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General Information
Symbol
Dmel\dsh1
Species
D. melanogaster
Name
FlyBase ID
FBal0003138
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dsh1
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
A11357603T
Amino acid change:
K417M | dsh-PA
Reported amino acid change:
K417M
Comment:
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: K417M.
Amino acid replacement: K417M. K417 falls in the DEP domain.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
adult thorax & microchaeta
axon & dorsal cluster neuron
leg & joint
mesothoracic tergum & trichome
Detailed Description
Statement
Reference
dsh1/dsh1 flies display misoriented hair patterns on the wing, thorax and eyes, while heterozygotes exhibit phenotypes similar to wild-type controls.
dsh1/Y flies are viable and have ommatidial rotation defects (planar cell polarity-like defects) in the eye, as well as mushroom body axon growth and guidance defects.
Dorsal cluster neurons axon branching at the third branching point is unaffected in dsh1 mutant males.
Mutants have ectopic joints in the leg.
The majority of sensory organs of the leg of mutant flies project protrusions indistinguishable in morphology and orientation from those of wild type at 24 hours after puparium formation. However, improperly positioned bract cells and misdirected protrusions from the sensory organs are observed at similar, low frequencies (2.3 +/- 1.4% and 3.0 +/- 1.6%, respectively) and at similar but higher frequencies in the tarsi (8.5 +/- 2.9% and 17.1 +/- 3.3%, respectively) of mutant flies. These errors are not seen in wild type.
dsh1 hemizygotes display ommatidial planar cell polarity (PCP) defects in the eye.
The number of dendritic branches is decreased in the class IV da neurons of homozygous larvae.
dsh1 mutants display PCP defects.
dsh1 maternal/zygotic mutants show little to no epidermal cell shape and denticle alignment defects.
In wild-type wings, the ratio of non-hexagonally shaped cells relative to hexagonally shaped cells is around 11%, whereas in dsh1 homozygous mutant wings this ratio increases to 28%.
In dsh1/dsh1 pupal sensory mother cells, mitotic spindle orientation is parallel to the plane of the epithelium; the orientation of mitotic spindle is also randomized relative to the anterior-posterior axis.
Homozygous stage 16 embryos have longer dorsal trunks than normal.
Many dsh1 ommatidia mis-rotate; the variance (s.d.) in degree of rotation is greater than in wild type in adult eyes.
Wing membrane ridges in the anterior region of the wings of wild-type flies have an anterior-posterior orientation, but have a proximal-distal orientation in a dsh1 mutant.
Border cell clusters from dsh1 mutants show an average of 38.4 actin protrusions, reduced compared to the average of 94.8 in wild-type clusters.
Hemizygous males have polarity defects in the wing such as swirling hair patterns and multiple wing hairs.
Hemizygotes show defects in ommatidial polarity.
The orientation of bristles on the nota of dsh1 flies is disturbed.
The average number of dorsal cluster neuron axons that cross between the lobula and the medulla is reduced from the wild-type number of 11.7 to 7.4 in the brains of dsh1/+ mutants. In dsh1 homozygotes the number is further reduced to 4.7.
dsh1 wing hairs show planar polarity defects.
Flies have a planar cell polarity phenotype in the eye.
dsh1/Y mutants have wings with altered planar polarity that contain multiple wing hairs.
Cells in the wing produce double hairs at a frequency of 6.3 +/- 1.0% in dsh1 flies.
Females exhibit reduced fecundity. dsh1/dsh4 heterozygotes show an ovary phenotype like that of Wnt4 mutants, though with reduced penetrance, with germaria flopped over the older egg chambers due to inadequate ovary sheath.
Mutant clones in the wing show disruption of polarity, as indicated by wing hairs.
dsh1/Y and dsh1/dsh3 flies have planar polarity defects, resulting in an aberrant orientation of bristles and hairs.
dsh1 mutants show disrupted orientation of wing hairs and random orientation of hairs on the notum.
Mutant animals have a mutant planar cell polarity phenotype.
12% of cells in a defined region of the wing (the ventral surface of the proximal-anterior region) have multiple hairs in hemizygous males. Ectopic F-actin prehairs are seen in pupal wing cells. A hair misorientation phenotype is seen.
Proximal-distal planar polarity is roughly normal at the distal wing tip in the dorsal epidermis of mutant flies.
