Allele Dmel\Egfr^E1

General Information
Symbol	Dmel\Egfr^E1	Species	D. melanogaster
Name	Ellipse	FlyBase ID	FBal0003526
Feature type	allele	Associated gene	Dmel\Egfr
Also Known As	Elp¹, egfr^Elp, Elp, Ellipse¹, dEGFR^Elp, DER^Elp1, Egfr^E

Map ( GBrowse )
Allele class	hypermorphic allele - genetic evidence, gain of function allele
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	gain of function allele (Rogge et al., 1991, Brunner et al., 1994, Doberstein et al., 1995, Rogge et al., 1995, Lim et al., 1997) hypermorphic allele - genetic evidence (Verheyen et al., 1996, )
Mutagen	spontaneous (Baker and Rubin, 1989)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:17,410,608..17,410,608 evidence=experimental na_change=C17410608A pr_change=S5R\|Egfr-PA reported_na_change=C14A reported_pr_change=S5R comment=One of two nucleotide substitutions affecting the amino acid sequence in the Egfr^E1 mutant relative to the reference sequence. (Lesokhin et al., 1999) point mutation 2R:17,445,112..17,445,112 evidence=experimental na_change=G17445112A pr_change=A887T\|Egfr-PA,A936T\|Egfr-PB reported_na_change=G3165A reported_pr_change=A887T comment=One of two nucleotide substitutions affecting the amino acid sequence in the Egfr^E1 mutant relative to the reference sequence. A L21W change is also reported in FBrf0105872 but a W already exists at this location in the reference sequence. (Lesokhin et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AF109078 AAD26132 AF109078 AAD26133 AF109082 AF109084

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: S5R. Amino acid replacement: L21W. Amino acid replacement: A887T. Figure 1 and the text concerning this allele are at odds - the text is correct (note from N. Baker). (Lesokhin et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	hyperactive \| dominant (Doyle and Bishop, 1993) viable (Diaz-Benjumea and Garcia-Bellido, 1990) visible (Baker and Rubin, 1989, Adachi-Yamada et al., 1999, Polaczyk et al., 1998, Baker et al., 2002, Tio et al., 1994, Sullivan and Rubin, 2002, Butchar et al., 2012, Oishi et al., 2006) visible (with Egfr^E3) (Lesokhin et al., 1999) visible \| dominant (Rusconi et al., 2004, Li and Li, 2003, Kumar et al., 1998, Shamloula et al., 2002, Lamb et al., 1998, Spencer and Cagan, 2003, Ashton-Beaucage et al., 2010, Baker and Rubin, 1992, Brunner et al., 1994, Kotarski et al., 1998, Rogge et al., 1991, Read et al., 2005, Spencer et al., 1998, Iyadurai et al., 2008, Haberman et al., 2010)
Phenotype Manifest In
	eye (Kolodkin et al., 1994, Kumar et al., 1998, Shamloula et al., 2002, Ghiglione et al., 2003, Lamb et al., 1998, Spencer and Cagan, 2003, Polaczyk et al., 1998, Baker and Rubin, 1992, Brunner et al., 1994, Kotarski et al., 1998, Rogge et al., 1991, Frankfort and Mardon, 2004, Read et al., 2005, Spencer et al., 1998, Sullivan and Rubin, 2002, Iyadurai et al., 2008, Haberman et al., 2010) eye (with Egfr^E3) (Lesokhin et al., 1999) ommatidial precursor cluster (Kumar et al., 1998) ommatidium (Baker and Rubin, 1989, Rogge et al., 1995, Baker and Zitron, 1995, Rusconi et al., 2004, Doyle and Bishop, 1993, Ghiglione et al., 2003, Polaczyk et al., 1998, Kotarski et al., 1998, Baker et al., 1990, Tio et al., 1994, Frankfort and Mardon, 2004, Iyadurai et al., 2008) photoreceptor cell R7 of yellow ommatidium (Birkholz et al., 2009) photoreceptor cell R8 of pale ommatidium (Birkholz et al., 2009) wing (Adachi-Yamada et al., 1999, Baker and Rubin, 1992, Oishi et al., 2009) wing (with Egfr^E3) (Lesokhin et al., 1999) wing vein (Baker and Rubin, 1989, Baker and Rubin, 1992, Tien et al., 2008, Oishi et al., 2009) wing vein \| ectopic (Li and Li, 2003, Ghiglione et al., 2003, Ashton-Beaucage et al., 2010, Baker et al., 2002, Brunner et al., 1994, Butchar et al., 2012, Oishi et al., 2006) wing vein \| ectopic (with Egfr^E3) (Lesokhin et al., 1999) wing vein L2 (Iyadurai et al., 2008)
Detailed Description
	Statement Reference Mutant flies have an extra wing vein phenotype with an additional vein fragment above vein L2 and some vein deltas. (Butchar et al., 2012) Heterozygotes have extra wing vein material in the wing. (Ashton-Beaucage et al., 2010) In Egfr[E1]/+ adults, the number of ommatidia with pale-type R8 cells and yellow-type R7 cells is significantly increased. Many of these are found in pale-yellow hybrid ommatidia with a yellow-type R7 and a pale-type R8. (Birkholz et al., 2009) Egfr[E1] mutants exhibit ectopic wing veins. (Oishi et al., 2009) Heterozygotes have a rough eye phenotype, with elliptical eyes and disarranged ommatidial arrays, and wing vein L2 shows an abnormal broadening at the wing margin. (Iyadurai et al., 2008) Egfr[E1] heterozygotes exhibit a slight rough eye phenotype. (Melicharek et al., 2008) Egfr[E1] mutants exhibit ectopic wing vein formation. (Tien et al., 2008) Egfr^E1 homozygous adults are small and have greatly reduced numbers of ommatidia with large gaps of pigmented tissue between them. Heterozygous adults have normal eyes. (Frankfort and Mardon, 2004) Heterozygous adults have smaller eyes than normal which have moderate rough phenotype. (Rusconi et al., 2004) Egfr^E1/+ flies have rough eyes and a weak extra wing vein phenotype. (Ghiglione et al., 2003) Wings of heterozygous and homozygous flies have extra wing vein material. (Li and Li, 2003) Heterozygotes have smaller eyes than normal which are mispatterned. (Spencer and Cagan, 2003) Egfr^E1/+ flies have a rough eye phenotype. (Sullivan and Rubin, 2002) Heterozygous mutants do not cause any defects in the ocellar sensory system (OSS) neurogenesis or axon guidance. (Garcia-Alonso et al., 2000) Heterozygotes have smaller eyes than normal and lack some ommatidia, producing an irregular arrangement of facets. (Kotarski et al., 1998) Heterozygotes have rough eyes. This phenotype is suppressed towards wild-type in transheterozygous combination with Egfr^f24. This phenotype is suppressed towards wild-type in transheterozygous combination with Egfr^tsla at 28^oC but not at 18^oC. Heterozygotes show greatly reduced ommatidial cluster formation in the morphogenetic furrow of the eye disc. (Kumar et al., 1998) Heterozygotes have