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General Information
Symbol
Dmel\dpps4
Species
D. melanogaster
Name
FlyBase ID
FBal0003074
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dppshv4, shvS4
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Truncation mutant lacking most of dpp 5' flanking sequences.
Breakpoint allele.
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The wings of dpps4/dpps22 flies have dramatically shortened L2, L4 and L5 wing veins and lack both cross veins.
dpps4/dpps11 flies have a "shortvein" phenotype; the distal ends of L2, L4 and L5 are truncated. The posterior crossvein is missing.
Wings derived from dppd6/dpps4 animals lack only the anterior crossvein.
dpps4/dpps8 flies lack the distal ends of wing veins LII, LIV and LV. dpps4/dpps8 flies lack most of wing veins LII, LIV and LV.
Late embryos fail to evaginate gastric caeca and fail to form secondary midgut constrictions, and the primary midgut constriction is posteriorly displaced.
Midguts from dpps4/dpps22 larvae lack all four gastric caecae.
Used to show absolute dependence on dpp of lab expression in midgut.
dpps4 homozygotes lack the second midgut constriction.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
dpps4/dpp[+] is a suppressor of visible | heat sensitive phenotype of HC2.hs
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
dpps4/dpps8 has wing vein phenotype, enhanceable by tkv1/tkv8
Suppressed by
Statement
Reference
dpps4/dppd6 has anterior crossvein phenotype, suppressible by gbb1
NOT Enhancer of
Statement
Reference
dpps4/dpp[+] is a non-enhancer of crossvein | somatic clone phenotype of gbb1
dpps4/dpp[+] is a non-enhancer of wing vein L5 | somatic clone phenotype of gbb1
Suppressor of
Statement
Reference
dpps4/dpp[+] is a suppressor of wing vein | ectopic | heat sensitive phenotype of HC2.hs
dpps4/dpp[+] is a suppressor of wing | heat sensitive phenotype of HC2.hs
dpps4/dpps8 is a suppressor of phenotype of tkv1/tkv8
dpps4/dpps8 is a suppressor of wing vein | ectopic phenotype of rhohs.PSt
dpps4/dpps8 is a suppressor of wing vein | ectopic phenotype of Ras64BAct5C.PC
Other
Additional Comments
Genetic Interactions
Statement
Reference
gbb1, dpps4/+ clones induced in the anterior of the wing show no enhancement of the wing vein phenotypes caused by gbb1 clones.
The anterior crossvein is restored in dppd6/dpps4 flies carrying one copy of gbb1. The wing is reduced in size in these animals and viability is significantly reduced.
dpps4 wgl-17 embryos lack the second and third midgut constrictions.
The dpp shortvein phenotype is strongly enhanced, and the tkv phenotype is suppressed, in dpps4 tkv1/dpps8 tkv8 double mutant flies. The rhohs.PSt and Ras64BAct5C.PC ectopic vein phenotypes are suppressed in combination with dpps4/dpps8. dpps4/dpps8 NAx-1 double mutant flies show pronounced wing vein loss. The dpp loss of vein phenotype is epistatic in dpps4/dpps8 Nnd-3 double mutants, and the vein thickening characteristic of Nnd-3 is eliminated.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Partially rescued by
Comments
The wings of dppScer\UAS.cSa; Scer\GAL4dpp.3KK flies are covered in ectopic vein tissue. This phenotype is rescued by dpps22/dpps4. The resulting flies have a milder shortvein phenotype than dpps22/dpps4 flies.
dppdpp.674 completely rescues the second midgut constriction phenotype of dpps4/dpps12 mutant embryos.
Belongs to the shv-lnc class alleles. Fails to fully complement disk region mutants.
Allele class: shv-lnc
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments
The alleles that were "shvS2" and "shvS4" proved to be molecularly absolutely identical.
The dpp gene product is expressed in the ectoderm but not in the visceral mesoderm.
Used to examine regulation of dpp-Ecol\lacZ promoter fusions, whose expression depends on endogenous dpp function demonstrating that positive autoregulation maintains dpp expression in the visceral mesoderm.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
References (43)