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General Information
Symbol
Dmel\E(Pc)1
Species
D. melanogaster
Name
FlyBase ID
FBal0003311
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
In E(Pc)1 mutants, PBac{GH146-GAL4.B}-marked DL1 olfactory projection neurons mistarget some of their dendrites to the dorsolateral glomerulus DA41 in the anterior of the antennal lobe instead of the DL1 glomerulus in the posterior of the antennal lobe as in wild type. However, arborization of mutant axons is not obviously altered. PBac{GH146-GAL4.B}-marked anterodorsal and lateral projection neuron neuroblast clones in domLL05537 mutants have a very mild reduction in cell number and their dendrites do no t traget to the full set of proper glomeruli. PBac{GH146-GAL4.B}-marked ventral projection neuron neuroblast clones in domLL05537 mutants exhibit incomplete targeting throughout the antennal lobe.
Heterozygotes show a significant increase in double strand break (DSB) repair via homologous recombination and a corresponding decrease in DSB repair by nonhomologous end-joining compared to controls in a somatic DSB repair assay, when either whd80k17 or whd-y+ is used as the recipient allele bearing the target break site. The genome of E(Pc)1/+ flies appears to be significantly more stable following exposure to irradiation (seen as induction of fewer bristles with a Minute phenotype) compared to control flies. Heterozygous wing discs show an approximately twofold reduction in radiation-induced apoptosis compared to controls. Heterozygotes show an increased survival rate following irradiation compared to control animals.
Viable in transheterozygous combination with E(Pc)rv4, E(Pc)rv9 or E(Pc)rv10. Dominantly suppresses position effect variegation (PEV) at the w locus caused by In(1)wm4, PEV at the B locus caused by Dp(1;Y)BSCV, PEV at the Sb locus caused by T(2;3)SbV and PEV at the bw locus caused by In(2R)bwVDe2.
Mutation changes the level of w expression in ph-plac+3 flies; eye colour is darker.
The cuticles of embryos lacking both maternal and zygotic E(Pc) product appear wild type.
No homeotic phenotype in embryos or adults. Strong enhancers of Pc, Pcl and pho mutations (FBrf0040741).
E(Pc)1 heterozygotes are cuticularly normal as larvae and adults. E(Pc)1 is a recessive lethal mutation; homozygotes and hemizygotes die as late embryos or larvae, which appear cuticularly normal.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
E(Pc)[+]/E(Pc)1 is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm2, trxE2
E(Pc)[+]/E(Pc)1 is an enhancer of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]
E(Pc)1 is an enhancer of visible | dominant phenotype of Pc4
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhancer of
Statement
Reference
E(Pc)1 is an enhancer of eye phenotype of CycEJP
E(Pc)[+]/E(Pc)1 is an enhancer of adult abdominal segment 4 | ectopic phenotype of E(z)Trm
E(Pc)[+]/E(Pc)1 is an enhancer of adult abdominal segment 5 phenotype of E(z)Trm
E(Pc)[+]/E(Pc)1 is an enhancer of adult metathoracic segment phenotype of brm[+]/brm2, trxE2
E(Pc)[+]/E(Pc)1 is an enhancer of adult metathoracic segment phenotype of ash117, trxB11/trx[+]
E(Pc)1 is an enhancer of leg phenotype of Pc4
E(Pc)[+]/E(Pc)1 is an enhancer of sex comb | ectopic phenotype of Pc4
E(Pc)1 is an enhancer of phenotype of Pcl11
E(Pc)1 is an enhancer of phenotype of Pcl12
E(Pc)1 is an enhancer of phenotype of pho1
E(Pc)1 is an enhancer of phenotype of esc1
E(Pc)1 is an enhancer of phenotype of Pclunspecified
E(Pc)1 is an enhancer of phenotype of Pcunspecified
Suppressor of
Statement
Reference
E(Pc)[+]/E(Pc)1 is a suppressor | partially of adult mesothoracic segment | ectopic phenotype of E(z)Trm
E(Pc)[+]/E(Pc)1 is a suppressor | partially of adult metathoracic segment phenotype of E(z)Trm
E(Pc)[+]/E(Pc)1 is a suppressor of adult prothoracic segment phenotype of E(z)Trm
NOT Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference
The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is ameliorated by combination with a single copy of E(Pc)1.
The wing nicking phenotype caused by expression of domdsRNA.Sym.Scer\UAS under the control of Scer\GAL4bbg-C96 is enhanced if the flies are also carrying E(Pc)1.
Expression of Bap55Scer\UAS.cTa using Scer\GAL4GH146.PB in a domLL05537 background causes dendrites to mistarget to both DA41 and DM6 glomeruli, and results in axons targeting ventrally to the lateral horn.
An E(Pc)1 background weakly suppresses the rough eye phenotype found in flies expressing DrefScer\UAS.cSa under the control of Scer\GAL4GMR.PS.
No significant modification of the number of sex combs is seen in E(Pc)1/+ corto420/+ double heterozygotes compared to E(Pc)1/+ single heterozygotes.
Weak suppressor of eye pigment phenotype of wT81.
Dominantly enhances the extra sex combs phenotype of Pc4.
E(Pc)1 acts zygotically as a dominant enhancer of the adult homoeotic syndrome of flies heterozygous for Pc mutations or Df(3L)Pc-MK. Heterozygosity for E(Pc)1 also enhances the adult homoeotic syndrome of Pcl mutations or Pcl deficiency heterozygotes and renders the normally recessive mutations esc1 and pho1 slightly pseudodominant, but has no effect on phenotypes associated with AntpNs, Antp73b, AntpScx, ScrMsc, UbxCbx-1, Ubx1, Ubxbx-34e or Ubxabx-1, Ubxbx-3, Ubxpbx-1 heterozygotes. E(Pc)1 has dominant maternal as well as zygotic effect on the severity of the embryonic homoeotic syndrome of Pc3 or Df(3L)Pc-MK homozygotes. Zygotic homozygosity for E(Pc)1 also enhances the embryonic effects of Pcl11, Df(2R)Pcl-W5 and Pcl12, and E(Pc)1; pho1 doubly homozygous embryos from heterozygous mothers show incomplete head involution, presumably due to a cryptic homoeotic effect.
Xenogenetic Interactions
Statement
Reference
The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is ameliorated by combination with a single copy of E(Pc)1.
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (5)
Notes on Origin
Discoverer
Comments
Comments
Weak derepression of en expression.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (27)