Allele Dmel\Egfr^E3

General Information
Symbol	Dmel\Egfr^E3	Species	D. melanogaster
Name		FlyBase ID	FBal0003528
Feature type	allele	Associated gene	Dmel\Egfr
Also Known As	Elp^B1, Egfr^ElpB1, DER^elpB1, Egfr^EB1

Map ( GBrowse )
Allele class	hypermorphic allele - genetic evidence, gain of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
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Nature of the Allele
Allele class	gain of function allele (Brunner et al., 1994, Stemerdink and Jacobs, 1997, Weber et al., 2003) hypermorphic allele - genetic evidence (Baker et al., 1992, Xu and Rubin, 1993, Mardon et al., 1994, )
Mutagen	ethyl methanesulfonate (Baker and Rubin, 1989)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:17,410,636..17,410,636 evidence=experimental na_change=T17410636C pr_change=W15R\|Egfr-PA reported_na_change=T43C reported_pr_change=W15R comment=One of three nucleotide substitutions affecting the amino acid sequence in the Egfr^E3 mutant relative to the reference sequence. (Lesokhin et al., 1999) point mutation 2R:17,445,112..17,445,112 evidence=experimental na_change=G17445112A pr_change=A887T\|Egfr-PA,A936T\|Egfr-PB reported_na_change=G3165A reported_pr_change=A887T comment=One of three nucleotide substitutions affecting the amino acid sequence in the Egfr^E3 mutant relative to the reference sequence. (Lesokhin et al., 1999) point mutation 2R:17,410,663..17,410,663 evidence=experimental na_change=C17410663G pr_change=L24V\|Egfr-PA reported_na_change=C70G reported_pr_change=L24V comment=One of three nucleotide substitutions affecting the amino acid sequence in the Egfr^E3 mutant relative to the reference sequence. (Lesokhin et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AF109079 AAD26130 AF109079 AAD26131 AF109081 AF109083

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: W15R. Amino acid replacement: L24V. Amino acid replacement: A887T. Figure 1 and the text concerning this allele are at odds - the text is correct (note from N. Baker). (Lesokhin et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Diaz-Benjumea and Garcia-Bellido, 1990) viable \| poor (Luschnig et al., 2000) visible (Baker et al., 1992, Baker and Rubin, 1989, Baker and Yu, 2001, Friedman and Perrimon, 2006) visible (with Egfr^E1) (Lesokhin et al., 1999) visible \| dominant (Bai et al., 2001, Brunner et al., 1994, Baker and Rubin, 1992, Mardon et al., 1994, Ciapponi et al., 2001, Freeman, 1994, Herr et al., 2010) visible \| semidominant (Luschnig et al., 2000)
Phenotype Manifest In
	crossvein \| supernumerary (Weber et al., 2003) crossvein \| supernumerary (with Df(3L)Ar14-8) (Weber et al., 2003) crossvein \| supernumerary (with Egfr^t1) (Weber et al., 2003) eye (Baker et al., 1992, Bai et al., 2001, Zak and Shilo, 1992, Brunner et al., 1994, Baker and Rubin, 1992, Mardon et al., 1994, Ciapponi et al., 2001, Weber et al., 2003, Luschnig et al., 2000, Freeman, 1994, Herr et al., 2010) eye (with Egfr^E1) (Lesokhin et al., 1999) eye disc (Baker et al., 1992, Baker and Yu, 2001) eye disc & mitotic cell cycle (Baker and Yu, 2001) eye photoreceptor cell (Lim et al., 1997, Weber et al., 2003) macrochaeta (Diaz-Benjumea and Hafen, 1994) midline glial cell (Stemerdink and Jacobs, 1997) ommatidium (Baker and Rubin, 1989, Baker et al., 1992, Baker and Zitron, 1995, Kunes et al., 1993, Luschnig et al., 2000, Baker and Yu, 2001, Freeman, 1994) wing (Baker and Rubin, 