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General Information
Symbol
Dmel\E(z)5
Species
D. melanogaster
Name
FlyBase ID
FBal0003384
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
pco1902
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

E(z)5 dominantly suppresses variegation of the w gene caused by In(1)wm4.

E(z)5 does not dominantly suppress variegation of the w gene caused by P{RS3}panCB-5204-3, P{RS5}5-HA-1902, P{RS5}5-HA-1992 and T(2;3)V21-P{lacW}92E.x3.

The total level of hydrocarbons and the level of 7-monoenes is normal in heterozygous males. The total level of hydrocarbons is normal and the level of 7,11-dienes is significantly decreased in heterozygous females compared to controls.

Phenotypically like ash129. Larval hemizygotes express a small imaginal disc phenotype. Acridine orange staining suggests small size is not due to cell death.

Mutation does not affect the level of w expression in ph-plac+3 flies.

Homozygous and E(z)5/Df(3L)lxd6 animals die just after puparium formation. There are almost no discernible mitotic figures in E(z)5/Df(3L)lxd6 larval brains. E(z)5/E(z)28 males have reduced viability and increased numbers of sex combs compared to wild-type flies. This phenotype increases as the flies are raised at higher temperatures, and is more severe than the phenotype of E(z)5/E(z)28 males at all temperatures.

Imaginal discs of homozygous larvae are small. Defects in the cell cycle: few or no dividing cells, affects chromosome condensation and arrest of the cell cycle at metaphase.

More than 50% of homozygous larvae form puparia, although none of them metamorphose. Mutant larvae have smaller imaginal discs than normal (the maximum size is larger than the size of wild-type late second instar discs but smaller than the size of wild-type young third instar discs) which cannot differentiate into adult structures when injected into metamorphosing normal larvae. The eye-antenna, leg, wing, haltere and genital discs are abnormal. Late second instar mutant wing discs and eye-antenna-brain complexes injected into wild-type adult females grow slightly in in vivo culture, but do not reach the size of wild-type early third instar discs, and are unable to differentiate into adult structures when injected into metamorphosing normal larvae. Wings discs from early third instar wild-type larvae injected into late second or early third instar mutant larvae grow almost as much as control wild-type discs injected into wild-type larvae. These discs can differentiate when injected into metamorphosing larvae. Homozygous clones contain morphologically abnormal structures.

Dominant suppressor of z mutants.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

E(z)[+]/E(z)5 is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm2, trxE2

E(z)[+]/E(z)5 is an enhancer of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]

Other
Phenotype Manifest In
Enhancer of
Statement
Reference

E(z)[+]/E(z)5 is an enhancer of adult metathoracic segment phenotype of brm[+]/brm2, trxE2

E(z)[+]/E(z)5 is an enhancer of adult metathoracic segment phenotype of ash117, trxB11/trx[+]

Suppressor of
Statement
Reference

E(z)5 is a suppressor of phenotype of z1

Other
Additional Comments
Genetic Interactions
Statement
Reference

Double heterozygotes with ash122 show T3 to T2 transformations.

Double heterozygotes of E(z)5 with ash128 or ash129 result in transformations of the third leg to the second leg and first leg to second leg. This phenotype is that expected from partial loss of function of Scr and Ubx.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (20)