FlyBase Allele Report: Dmel\dpp[s4]

General Information

Symbol

Dmel\dpp^s4

Species

D. melanogaster

Name

FlyBase ID

FBal0003074

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Also Known As

dpp^shv4, shv^S4

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Aspland and White, 1997)

loss of function allele

(Riese et al., 1997)

Mutagen

X ray

(Segal and Gelbart, 1985)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Truncation mutant lacking most of dpp 5' flanking sequences.

(Immergluck et al., 1990)

Breakpoint allele.

(St. Johnston et al., 1990)

Caused by aberration

In(2L)dpp^s4

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal | recessive

(Segal and Gelbart, 1985)

lethal - all die before end of larval stage

(St. Johnston et al., 1990)

some die during larval stage

(St. Johnston et al., 1990)

visible (with dpp^s11)

(Ray and Wharton, 2001)

visible | dominant

(Segal and Gelbart, 1985)

visible | recessive

(Khalsa et al., 1998)

Phenotype Manifest In

anterior crossvein

(Khalsa et al., 1998)

embryonic/larval midgut

(Masucci and Hoffmann, 1993)

embryonic midgut constriction 1

(Hursh et al., 1993)

embryonic midgut constriction 2

(Hursh et al., 1993, Immergluck et al., 1990)

gastric caecum

(Masucci and Hoffmann, 1993)

gastric caecum primordium

(Hursh et al., 1993)

posterior crossvein (with dpp^s11)

(Ray and Wharton, 2001)

wing vein

(Immergluck et al., 1990)

wing vein L2

(de Celis, 1997)

wing vein L2 (with dpp^s22)

(Sotillos and de Celis, 2006)

wing vein L2 | distal

(de Celis, 1997)

wing vein L2 | distal (with dpp^s11)

(Ray and Wharton, 2001)

wing vein L4

(de Celis, 1997)

wing vein L4 (with dpp^s22)

(Sotillos and de Celis, 2006)

wing vein L4 | distal

(de Celis, 1997)

wing vein L4 | distal (with dpp^s11)

(Ray and Wharton, 2001)

wing vein L5

(de Celis, 1997)

wing vein L5 (with dpp^s22)

(Sotillos and de Celis, 2006)

wing vein L5 | distal

(de Celis, 1997)

wing vein L5 | distal (with dpp^s11)

(Ray and Wharton, 2001)

Detailed Description

Statement

Reference

The wings of dpp^s4/dpp^s22 flies have dramatically shortened L2, L4 and L5 wing veins and lack both cross veins.

(Sotillos and de Celis, 2006)

dpp^s4/dpp^s11 flies have a "shortvein" phenotype; the distal ends of L2, L4 and L5 are truncated. The posterior crossvein is missing.

(Ray and Wharton, 2001)

Wings derived from dpp^d6/dpp^s4 animals lack only the anterior crossvein.

(Khalsa et al., 1998)

dpp^s4/dpp^s8 flies lack the distal ends of wing veins LII, LIV and LV. dpp^s4/dpp^s8 flies lack most of wing veins LII, LIV and LV.

(de Celis, 1997)

Late embryos fail to evaginate gastric caeca and fail to form secondary midgut constrictions, and the primary midgut constriction is posteriorly displaced.

(Hursh et al., 1993)

Midguts from dpp^s4/dpp^s22 larvae lack all four gastric caecae.

(Masucci and Hoffmann, 1993)

Used to show absolute dependence on dpp of lab expression in midgut.

(Tremml and Bienz, 1992)

dpp^s4 homozygotes lack the second midgut constriction.

(Immergluck et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

dpp^s4/dpp[+] is a suppressor of visible | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

Other

Statement

Reference

dpp^s4/dpp^d6, gbb¹ has visible phenotype

(Khalsa et al., 1998)

dpp^s4/dpp^d6, gbb¹ has partially lethal phenotype

(Khalsa et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^s4/dpp^s8 has wing vein phenotype, enhanceable by tkv¹/tkv⁸

(de Celis, 1997)

Suppressed by

Statement

Reference

dpp^s4/dpp^d6 has anterior crossvein phenotype, suppressible by gbb¹

(Khalsa et al., 1998)

NOT Enhancer of

Statement

Reference

dpp^s4/dpp[+] is a non-enhancer of crossvein | somatic clone phenotype of gbb¹

(Bangi and Wharton, 2006)

dpp^s4/dpp[+] is a non-enhancer of wing vein L5 | somatic clone phenotype of gbb¹

(Bangi and Wharton, 2006)