Legs develop ectopic joints in homozygous flies. These ectopic joints have reversed orientation of the "ball and socket" of the joint and are formed proximal to the normal joints.
dsh1 flies have rough eyes and only 55% of ommatidia have correct rotation and chirality.
Does not affect the eye polarity phenotype of Nact.sev.
The dsh1 tissue polarity phenotype in the wing is suppressed by expression of dshhs.PA.
Eyes show disruption of ommatidial arrangement in 55.5% of ommatidia, with random or no chirality and misrotations of single ommatidia. The equator is not evident.
Mutants exhibit randomly oriented pI divisions in the epithelial plane. The socket, shaft and pIIb cells are always localised in the region of the cell in contact with pIIb. The socket cells always occupies an eccentric position.
Homozygotes display a strong tissue polarity phenotype. Homozygotes in combination with P{hsfzI} heat shocked to induce a strong hsfz-late phenotype exhibit suppression of the MHC phenotype.
Sections of dsh1-dsh3 double mutant eyes show a disturbed ommatidial polarity within each ommatidium having the normal arrangement of photoreceptor cells.
All cells in which planar polarity is evident are affected by dsh mutations. Leg bracts are induced in the wrong position relative to the bristle. Legs show extra mirror image duplications of tarsal joints. Rough eye phenotype reflects abnormal facet packing. Antidromic illumination reveals that although each photoreceptor cluster has the normal trapezoidal arrangement the clusters are misoriented reflecting an abnormal polarity of the whole ommatidium. Some ommatidia are rotated from their normal orientation but have normal handedness. Others are reversed in the A/P or D/V axis.
Most wing cells of homozygous flies form a single hair. Homozygous flies have disruptions in the pattern of wing hair polarity. The prehair initiation site is moved to near the cell centre in pupal wing cells. Double mutants of dsh1 with in1, fy2 or mwh1 resemble in1, fy2 or mwh1 single mutants respectively.
No maternal effect. Hemizygous males and homozygous females have poor viability due to a second site mutation, hemizygous females are fully viable.
Thoracic hairs deranged, males have poor fertility.
Thoracic microchaetae are completely deranged. One or more macrochaetae are abnormally curved. The wings are abnormally inserted, and are usually divergent or slightly upheld. Occasionally one wing is completely deformed, small and blistered. The eyes are ellipsoid with some derangement of the ommatidia.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
dsh1 has neuroanatomy defective phenotype, enhanceable by DAAM[+]/DAAMEx1
dsh1 has planar polarity defective phenotype, enhanceable by bdg[+]/bdgGMREP
dsh1 has planar polarity defective phenotype, enhanceable by bdg164/bdg[+]
dsh1 has neuroanatomy defective phenotype, enhanceable by Wnt5400/Wnt5[+]
dsh1 has visible | recessive phenotype, enhanceable by Rok2
dsh1 has visible | recessive phenotype, enhanceable by sqhA21.Tag:FLAG
dsh1 has visible | recessive phenotype, enhanceable by zip[+]/zip1
NOT Enhanced by
Statement
Reference
dsh1 has planar polarity defective | adult stage phenotype, non-enhanceable by Frl[+]/FrlEx83
dsh1 has neuroanatomy defective | adult stage phenotype, non-enhanceable by Frl[+]/FrlEx83
dsh1 has planar polarity defective | adult stage phenotype, non-enhanceable by Frl[+]/FrlExK62
dsh1 has neuroanatomy defective | adult stage phenotype, non-enhanceable by Frl[+]/FrlEx88
Suppressed by
Statement
Reference
dsh1 has planar polarity defective phenotype, suppressible | partially by pk[+]/pk1
