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General Information
Symbol
Dmel\E(SD)1
Species
D. melanogaster
Name
FlyBase ID
FBal0003316
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Segregation distortion can occur in the absence of RanGAPSd if flies are homozygous for E(SD)1 : Flies carrying chromosome SD-5[R7] (E(SD)1, Rspi M(SD)1 St(SD)1) / chromosome ReR-5 (E(SD)1 Rsps) exhibit moderate segregation distortion (k=0.74 +/-0.014) against ReR-5. This can be suppressed by the presence of RanβTub85D.PK or Rcc1βTub85D.PK. RanGAPβTub85D.PK causes very strong segregation distortion in the presence of the "SD-5[R7]" chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss. Segregation distortion does not occur if the target homolog chromosome carries Rspi in place of Rspss. Overexpression of RanGAPβTub85D.PK does not cause segregation distortion in the presence of the "SD-5[R16]" chromosome (which carries a strong suppressor of SD in addition to RanGAPSd, E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss. RanβTub85D.PK and Rcc1βTub85D.PK can both suppress the segregation distortion phenotype caused by RanGAPβTub85D.PK in the presence of the "SD-5[R7]" chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss.

Segregation distortion is not seen RanGAPSd.tPa.1 flies in the presence of E(SD)1 or of the SD-5[R7] chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1). RanGAPSd.tPa induces high levels of segregation distortion in the presence of the SD-5[R7] chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss or Rsps.

In the presence of E(SD)1, either in coupling or repulsion, RanGapSD mutants characterized by k values of > 0.95. Deletion of E(SD)1 reduces k values to allele or a nonenhancing allele. E(SD)1 in the absence of RanGapSD able to cause differential recovery of Rsp+ and Rsp- chromosomes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (7)
Notes on Origin
Discoverer

Associated with: SD chromosomes.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
E(SD)1
Name Synonyms
Secondary FlyBase IDs
    References (3)