a rough eye phenotype. (Lamb et al., 1998, Shamloula et al., 2002, Haberman et al., 2010) Heterozygotes exhibit roughening of patches on both eyes. Homozygotes exhibit strong blistering, including loss of pigmentation, in patches on both eyes. Rhabdomere assembly is disordered with extra material at the apical ends of the ommatidia. Ommatidia pattern is disordered. (Polaczyk et al., 1998) Heterozygotes have rough eyes. (Spencer et al., 1998) Homozygous flies have a few, widely separated ommatidia. Each ommatidium contains a single R8 cell, as in wild-type flies, and this phenotype is not altered in sca^WB1/sca^OB7 Egfr^E3/Egfr^E1 double homozygotes. (Baker and Zitron, 1995) Increase the penetrance of extra crossveins in chic^gdh-5/Egfr^E1 heterozygotes. (Doberstein et al., 1995) Heterozygotes have a mild rough eye phenotype due to a disrupted ommatidial array. (Rogge et al., 1995) Displays locomotor activity rhythm with an approximately 24h period. (Vosshall and Young, 1995) Extra wing veins close to the wing margin. (Brunner et al., 1994) Mutation has no effect on rho^hs.sev rough eye phenotype. (Freeman, 1994) Rough eye phenotype: eyes are small and rough at the perimeter, ommatidia and hairs are in an irregular pattern. (Doyle and Bishop, 1993) Heterozygous rho^ve-1 dominantly suppresses the homozygous and heterozygous phenotype. Heterozygous rho^Wk, rho^Mod and rho^Stg enhance the heterozygous phenotype. (Sturtevant et al., 1993) Homozygous eye discs have fewer ommatidia than wild-type. Outgrowth of photoreceptor axons is disturbed, occurring in many directions. Cell death is abundant in the region approximately corresponding to columns 10-15 in wild-type. In the adult eye the ommatidia are separated by numerous pigment cells and mechanosensory bristles. Wing veins show thickening and plexus formation. Enhances the wing phenotype of Df(1)N-54l9, N^264-39, Dl^9P, and Dl^KX6 mutations, and the eye phenotype of N^spl-1. (Baker and Rubin, 1992) Shows a rough eye phenotype in combination with Egfr^f6, Egfr^f8 or Egfr^f10. (Raz et al., 1991) Mild roughening of the eye. (Rogge et al., 1991) Homozygotes have fewer ommatidia than wild-type. (Baker et al., 1990) The array of ommatidia is less regular in heterozygotes than in wild-type flies, and there is a slight disturbance in the wing vein pattern. Homozygotes have much smaller eyes than normal, containing many fewer ommatidia, and some regions lack ommatidia entirely. These regions contain cells resembling the pigment cells that normally surround each ommatidium, and also mechanosensory bristles. Most ommatidia contain the normal number and arrangement of cells. Only approximately one tenth of the normal number of preclusters differentiate in the eye imaginal discs. (Baker and Rubin, 1989) Eyes of Egfr^E1/+ heterozygotes rough and more oval than wild type; also display a slight disturbance of the wing-vein pattern. Homozygotes have smaller eyes with many fewer ommatidia and some regions lack them entirely; those ommatidia that are formed contain the normal number and arrangement of cells; the regions without ommatidia contain cells that resemble pigment cells and mechanosensory bristles; only about one tenth the normal number of preommatidial cell clusters differentiate behind the morphogenetic furrow. Egfr^E1 in heterozygous combination with a deficiency or null mutation for Egfr is normal in phenotype indicating that Egfr^E1 alleles are hypermorphic.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Egfr^E1 has visible \| dominant phenotype, enhanceable by ast^K6/ast[+] (Kotarski et al., 1998) Egfr^E1 has visible \| dominant phenotype, enhanceable by Dhc64C[+]/Dhc64C^8-1 (Iyadurai et al., 2008) Egfr^E1 has visible \| dominant phenotype, enhanceable by Dhc64C^1-1 (Iyadurai et al., 2008) Egfr^E1 has visible \| dominant phenotype, enhanceable by Dhc64C^4-19 (Iyadurai et al., 2008) Egfr^E1 has visible \| dominant phenotype, enhanceable by Dhc64C^6-6 (Iyadurai et al., 2008) Egfr^E1 has visible \| dominant phenotype, enhanceable by Dhc64C^6-10 (Iyadurai et al., 2008) Egfr^E1 has visible \| dominant phenotype, enhanceable by ed[+]/ed^k01102 (Spencer and Cagan, 2003) Egfr^E1 has visible \| dominant phenotype, enhanceable by Gl[+]/Gl¹ (Iyadurai et al., 2008) Egfr^E1 has visible \| dominant phenotype, enhanceable by hh[+]/hh^rJ413 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by l(3)06803[+]/l(3)06803⁰⁶⁸⁰³ (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by l(3)S001405^S001405/l(3)S001405[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by l(3)S003704^S003704/l(3)S003704[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by l(3)S057101[+]/l(3)S057101^S057101 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by Mi-2^S047526/Mi-2[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by msn[+]/msn^j1E2 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by Pp1-87B[+]/Pp1-87B^j6E7 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by px[+]/px^k08316 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by S[+]/S^k09538a (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by scrib[+]/scrib^j7B3 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by spi^s3547/spi[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by tws^S049902/tws[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, enhanceable by vn[+]/vn^unspecified (Spencer et al., 1998) Egfr^E1 has visible phenotype, enhanceable by Scer\GAL4^Act5C.PU/CG4096^KK108644 (Butchar et al., 2012) Egfr^E3/Egfr^E1 has visible phenotype, enhanceable by aos^W11 (Lesokhin et al., 1999)
NOT Enhanced by
