, Bangi and Wharton, 2006, Ray and Wharton, 2001, Adachi-Yamada et al., 1999)

visible (with dpp^d8)

(Adachi-Yamada et al., 1999)

Phenotype Manifest In

abdominal segment 7

(Wharton et al., 1996)

abdominal segment 8

(Wharton et al., 1996)

anterior crossvein (with dpp^d5)

(Liu et al., 2011)

cephalopharyngeal skeleton

(Wharton et al., 1996)

crossvein (with dpp^d5)

(Bangi and Wharton, 2006)

cytoneme & dorsal mesothoracic disc | somatic clone (with dpp^hr4)

(Hsiung et al., 2005)

discal wing cell (with dpp^d5)

(Ray and Wharton, 2001)

dorsal appendage | heat sensitive

(Twombly et al., 1996)

egg | heat sensitive

(Twombly et al., 1996)

egg chorion | ectopic | heat sensitive

(Twombly et al., 1996)

egg operculum | heat sensitive

(Twombly et al., 1996)

embryonic abdomen

(Irish and Gelbart, 1987)

embryonic dorsal epidermis

(Wharton et al., 1996)

embryonic head

(Irish and Gelbart, 1987)

embryonic head epidermis | dorsal

(Chang et al., 2003)

embryonic optic lobe primordium

(Chang et al., 2003)

embryonic thorax

(Wharton et al., 1996)

eye disc morphogenetic furrow

(Chanut and Heberlein, 1997)

female germline cyst | progressive

(Pan et al., 2007)

female germline stem cell

(Xie and Spradling, 1998)

female germline stem cell | progressive

(Pan et al., 2007)

filzkorper

(Wharton et al., 1996)

germarium

(Xie and Spradling, 1998)

germarium | progressive

(Pan et al., 2007)

micropyle | heat sensitive

(Twombly et al., 1996)

ommatidium | heat sensitive

(Chanut and Heberlein, 1997)

ovary | larval stage (with dpp^d12)

(Liu et al., 2024)

retina | heat sensitive

(Chanut and Heberlein, 1997)

wing (with dpp^d5)

(Twombly et al., 2009, Adachi-Yamada et al., 1999)

wing (with dpp^d8)

(Adachi-Yamada et al., 1999)

wing cell (with dpp^d5)

(Zeng et al., 2007)

wing cell (with dpp^hr4)

(Zeng et al., 2007)

wing disc (with dpp^d12)

(Bangi and Wharton, 2006)

wing vein (with dpp^d5)

(Zeng et al., 2007)

wing vein L2 (with dpp^d5)

(Bangi and Wharton, 2006)

wing vein L4 (with dpp^d5)

(Ray and Wharton, 2001)

wing vein L5 (with dpp^d5)

(Ray and Wharton, 2001)

Detailed Description

Statement

Reference

dpp^hr56 heterozygous females show the expected mating-induced increase in germline stem cells in the germarium.

(Ameku et al., 2018)

The anterior crossvein is absent in dpp^hr56/dpp^d5 wings.

(Liu et al., 2011)

dpp^d5/dpp^hr56 mutants show abnormal wing phenotypes and reduced viability.

(Twombly et al., 2009)

7-day old dpp^hr56/+ germaria have normal numbers of germline stem cells (GSCs), but at 63-days old, these germaria have significantly lower GSC numbers compared to controls - most have only one or no GSCs. 35-day old and 63-day old heterozygous germaria also contain significantly fewer cysts than controls, although cap cells are maintained at normal numbers.

(Pan et al., 2007)

dpp^d5/dpp^hr56 flies show reductions in wing vein spacing and loss of wing veins.

(Zeng et al., 2007)

The wings of dpp^d5/dpp^hr56 transheterozygotes show a truncation of the L2 vein (40% penetrance), reduction of the L4-L5 intervein (48% penetrance) and partial fusion of the L4-L5 intervein (52% penetrance).

The wing pouch of dpp^d12/dpp^hr56 wing discs is reduced to essentially a dorsal/ventral margin with no detectable vein primordia.

(Bangi and Wharton, 2006)

When single cell dpp^hr4/dpp^hr56 clones are made in the wing imaginal disc, cytonemes in the wing primordium are affected. At the non-permissive temperature (29^oC) cytonemes emanating from cells at the lateral flanks of discs do not orient themselves towards the anterior posterior organiser (as those see in wild-type do). Cytonemes in these discs are also more numerous than in wild-type, and unlike in the wild-type, are sometimes seen to be bent, curved or crossing over each other. These effects are not observed if mutant larvae are heatshocked and returned to permissive temperatures.