1992, Kockel et al., 1997, Luschnig et al., 2000) wing (with Egfr^E1) (Lesokhin et al., 1999) wing \| ectopic (Ciapponi et al., 2001) wing vein (Baker and Rubin, 1989, Baker and Rubin, 1992, Diaz-Benjumea and Hafen, 1994) wing vein \| ectopic (Morey et al., 2001, Brunner et al., 1994, Diaz-Benjumea and Hafen, 1994, Luschnig et al., 2000, Friedman and Perrimon, 2006, Vaccari et al., 2009) wing vein \| ectopic (with Egfr^E1) (Lesokhin et al., 1999) wing vein \| supernumerary (Bai et al., 2001) wing vein L2 (Angulo et al., 2004)
Detailed Description
	Statement Reference Egfr[E3]/+ produces a small rough eye phenotype compared with wild-type. (Herr et al., 2010) Adult wings carrying Egfr[E3] mutations exhibit extra wing veins. (Vaccari et al., 2009) Egfr[E3]/+ adults have extra vein tissue at the distal end of L2. (Angulo et al., 2004) Egfr^E3/+ mutants have eyes that are reduced in size with fewer photoreceptors than wild type. Additionally these mutants have, on average, more than two extra crossveins at the tip of L2 in the wing. Egfr^E3/Egfr^t1 transheterozygotes show a less severe wing phenotype, with the majority of flies exhibiting either no, or one extra crossvein. This phenotype is reduced further in Egfr^E3/Egfr^top-18A transheterozygotes, with the vast majority of flies showing no extra crossveins. Flies that are Egfr^E3/+ and also carry the deficiency Df(3L)Ar14-8 have a slightly reduced wing phenotype, with a quarter of flies exhibiting no extra crossveins, while a quarter of these flies still exhibit more than two extra crossveins in the wing. (Weber et al., 2003) Eye of Egfr^E3/+ heterozygotes is rough. Extra wing veins form. (Bai et al., 2001) Few ommatidia are seen in homozygous eye discs, in a background of G2-arrested cells. Some mitotic cells are seen adjacent to differentiating ommatidia. Apoptotic cells are seen in columns 7-15 of the developing eye disc. (Baker and Yu, 2001) Mutant flies develop wing with ectopic wing material. Egfr^E3 dominantly causes an abnormal eye phenotype. The eye is rough lacking the occasional outer photoreceptor. (Ciapponi et al., 2001) Heterozygous mutant wings have ectopic wing vein material. (Morey et al., 2001) Heterozygous mutants do not cause any defects in the ocellar sensory system (OSS) neurogenesis or axon guidance. (Garcia-Alonso et al., 2000) Heterozygous flies have rough eyes and show a slight overproduction of wing vein material. The eyes of homozygotes are severely reduced in size and contain very few ommatidia. Homozygotes are poorly viable. (Luschnig et al., 2000) Heterozygotes occasionally lack some outer photoreceptor cells. This phenotype is not significantly altered if the flies are also homozygous for Dsor1^Su1 or Dsor1^Su7. (Lim et al., 1997) Homozygous embryos have slightly more midline glia cells than normal, at least until stage 15. Homozygous first instar larvae have a normal number of midline glia. (Stemerdink and Jacobs, 1997) Homozygous flies have a few, widely separated ommatidia. Each ommatidium contains a single R8 cell, as in wild-type flies, and this phenotype is not altered in sca^WB1/sca^OB7 Egfr^E3/Egfr^E1 double homozygotes. (Baker and Zitron, 1995) Extra wing veins close to the wing margin. (Brunner et al., 1994) Clonal analysis reveals phenotypes in the adult including loss of wing vein, ectopic wing vein, reduced cell size, extra bristles, cell lethality and tergite bristle