Allele Dmel\E(z)¹

General Information
Symbol	Dmel\E(z)¹	Species	D. melanogaster
Name		FlyBase ID	FBal0003380
Feature type	allele	Associated gene	Dmel\E(z)
Also Known As	E(z)1

Map ( GBrowse )
Allele class	neomorphic allele - genetic evidence, antimorphic allele - genetic evidence, gain of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	antimorphic allele - genetic evidence (Laible et al., 1997) gain of function allele (Jones and Gelbart, 1990, Jones and Gelbart, 1993, Cheng et al., 1994) neomorphic allele - genetic evidence (LaJeunesse and Shearn, 1996)
Mutagen	ethyl methanesulfonate (Kalisch and Rasmuson, 1974, Phillips and Shearn, 1990)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:10,628,058..10,628,058 na_change=T10628058A pr_change=Y655N \| E(z)-PB; Y655N \| E(z)-PA; Y660N \| E(z)-PC reported_pr_change=Y655N comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. (Joshi et al., 2008)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology	Polytene chromosomes normal. (Jones and Gelbart, 1990)
Phenotypic Data
Phenotypic Class
	eye color defective (Jones and Gelbart, 1993) lethal \| recessive (Phillips and Shearn, 1990, Jones and Gelbart, 1990, Kalisch and Rasmuson, 1974)
Phenotype Manifest In
	pigment cell (Kalisch and Rasmuson, 1974)
Detailed Description
	Statement Reference A significant change in repression of the w^H19.UZA gene compared to offspring from the same cross carrying the balancer chromosome is observed in E(z)¹ flies. Β-galactosidase assays on heterozygous larvae with the E(z)¹ allele show a two- to threefold stronger repression of Ecol\lacZ compared to Ecol\lacZ wild-type flies. (Erhardt et al., 2003) The total level of hydrocarbons and the level of 7-monoenes is significantly increased in heterozygous males compared to controls. The total level of hydrocarbons is significantly increased and the level of 7,11-dienes is significantly decreased in heterozygous females compared to controls. (Wicker-Thomas and Jallon, 2000) Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w^+mW.hs allele at the telomeres of the second and third chromosomes. (Cryderman et al., 1999) Phenotypically like ash1²⁹. (LaJeunesse and Shearn, 1996) In z¹ w^zm strain mutation causes reduction of eye pigmentation. (Georgiev, 1994) Dominant enhancer of z¹. (Jones and Gelbart, 1990) The z enhancement phenotype of E(z)¹ is unaffected by Dp(3;3)S2a3. (Phillips and Shearn, 1990) gain-of-function allele
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference E(z)[+]/E(z)¹ is an enhancer of eye color defective \| female phenotype of g^53d, z[+]/z¹ (Lloyd et al., 2002) E(z)[+]/E(z)¹ is an enhancer of eye color defective \| female phenotype of g^53d/g[+], z¹ (Lloyd et al., 2002) E(z)¹ is an enhancer of eye color defective \| male phenotype of g^53d, z¹ (Lloyd et al., 2002) E(z)¹ is an enhancer of eye color defective phenotype of w^H19.UZA (Erhardt et al., 2003)
NOT Enhancer of
Statement Reference E(z)¹ is a non-enhancer of eye color defective phenotype of g² (Lloyd et al., 2002) E(z)¹ is a non-enhancer of eye color defective phenotype of g⁴ (Lloyd et al., 2002)
Phenotype Manifest In
Enhancer of
Statement Reference E(z)[+]/E(z)¹ is an enhancer of pigment cell \| female phenotype of g^53d, z[+]/z¹ (Lloyd et al., 2002) E(z)[+]/E(z)¹ is an enhancer of pigment cell \| female phenotype of g^53d/g[+], z¹ (Lloyd et al., 2002) E(z)¹ is an enhancer \| male of pigment cell phenotype of g^53d, z¹ (Lloyd et al., 2002) E(z)¹ is an enhancer of phenotype of z¹ (Kalisch and Rasmuson, 1974, Jones and Gelbart, 1990) E(z)¹ is an enhancer of pigment cell \| male phenotype of g^53d, z¹ (Lloyd et al., 2002)
NOT Enhancer of
Statement Reference E(z)¹ is a non-enhancer of pigment cell phenotype of g² (Lloyd et al., 2002) E(z)¹ is a non-enhancer of pigment cell phenotype of g⁴ (Lloyd et al., 2002)
Other
Statement Reference E(z)¹, ash1²⁸ has metathoracic leg phenotype (LaJeunesse and Shearn, 1996, LaJeunesse and Shearn, 1996) E(z)¹, ash1²⁸ has prothoracic leg phenotype (LaJeunesse and Shearn, 1996, LaJeunesse and Shearn, 1996) E(z)¹, ash1²⁹ has metathoracic leg phenotype (LaJeunesse and Shearn, 1996, LaJeunesse and Shearn, 1996) E(z)¹, ash1²⁹ has prothoracic leg phenotype (LaJeunesse and Shearn, 1996, LaJeunesse and Shearn, 1996)
Additional Comments
Genetic Interactions
Statement Reference Male E(z)¹/+, g^53d, z¹ triple mutants have less red pigment in the eye than g^53d, z¹ double mutants. Likewise, female E(z)¹/+, g^53d/+, z¹/+ triple mutants have a reduction in red eye pigment compared to g^53d/+, z¹/+ double mutants. The E(z)¹ mutation does not affect levels of red pigment in the eye of g² or g⁴ mutants. (Lloyd et al., 2002) Double heterozygotes of E(z)¹ with ash1²⁸ or ash1²⁹ result in transformations of the third leg to the second leg and first leg to second leg. This phenotype is that expected from partial loss of function of Scr and Ubx. (LaJeunesse and Shearn, 1996) Strongly influences the z/w interaction causing the eye colour to change to intense yellow or yellow-brown. (Kalisch and Rasmuson, 1974)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	E(z)⁵ (Phillips and Shearn, 1990)
Rescued by	E(z)¹ is rescued by E(z)^+t8.8 (Jones and Gelbart, 1993)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Acts as an antimorphic trx-group mutation. (LaJeunesse and Shearn, 1995)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	E(z)1 (Lloyd et al., 2002, Gvozdev et al., 2000) E(z)¹ (Wicker-Thomas and Jallon, 2000)
Name Synonym
Secondary FlyBase IDs

References ( 23 )

Generate a list of	All references relating to this allele ( 23 )

List References by type	Research paper ( 21 ) Review ( 1 ) Abstract ( 1 )
Recent research papers (0)
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Recent reviews (0)
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Allele Dmel\E(z)1

Allele Dmel\E(z)¹