(Hsiung et al., 2005)

In females carrying the temperature sensitive allelic combination dpp^hr56/dpp^e90 raised at 18^oC and shifted to 29^oC (the non-permissive temperature) for 10, germaria are agametic but contain only slightly less follicle cells than control agametic germaria (bam^hs.PO 10 days after two 2 hour heat shock treatments.

(Kirilly et al., 2005)

dpp^e90/dpp^hr56 or dpp^hr4/dpp^hr56 males raised at 18^oC to eclosion and then shifted to 29^oC, show no significant loss of germline stem cells after 1 week.

(Kawase et al., 2004)

In mutant embryos, the dorsal medial head epidermis fails to develop as reflected by the presence of a continuous optic placode across the dorsal midline. Cell death is decreased in the dorsal midline region of the embryo.

(Chang et al., 2003)

dpp^hr27/dpp^hr56 males that have been raised at 18^oC and then shifted to the restrictive temperature of 29^oC upon eclosion do not have any overt morphological abnormalities in the testes after 7 days at 29^oC and the testes contain germ cells in all stages and in quantities indistinguishable from that of controls.

(Shivdasani and Ingham, 2003)

dpp^d5/dpp^hr56 flies show loss of wing veins L2 and L4 and loss of the intervein region between veins L4 and L5.

(Ray and Wharton, 2001)

Heterozygotes show a mild reduction in size compared to wild type.

(McCartney et al., 2000)

dpp^hr56/dpp^d5 flies occasionally show notching of the wing margin.

(Adachi-Yamada et al., 1999)

dpp^d8/dpp^hr56 flies show a small notching of the wing tip in less than 10% of cases.

(Adachi-Yamada et al., 1999)

Eggs laid by dpp^hr56/+ show 99.1% wild type dorsal appendages, 0.7% broad dorsal appendages and normal egg length and 0.2% abnormal dorsal appendages with short egg length.

(Mantrova et al., 1999)

Females carrying temperature sensitive combinations dpp^e90/dpp^hr56 or dpp^hr4/dpp^hr56 after shifting to the restrictive temperature for one week show 40-50% of germaria that are significantly smaller than wild type. The effect is more pronounced in older females. Stem cell number is reduced, stem cells have differentiated into cysts. Some effect on egg chamber budding is seen.

(Xie and Spradling, 1998)

Eye discs from dpp^hr4/dpp^hr56 larvae grown at 29^oC for 48 hrs show several phenotypes including failure of retinal differentiation or partial ommatidial differentiation, ommatidia are retricted to the posterior part of the disc and absent from the lateral margins. Occasionally eye discs show normal size and morphology. These eye discs show anterior-most ommatidia that are abnormal mature in comparison to wild type ommatidia at similar positions. Also, cell death is observed ahead of the differentiated region. Surviving adults show slightly roughened eyes that are reduced along the anterior-posterior axis, consistent with a failure of normal morphgenetic progression.

(Chanut and Heberlein, 1997)

At 25^oC, dpp^e87/dpp^hr56 animals die, while at 18^oC many survive to adulthood. Surviving females shifted to 25^oC lay eggs of which some show anterior eggshell defects: reduced opercula, slightly reduced dorsal appendages and some show reduced egg length. The operculum defects are often accompanied by small protrusions of ectopic eggshell extending off the anterior pole, and more rarely malformations of the micropyle.

(Twombly et al., 1996)

Embryos show cuticular holes, disorganization of the head skeleton, internalization of the seventh and eighth abdominal segments and the filzkorper and a thoracic constriction. A significant percentage of surviving transheterozygotes between dpp^hr56 and dpp^hr4 or dpp^hr27 have a split notum. dpp^hr56 shows a temperature sensitive embryonic lethality: percentage embryonic lethality drops from 26% at 25^oC to 5% at 18^oC. Temperature sensitivity is evident in denticle pattern as well as survival. dpp^hr56 is differentially temperature sensitive to embryonic and imaginal requirements for dpp. Outcrossed lines retain lethality at 18^oC, though this lethality acts at the pharate/pupal adult stage. Homozygotes exhibit canonical dpp disc phenotypes, with small roughened eyes, reduced wings and short truncated legs. dpp^hr56 is affecting a dpp function that is required differentially in embryonic and imaginal tissue.

(Wharton et al., 1996)

Survival of heterozygotes is reduced if also heterozygous for certain alleles of tld.

(Finelli et al., 1994)

dpp^hr56/+ embryos derived from sax¹/+, sax²/+ or tkv⁷/+ females show ventralized phenotypes.