abnormalities. Phenotype is cell autonomous. rl¹/Df(2R)rl10a suppresses the wing phenotype of Egfr^E3. (Diaz-Benjumea and Hafen, 1994) Rough eye phenotype, which is characterised by disorganised ommatidia and reduction in the size of the eye. (Freeman, 1994) Eyes are reduced and roughened. (Mardon et al., 1994) Eyes contain only 10% of normal ommatidial complement. This is first evident in the imaginal disc where areas of ommatidia are separated by large distances creating completely isolated groups of ommatidia. Axons from these isolated photoreceptor clusters with no near neighbours can project to the larval brain via the optic stalk. (Kunes et al., 1993) Homozygous clones in the eye disc are rescued by surrounding heterozygous or wild type cells. (Xu and Rubin, 1993) Homozygous eye discs have fewer ommatidia than wild-type. Outgrowth of photoreceptor axons is disturbed, occurring in many directions. Cell death is abundant in the region approximately corresponding to columns 10-15 in wild-type. The pattern of cell division in the eye disc is altered. In the adult eye the ommatidia are separated by numerous pigment cells and mechanosensory bristles. Wing veins show thickening and plexus formation. The eye and wing phenotype is more extreme in the homozygote than the heterozygote. Enhances the wing phenotype of Df(1)N-54l9, N^264-39, Dl^9P, and Dl^KX6 mutations, and the eye phenotype of N^spl-1. (Baker and Rubin, 1992) A morphogenetic furrow crosses the eye disc in homozygotes, but very few ommatidia form. Adults have smaller eyes than normal, with a small number of ommatidia, many of which have the normal cellular constitution. Ommatidia are separated by pigment cells and bristle organs. (Baker et al., 1992) The array of ommatidia is less regular in heterozygotes than in wild-type flies, and there is a slight disturbance in the wing vein pattern. Homozygotes have much smaller eyes than normal, containing many fewer ommatidia, and some regions lack ommatidia entirely. These regions contain cells resembling the pigment cells that normally surround each ommatidium, and also mechanosensory bristles. Most ommatidia contain the normal number and arrangement of cells. (Baker and Rubin, 1989)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Egfr^E3/Egfr^E1 has visible phenotype, enhanceable by aos^W11 (Lesokhin et al., 1999) Egfr^E3 has visible \| dominant phenotype, enhanceable by ed[+]/ed^1X5 (Bai et al., 2001) Egfr^E3 has visible \| dominant phenotype, enhanceable by ed[+]/ed^lF20 (Bai et al., 2001) Egfr^E3 has visible \| dominant phenotype, enhanceable by Gap1[+]/RasGAP1^B2 (Bai et al., 2001) Egfr^E3 has visible \| dominant phenotype, enhanceable by geminin[+]/geminin^k03202b (Herr et al., 2010) Egfr^E3 has visible \| recessive phenotype, enhanceable by emc¹/emc¹¹ (Baonza and Garcia-Bellido, 1999)
Suppressed by
Statement Reference Egfr^E3/Egfr^E1 has visible phenotype, suppressible by aos^W11 (Lesokhin et al., 1999) Egfr^E3/Egfr^E1 has visible phenotype, suppressible by N^l1N-ts1 (Lesokhin et al., 1999) Egfr^E3 has visible \| dominant phenotype, suppressible by brm[+]/brm² (Herr et al., 2010) Egfr^E3 has visible \| dominant phenotype, suppressible by brm^{K804R.T:Ivir\HA1}/brm[+] (Herr et al., 2010) Egfr^E3 has visible \| dominant phenotype, suppressible by kay² (Ciapponi et al., 2001) Egfr^E3 has visible \| recessive phenotype, suppressible by emc^D/emc^D (Baonza and Garcia-Bellido, 1999) Egfr^E3 has visible \| semidominant phenotype, suppressible by Shc^111-40/Shc[+] (Luschnig et al., 2000) Egfr^E3 has visible \| semidominant phenotype, suppressible by Shc^BG/Shc[+] (Luschnig et al., 2000) Egfr^E3 has visible phenotype, suppressible by Ppm1^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^Bx-MS1096 (Friedman and Perrimon, 2006)