Statement Reference Egfr^E1 has visible \| dominant phenotype, non-enhanceable by crb^j1B5/crb[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by Csk^j1D8/Csk[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by CycA^S054513/CycA[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by Dl^S049520/Dl[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by drk[+]/drk¹⁰⁶²⁶ (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by drk[+]/drk^k13809 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by ebi[+]/ebi^k16213 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)06906[+]/l(3)06906⁰⁶⁹⁰⁶ (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)j4B9^j4B9/l(3)j4B9[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)j5B6^j5B6/l(3)j5B6[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S000710[+]/l(3)S000710^S000710 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S000718[+]/l(3)S000718^S000718 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S009515[+]/l(3)S009515^S009515 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S012805^S012805/l(3)S012805[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S016805[+]/l(3)S016805^S016805 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S019203^S141715/l(3)S019203[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S023549^S023549/l(3)S023549[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S023549^S090101/l(3)S023549[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S023708[+]/l(3)S023708^S023708 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S023901[+]/l(3)S023901^S023901 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S024329^S024329/l(3)S024329[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S024833[+]/l(3)S024833^S024833 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S026238^S026238/l(3)S026238[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S026421^S026421/l(3)S026421[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S046604^S046604/l(3)S046604[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S056113[+]/l(3)S056113^S056113 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S066607[+]/l(3)S066607^S066607 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S068808^S068808/l(3)S068808[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S081003^S145911/l(3)S081003[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S090114[+]/l(3)S090114^S090114 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S092708[+]/l(3)S092708^S092708 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S133117[+]/l(3)S133117^S133117 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S135703^S135703/l(3)S135703[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by l(3)S142909^S142909/l(3)S142909[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by Mi-2^S005504/Mi-2[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by Mi-2^S147412/Mi-2[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by neur[+]/neur^j6B12 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by Sin3A[+]/Sin3A⁰⁸²⁶⁹ (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-enhanceable by stg^S024503/stg[+] (Read et al., 2005)
Suppressed by
Statement Reference Egfr^E1 has visible \| dominant phenotype, suppressible by Acn²⁷/Acn[+] (Haberman et al., 2010) Egfr^E1 has visible \| dominant phenotype, suppressible by bon^S048706/bon[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, suppressible by cora¹ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora² (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora³ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora⁴ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora⁵ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora⁶ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora⁷ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora⁸ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora¹⁰ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora¹² (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora¹³ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora¹⁴ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by cora¹⁵ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, suppressible by drk^k02401/drk[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, suppressible by Gl[+]/Gl¹ (Iyadurai et al., 2008) Egfr^E1 has visible \| dominant phenotype, suppressible by l(3)j2D5^j2D5/l(3)j2D5[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, suppressible by mago¹/mago[+] (Ashton-Beaucage et al., 2010) Egfr^E1 has visible \| dominant phenotype, suppressible by rl[+]/rl¹ (Ashton-Beaucage et al., 2010) Egfr^E1 has visible phenotype, suppressible by klu[+]/klu^unspecified (Rusconi et al., 2004) Egfr^E1 has visible phenotype, suppressible by Ras85D[+]/Ras85D^Sutor-404 (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Ras85D^Sutor-341/Ras85D[+] (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Scer\GAL4^Act5C.PU/Sulf1^Scer\UAS.cBa (Butchar et al., 2012) Egfr^E1 has visible phenotype, suppressible by Sos[+]/Sos^Sutor-157 (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Sos^Sutor-405/Sos[+] (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Su(tor)1-1[+]/Su(tor)1-1¹³⁴ (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Su(tor)1-1¹⁹/Su(tor)1-1[+] (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Su(tor)2-3[+]/Su(tor)2-3¹ (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Su(tor)2-3[+]/Su(tor)2-3³⁶¹ (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Su(tor)2-180[+]/Su(tor)2-180¹ (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Su(tor)2-237¹/Su(tor)2-237[+] (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Su(tor)2-278[+]/Su(tor)2-278¹ (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Su(tor)2-321[+]/Su(tor)2-321¹ (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Su(tor)2-408¹/Su(tor)2-408[+] (Doyle and Bishop, 1993) Egfr^E1 has visible phenotype, suppressible by Su(tor)3-1[+]/Su(tor)3-1³⁸ (Doyle and Bishop, 1993) Egfr^E3/Egfr^E1 has visible phenotype, suppressible by aos^W11 (Lesokhin et al., 1999) Egfr^E3/Egfr^E1 has visible phenotype, suppressible by N^l1N-ts1 (Lesokhin et al., 1999)
NOT suppressed by