(Nellen et al., 1994)

Clonal analysis in the developing eye (using the FLP/FRT system) revealed nonautonomous phenotypes with large clones showing posterior-lateral eye parts missing.

(Heberlein et al., 1993)

Dominant lethality less than 50%. Homozygous and transheterozygous embryos were examined with respect to 25 cuticular markers, results demonstrate a graded requirement for dpp along the dorso-ventral axis.

(Wharton et al., 1993)

Fully rescued to adulthood by two wild type copies of dpp.

(Hoffmann and Goodman, 1987)

Trans-heterozygotes display normal dorsal ventral polarity but show defects in head and cauda formation.

(Irish and Gelbart, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dpp^d5/dpp^hr56 has partially lethal - majority die phenotype, enhanceable by sax⁵

(Twombly et al., 2009)

dpp^d5/dpp^hr56 has visible phenotype, enhanceable by gbb¹/gbb[+]

(Bangi and Wharton, 2006)

dpp^hr56/dpp^d8 has visible phenotype, enhanceable by puc^E69/puc[+]

(Adachi-Yamada et al., 1999)

dpp^hr56/dpp^d8 has visible phenotype, enhanceable by hep[+]/hep^CA

(Adachi-Yamada et al., 1999)

Enhancer of

Statement

Reference

dpp^hr56/dpp[+] is an enhancer of visible | recessive phenotype of Mer³

(McCartney et al., 2000)

Suppressor of

Statement

Reference

dpp^hr56 is a suppressor | partially of abnormal cell number | oogenesis phenotype of Scer\GAL4^C587, dlp^UAS.cUa

(Tu et al., 2020)

dpp^hr56/dpp[+] is a suppressor | partially of neoplasia | female | adult stage phenotype of Psc^GD4481, Scer\GAL4^C587, Su(z)2^GD16388

(Li et al., 2016)

dpp^hr56/dpp[+] is a suppressor | partially of increased cell number | female | adult stage phenotype of Scer\GAL4^C587, ph-p^GD17398

(Li et al., 2016)

dpp^hr56/dpp[+] is a suppressor | partially of neoplasia | female | adult stage phenotype of Scer\GAL4^C587, ph-p^GD17398

(Li et al., 2016)

dpp^hr56/dpp[+] is a suppressor | partially of increased cell number | female | adult stage phenotype of Psc^GD4481, Scer\GAL4^C587, Su(z)2^GD16388

(Li et al., 2016)

Other

Statement

Reference

NPFR^sk8, dpp^hr56/dpp[+] has decreased cell number | oogenesis | conditional phenotype

(Ameku et al., 2018)

Med[+]/Med¹⁵, dpp^hr56 has lethal | maternal effect | maternal effect phenotype

(Quijano et al., 2016)

Df(2R)Pcl11B/+, dpp^hr56 has partially lethal - majority die | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr56, lolal^k02512/lolal[+] has partially lethal - majority die | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr56, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr56/dpp[+], sax¹ has lethal | dominant | maternal effect phenotype

(Twombly et al., 2009)

dpp^hr56/dpp[+], sax² has lethal | dominant | maternal effect phenotype

(Twombly et al., 2009)

dpp^hr56/dpp[+], sax^P has partially lethal - majority die | dominant | maternal effect phenotype

(Twombly et al., 2009)

dpp^hr56, ex⁶⁹⁷ has visible phenotype

(McCartney et al., 2000)

dpp^hr56, ex⁶⁹⁷ has visible | recessive phenotype

(McCartney et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^d5/dpp^hr56 has crossvein phenotype, enhanceable by gbb¹/gbb[+]

(Bangi and Wharton, 2006)

dpp^d5/dpp^hr56 has wing vein L2 phenotype, enhanceable by gbb¹/gbb[+]

(Bangi and Wharton, 2006)

dpp^hr56/dpp^d8 has wing phenotype, enhanceable by puc^E69/puc[+]

(Adachi-Yamada et al., 1999)

dpp^hr56/dpp^d8 has wing phenotype, enhanceable by hep[+]/hep^CA

(Adachi-Yamada et al., 1999)

dpp^hr56 has phenotype, enhanceable by Df(3L)66C-G28/+

(Nicholls and Gelbart, 1998)

dpp^hr56 has phenotype, enhanceable by Mad¹⁰

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad¹¹

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad¹²

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad¹

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad²

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad³

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad⁴

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad⁵

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad⁶

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad⁷

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad⁸

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad⁹

(Sekelsky et al., 1995)

dpp^hr56 has phenotype, enhanceable by Mad^P1

(Sekelsky et al., 1995)