NOT suppressed by
Statement Reference Egfr^E3 has visible \| dominant phenotype, non-suppressible by kay^hs.PZ/kay² (Ciapponi et al., 2001) Egfr^E3 has visible phenotype, non-suppressible by Ppm1^{D228A.Scer\UAS.T:Ivir\HA1}/Scer\GAL4^Bx-MS1096 (Friedman and Perrimon, 2006)
Enhancer of
Statement Reference Egfr^E3/Egfr[+] is an enhancer of visible phenotype of Mkp3¹/Mkp3², Scer\GAL4[-] (Rintelen et al., 2003)
Suppressor of
Statement Reference Egfr^E3/Egfr[+] is a suppressor of visible phenotype of CycE^JP (Brumby et al., 2004)
Other
Statement Reference Egfr^E3, Shc^111-40 has viable phenotype (Luschnig et al., 2000, Luschnig et al., 2000) Egfr^E3, Shc^BG has viable phenotype (Luschnig et al., 2000, Luschnig et al., 2000)
Phenotype Manifest In
Enhanced by
Statement Reference Egfr^E3/Egfr^E1 has wing phenotype, enhanceable by aos^W11 (Lesokhin et al., 1999) Egfr^E3/Egfr^E1 has wing vein \| ectopic phenotype, enhanceable by aos^W11 (Lesokhin et al., 1999) Egfr^E3 has eye phenotype, enhanceable by ed[+]/ed^1X5 (Bai et al., 2001) Egfr^E3 has eye phenotype, enhanceable by ed[+]/ed^lF20 (Bai et al., 2001) Egfr^E3 has eye phenotype, enhanceable by Gap1[+]/RasGAP1^B2 (Bai et al., 2001) Egfr^E3 has eye phenotype, enhanceable by geminin[+]/geminin^k03202b (Herr et al., 2010) Egfr^E3 has eye phenotype, enhanceable by rl[+]/rl^Sem (Brunner et al., 1994) Egfr^E3 has phenotype, enhanceable by net^unspecified/net^unspecified (Diaz-Benjumea and Garcia-Bellido, 1990) Egfr^E3 has phenotype, enhanceable by px^unspecified/px^unspecified (Diaz-Benjumea and Garcia-Bellido, 1990) Egfr^E3 has wing phenotype, enhanceable by ash2^S112411/ash2^S112411 (Angulo et al., 2004) Egfr^E3 has wing vein \| ectopic phenotype, enhanceable by rl^Sem (Brunner et al., 1994) Egfr^E3 has wing vein \| supernumerary phenotype, enhanceable by ed[+]/ed^1X5 (Bai et al., 2001) Egfr^E3 has wing vein phenotype, enhanceable by ash2^S112411/ash2^S112411 (Angulo et al., 2004) Egfr^E3 has wing vein phenotype, enhanceable by ed^1X5 (Hsu et al., 1998) Egfr^E3 has wing vein phenotype, enhanceable by emc¹/emc¹¹ (Baonza and Garcia-Bellido, 1999)
Suppressed by
Statement Reference Egfr^E3/Egfr^E1 has eye phenotype, suppressible by aos^W11 (Lesokhin et al., 1999) Egfr^E3/Egfr^E1 has eye phenotype, suppressible by N^l1N-ts1 (Lesokhin et al., 1999) Egfr^E3 has crossvein \| supernumerary phenotype, suppressible by Cct1[+]/Scer\GAL4[-]/Cct1^EP831 (Weber et al., 2003) Egfr^E3 has crossvein \| supernumerary phenotype, suppressible by Cct1¹⁶⁹¹⁹/Cct1[+] (Weber et al., 2003) Egfr^E3 has crossvein \| supernumerary phenotype, suppressible by Scer\GAL4^sd-SG29.1/Cct1^Ala.Scer\UAS (Weber et al., 2003) Egfr^E3 has eye phenotype, suppressible by brm[+]/brm² (Herr et al., 2010) Egfr^E3 has eye phenotype, suppressible by brm^{K804R.T:Ivir\HA1}/brm[+] (Herr et al., 2010) Egfr^E3 has eye phenotype, suppressible by kay² (Ciapponi et al., 2001) Egfr^E3 has eye phenotype, suppressible by Shc^111-40/Shc[+] (Luschnig et al., 2000) Egfr^E3 has eye phenotype, suppressible by