Allele Dmel\dsx^T

General Information
Symbol	Dmel\dsx^T	Species	D. melanogaster
Name		FlyBase ID	FBal0003205
Feature type	allele	Associated gene	Dmel\dsx

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	spontaneous (Nothiger et al., 1987, Nagoshi and Baker, 1990)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:3,761,245..3,761,247 (Lindsley and Zimm, 1992, Nagoshi and Baker, 1990)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of a 4.5kb middle repetitive element 127bp 3' of the female-specific splice acceptor site and within the female-specific exon. (Nagoshi and Baker, 1990) insertion
Caused by insertion	?{}dsx^T (Lindsley and Zimm, 1992, Nagoshi and Baker, 1990)
Cytology
Phenotypic Data
Phenotypic Class
	sex-determination defective \| dominant \| female (Nothiger et al., 1987)
Phenotype Manifest In
	anal plate \| female (Nothiger et al., 1987) female analia (Nothiger et al., 1987) female genitalia (Nothiger et al., 1987) female gonopod (Nothiger et al., 1987) female terminalia (Nothiger et al., 1987) genitalia (Nothiger et al., 1987) germline cell (Nagoshi et al., 1995) prothoracic leg \| female (Nothiger et al., 1987)
Detailed Description
	Statement Reference No more than 26% of XX dsx^T/dsx¹ mutant pseudomales produce gonads with the most severe group 1 pseudotestes phenotype. The remaining pseudomales have a less severe phenotype, with viable germ cells. otu¹⁰ and Df(1)otu-PΔ1 cause an increase in severity of this phenotype: over 70% of the resulting gonads were of group 1. (Nagoshi et al., 1995) Only affects XX flies: the terminalia of XX heterozygous flies carry abnormal male and female elements, with the female genitalia anterior to the male genitalia. The male genitalia are well developed, but the penis apparatus is reduced, the hypandrium is mostly absent and many bristles are abnormal. The female vaginal plate is always present, but is reduced in size with abnormal bristles. There is often a mass of yellow, chitinised material between the vaginal plates, which is a secondary rudimentary penis apparatus. The anal plates have a sexually intermediate shape, and a bristle pattern which is a mosaic of male, female and intermediate bristles. The basitarsus of the foreleg carries a sex comb whose position and shape are intermediate between male and female. XX hemizygotes are sterile pseudomales. (Nothiger et al., 1987)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Gehring.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	dsx^T
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Nagoshi et al., 1995, Development 121(2): 579--587 The somatic sex determines the requirement for ovarian tumor gene activity in the proliferation of the Drosophila germline. [FBrf0076142] Wayne et al., 1995, Genetics 139(3): 1309--1320 Genetic characterization of small ovaries, a gene required in the soma for the development of the Drosophila ovary and the female germline. [FBrf0080470] Nagoshi and Baker, 1990, Genes Dev. 4: 89--97 Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns. [FBrf0051864] Nothiger et al., 1987, Genet. Res. (Camb.) 50(2): 113--124 Genetic and developmental analysis of the sex-determining gene doublesex dsx of Drosophila melanogaster. [FBrf0046300]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Allele Dmel\dsxT

Allele Dmel\dsx^T