dsh1 has visible phenotype, suppressible by MoeG0323/Moe[+]
dsh1 has visible | recessive phenotype, suppressible | partially by sqhE20.E21
dsh1 has visible | recessive phenotype, suppressible by ck13
dsh1 has visible | recessive phenotype, suppressible | partially by ck07130
dsh1 has visible | recessive phenotype, suppressible | partially by sqhA20.E21
NOT suppressed by
Statement
Reference
dsh1 has planar polarity defective | adult stage phenotype, non-suppressible by Frl[+]/FrlEx83
dsh1 has planar polarity defective | adult stage phenotype, non-suppressible by Frl[+]/FrlExK62
dsh1 has visible phenotype, non-suppressible by Scer\GAL4ap-md544/dxUAS.cMa
dsh1 has visible phenotype, non-suppressible by Scer\GAL4ap-md544/dxΔPRM.UAS
dsh1 has visible phenotype, non-suppressible by Scer\GAL4ap-md544/dxmRZF.UAS
dsh1 has planar polarity defective phenotype, non-suppressible by MbsT541/Mbs[+]
dsh1 has planar polarity defective phenotype, non-suppressible by sqhE20.E21
Enhancer of
Statement
Reference
dsh1/dsh1 is an enhancer of visible | adult stage phenotype of meru1
dsh1/dsh[+] is an enhancer of neuroanatomy defective | dominant | adult stage phenotype of tapGal4
dsh1/dsh[+] is an enhancer of neuroanatomy defective phenotype of DAAMEx1
dsh1/dsh[+] is an enhancer of neuroanatomy defective phenotype of Wnt5400
dsh1/dsh[+] is an enhancer of cell polarity defective phenotype of fz20/fz19
dsh1/dsh[+] is an enhancer of planar polarity defective phenotype of dgo269
NOT Enhancer of
Suppressor of
Statement
Reference
dsh1/dsh[+] is a suppressor of planar polarity defective phenotype of bdgGMREP
dsh1/dsh[+] is a suppressor of visible | heat sensitive phenotype of fzI.hs
NOT Suppressor of
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
dsh1 has mushroom body alpha-lobe phenotype, enhanceable by DAAM[+]/DAAMEx1
dsh1 has mushroom body beta-lobe phenotype, enhanceable by DAAM[+]/DAAMEx1
dsh1 has ommatidium phenotype, enhanceable by ed[+]/ed1X5
dsh1 has ommatidium phenotype, enhanceable by bdg[+]/bdgGMREP
dsh1 has ommatidium phenotype, enhanceable by bdg164/bdg[+]
dsh1 has axon & dorsal cluster neuron phenotype, enhanceable by Wnt5400/Wnt5[+]
dsh1 has axon & dorsal cluster neuron phenotype, enhanceable by bskDN.UAS/Scer\GAL4ato.3.6
dsh1 has wing hair | supernumerary phenotype, enhanceable by Rok2
dsh1 has wing hair | supernumerary phenotype, enhanceable by zip[+]/zip1
NOT Enhanced by
Statement
Reference
dsh1 has ommatidium phenotype, non-enhanceable by Frl[+]/FrlEx83
dsh1 has axon | adult stage phenotype, non-enhanceable by Frl[+]/FrlEx83
dsh1 has mushroom body beta-lobe | adult stage phenotype, non-enhanceable by Frl[+]/FrlEx83
dsh1 has mushroom body alpha-lobe | adult stage phenotype, non-enhanceable by Frl[+]/FrlEx83
dsh1 has ommatidium phenotype, non-enhanceable by Frl[+]/FrlExK62
dsh1 has axon | adult stage phenotype, non-enhanceable by Frl[+]/FrlEx88
dsh1 has mushroom body beta-lobe | adult stage phenotype, non-enhanceable by Frl[+]/FrlEx88
dsh1 has mushroom body alpha-lobe | adult stage phenotype, non-enhanceable by Frl[+]/FrlEx88
dsh1 has phenotype, non-enhanceable by Glidv5
Suppressed by
Statement
Reference
dsh1 has axon & dorsal cluster neuron phenotype, suppressible by Rac1N17.UAS/Scer\GAL4ato.3.6
dsh1 has axon & dorsal cluster neuron phenotype, suppressible by hepUAS.cBa/Scer\GAL4ato.3.6
dsh1 has axon & dorsal cluster neuron phenotype, suppressible by btlDN.UAS/Scer\GAL4ato.3.6
dsh1 has ommatidium phenotype, suppressible | partially by pk[+]/pk1
dsh1 has wing hair | supernumerary phenotype, suppressible by MbsT541/Mbs[+]
dsh1 has wing hair | supernumerary phenotype, suppressible by MoeG0323/Moe[+]
