Allele Dmel\ea^D8

General Information
Symbol	Dmel\ea^D8	Species	D. melanogaster
Name		FlyBase ID	FBal0003481
Feature type	allele	Associated gene	Dmel\ea
Also Known As	ea²⁰ⁿ

Map ( GBrowse )
Allele class	gain of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	gain of function allele (Chasan and Anderson, 1989)
Mutagen	ethyl methanesulfonate (Erdelyi and Szabad, 1989)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:11,155,232..11,155,232 evidence=experimental na_change=G11155232A pr_change=G131E\|ea-PA reported_na_change=G595A reported_pr_change=G131E (Jin and Anderson, 1990)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotide substitution: G595A. (Jin and Anderson, 1990) Amino acid replacement: G131E. (Jin and Anderson, 1990)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile \| dominant (Chasan and Anderson, 1989) lethal \| dominant \| maternal effect (Jin and Anderson, 1990) lethal \| embryonic stage \| maternal effect (Erdelyi and Szabad, 1989)
Phenotype Manifest In
	embryonic/first instar larval cuticle \| maternal effect (Chang and Morisato, 2002, Jin and Anderson, 1990) embryonic/first instar larval cuticle \| maternal effect (with Df(3R)ea-5022rx1) (Chang and Morisato, 2002)
Detailed Description
	Statement Reference Embryos laid by heterozygous females are either ventralised or lateralised. Embryos laid by ea^D8/Df(3R)ea-5022rx1 females are markedly more elongated and have fewer denticle bands than embryos laid by ea^D8/+ females. All embryos laid by ea^D8/Df(3R)ea-5022rx1 females develop a lateralised head fold during gastrulation. (Chang and Morisato, 2002) Embryos are lateralized and exhibit an almost apolar phenotype in which laterally derived denticles develop all around the embryo circumference. Perivitelline fluid transplantation using ea^D8 embryos as donors and ea¹/ea² embryos as recipients demonstrated that the rescue of the ea phenotype results from the transplantation of the ea gene product. (Stein and Nusslein-Volhard, 1992) Embryos lateralized. (Jin and Anderson, 1990) Embryos have a lateralized phenotype: differentiate rings of ventral denticles around the entire dorso-lateral circumference and do not form the ventrally derived mesoderm. (Chasan and Anderson, 1989) Female viability and male fertility are not reduced. Embryos exhibit ventralised phenotype. (Erdelyi and Szabad, 1989)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	ea²⁰ⁿ (Chang and Morisato, 2002, Chasan and Anderson, 1989, Jin and Anderson, 1990) ea^D8 ea^D20m (Erdelyi and Szabad, 1989) ea^D20n (Stein and Nusslein-Volhard, 1992, )
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Chang and Morisato, 2002, Development 129(24): 5635--5645 Regulation of Easter activity is required for shaping the Dorsal gradient in the Drosophila embryo. [FBrf0151943] Stein and Nusslein-Volhard, 1992, Cell 68(3): 429--440 Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity. [FBrf0055562] Jin and Anderson, 1990, Cell 60: 873--881 Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain. [FBrf0051391] Chasan and Anderson, 1989, Cell 56: 391--400 The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo. [FBrf0049353] Erdelyi and Szabad, 1989, Genetics 122: 111--127 Isolation and characterization of dominant female sterile mutations of Drosophila melanogaster. [FBrf0051088]

Allele Dmel\eaD8

Allele Dmel\ea^D8