Allele Dmel\dpp^s8

General Information
Symbol	Dmel\dpp^s8	Species	D. melanogaster
Name		FlyBase ID	FBal0003078
Feature type	allele	Associated gene	Dmel\dpp

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Segal and Gelbart, 1985)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology	Polytene chromosomes normal. Polytene chromosomes normal. (Segal and Gelbart, 1985) Polytene chromosomes normal. (St. Johnston et al., 1990)
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Segal and Gelbart, 1985) visible \| dominant (Segal and Gelbart, 1985)
Phenotype Manifest In
	wing vein L2 \| distal (de Celis, 1997) wing vein L4 \| distal (de Celis, 1997) wing vein L5 \| distal (de Celis, 1997)
Detailed Description
	Statement Reference dpp^s4/dpp^s8 flies lack the distal ends of wing vein LII, LIV and LV. (de Celis, 1997) A posterior clone runs along the antero-posterior boundary until it reaches a gap in wing vein 4 (a region sensitive to lack of dpp) where the border of the clone becomes irregular. (Hidalgo, 1994)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference dpp^d12/dpp^s8, nub¹ has visible phenotype (Cifuentes and Garcia-Bellido, 1997) dpp^d12/dpp^s8, nub² has visible phenotype (Cifuentes and Garcia-Bellido, 1997) dpp^s8, nub¹ has visible phenotype (Cifuentes and Garcia-Bellido, 1997) dpp^s8, nub² has visible phenotype (Cifuentes and Garcia-Bellido, 1997)
Phenotype Manifest In
Enhanced by
Statement Reference dpp^s4/dpp^s8 has wing vein phenotype, enhanceable by tkv¹/tkv⁸ (de Celis, 1997)
Suppressor of
Statement Reference dpp^s4/dpp^s8 is a suppressor of phenotype of tkv¹/tkv⁸ (de Celis, 1997) dpp^s4/dpp^s8 is a suppressor of wing vein \| ectopic phenotype of Ras64B^Act5C.PC (de Celis, 1997) dpp^s4/dpp^s8 is a suppressor of wing vein \| ectopic phenotype of rho^hs.PSt (de Celis, 1997)
Other
Statement Reference dpp^d12/dpp^s8, nub¹ has wing phenotype (Cifuentes and Garcia-Bellido, 1997) dpp^d12/dpp^s8, nub² has wing phenotype (Cifuentes and Garcia-Bellido, 1997) dpp^s8, nub¹ has wing phenotype (Cifuentes and Garcia-Bellido, 1997) dpp^s8, nub² has wing phenotype (Cifuentes and Garcia-Bellido, 1997) N^Ax-1, dpp^s4/dpp^s8 has wing vein phenotype (de Celis, 1997, de Celis, 1997)
Additional Comments
Genetic Interactions
Statement Reference Double mutant clones with nub¹ or nub² cause dramatic reduction of cell number in the wing pouch. (Cifuentes and Garcia-Bellido, 1997) The dpp shortvein phenotype is strongly enhanced, and the tkv phenotype is suppressed, in dpp^s4 tkv¹/dpp^s8 tkv⁸ double mutant flies. The rho^hs.PSt and Ras64B^Act5C.PC ectopic vein phenotypes are suppressed in combination with dpp^s4/dpp^s8. dpp^s4/dpp^s8 N^Ax-1 double mutant flies show pronounced wing vein loss. The dpp loss of vein phenotype is epistatic in dpp^s4/dpp^s8 N^nd-3 double mutants, and the vein thickening characteristic of N^nd-3 is eliminated. (de Celis, 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments	Allele class: shv-lnc
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	dpp^S8 (Cifuentes and Garcia-Bellido, 1997) dpp^s8 shv^S8 (Segal and Gelbart, 1985)
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Cifuentes and Garcia-Bellido, 1997, Proc. Natl. Acad. Sci. U.S.A. 94(21): 11405--11410 Proximo-distal specification in the wing disc of Drosophila by the nubbin gene. [FBrf0098758] de Celis, 1997, Development 124(5): 1007--1018 Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing. [FBrf0092741] Dominguez et al., 1996, Science 272(5268): 1621--1625 Sending and receiving the hedgehog signal: Control by the Drosophila Gli protein cubitus interruptus. [FBrf0088080] Hidalgo, 1994, Curr. Biol. 4(12): 1087--1098 Three distinct roles for the engrailed gene in Drosophila wing development. [FBrf0080091] Diaz-Benjumea and Garcia-Bellido, 1990, Rouxs Arch. Dev. Biol. 198(6): 336--354 Genetic analysis of the wing vein pattern of Drosophila. [FBrf0052918] St. Johnston et al., 1990, Genes Dev. 4: 1114--1127 Molecular organization of the decapentaplegic gene in Drosophila melanogaster. [FBrf0051824] Segal and Gelbart, 1985, Genetics 109: 119--143 Shortvein, a new component of the decapentaplegic gene complex in Drosophila melanogaster. [FBrf0042626]

Allele Dmel\dpps8

Allele Dmel\dpp^s8