dsh1 has wing hair | supernumerary phenotype, suppressible by ck13
dsh1 has wing hair | supernumerary phenotype, suppressible | partially by ck07130
dsh1 has eye phenotype, suppressible by Rac1hs.sev
dsh1 has ommatidium phenotype, suppressible by Rac1hs.sev
dsh1 has phenotype, suppressible by Jrahs.sev
dsh1 has phenotype, suppressible by Rho1V14.sev
NOT suppressed by
Statement
Reference
dsh1 has ommatidium phenotype, non-suppressible by Frl[+]/FrlEx83
dsh1 has ommatidium phenotype, non-suppressible by Frl[+]/FrlExK62
dsh1 has joint | ectopic phenotype, non-suppressible by Scer\GAL4ap-md544/dxUAS.cMa
dsh1 has leg phenotype, non-suppressible by Scer\GAL4ap-md544/dxUAS.cMa
dsh1 has joint | ectopic phenotype, non-suppressible by Scer\GAL4ap-md544/dxΔPRM.UAS
dsh1 has leg phenotype, non-suppressible by Scer\GAL4ap-md544/dxΔPRM.UAS
dsh1 has joint | ectopic phenotype, non-suppressible by Scer\GAL4ap-md544/dxmRZF.UAS
dsh1 has leg phenotype, non-suppressible by Scer\GAL4ap-md544/dxmRZF.UAS
dsh1 has phenotype, non-suppressible by Glidv5
dsh1 has wing hair phenotype, non-suppressible by RokαTub84B.PW
dsh1 has wing hair phenotype, non-suppressible by sqhE20.E21
dsh1 has phenotype, non-suppressible by fzhs.sev
Enhancer of
Statement
Reference
dsh1/dsh1 is an enhancer of wing margin bristle phenotype of meru1
dsh1/dsh[+] is an enhancer of mushroom body alpha-lobe phenotype of DAAMEx1
dsh1/dsh[+] is an enhancer of mushroom body beta-lobe phenotype of DAAMEx1
dsh1 is an enhancer of wing hair phenotype of shaVB13
dsh1 is an enhancer of axon & dorsal cluster neuron phenotype of Scer\GAL4ato.3.6, bskDN.UAS
dsh1/dsh[+] is an enhancer of axon & dorsal cluster neuron phenotype of Wnt5400
dsh1/dsh[+] is an enhancer of ommatidium phenotype of fz20/fz19
dsh1/dsh[+] is an enhancer of ommatidium phenotype of dgo269
dsh1 is an enhancer of ommatidium phenotype of pkpk.sev
dsh1 is an enhancer of ommatidium phenotype of fz20/fz19
dsh1 is an enhancer of wing hair & 1st posterior cell phenotype of inII53
NOT Enhancer of
Statement
Reference
dsh1/dsh[+] is a non-enhancer of ommatidium phenotype of Scer\GAL4hs.2sev, nmoUAS.cUa
dsh1/dsh[+] is a non-enhancer of wing hair phenotype of Scer\GAL4en-e16E, kermitGS2053
dsh1 is a non-enhancer of axon & dorsal cluster neuron phenotype of Rac1N17.UAS, Scer\GAL4ato.3.6
dsh1 is a non-enhancer of phenotype of Glidv5
Suppressor of
Statement
Reference
dsh1/dsh[+] is a suppressor of ommatidium phenotype of bdgGMREP
dsh1/dsh[+] is a suppressor of axon & dorsal cluster neuron & adult brain phenotype of Scer\GAL4ato.3.6, btlDN.UAS
dsh1/dsh[+] is a suppressor of ommatidium phenotype of Scer\GAL4hs.2sev, dgoUAS.cFa
dsh1/dsh[+] is a suppressor of wing hair | supernumerary phenotype of fzI.hs
NOT Suppressor of
Statement
Reference
dsh1/dsh[+] is a non-suppressor of mushroom body phenotype of DAAMC.UASp, Scer\GAL4ey-OK107
dsh1/dsh[+] is a non-suppressor of ommatidium phenotype of Scer\GAL4hs.2sev, nmoUAS.cUa
dsh1/dsh[+] is a non-suppressor of wing hair phenotype of Scer\GAL4en-e16E, kermitGS2053
dsh1 is a non-suppressor of axon & dorsal cluster neuron phenotype of Rac1N17.UAS, Scer\GAL4ato.3.6
dsh1 is a non-suppressor of phenotype of Glidv5
dsh1 is a non-suppressor of wing hair | somatic clone | cell autonomous phenotype of fz23
dsh1 is a non-suppressor of wing hair | somatic clone | cell non-autonomous phenotype of fz23
Other
Additional Comments
Genetic Interactions
Statement
Reference
Double-heterozygous flies of the genotype dsh[1]/+ together with either kmr1/+ or kmr2/+ display misoriented hair patterns on the wing, thorax and eyes, while single heterozygotes exhibit phenotypes similar to wild-type controls.
