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General Information
Symbol
Dmel\e(y)11
Species
D. melanogaster
Name
FlyBase ID
FBal0003366
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
e(y)u1, e(y)1u1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a Stalker element in the second exon, in the opposite direction to that of e(y)1 transcription. This results in a chimeric protein in which the 25 carboxyl amino acids of e(y)1 are replaced with 17 amino acids encoded by Stalker sequence.

Insertion of Stalker element.

Stalker insertion

Insertion components
Stalker{}e(y)11
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous adults show no visible morphological changes compared to wild type. Homozygous females are sterile; the ovaries are dramatically underdeveloped and do not contain mature oocytes.

The pigmentation of y2 e(y)21 flies is not altered by Su(mg)1-61-6, Su(mg)1-71-7 or Su(mg)1-81-8.

No mutant phenotype in the wing.

Stable mutation. Has no effect on the y+ phenotype.

head and thorax bristles yellow; microchaetae yellow; female-sterile

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference

e(y)11 is an enhancer of eye color defective phenotype of w+mC

e(y)11 is an enhancer of body color defective phenotype of y2PR1

e(y)11 is an enhancer of body color defective phenotype of y2PR2

e(y)11 is an enhancer of eye color defective phenotype of wsp2, zv77h

e(y)11 is an enhancer of eye color defective phenotype of wsp2, z1

e(y)11 is an enhancer of eye color defective phenotype of wsp4, zv77h

e(y)11 is an enhancer of eye color defective phenotype of wsp4, z1

e(y)11 is an enhancer of eye color defective phenotype of wsp1, zv77h

e(y)11 is an enhancer of eye color defective phenotype of wsp1, z1

Other
Phenotype Manifest In
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference

e(y)11 is an enhancer of pigment cell phenotype of w+mC

e(y)11 is an enhancer of pigment cell phenotype of wBR.E.BR, zv77h

e(y)11 is an enhancer of pigment cell phenotype of wE.BR, zv77h

e(y)11 is an enhancer of leg & external sensory organ phenotype of y76d28

e(y)11 is an enhancer of adult thorax & macrochaeta phenotype of y76d28

e(y)11 is an enhancer of adult abdomen & macrochaeta phenotype of y76d28

e(y)11 is an enhancer of phenotype of wsp2

e(y)11 is an enhancer of pigment cell phenotype of wsp2, zv77h

e(y)11 is an enhancer of pigment cell phenotype of wsp2, z1

e(y)11 is an enhancer of phenotype of wsp4

e(y)11 is an enhancer of pigment cell phenotype of wsp4, zv77h

e(y)11 is an enhancer of pigment cell phenotype of wsp4, z1

e(y)11 is an enhancer of phenotype of zop6

e(y)11 is an enhancer of phenotype of wsp1

e(y)11 is an enhancer of pigment cell phenotype of wsp1, zv77h

e(y)11 is an enhancer of pigment cell phenotype of wsp1, z1

e(y)11 is an enhancer of phenotype of zv77h

NOT Enhancer of
Statement
Reference

e(y)11 is a non-enhancer of phenotype of y+1MC

e(y)11 is a non-enhancer of phenotype of y+3MC

Suppressor of
Statement
Reference

e(y)11 is a suppressor of phenotype of scD1

NOT Suppressor of
Statement
Reference

e(y)11/Su(mg)1-61-6 is a non-suppressor of phenotype of y2

e(y)11/Su(mg)1-71-7 is a non-suppressor of phenotype of y2

e(y)11/Su(mg)1-81-8 is a non-suppressor of phenotype of y2

e(y)11 is a non-suppressor of anterior notopleural bristle phenotype of sc+2MC, y+2MC

e(y)11 is a non-suppressor of anterior notopleural bristle phenotype of sc2#+9, y2#+9

Other
Statement
Reference

e(y)11, y+2MC has leg & external sensory organ phenotype

e(y)11, y+2MC has adult thorax & macrochaeta phenotype

e(y)11, y2PR1 has leg & external sensory organ phenotype

e(y)11, y2PR1 has adult thorax & macrochaeta phenotype

e(y)11, y2 has leg & external sensory organ phenotype

e(y)11, y2 has adult thorax & macrochaeta phenotype

e(y)11, y+2MC has adult abdomen & macrochaeta phenotype

e(y)11, y2PR2 has leg & external sensory organ phenotype

e(y)11, y2PR2 has adult thorax & macrochaeta phenotype

Additional Comments
Genetic Interactions
Statement
Reference

The lethality of e(y)21 e(y)11 double mutants is rescued by e(y)2+tGa or by e(y)1+tSa.

The lethality of e(y)21 e(y)11 double mutants is not rescued by e(y)11.tSa.

Does not affect the y+1MC or y+3MC phenotypes. Enhances the y2, y+2MC, y2PR1, y2PR2 and y76d28 phenotypes; reducing the levels of pigmentation in adult bristles, but not in the body or wings. The enhancing effect of e(y)11 on the y2 phenotype is partially suppressed by e(y)11.tSa and completely suppressed by e(y)1+tSa. Lethal in combination with e(y)34. Viability is rescued by e(y)1+tSa and partially rescued by e(y)11.tSa. Eye colour: the eye pigmentation of flies carrying w+mC in a w1118 background is reduced by e(y)11 in a number of different P{CaSpeR-3} insertion strains. Eye colour: flies carrying wBR.E.BR have red eyes. The eye colour is not affected if the flies are also carrying e(y)11 and zv77h. Flies that are also carrying e(y)11, zv77h and su(Hw)2/su(Hw)V have reduced eye pigmentation. Eye colour: flies carrying wE.BR have brown eyes. The eye pigmentation is reduced if these flies are also carrying e(y)11 and zv77h.

Suppresses the scD1 phenotype slightly in males and strongly in females. Has no effect on ANP bristle formation caused by y+2MC, sc+2MC and y2#+9, sc2#+9. Has no effect on the Df(1)ase-1, sc5 or sc6 phenotype.

No effect on mutant wing phenotype of ct6, ctpN2s, ctn2s, ct2s or ct4s. z1 and e(y)11 have no effect on the mod(mdg4)ul effect on ct6.

Heterozygotes with e(y)34 are lethal. Heterozygous males with e(y)21 have very low viability and are completely sterile. In z1 wzm strain e(y)11 causes a significant reduction in eye pigmentation.

Enhances the y2 phenotype; head and thorax bristles, and hairs are yellow. This enhancer effect is not suppressed by su(Hw)2.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Partially rescued by

e(y)11 is partially rescued by e(y)11.tSa

Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Mutation enhances the negative effect of z point mutations, zv77h or z1, on w expression. w expression levels of wsp1, wsp2 and wsp4 are strongly reduced, exhibited by a reduced level of eye pigmentation, by e(y)11.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (13)