A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Allele Dmel\Dr1

General Information
SymbolDmel\Dr1SpeciesD. melanogaster
NameFlyBase IDFBal0003107
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\Dr
Allele classgain of function
MutagenX ray
hide Nature of the Allele
Allele class
gain of function
(Tearle et al., 1994, Mozer and Easwarachandran, 1999)
Mutagen
X ray
(Krivshenko, 1954, Mozer, 2001)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      Cytological analysis does not reveal any aberrations.
      (Krivshenko, 1954)
      Insertion and additional rearrangements 35kb upstream of the start of Dr transcription.
      (Mozer, 2001)
      Assay mode
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      viable (with Df(3R)KE)
      (Mozer, 2001)
      viable (with Drltt-EMS)
      (Mozer, 2001)
      lethal | recessive
      (Krivshenko, 1954)
      lethal | embryonic stage | recessive
      (Tearle et al., 1994)
      visible | dominant
      (Krivshenko, 1954, Mozer, 2001, Tearle et al., 1994)
      locomotor behavior defective
      (Tearle et al., 1994)
      uncoordinated (with DrMio)
      (Tearle et al., 1994)
      hide Phenotype Manifest In
      eye
      (Krivshenko, 1954, Mozer, 2001, Tearle et al., 1994)
      macrochaeta
      (Tearle et al., 1994)
      hide Detailed Description
      Statement
      Reference
      homozygous lethal
       
      Number of facets varies from 1 to 10. The region of the surface of the eye, which has a red colour, resembles a drop.
      (Krivshenko, 1954)
      Severe disruption of eye development. Heterozygotes with DrMio are semi-lethal, 10-30% adults survive to eclosion, surviving adults exhibit reduced eye, deranged bristle pattern on the thorax, abdomen, legs and wing margins and locomotor defects so the flies could hardly move. A similar phenotype is seen when heterozygous with DrMio revertant alleles and stg alleles. Heterozygotes with Wedge1 only exhibit the reduced eye phenotype. Interact in trans with lesions in stg causing loss and derangement of bristles and loss of neuromuscular coordination.
      (Tearle et al., 1994)
      Heterozygotes show a severe reduction in eye size.
      (Mozer, 2001)
      Heterozygous flies show a normal activity profile in an open field arena over a 10-minute assay.
      (Liu et al., 2007)
      hide Interactions
      hide Phenotypic Class
      hide Phenotype Manifest In
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 32 )
      Kyoto
      105896
      Dr1/TMS, P{Δ2-3}99B
      105980
      Pr1 Dr1/TM3
      106416
      w*; Dr1/TMS, P{Δ2-3}99B
      101655
      In(1)wm4h ; Pr1 Dr1 / TM3
      106308
      pn1; ry506 Dr1 P{Δ2-3}99B/TM6
      106968
      Pr1 Dr1/TM3, Sb1 tld17
      Bloomington
      560
      Pr1 Dr1/TM3
      1610
      w*; Dr1/TMS, P{Δ2-3}99B
      1429
      pn1; ry506 Dr1 P{Δ2-3}99B/TM6
      3303
      Pr1 Dr1/TM3, Sb1 tld17
      7758
      w1118; P{hs-hid}3, Dr1/TM6B, Tb1
      4345
      Ki1 rsd1 Ubx1 Dr1/TM6B, Tb1
      hide Notes on Origin
      Discoverer
      Krivshenko, 25th March 1954.
      Associated with: stgDr-1.
      (Mozer and Easwarachandran, 1999)
      hide Synonyms & Secondary IDs ( 3 )
      Reported As
      Symbol Synonym
      Dp
       
      Dr1
      (Jordan et al., 2006, Liu et al., 2007)
      unnamed
      (Krivshenko, 1954)
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 9 )
        Research paper
        Liu et al., 2007, Genetics 175(3): 1197--1212
        Exploratory activity in Drosophila requires the kurtz nonvisual arrestin. [FBrf0200160]
        Jordan et al., 2006, Genetics 174(1): 271--284
        Quantitative trait loci for locomotor behavior in Drosophila melanogaster. [FBrf0193517]
        Mozer, 2001, Dev. Biol. 233(2): 380--393
        Dominant Drop mutants are gain-of-function alleles of the muscle segment homeobox gene (msh) whose overexpression leads to the arrest of eye development. [FBrf0136848]
        Mozer and Easwarachandran, 1999, Dev. Biol. 213(1): 54--69
        Pattern formation in the absence of cell proliferation: tissue-specific regulation of cell cycle progression by string (stg) during Drosophila eye development. [FBrf0111437]
        Tearle et al., 1994, Molec. gen. Genet. 244(4): 426--434
        The dominant Drop eye mutations of Drosophila melanogaster define two loci implicated in normal eye development. [FBrf0076958]
        Krivshenko, 1954, D. I. S. 28: 74--75
        [New mutants report.] [FBrf0063596]
        Personal communication to FlyBase
        Bloomington Drosophila Stock Center, 1997.1.15, Assorted alleles and aberrations at Bloomington that are not in FlyBase.
        Assorted alleles and aberrations at Bloomington that are not in FlyBase. [FBrf0091344]
        Abstract
        Mozer, 1997, A. Dros. Res. Conf. 38: 124A
        Cell fate defects during eye development in a viable allele of the Drop locus. [FBrf0091949]
        Mozer, 1997, Doe, Hall, 1997: 133
        The Drop-proximal (Drprox) gene negatively regulates neuronal cell fate determination during eye development. [FBrf0099410]