Statement Reference Egfr^E1 has visible \| dominant phenotype, non-suppressible by cora⁹ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, non-suppressible by cora¹¹ (Lamb et al., 1998) Egfr^E1 has visible \| dominant phenotype, non-suppressible by crb^j1B5/crb[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by Csk^j1D8/Csk[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by CycA^S054513/CycA[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by Dl^S049520/Dl[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by drk[+]/drk¹⁰⁶²⁶ (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by drk[+]/drk^k13809 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by ebi[+]/ebi^k16213 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)06906[+]/l(3)06906⁰⁶⁹⁰⁶ (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)j4B9^j4B9/l(3)j4B9[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)j5B6^j5B6/l(3)j5B6[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S000710[+]/l(3)S000710^S000710 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S000718[+]/l(3)S000718^S000718 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S009515[+]/l(3)S009515^S009515 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S012805^S012805/l(3)S012805[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S016805[+]/l(3)S016805^S016805 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S019203^S141715/l(3)S019203[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S023549^S023549/l(3)S023549[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S023549^S090101/l(3)S023549[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S023708[+]/l(3)S023708^S023708 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S023901[+]/l(3)S023901^S023901 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S024329^S024329/l(3)S024329[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S024833[+]/l(3)S024833^S024833 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S026238^S026238/l(3)S026238[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S026421^S026421/l(3)S026421[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S046604^S046604/l(3)S046604[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S056113[+]/l(3)S056113^S056113 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S066607[+]/l(3)S066607^S066607 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S068808^S068808/l(3)S068808[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S081003^S145911/l(3)S081003[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S090114[+]/l(3)S090114^S090114 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S092708[+]/l(3)S092708^S092708 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S133117[+]/l(3)S133117^S133117 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S135703^S135703/l(3)S135703[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by l(3)S142909^S142909/l(3)S142909[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by Mi-2^S005504/Mi-2[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by Mi-2^S147412/Mi-2[+] (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by neur[+]/neur^j6B12 (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by Sin3A[+]/Sin3A⁰⁸²⁶⁹ (Read et al., 2005) Egfr^E1 has visible \| dominant phenotype, non-suppressible by stg^S024503/stg[+] (Read et al., 2005) Egfr^E1 has visible phenotype, non-suppressible by msk⁴ (Baker et al., 2002) Egfr^E1 has visible phenotype, non-suppressible by msk⁵ (Baker et al., 2002)
Enhancer of
Statement Reference Egfr[+]/Egfr^E1 is an enhancer of visible \| heat sensitive phenotype of H^C2.hs (Johannes and Preiss, 2002) Egfr[+]/Egfr^E1 is an enhancer of visible phenotype of Pi3K68D^{KD.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^69B (MacDougall et al., 2004) Egfr^E1 is an enhancer of visible phenotype of BacA\p35^GMR.PH, Dp^GMR.PD, E2f^GMR.PD (Staehling-Hampton et al., 1999)
NOT Enhancer of
Statement Reference Egfr^E1 is a non-enhancer of visible phenotype of os^GMR.PB (Bach et al., 2003)
Suppressor of
Statement Reference Egfr[+]/Egfr^E1 is a suppressor of visible phenotype of rg^γ6 (Shamloula et al., 2002)
NOT Suppressor of
Statement Reference Egfr^E1 is a non-suppressor of visible phenotype of os^GMR.PB (Bach et al., 2003)
Other
Statement Reference Egfr[+]/Egfr^E1, Pi3K68D^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^69B has visible phenotype (MacDougall et al., 2004)
Phenotype Manifest In
Enhanced by
Statement Reference Egfr^E1 has eye phenotype, enhanceable by ast^K6/ast[+] (Kotarski et al., 1998) Egfr^E1 has eye phenotype, enhanceable by Df(2L)ast2 (Kolodkin et al., 1994) Egfr^E1 has eye phenotype, enhanceable by Dhc64C[+]/Dhc64C^8-1 (Iyadurai et al., 2008) Egfr^E1 has eye phenotype, enhanceable by Dhc64C^1-1 (Iyadurai et al., 2008) Egfr^E1 has eye phenotype, enhanceable by Dhc64C^4-19 (Iyadurai et al., 2008) Egfr^E1 has eye phenotype, enhanceable by Dhc64C^6-6 (Iyadurai et al., 2008) Egfr^E1 has eye phenotype, enhanceable by Dhc64C^6-10 (Iyadurai et al., 2008) Egfr^E1 has eye phenotype, enhanceable by ed[+]/ed^k01102 (Spencer and Cagan, 2003) Egfr^E1 has eye phenotype, enhanceable by ed^1X5 (Hsu et al., 1998) Egfr^E1 has eye phenotype, enhanceable by Gl[+]/Gl¹ (Iyadurai et al., 2008) Egfr^E1 has eye phenotype, enhanceable by hh[+]/hh^rJ413 (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by kek1^unspecified/kek1^unspecified (Ghiglione et al., 2003) Egfr^E1 has eye phenotype, enhanceable by l(3)06803[+]/l(3)06803⁰⁶⁸⁰³ (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by l(3)S001405^S001405/l(3)S001405[+] (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by l(3)S003704^S003704/l(3)S003704[+] (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by l(3)S057101[+]/l(3)S057101^S057101 (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by Mi-2^S047526/Mi-2[+] (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by msn[+]/msn^j1E2 (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by Pp1-87B[+]/Pp1-87B^j6E7 (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by px[+]/px^k08316 (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by rl[+]/rl^Sem (Brunner et al., 1994) Egfr^E1 has eye phenotype, enhanceable by S[+]/S¹ (Kolodkin et al., 1994) Egfr^E1 has eye phenotype, enhanceable by S[+]/S^k09538a (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by scrib[+]/scrib^j7B3 (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by spi^s3547/spi[+] (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by tws^S049902/tws[+] (Read et al., 2005) Egfr^E1 has eye phenotype, enhanceable by vn[+]/vn^unspecified (Spencer et al., 1998) Egfr^E1 has ommatidium phenotype, enhanceable by aop[+]/aop¹ (Rogge et al., 1995) Egfr^E1 has