NOT Enhanced by

Statement

Reference

dpp^Sal20, dpp^hr56 has phenotype, non-enhanceable by Df(3L)66C-G28/+

(Nicholls and Gelbart, 1998)

Suppressed by

Statement

Reference

dpp^d5/dpp^hr56 has wing phenotype, suppressible | partially by Df(2R)H23

(Twombly et al., 2009)

dpp^d5/dpp^hr56 has wing phenotype, suppressible | partially by sax⁴

(Twombly et al., 2009)

NOT suppressed by

Statement

Reference

dpp^d5/dpp^hr56 has wing phenotype, non-suppressible by sax⁵

(Twombly et al., 2009)

Enhancer of

Statement

Reference

dpp^hr56/dpp[+] is an enhancer of eye phenotype of Mer³

(McCartney et al., 2000)

dpp^hr56/dpp[+] is an enhancer of ommatidium phenotype of Mer³

(McCartney et al., 2000)

dpp^hr56/dpp[+] is an enhancer of interommatidial bristle phenotype of Mer³

(McCartney et al., 2000)

dpp^hr56/dpp[+] is an enhancer of adult head & cuticle phenotype of Mer³

(McCartney et al., 2000)

Suppressor of

Statement

Reference

dpp^hr56 is a suppressor | partially of female germline cell | increased number phenotype of Scer\GAL4^C587, dlp^UAS.cUa

(Tu et al., 2020)

dpp^hr56 is a suppressor | partially of germarium phenotype of Scer\GAL4^C587, dlp^UAS.cUa

(Tu et al., 2020)

dpp^hr56/dpp[+] is a suppressor | partially of germarium phenotype of Scer\GAL4^C587, ph-p^GD17398

(Li et al., 2016)

dpp^hr56/dpp[+] is a suppressor | partially of germarium phenotype of Psc^GD4481, Scer\GAL4^C587, Su(z)2^GD16388

(Li et al., 2016)

dpp^hr56/dpp[+] is a suppressor | partially of germarium phenotype of Cul2^GD8913, Scer\GAL4^ptc.PU

(Ayyub et al., 2015)

dpp^hr56/dpp[+] is a suppressor | partially of spectrosome phenotype of Cul2^GD8913, Scer\GAL4^ptc.PU

(Ayyub et al., 2015)

dpp^hr56 is a suppressor | partially of female germline stem cell | increased number phenotype of Su(var)3-3^ΔN

(Eliazer et al., 2011)

dpp^hr56/dpp[+] is a suppressor of wing vein phenotype of Ctdnep1^G0269

(Liu et al., 2011)

dpp^hr56/dpp[+] is a suppressor of germarium phenotype of stet^1A3

(Liu et al., 2010)

dpp^hr56/dpp[+] is a suppressor of spectrosome | increased number phenotype of stet^1A3

(Liu et al., 2010)

Other

Statement

Reference

NPFR^sk8, dpp^hr56/dpp[+] has female germline stem cell | conditional phenotype

(Ameku et al., 2018)

dpp^hr56/dpp^e90, gbb^D4 has male germline stem cell phenotype

(Kawase et al., 2004)

dpp^hr56/dpp^hr4, gbb^D4 has male germline stem cell phenotype

(Kawase et al., 2004)

dpp^hr56/dpp^hr4, gbb[+]/gbb^D4 has male germline stem cell phenotype

(Kawase et al., 2004)

dpp^hr56/dpp^e90, gbb[+]/gbb^D4 has male germline stem cell phenotype

(Kawase et al., 2004)

dpp^hr56, ex⁶⁹⁷ has tarsal segment phenotype

(McCartney et al., 2000)

dpp^hr56, ex⁶⁹⁷ has leg phenotype

(McCartney et al., 2000)

Mef2⁴²⁴, dpp^hr56 has egg phenotype

(Mantrova et al., 1999)

Mef2⁴²⁴, dpp^hr56 has dorsal appendage phenotype

(Mantrova et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

NPFR^sk8, dpp^hr56 double heterozygous females fail to show the expected mating-induced increase in germline stem cells in the germarium, as compared to heterozygous controls.

(Ameku et al., 2018)

The tumorigenic accumulation of germline stem cell-like cells in germaria, characteristic for females expressing either ph-p^GD17398 alone or Psc^GD4481 and Su(z)2^GD16388 simultaneously under the control of Scer\GAL4^C587 (together with tub-Gal80[ts] to limit the time of expression to adulthood) is strongly suppressed by combination with a single copy of dpp^hr56.

