Open Close
General Information
Symbol
Dmel\egMz360
Species
D. melanogaster
Name
FlyBase ID
FBal0003524
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
eg-Gal4, eagle-GAL4, MZ360, eagleGal4, egGAL4
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a P{GawB} element approximately 200bp upstream of 5' exon A2.

Insertion components
P{GawB}egMz360
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In the ventral nerve cords of stage 16 egMz360 mutant embryos, there is a loss of ability to take up serotonin in approximately 1/4 of hemisegments.

Homozygotes have a held out wing phenotype.

Mutants exhibit an almost wild type pattern of serotonin neurons in the abdominal region but only single cells in the thoracic segments. nub and zfh2 staining reveals the more medial serotonin cell of the mitotic pair is lost: the EW1 neuron.

Homozygotes have a 'wings held out' phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

egMz360 has serotonin neuron & ventral nerve cord phenotype, non-enhanceable by robo2X123/robo2X123

Suppressed by
Statement
Reference

egMz360 has serotonin neuron & ventral nerve cord phenotype, suppressible by Scer\GAL4[-], robo2EP2582/robo2EP2582

NOT Enhancer of
Statement
Reference

egMz360/egMz360 is a non-enhancer of serotonin neuron & ventral nerve cord phenotype of robo2X123

Additional Comments
Genetic Interactions
Statement
Reference

In the ventral nerve cords from stage 16 egMz360/egMz360 embryos, the number of hemisegments showing loss of ability to take up serotonin is not significantly increased by leaX123/leaX123. Loss of serotonin uptake activity in the ventral nerve cords of stage 16 egMz360/egMz360 embryos is suppressed by the presence of leaEP2582/leaEP2582.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)