The severity of both the wing margin bristle and the thoracic macrochaetae defects observed in meru1 or dsh1 flies are also significantly worsened in the double mutants.
Presence of FrlEx83/+ or FrlExK62/+ does not significantly alter eye phenotypes seen in dsh1/Y flies. Presence of dsh1/Y (or dsh1/+ females) does not significantly alter eye phenotypes in FrlEx83/FrlEx83 or FrlExK62/FrlExK62 clones. Presence of FrlEx83/+ or FrlEx88/+ does not enhance mushroom body axon growth defects seen in dsh1/Y flies.
dsh1/+ significantly enhances frequency of mushroom body beta lobe axon overgrowth defects (midline crossing) in tapGal4/+ brains.
One copy of dsh1 enhances the axonal projection defects seen in the α and β lobes of DAAMEx1 mutant mushroom bodies in females. Very few, if any, defects are seen in dsh1 DAAMEx1 double heterozygotes. DAAMEx1 enhances the axon projection phenotypes seen in dsh1/Y males alone. Many of these double hemizygous males exhibit an early growth termination phenotype not seen in either mutant alone. dsh1 does not suppress the growth and guidance defects seen in the mushroom body axons of flies expressing DAAMC.Scer\UAS.P\T under the control of Scer\GAL4ey-OK107. Hemizygous dsh1 mutant males with one copy of Rac1J11 exhibit an early growth termination phenotype in the mushroom body axons that is not observed in either dsh1/Y or Rac1J11/+ males alone. Hemizygous dsh1 partially suppresses the medial lobe fusion phenotype seen when VangScer\UAS.T:Avic\GFP-m6 is expressed in male flies under the control of Scer\GAL4ey-OK107. Hemizygous dsh1 partially suppresses the medial lobe fusion phenotype seen when Wnt5Scer\UAS.cFa is expressed in male flies under the control of Scer\GAL4ey-OK107.
Expression of Rab5Scer\UAS.cEa under the control of Scer\GAL4ap-md544 partially suppresses the dsh1 ectopic leg joint phenotype, with partial suppression being seen in 80% of the legs examined. Expression of either dxScer\UAS.cMa, dxΔPRM.Scer\UAS or dxmRZF.Scer\UAS under the control of Scer\GAL4ap-md544 has no effect on the ectopic leg joint phenotype of dsh1 flies. Expression of dxΔNBS.Scer\UAS under the control of Scer\GAL4ap-md544 in a dsh1 background partially inhibits normal joint formation (this phenotype seen in dxΔNBS.Scer\UAS, Scer\GAL4ap-md544 single mutant) and partially suppresses the formation of ectopic leg joints seen in dsh1 single mutants.
The dsh1 planar cell polarity (PCP) phenotype in the eye is strongly enhanced by the expression of CG15283GD13108 under the control of Scer\GAL4hs.2sev.
Mitotic spindle is aligned with the pins crescent is most dsh1/dsh1 pupal sensory mother cells in metaphase, but spindle fails to align in dsh1;mud4 or dsh1;mudf01205 double mutants.
ed1X5 dominantly enhances the phenotype of mis-rotation of ommatidia that is seen in dsh1 animals.
The multiple wing hair phenotype seen in dsh1/Y flies is suppressed by tow754/+, but the defects in polarity of the hairs is not affected.
The ommatidial polarity defects caused by dsh1 are enhanced by one copy of bdgGMREP or bdg164. The ommatidial polarity defects seen in bdgGMREP homozygotes are dominantly suppressed by dsh1.
Clones expressing fzScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4Act5C.PI in a dsh1 background result in non-clonal cells pointing their trichomes away from the clone. This effect extends at most 3-4 cells from the clone boundary.
A dsh1/+ background does not affect the Scer\GAL4hs.2sev>shgdCR3h.Scer\UAS.T:Avic\GFP-rs ommatidial phenotype.