(Li et al., 2016)

The progeny from dpp^hr56/+ fathers exhibit lethality when mothers are Med¹⁵/+, and exhibit semi-lethality when mothers are either Df(2R)Pcl11B/+, lolal^k02512/+ or lolal¹¹²²/+, but do not exhibit significant mortality when mothers are either Mad¹²/+, lolal¹⁷²²/+ or lolal^G9603/+, as compared to controls.

(Quijano et al., 2016)

The increased number of spectrosome-containing cells in germaria characteristic for adult females expressing Cul2^GD8913 RNAi under the control of the Scer\GAL4^ptc.PU can be partially rescued by combination with either dpp^hr92, dpp^hr56 or tkv⁷ in a heterozygous state or by knocking-down dpp by co-expression of either dpp^JF01090 or dpp^JF01091 RNAi.

(Ayyub et al., 2015)

dpp^hr56/+ partially suppresses the Su(var)3-3^ΔN mutant supernumerary germline cell phenotype resulting in an increased number of germline cysts with branched fusomes and maturing egg chambers.

(Eliazer et al., 2011)

The aberrant wing vein phenotype seen in Dd^G0269/Y animals is suppressed by dpp^hr56/+.

(Liu et al., 2011)

Df(2R)H23 slightly suppresses the dpp^d5/dpp^hr56 wing phenotype.

sax⁴ slightly suppresses the dpp^d5/dpp^hr56 wing phenotype.

sax⁵ does not suppress the dpp^d5/dpp^hr56 wing phenotype. sax⁵ enhances the lethality associated with dpp^d5/dpp^hr56.

(Twombly et al., 2009)

dpp^e90/dpp^hr56; gbb^D4/+ males raised at 18^oC to eclosion and then shifted to 29^oC for one week have an average of 5.6 germ-line stem cells per testis, compared to 8.6 in gbb^D4/+. In identically treated dpp^e90/dpp^hr56; gbb^D4/+ this is reduced to 3.1 per ovary.

(Kawase et al., 2004)

Shows no genetic interaction with lilli^unspecified.

(Su et al., 2001)

Dominantly enhances the phenotype of Mer³ hemizygotes; the eye is smaller and more roughened and there is increased expansion of peripheral head cuticle. Numerous interommatidial bristle duplications are seen. ex⁶⁹⁷ dpp^hr56/ex⁶⁹⁷ flies have truncated legs in which the distal tarsal segments are absent (significant leg defects are not seen in either dpp^hr56/+ or ex⁶⁹⁷ single homozygote flies).

(McCartney et al., 2000)

The dpp^d8/dpp^hr56 phenotype is significantly enhanced by a single copy of puc^E69 or hep^CA, and in the case of hep^CA a wide region of the wing blade is lost, leaving only the base of the wing.

(Adachi-Yamada et al., 1999)

Eggs laid by Mef2⁴²⁴/dpp^hr56 females show 92.3% wild type dorsal appendages, 0.9% reduced dorsal appendages, 3.0% broad dorsal appendages and short egg length, 0.4% broad dorsal appendages and normal egg length and 2.8% abnormal dorsal appendages with short egg length.

(Mantrova et al., 1999)

Early embryonic dpp phenotype is dominantly maternally enhanced by Mad mutations.

(Sekelsky et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

dpp^hr4

(Chanut and Heberlein, 1997)

Comments

The transheterozygous combination dpp^hr4/dpp^hr56 allows development to adult-hood in a temperature-sensitive manner. The permissive temperature is 17^oC and the restrictive temperature is 29^oC.

(Chanut and Heberlein, 1997)

Allele class: hin-r

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36528

dpp^hr56 cn¹ bw¹/CyO

Notes on Origin

Discoverer

Comments

Based on considerations of degree of dominant lethality, dpp alleles can be placed in an allelic series. Progressing from weakest to most severe the series is: dpp^e87 < dpp^e90 < dpp^hr56 < dpp^hr4 < dpp^hr92 < dpp^hr27 < dpp^hr93 < dpp^H94 < dpp^H95 < dpp^H96 = dpp^H91 = dpp^H46.

(Wharton et al., 1993)

dpp^hr56 shows interallelic complementation at 18^oC with dpp^e90, dpp^hr4 and dpp^hr27.

(Wharton et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

dpp⁵⁶

(Roy et al., 2014, Hsiung et al., 2005, Iwaki and Lengyel, 2002)

dpp^Hin56

(Chang et al., 2003)

dpp^hin-r56

(Irish and Gelbart, 1987)

dpp^hinr56

(Hoffmann and Goodman, 1987)

dpp^hr-56

(Pan and Rubin, 1995)

Name Synonyms

Secondary FlyBase IDs

References (58)

Report Sections

Open Close