The total level of hydrocarbons and the level of 7-monoenes is normal in heterozygous males. The total level of hydrocarbons is normal and the level of 7,11-dienes is significantly decreased in heterozygous females compared to controls.
Phenotypically like ash129. Larval hemizygotes express a small imaginal disc phenotype. Acridine orange staining suggests small size is not due to cell death.
Mutation does not affect the level of w expression in ph-plac+3 flies.
Homozygous and E(z)5/Df(3L)lxd6 animals die just after puparium formation. There are almost no discernible mitotic figures in E(z)5/Df(3L)lxd6 larval brains. E(z)5/E(z)28 males have reduced viability and increased numbers of sex combs compared to wild-type flies. This phenotype increases as the flies are raised at higher temperatures, and is more severe than the phenotype of E(z)5/E(z)28 males at all temperatures.
Imaginal discs of homozygous larvae are small. Defects in the cell cycle: few or no dividing cells, affects chromosome condensation and arrest of the cell cycle at metaphase.
More than 50% of homozygous larvae form puparia, although none of them metamorphose. Mutant larvae have smaller imaginal discs than normal (the maximum size is larger than the size of wild-type late second instar discs but smaller than the size of wild-type young third instar discs) which cannot differentiate into adult structures when injected into metamorphosing normal larvae. The eye-antenna, leg, wing, haltere and genital discs are abnormal. Late second instar mutant wing discs and eye-antenna-brain complexes injected into wild-type adult females grow slightly in in vivo culture, but do not reach the size of wild-type early third instar discs, and are unable to differentiate into adult structures when injected into metamorphosing normal larvae. Wings discs from early third instar wild-type larvae injected into late second or early third instar mutant larvae grow almost as much as control wild-type discs injected into wild-type larvae. These discs can differentiate when injected into metamorphosing larvae. Homozygous clones contain morphologically abnormal structures.
Dominant suppressor of z mutants.