ommatidium phenotype, enhanceable by aop[+]/aop² (Rogge et al., 1995) Egfr^E1 has ommatidium phenotype, enhanceable by aop[+]/aop^e2d (Rogge et al., 1995) Egfr^E1 has ommatidium phenotype, enhanceable by ast^K6/ast[+] (Kotarski et al., 1998) Egfr^E1 has ommatidium phenotype, enhanceable by kek1^unspecified/kek1^unspecified (Ghiglione et al., 2003) Egfr^E1 has phenotype, enhanceable by lilli^s35 (Tang et al., 2001) Egfr^E1 has phenotype, enhanceable by lilli^XS407 (Tang et al., 2001) Egfr^E1 has phenotype, enhanceable by lilli^XS575 (Tang et al., 2001) Egfr^E1 has phenotype, enhanceable by spi¹ (Tio et al., 1994) Egfr^E1 has phenotype, enhanceable by spi^SC1 (Tio et al., 1994) Egfr^E1 has phenotype, enhanceable by spi^SC2 (Tio et al., 1994) Egfr^E1 has phenotype, enhanceable by spi^SC3 (Tio et al., 1994) Egfr^E1 has wing vein \| ectopic phenotype, enhanceable by kek1^unspecified/kek1^unspecified (Ghiglione et al., 2003) Egfr^E1 has wing vein \| ectopic phenotype, enhanceable by rl^Sem (Brunner et al., 1994) Egfr^E1 has wing vein \| ectopic phenotype, enhanceable by Scer\GAL4^Act5C.PU/CG4096^KK108644 (Butchar et al., 2012) Egfr^E3/Egfr^E1 has wing phenotype, enhanceable by aos^W11 (Lesokhin et al., 1999) Egfr^E3/Egfr^E1 has wing vein \| ectopic phenotype, enhanceable by aos^W11 (Lesokhin et al., 1999)
NOT Enhanced by
Statement Reference Egfr^E1 has eye phenotype, non-enhanceable by crb^j1B5/crb[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by Csk^j1D8/Csk[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by CycA^S054513/CycA[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by Dl^S049520/Dl[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by drk[+]/drk¹⁰⁶²⁶ (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by drk[+]/drk^k13809 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by ebi[+]/ebi^k16213 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)06906[+]/l(3)06906⁰⁶⁹⁰⁶ (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)j4B9^j4B9/l(3)j4B9[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)j5B6^j5B6/l(3)j5B6[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S000710[+]/l(3)S000710^S000710 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S000718[+]/l(3)S000718^S000718 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S009515[+]/l(3)S009515^S009515 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S012805^S012805/l(3)S012805[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S016805[+]/l(3)S016805^S016805 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S019203^S141715/l(3)S019203[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S023549^S023549/l(3)S023549[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S023549^S090101/l(3)S023549[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S023708[+]/l(3)S023708^S023708 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S023901[+]/l(3)S023901^S023901 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S024329^S024329/l(3)S024329[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S024833[+]/l(3)S024833^S024833 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S026238^S026238/l(3)S026238[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S026421^S026421/l(3)S026421[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S046604^S046604/l(3)S046604[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S056113[+]/l(3)S056113^S056113 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S066607[+]/l(3)S066607^S066607 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S068808^S068808/l(3)S068808[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S081003^S145911/l(3)S081003[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S090114[+]/l(3)S090114^S090114 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S092708[+]/l(3)S092708^S092708 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S133117[+]/l(3)S133117^S133117 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S135703^S135703/l(3)S135703[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by l(3)S142909^S142909/l(3)S142909[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by Mi-2^S005504/Mi-2[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by Mi-2^S147412/Mi-2[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by neur[+]/neur^j6B12 (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by Sin3A[+]/Sin3A⁰⁸²⁶⁹ (Read et al., 2005) Egfr^E1 has eye phenotype, non-enhanceable by stg^S024503/stg[+] (Read et al., 2005)
Suppressed by
Statement Reference Egfr^E1 has eye phenotype, suppressible \| partially by cora[+]/cora¹ (Fehon et al., 1994) Egfr^E1 has eye phenotype, suppressible \| partially by Scer\GAL4^ey.PB/sens^Scer\UAS.cNa (Frankfort and Mardon, 2004) Egfr^E1 has eye phenotype, suppressible by Acn²⁷/Acn[+] (Haberman et al., 2010) Egfr^E1 has eye phenotype, suppressible by bon^S048706/bon[+] (Read et al., 2005) Egfr^E1 has eye phenotype, suppressible by cora¹ (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora² (Fehon et al., 1994, Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora³ (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora⁴ (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora⁵ (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora⁶ (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora⁷ (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora⁸ (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora¹⁰ (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora¹² (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora¹³ (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora¹⁴ (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by cora¹⁵ (Lamb et al., 1998) Egfr^E1 has eye phenotype, suppressible by drk^k02401/drk[+] (Read et al., 2005) Egfr^E1 has eye phenotype, suppressible by l(3)j2D5^j2D5/l(3)j2D5[+] (Read et al., 2005) Egfr^E1 has eye phenotype, suppressible by Ras85D[+]/Ras85D^Sutor-404 (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Ras85D^Sutor-341/Ras85D[+] (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Sos[+]/Sos^Sutor-157 (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Sos^Sutor-405/Sos[+] (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Su(tor)1-1[+]/Su(tor)1-1¹³⁴ (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Su(tor)1-1¹⁹/Su(tor)1-1[+] (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Su(tor)2-3[+]/Su(tor)2-3¹ (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Su(tor)2-3[+]/Su(tor)2-3³⁶¹ (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Su(tor)2-180[+]/Su(tor)2-180¹ (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Su(tor)2-237¹/Su(tor)2-237[+] (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Su(tor)2-278[+]/Su(tor)2-278¹ (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Su(tor)2-321[+]/Su(tor)2-321¹ (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Su(tor)2-408¹/Su(tor)2-408[+] (Doyle and Bishop, 1993) Egfr^E1 has eye phenotype, suppressible by Su(tor)3-1[+]/Su(tor)3-1³⁸ (Doyle and Bishop, 1993) Egfr^E1 has ommatidium phenotype, suppressible \| partially by Scer\GAL4^ey.PB/sens^Scer\UAS.cNa (Frankfort and Mardon, 2004) Egfr^E1 has ommatidium phenotype, suppressible by klu[+]/klu^unspecified (Rusconi et al., 2004) Egfr^E1 has phenotype, suppressible by Sos^eCN6 (Verheyen et al., 1996) Egfr^E1 has phenotype, suppressible by Sos^eCS3 (Verheyen et al., 1996) Egfr^E1 has phenotype, suppressible by Sos^eDN4 (Verheyen et al., 1996) Egfr^E1 has phenotype, suppressible by Sos^eJ2 (Verheyen et al., 1996) Egfr^E1 has phenotype, suppressible by Sos^eN6 (Verheyen et al., 1996) Egfr^E1 has photoreceptor cell R7 of yellow ommatidium phenotype, suppressible by sev¹⁴/sev¹⁴ (Birkholz et al., 2009) Egfr^E1 has photoreceptor cell R8 of pale ommatidium phenotype, suppressible by sev¹⁴/sev¹⁴ (Birkholz et al., 2009) Egfr^E1 has wing vein \| ectopic phenotype, suppressible by mago¹/mago[+] (Ashton-Beaucage et al., 2010) Egfr^E1 has wing vein \| ectopic phenotype, suppressible by phl^unspecified (Li and Li, 2003) Egfr^E1 has wing vein \| ectopic phenotype, suppressible by Ras85D[+]/Ras85D^unspecified (Li and Li, 2003) Egfr^E1 has wing vein \| ectopic phenotype, suppressible by rl[+]/rl¹ (Ashton-Beaucage et al., 2010) Egfr^E1 has wing vein \| ectopic phenotype, suppressible by Scer\GAL4^Act5C.PU/Sulf1^Scer\UAS.cBa (Butchar et al., 2012) Egfr^E1 has wing vein \| ectopic phenotype, suppressible by Stat92E^unspecified/Stat92E[+] (Li and Li, 2003) Egfr^E1 has wing vein L2 phenotype, suppressible by Gl[+]/Gl¹ (Iyadurai et al., 2008) Egfr^E3/Egfr^E1 has eye phenotype, suppressible by aos^W11 (Lesokhin et al., 1999) Egfr^E3/Egfr^E1 has eye phenotype, suppressible by N^l1N-ts1 (Lesokhin et al., 1999)
NOT suppressed by
Statement Reference Egfr^E1 has eye phenotype, non-suppressible by cora⁹ (Lamb et al., 1998) Egfr^E1 has eye phenotype, non-suppressible by cora¹¹ (Lamb et al., 1998) Egfr^E1 has eye phenotype, non-suppressible by crb^j1B5/crb[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by Csk^j1D8/Csk[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by CycA^S054513/CycA[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by Dl^S049520/Dl[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by drk[+]/drk¹⁰⁶²⁶ (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by drk[+]/drk^k13809 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by ebi[+]/ebi^k16213 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)06906[+]/l(3)06906⁰⁶⁹⁰⁶ (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)j4B9^j4B9/l(3)j4B9[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)j5B6^j5B6/l(3)j5B6[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S000710[+]/l(3)S000710^S000710 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S000718[+]/l(3)S000718^S000718 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S009515[+]/l(3)S009515^S009515 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S012805^S012805/l(3)S012805[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S016805[+]/l(3)S016805^S016805 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S019203^S141715/l(3)S019203[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S023549^S023549/l(3)S023549[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S023549^S090101/l(3)S023549[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S023708[+]/l(3)S023708^S023708 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S023901[+]/l(3)S023901^S023901 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S024329^S024329/l(3)S024329[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S024833[+]/l(3)S024833^S024833 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S026238^S026238/l(3)S026238[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S026421^S026421/l(3)S026421[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S046604^S046604/l(3)S046604[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S056113[+]/l(3)S056113^S056113 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S066607[+]/l(3)S066607^S066607 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S068808^S068808/l(3)S068808[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S081003^S145911/l(3)S081003[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S090114[+]/l(3)S090114^S090114 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S092708[+]/l(3)S092708^S092708 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S133117[+]/l(3)S133117^S133117 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S135703^S135703/l(3)S135703[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by l(3)S142909^S142909/l(3)S142909[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by Mi-2^S005504/Mi-2[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by Mi-2^S147412/Mi-2[+] (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by neur[+]/neur^j6B12 (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by Sin3A[+]/Sin3A⁰⁸²⁶⁹ (Read et al., 2005) Egfr^E1 has eye phenotype, non-suppressible by stg^S024503/stg[+] (Read et al., 2005) Egfr^E1 has photoreceptor cell R8 of pale ommatidium phenotype, non-suppressible \| somatic clone by rho^PΔ5/rho^PΔ5 (Birkholz et al., 2009) Egfr^E1 has wing phenotype, non-suppressible by p38b^DN.Scer\UAS/Scer\GAL4^unspecified (Adachi-Yamada et al., 1999) Egfr^E1 has wing vein \| ectopic phenotype, non-suppressible by Mad[+]/Mad^unspecified (Li and Li, 2003) Egfr^E1 has wing vein \| ectopic phenotype, non-suppressible by msk⁴ (Baker et al., 2002) Egfr^E1 has wing vein \| ectopic phenotype, non-suppressible by msk⁵ (Baker et al., 2002) Egfr^E1 has wing vein \| ectopic phenotype, non-suppressible by tkv^unspecified/tkv[+] (Li and Li, 2003) Egfr^E1 has wing vein phenotype, non-suppressible by Ero1L[+]/Ero1L^23T (Tien et al., 2008)
