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General Information
Symbol
Dmel\dsxM
Species
D. melanogaster
Name
FlyBase ID
FBal0003202
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dsxMas
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a 3.9kb F-element 175bp 3' of the female-specific splice acceptor site and within the female-specific exon.

Insertion of 3.9kb DNA, an unknowm mobile middle repeat element, within region important for regulation of dsx expression.

Insertion components
F{}dsxM
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

dsxM/+ genital discs are intersexual; both male and female genital primordia develop in these discs.

Intersex phenotype. Cells derived from the female genital disc can develop male genital structures.

XX dsxM/+ flies do not show any male-specific courtship when paired with mature virgin females. 100% of XY dsxM/+ flies show male-specific courtship when paired with mature virgin females.

Sex specific neuroblasts fail to undergo any postembryonic divisions in male or female larval nervous systems.

Chromosomal females (XX) mutant for dsx are transformed into "pseudomales". They are sterile even in the presence of a Y chromosome. The gonads form testes.

Only affects XX flies: the terminalia of XX heterozygous flies carry abnormal male and female elements, with the female genitalia anterior to the male genitalia. The male genitalia are well developed, but the penis apparatus is reduced, the hypandrium is mostly absent and many bristles are abnormal. The female vaginal plate is always present, but is reduced in size with abnormal bristles. There is often a mass of yellow, chitinised material between the vaginal plates, which is a secondary rudimentary penis apparatus. The anal plates have a sexually intermediate shape, and a bristle pattern which is a mosaic of male, female and intermediate bristles. The basitarsus of the foreleg carries a sex comb whose position and shape are intermediate between male and female. XX hemizygotes are sterile pseudomales.

dominant; affects XX only

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Mischaikow, Sep. 1958.

Comments
Comments

Mutation only affects males.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Masculinizer
Secondary FlyBase IDs
    References (14)