Allele Dmel\dwg⁸

General Information
Symbol	Dmel\dwg⁸	Species	D. melanogaster
Name		FlyBase ID	FBal0003230
Feature type	allele	Associated gene	Dmel\dwg
Also Known As	zw-5^62j1, l(1)zw5^j1

Map ( GBrowse )
Allele class
Mutagen	X ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	X ray
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation X:2,621,907..2,621,907 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C2621907G pr_change=R15G\|dwg-PA reported_pr_change=R14G (Gaszner et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: R14G. (Gaszner et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage \| recessive (Shannon et al., 1972) lethal \| recessive (Liu and Lim, 1975, Judd et al., 1972, Robbins, 1983)
Phenotype Manifest In

Detailed Description
	Statement Reference Growth rate of first instar larvae is variable. Mosaic analysis demonstrates mutant phenotype is autonomous. Individuals survive when Dp(1;4)w^m65g, Dp(1;3)w^m49a or Dp(1;3)N^264-58 is present. Surviving males have rough, reduced darkened eyes, vibrissae are sparse and orbital, ocellar and vertical bristles often absent. Wing veins are thick and the inner wing margin has incisions. Males are fertile. (Shannon et al., 1972)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference dwg⁸ is a suppressor of eye color defective phenotype of w^E4xMRwtW (Gaszner et al., 1999)
Phenotype Manifest In
Enhancer of
Statement Reference dwg⁸ is an enhancer of eye phenotype of BEAF-32^Scer\UAS.cYa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Blanton et al., 2003)
Suppressor of
Statement Reference dwg⁸ is a suppressor of pigment cell phenotype of w^E4xMRwtW (Gaszner et al., 1999)
NOT Suppressor of
Statement Reference dwg⁸ is a non-suppressor of phenotype of w^E4xBSwtW (Gaszner et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	dwg⁸ is rescued by dwg^Hsp83.PG (Gaszner et al., 1999)
Comments
Stocks ( 2 )
Bloomington	4094 dwg⁸/FM7a/Dp(1;2;Y)w⁺
Kyoto	107583 dwg⁸/FM7a/Dp(1;2;Y)w⁺
Notes on Origin
Discoverer	Judd, 1 Oct. 1962.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	62j1 (Thierry-Mieg, 1982) dwg⁸ l(1)zw5^j1 (Shannon et al., 1972, Judd et al., 1972, ) zw-5^62j1 (Blanton et al., 2003, Liu and Lim, 1975) zw5^62j1 (Gaszner et al., 1999) zw5^j1 (Robbins, 1983)
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Gaszner et al., 1999, Genes Dev. 13(16): 2098--2107 The Zw5 protein, a component of the scs chromatin domain boundary, is able to block enhancer-promoter interaction. [FBrf0111369] Robbins, 1983, Genetics 103: 633--648 Maternal-zygotic lethal interactions in Drosophila melanogaster: zeste-white region single-cistron mutations. [FBrf0039468] Thierry-Mieg, 1982, Genetics 100: 209--237 Paralog, a control mutant in Drosophila melanogaster. [FBrf0038033] Liu and Lim, 1975, Genetics 79: 601--611 Complementation analysis of methyl methanesulfonate-induced recessive lethal mutations in the zeste-white region of the X chromosome of Drosophila melanogaster. [FBrf0027515] Judd et al., 1972, Genetics 71: 139--156 The anatomy and function of a segment of the X chromosome of Drosophila melanogaster. [FBrf0023906] Shannon et al., 1972, Genetics 72: 615--638 Lethality patterns and morphology of selected lethal and semi-lethal mutations in the zeste-white region of Drosophila melanogaster. [FBrf0023990]
Review	Blanton et al., 2003, Genes Dev. 17(5): 664--675 Protein:protein interactions and the pairing of boundary elements in vivo. [FBrf0158943]

Allele Dmel\dwg8

Allele Dmel\dwg⁸