Enhancer of
Statement Reference Egfr[+]/Egfr^E1 is an enhancer of eye phenotype of S¹ (Kolodkin et al., 1994) Egfr[+]/Egfr^E1 is an enhancer of wing \| heat sensitive phenotype of H^C2.hs (Johannes and Preiss, 2002) Egfr[+]/Egfr^E1 is an enhancer of wing vein \| ectopic \| heat sensitive phenotype of H^C2.hs (Johannes and Preiss, 2002) Egfr[+]/Egfr^E1 is an enhancer of wing vein \| ectopic phenotype of Adv¹ (Srivastava et al., 2002) Egfr[+]/Egfr^E1 is an enhancer of wing vein \| ectopic phenotype of Pi3K68D^{KD.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^69B (MacDougall et al., 2004) Egfr[+]/Egfr^E1 is an enhancer of wing vein \| ectopic phenotype of Snr1^E1 (Marenda et al., 2004) Egfr[+]/Egfr^E1 is an enhancer of wing vein L1 phenotype of Adv¹ (Srivastava et al., 2002) Egfr[+]/Egfr^E1 is an enhancer of wing vein L2 phenotype of Adv¹ (Srivastava et al., 2002)
NOT Enhancer of
Statement Reference Egfr^E1 is a non-enhancer of eye phenotype of os^GMR.PB (Bach et al., 2003) Egfr^E1 is a non-enhancer of phenotype of Doa^HD/Doa^Dem (Yun et al., 2000) Egfr^E1 is a non-enhancer of phenotype of Rho1^rev220 (Magie et al., 1999)
Suppressor of
Statement Reference Egfr[+]/Egfr^E1 is a suppressor of eye phenotype of rg^γ6 (Shamloula et al., 2002) Egfr^E1 is a suppressor of eye phenotype of W^GMR.PG/W^GMR.PG (Bergmann et al., 1998) Egfr^E1 is a suppressor of ommatidium phenotype of W^GMR.PG/W^GMR.PG (Bergmann et al., 1998) Egfr^E1 is a suppressor of phenotype of vn^ddd-13 (Schnepp et al., 1996) Egfr^E1 is a suppressor of phenotype of vn^L6 (Schnepp et al., 1996)
NOT Suppressor of
Statement Reference Egfr^E1 is a non-suppressor of eye phenotype of os^GMR.PB (Bach et al., 2003) Egfr^E1 is a non-suppressor of phenotype of Doa^HD/Doa^Dem (Yun et al., 2000) Egfr^E1 is a non-suppressor of phenotype of Rho1^rev220 (Magie et al., 1999)
Other
Statement Reference Df(3R)P14/14-3-3ε^j2B10, Egfr^E1 has photoreceptor cell R8 phenotype (Chen and Chien, 1999, Chen and Chien, 1999) Egfr[+]/Egfr^E1, Pi3K68D^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^69B has anterior crossvein phenotype (MacDougall et al., 2004) Egfr[+]/Egfr^E1, Pi3K68D^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^69B has posterior crossvein phenotype (MacDougall et al., 2004) Egfr[+]/Egfr^E1, sens^E2 has eye \| somatic clone phenotype (Frankfort and Mardon, 2004) Egfr[+]/Egfr^E1, sens^E2 has ommatidium \| somatic clone phenotype (Frankfort and Mardon, 2004) Egfr^E1, sens^E2 has eye \| somatic clone phenotype (Frankfort and Mardon, 2004) Egfr^E1, sens^E2 has eye phenotype (Frankfort and Mardon, 2004, Frankfort and Mardon, 2004) Egfr^E1, sens^E2 has ommatidium \| somatic clone phenotype (Frankfort and Mardon, 2004) Egfr^E1, sens^E2 has ommatidium phenotype (Frankfort and Mardon, 2004, Frankfort and Mardon, 2004)
Additional Comments
Genetic Interactions
Statement Reference Expression of CG4096[KK108644] under the control of Scer\GAL4[Act5C.PU] enhances the extra wing vein phenotype of Egfr[E1] flies. Expression of Sulf1[Scer\UAS.cBa] under the control of Scer\GAL4[Act5C.PU] suppresses the extra wing vein phenotype of Egfr[E1] flies. (Butchar et al., 2012) The extra wing vein phenotype seen in Egfr[E1]/+ flies is dominantly suppressed by rl[1] or mago[1]. (Ashton-Beaucage et al., 2010) The rough eye phenotype of Egfr[E1]/+ flies is suppressed by Acn[27]/+. (Haberman et al., 2010) In Egfr[E1]/+ adults, the number of ommatidia with pale-type R8 cells and yellow-type R7 cells is significantly increased. Many of these are found in pale-yellow hybrid ommatidia with a yellow-type R7 and a pale-type R8. This phenotype is suppressed by sev[14]/sev[14], but not by rho[PΔ5] homozygous somatic clones. (Birkholz et al., 2009) Dhc64C[8-1] dominantly enhances the eye phenotype of Egfr[E1]/+ flies, resulting in a reduced, narrower eye with fewer ommatidia. The abnormal broadening of wing vein L2 at the wing margin which is seen in Egfr[E1]/+ flies is suppressed by Gl[1]/+. (Iyadurai et al., 2008) An Egfr[E1] heterozygous background gives a dominant enhancement to the ato[1090]/Df(3R)p13 eye phenotype at 25[o]C. (Melicharek et al., 2008) A Ero1L[23T] heterozygous background does not affect the ectopic wing vein formation phenotype found in Egfr[E1] homozygous mutants. (Tien et al., 2008) Adult eyes containing sens^E2 homozygous somatic clones induced in an Egfr^E1/+ background are smaller than wild-type. Within the clone there are reduced numbers of ommatidia, as well as gaps of tissue between ommatidia, a phenotype similar to that seen in Egfr^E1 homozygotes. sens^Scer\UAS.cNa; Scer\GAL4^ey.PB partially rescues eye size and ommatidial number, and completely suppresses the formation of undifferentiated regions in Egfr^E1 homozygous adult eyes. (Frankfort and Mardon, 2004) Egfr[E1]/+ enhances the formation of an ectopic crossvein in flies expressing Pi3K68D[KD.Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[69B] at 25[o]C. Flies expressing Pi3K68D[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[69B] in a Egfr[E1]/+ background at 25[o]C show loss of the anterior and partial loss of the posterior crossvein. (MacDougall et al., 2004) klu^unspecified/+ suppresses the rough eye phenotype seen in Egfr^E1 adults. (Rusconi et al., 2004) The rough eye phenotype of Egfr^E1/+ flies is strongly enhanced by homozygosity for kek1^unspecified. These flies also have small eyes and more extra vein material than Egfr^E1/+ flies. (Ghiglione et al., 2003) ed^k01102/+ strongly enhances the Egfr^E1/+ phenotype, resulting in eyes that are approximately 1/3 the size of those of Egfr^E1/+ flies. (Spencer and Cagan, 2003) Egfr^E1/+ flies carrying Pp2B-14D^act.GMR and CanB^GMR.PS have a rough eye phenotype similar to that caused by Pp2B-14D^act.GMR and CanB^GMR.PS in an Egfr⁺ background. (Sullivan and Rubin, 2002) The number of ommatidia in the eyes of Egfr^E1/Egfr^E3 adults is not altered if the flies are also expressing BacA\p35^GMR.PH, but the number of pigment cells is increased in these animals. (Yu et al., 2002) Expression of p38b^DN.Scer\UAS under the control of Scer\GAL4^unspecified has no significant effect on the wing phenotype caused by Egfr^E1. (Adachi-Yamada et al., 1999) R8 photoreceptor cells fail to form in Egfr^E1/+ ; 14-3-3ε^j2B10/Df(3R)P14 eye discs. (Chen and Chien, 1999) argos^W11 enhances the extra wing vein phenotype of Egfr^E1/Egfr^E3 transheterozygotes but suppresses the eye phenotype. N^l1N-ts1 also suppresses the eye phenotype of Egfr^E1/Egfr^E3. (Lesokhin et al., 1999) Enhances the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies. (Staehling-Hampton et al., 1999) The eye phenotype of Egfr^E1 heterozygotes is dominantly enhanced by ast^K6. (Kotarski et al., 1998) The Egfr^E1/+ rough eye phenotype is completely suppressed by cora¹² or cora¹⁵. The Egfr^E1/+ phenotype is partially suppressed by cora¹, cora² or cora¹³; the eye is wild type in size with some roughening. The Egfr^E1/+ phenotype is partially suppressed by cora⁴, cora⁵, cora⁶ or cora¹⁴; the eye is smaller than wild type with some roughening. The Egfr^E1/+ rough eye phenotype is slightly suppressed by cora³, cora⁷, cora⁸ or cora¹⁰. The Egfr^E1/+ rough eye phenotype is not dominantly suppressed by cora⁹ or cora¹¹. (Lamb et al., 1998) The Egfr^E1/+ rough eye phenotype is strongly dominantly enhanced by vn^unspecified. (Spencer et al., 1998) Suppresses the viability of vn^ddd-13, the proliferation defects in vn^L6 and (partially) the small disc phenotype of vn^γ4. (Schnepp et al., 1996) Introduction of one copy of aop^e2d significantly enhances the Egfr^E1/+ phenotype, eyes are severely defective, reduced in size and very rough. aop¹ and aop² give a similar enhancement of the mutant eye phenotype. (Rogge et al., 1995) The heterozygous extra wing vein phenotype is enhanced when transheterozygous with rl^Sem. Flies heterozygous for Egfr^E1 and rl^Sem have smaller eyes than Egfr^E1 heterozygotes alone. (Brunner et al., 1994) Eye of double heterozygotes with S¹ are dramatically reduced with respect to those of either heterozygote alone. When heterozygous for Df(2L)ast2 (removing S and ast) the reduced phenotype becomes much more pronounced. (Kolodkin et al., 1994) Eye phenotype can be suppressed by mutations of spi. (Tio et al., 1994) Phenotype is suppressed by loss of function Sos alleles but enhanced by Sos^JC2. (Rogge et al., 1991)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 12 )
Bloomington	1564 nw^D Pu² Egfr^E1 Pin^Yt/SM1 5144 P{GawB}elav^C155 w^* P{neoFRT}19A; Bc¹ Egfr^E1/CyO 90 Df(2L)C144, dpp^d-ho ed¹/In(2LR)Gla, wg^Gla-1 Bc¹ Egfr^E1 4521 Dp(2;2)Cam5, bw¹ sp¹/In(2LR)Gla, wg^Gla-1 Bc¹ Egfr^E1 ap^* cn¹ bw¹ 8484 y¹ w^67c23; Egfr^E1/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7; Ki¹/TM3, P{GAL4-Kr.C}DC2, P{UAS-GFP.S65T}DC10, Sb¹ 5899 b¹ l(2)42Cd⁴⁴⁷ pr¹ cn¹ bw¹/In(2LR)Gla, wg^Gla-1 Bc¹ Egfr^E1 ap^* cn¹ bw¹
Kyoto	106389 nw^D Pu² Egfr^E1 Pin^Yt/SM1 106658 y¹ w^; CyO, H{PDelta2-3}HoP2.1/Bc¹ Egfr^E1 108075 P{GawB}elav^C155 w^ P{neoFRT}19A; Bc¹ Egfr^E1/CyO 103265 Df(2L)C144, dpp^d-ho ed¹ / wg^Gla-1 Bc¹ Egfr^E1 108889 Df(2L)C144, dpp^d-ho ed¹/In(2LR)Gla, wg^Gla-1 Bc¹ Egfr^E1 107775 Dp(2;2)Cam5, bw¹ sp¹/In(2LR)Gla, wg^Gla-1 Bc¹ Egfr^E1 ap^* cn¹ bw¹
Notes on Origin
Discoverer	E.H. Grell, Feb. 1957.

Comments
	Phenotype is highly sensitive to the wild-type genetic background. (Polaczyk et al., 1998) Rough eye phenotype is dominantly suppressed by cora¹ and cora². (Fehon et al., 1994) Mutations in S suppress the formation of ectopic wing veins in Egfr^E1 flies, but enhance the mutant phenotype in the eye. (Heberlein et al., 1993)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	dEGFR^Elp (Read et al., 2005, Rusconi et al., 2004) DER^E1 (Polaczyk et al., 1998) DER^Elp1 (Schnepp et al., 1996, Brunner et al., 1994) DER^Elp (Spencer et al., 1998) EGFR^E1 (Doronkin et al., 2002) egfr^E1 (Yu et al., 2002) Egfr^E1 (Goering and Gibson, 2005, Birkholz et al., 2009, Oishi et al., 2009, Wang et al., 2008, Haberman et al., 2010, Assaker et al., 2010, Melicharek et al., 2008, Oishi et al., 2006) Egfr^E (Rogge et al., 1995, Lindsley and Zimm, 1992) Egfr^Ellipse (Spencer and Cagan, 2003) Egfr^Elp1 (Kumar et al., 1998) egfr^Elp (Frankfort and Mardon, 2004) Egfr^Elp (Li and Li, 2003, Johannes and Preiss, 2002, Lamb et al., 1998, Kolodkin et al., 1994, Heberlein et al., 1993, Butchar et al., 2012, Fetting et al., 2009, Ashton-Beaucage et al., 2010) Egf-r^Elp (Sturtevant et al., 1993) EGFR^ElpE1 (MacDougall et al., 2004) Ellipse¹ (Ghiglione et al., 2003, Dworkin et al., 2003, Moses and Rubin, 1991) Elp (Tien et al., 2008, Shamloula et al., 2002, Fehon et al., 1994, Doyle and Bishop, 1993, Baker et al., 1990) Elp¹ (Garcia-Alonso et al., 2000, Kumar and Moses, 2000, Chen and Chien, 1999, Adachi-Yamada et al., 1999, Lesokhin et al., 1999, Lim et al., 1997, Schweitzer et al., 1995, Baker and Zitron, 1995, Baker and Rubin, 1992, Rogge et al., 1991, Diaz-Benjumea and Garcia-Bellido, 1990, Baker and Rubin, 1989, Almudi et al., 2009, Iyadurai et al., 2008) Elp^E1 (Bergmann et al., 1998)
Name Synonym	Ellipse (Frankfort and Mardon, 2002, Garcia-Alonso, 1999, Gallio et al., 1999, Kumar and Moses, 1998, Lamb and Fehon, 1997, Moses et al., 1997, Bach et al., 2003, Baker et al., 2002, Shamloula et al., 2002, Tang et al., 2001, Hsu et al., 1998, Verheyen et al., 1996, Rogge et al., 1995, Doberstein et al., 1995, Raz et al., 1991, ) Elp (Yun et al., 2000, Vosshall and Young, 1995, Jarman et al., 1995)
Secondary FlyBase IDs

References ( 82 )

Generate a list of	All references relating to this allele ( 82 )

List References by type	Research paper ( 71 ) Review ( 2 ) Abstract ( 8 ) Book ( 1 )
Recent research papers ( 1 )
	Butchar et al., 2012, Genetics 191(4): 1213--1226 New negative feedback regulators of egfr signaling in Drosophila. [FBrf0219175] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\EgfrE1

Allele Dmel\Egfr^E1