Suppressor of

Statement

Reference

dpp^s4/dpp[+] is a suppressor of wing vein | ectopic | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

dpp^s4/dpp[+] is a suppressor of wing | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

dpp^s4/dpp^s8 is a suppressor of phenotype of tkv¹/tkv⁸

(de Celis, 1997)

dpp^s4/dpp^s8 is a suppressor of wing vein | ectopic phenotype of rho^hs.PSt

(de Celis, 1997)

dpp^s4/dpp^s8 is a suppressor of wing vein | ectopic phenotype of Ras64B^Act5C.PC

(de Celis, 1997)

Other

Statement

Reference

dpp^s4/dpp^d6, gbb¹ has wing phenotype

(Khalsa et al., 1998)

dpp^s4, wg^l-17 has embryonic midgut constriction 2 phenotype

(Aspland and White, 1997)

dpp^s4, wg^l-17 has embryonic midgut constriction 3 phenotype

(Aspland and White, 1997)

N^Ax-1, dpp^s4/dpp^s8 has wing vein phenotype

(de Celis, 1997)

Additional Comments

Genetic Interactions

Statement

Reference

gbb¹, dpp^s4/+ clones induced in the anterior of the wing show no enhancement of the wing vein phenotypes caused by gbb¹ clones.

(Bangi and Wharton, 2006)

The anterior crossvein is restored in dpp^d6/dpp^s4 flies carrying one copy of gbb¹. The wing is reduced in size in these animals and viability is significantly reduced.

(Khalsa et al., 1998)

dpp^s4 wg^l-17 embryos lack the second and third midgut constrictions.

(Aspland and White, 1997)

The dpp shortvein phenotype is strongly enhanced, and the tkv phenotype is suppressed, in dpp^s4 tkv¹/dpp^s8 tkv⁸ double mutant flies. The rho^hs.PSt and Ras64B^Act5C.PC ectopic vein phenotypes are suppressed in combination with dpp^s4/dpp^s8. dpp^s4/dpp^s8 N^Ax-1 double mutant flies show pronounced wing vein loss. The dpp loss of vein phenotype is epistatic in dpp^s4/dpp^s8 N^nd-3 double mutants, and the vein thickening characteristic of N^nd-3 is eliminated.

(de Celis, 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dpp^s4/dpp^s12 is rescued by dpp^dpp.674

(Capovilla et al., 1994)

Partially rescued by

dpp^s4/dpp^s22 is partially rescued by dpp^UAS.cSa

(Sotillos and de Celis, 2006)

Rescues

dpp^s4, Scer\GAL4^dpp.3KK, dpp^s22 rescues dpp^UAS.cSa

(Sotillos and de Celis, 2006)

Comments

The wings of dpp^Scer\UAS.cSa; Scer\GAL4^dpp.3KK flies are covered in ectopic vein tissue. This phenotype is rescued by dpp^s22/dpp^s4. The resulting flies have a milder shortvein phenotype than dpp^s22/dpp^s4 flies.

(Sotillos and de Celis, 2006)

dpp^dpp.674 completely rescues the second midgut constriction phenotype of dpp^s4/dpp^s12 mutant embryos.

(Capovilla et al., 1994)

Belongs to the shv-lnc class alleles. Fails to fully complement disk region mutants.

(St. Johnston et al., 1990)

Allele class: shv-lnc

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

2064

In(2L)dpp^s4, ast¹ dpp^s4 dpp^d-ho ed¹ dpy^ov1 cl¹/CyO

Kyoto

106645

ast¹ dpp^s4 dpp^d-ho ed¹ dpy^ov1 cl¹/CyO

Notes on Origin

Discoverer

Comments

The alleles that were "shv^S2" and "shv^S4" proved to be molecularly absolutely identical.

(Gelbart, 1994.7.29)

The dpp gene product is expressed in the ectoderm but not in the visceral mesoderm.

(Immergluck et al., 1990)

Used to examine regulation of dpp-Ecol\lacZ promoter fusions, whose expression depends on endogenous dpp function demonstrating that positive autoregulation maintains dpp expression in the visceral mesoderm.

(Hursh et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

dpp^S4

(Stultz et al., 2006, Freeman and Bienz, 2001, Fuss and Hoch, 1998, Riesgo-Escovar and Hafen, 1997, Panganiban et al., 1990)

dpp^s4

(Matsuda and Shimmi, 2012, Knox et al., 2011, Quijano et al., 2011, Christoforou et al., 2008, Bangi and Wharton, 2006, Sotillos and de Celis, 2006, Grienenberger et al., 2003)

dpp^shv4

(Graba et al., 1995, Littleton and Bellen, 1994, Thuringer et al., 1993)

shv^S2

(Gelbart, 1994.7.29, Segal and Gelbart, 1985)

shv^S4

(Gelbart, 1994.7.29, Segal and Gelbart, 1985)

shv^s4

(Sotillos and de Celis, 2006)

Name Synonyms

Secondary FlyBase IDs

References (43)

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