Wnt5400/+, dsh1/+ double mutants show a more severe dorsal cluster neuron axon phenotype than dsh1/+ single mutants. Expression of Rac1N17.Scer\UAS, under the control of Scer\GAL4ato.3.6, in a dsh1 background results in a dorsal neuron cluster phenotype similar to when Rac1N17.Scer\UAS is expressed in a wild-type background, which is opposite to that seen in dsh1 mutants. Expression of hepScer\UAS.cBa, under the control of Scer\GAL4ato.3.6, in a dsh1 background results in a large increase of dorsal cluster neuron axons crossing the optic chiasm, indicating a complete dominance of the hep gain of function phenotype. Expression of one copy of bskDN.Scer\UAS, under the control of Scer\GAL4ato.3.6, in dsh1 mutant animals results in a synergistic reduction of extension of dorsal cluster neuron axons, with 60% showing no axons crossing the optic chiasm. Expression of btlDN.Scer\UAS under the control of Scer\GAL4ato.3.6 in a dsh1/+ background suppresses the reduction of dorsal cluster neuron axon extension phenotype seen in either single mutant, with the number of dorsal cluster neuron axons crossing the optic chiasm restored to almost wild-type levels.
The ommatidial polarity defects of fz19/fz20 mutants are enhanced in fz19/fz20; dsh1/+ double mutants.
The planar cell polarity defects seen in the eyes of flies expressing dgoScer\UAS.cFa under the control of Scer\GAL4hs.2sev are dominantly suppressed by dsh1/+. The weak planar cell polarity phenotype seen in the eyes of dgo269 homozygotes is enhanced by dsh1/+. The planar cell polarity phenotype seen in the eyes of dsh1/Y flies is partially suppressed by pk1/+.
Removing one copy of Mbs antagonizes the multiple wing hair formation in dsh1/Y mutants but has no effect on the planar polarity defects.
Glidv5/Glidv5, dsh1/+ animals exhibit an additive wing hair phenotype.
MoeG0323/+ suppresses the frequency of wing cells with double hairs in dsh1 flies to 1.2 +/- 0.2%.
The addition of dsh1/+ strongly enhances the eye cell polarity phenotype seen in fz19/fz20 animals.
ParpGMR.PU shows no genetic interaction with dsh1/+.
The average number of cells having multiple wing hairs in a defined region of the wing (the ventral surface of the proximal-anterior region) is reduced by more than 7-fold in dsh1 males that are also expressing rokαTub84B.PW compared to dsh1 single mutants. The hair misorientation phenotype is not suppressed. Suppression of ectopic F-actin-rich prehairs is seen in double mutant pupae, but the abnormal assembly of the prehair at the centre of the cell is not suppressed. Addition of rok2 to dsh1 mutants results in a 2.5-fold increase in the number of multiple wing hair cells compared to dsh1 single mutants. The dsh1 multiple hair phenotype but not the hair misorientation phenotype is suppressed by sqhE20.E21.
The presence of Rac1hs.sev significantly rescues the dsh1 eye phenotype, increasing the percentage of correctly polarised ommatidia.
The planar polarity defect in dsh1 wings that are expressing fzScer\UAS.cAa under the control of Scer\GAL471B is indistinguishable from the dsh1 single mutant phenotype.
The dsh1 phenotype is partially rescued by HLHmβScer\UAS.cdCa expressed under the control of Scer\GAL4salm-459.2.
Double mutants of VangTbs42, VangA3 or VangA5 with fz24, dsh1 inunspecified and mwhunspecified all showed hair polarity pattern typical of the fz-in group. Multiple hair cell phenotypes of the cell autonomous dsh, in and mwh mutants are epistatic to Vang. Show no interaction with the dominant wing basal cell 1 swirl phenotype of VangTbs42.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
dsh1 is partially rescued by dshmut6.EGFP
dsh1 is partially rescued by dshST8.EGFP
dsh1 is partially rescued by dshΔPDZ.hs.sev
dsh1 is partially rescued by dshw
Fails to rescue
dsh1 fails to rescue dsh1
dsh1 fails to rescue dsh1
Comments
dshT:Avic\GFP-EGFP rescues the ectopic leg joint phenotype of dsh1 animals. dshmut6.T:Avic\GFP-EGFP partially rescues the ectopic leg joint phenotype of dsh1 animals. dsh1.T:Avic\GFP-EGFP fails to rescue the ectopic leg joint phenotype of dsh1 animals.
Expression of dshY473F.T:Avic\GFP-EGFP is unable to rescue the PCP defects seen in dsh1 mutants.
Expression of dshST8.T:Avic\GFP-EGFP partially rescues the polarity defects of dsh1 mutants; most of the wing hairs show correct polarity but some regions are left with polarity defects.
Suppresses the ommatidial polarity defects seen in dshhs.sev.B.
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Fahmy, 1956.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (101)