Shc^BG/Shc[+] (Luschnig et al., 2000) Egfr^E3 has eye photoreceptor cell phenotype, suppressible by Cct1¹⁶⁹¹⁹/Cct1[+] (Weber et al., 2003) Egfr^E3 has phenotype, suppressible by dac^P (Mardon et al., 1994) Egfr^E3 has phenotype, suppressible by H²/H[+] (Diaz-Benjumea and Garcia-Bellido, 1990) Egfr^E3 has phenotype, suppressible by kni^unspecified/kni^unspecified (Diaz-Benjumea and Garcia-Bellido, 1990) Egfr^E3 has phenotype, suppressible by rho^unspecified/rho^unspecified (Diaz-Benjumea and Garcia-Bellido, 1990) Egfr^E3 has phenotype, suppressible by spi¹ (Freeman, 1994) Egfr^E3 has phenotype, suppressible by Vno^unspecified/Vno[+] (Diaz-Benjumea and Garcia-Bellido, 1990) Egfr^E3 has wing \| ectopic phenotype, suppressible by kay¹ (Ciapponi et al., 2001) Egfr^E3 has wing \| ectopic phenotype, suppressible by kay² (Ciapponi et al., 2001) Egfr^E3 has wing \| ectopic phenotype, suppressible by Scer\GAL4^32B/kay^Fbz.Scer\UAS (Ciapponi et al., 2001) Egfr^E3 has wing phenotype, suppressible by Jra¹ (Kockel et al., 1997) Egfr^E3 has wing phenotype, suppressible by Jra^IA109 (Kockel et al., 1997) Egfr^E3 has wing phenotype, suppressible by Shc^111-40/Shc[+] (Luschnig et al., 2000) Egfr^E3 has wing phenotype, suppressible by Shc^BG/Shc[+] (Luschnig et al., 2000) Egfr^E3 has wing vein \| ectopic phenotype, suppressible by Ppm1^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^Bx-MS1096 (Friedman and Perrimon, 2006) Egfr^E3 has wing vein \| ectopic phenotype, suppressible by SelD^k11320 (Morey et al., 2001) Egfr^E3 has wing vein phenotype, suppressible by emc^D/emc^D (Baonza and Garcia-Bellido, 1999)
NOT suppressed by
Statement Reference Egfr^E3 has eye disc phenotype, non-suppressible by Hsap\CDKN1A^GMR.PH (Baker and Yu, 2001) Egfr^E3 has eye phenotype, non-suppressible by kay^hs.PZ/kay² (Ciapponi et al., 2001) Egfr^E3 has wing \| ectopic phenotype, non-suppressible by kay^hs.PZ/kay² (Ciapponi et al., 2001) Egfr^E3 has wing vein \| ectopic phenotype, non-suppressible by Ppm1^{D228A.Scer\UAS.T:Ivir\HA1}/Scer\GAL4^Bx-MS1096 (Friedman and Perrimon, 2006)
Enhancer of
Statement Reference Egfr^E3/Egfr[+] is an enhancer of wing phenotype of ash2^S112411 (Angulo et al., 2004) Egfr^E3/Egfr[+] is an enhancer of wing phenotype of N^55e11 (Weber et al., 2003) Egfr^E3/Egfr[+] is an enhancer of wing vein \| ectopic phenotype of ash2^S112411 (Angulo et al., 2004) Egfr^E3/Egfr[+] is an enhancer of wing vein \| supernumerary phenotype of Mkp3¹/Mkp3², Scer\GAL4[-] (Rintelen et al., 2003) Egfr^E3/Egfr^E3 is an enhancer of phenotype of net^unspecified (Diaz-Benjumea and Garcia-Bellido, 1990, Diaz-Benjumea and Garcia-Bellido, 1990) Egfr^E3/Egfr^E3 is an enhancer of phenotype of px¹ (Diaz-Benjumea and Garcia-Bellido, 1990, Diaz-Benjumea and Garcia-Bellido, 1990)
NOT Enhancer of
Statement Reference Egfr^E3/Egfr[+] is a non-enhancer of axon & ocellus sensory structure phenotype of Scer\GAL4^sca-537.4, htl^{DN.Scer\UAS.cMb} (Garcia-Alonso et al., 2000) Egfr^E3 is a non-enhancer of wing disc phenotype of ft^k07918 (Garoia et al., 2000)
Suppressor of
Statement Reference Egfr^E3/Egfr[+] is a suppressor of eye phenotype of CycE^JP (Brumby et al., 2004) Egfr^E3/Egfr[+] is a suppressor of phenotype of H² (Diaz-Benjumea and Garcia-Bellido, 1990) Egfr^E3/Egfr[+] is a suppressor of phenotype of kni^unspecified (Diaz-Benjumea and Garcia-Bellido, 1990) Egfr^E3/Egfr[+] is a suppressor of phenotype of Vno^unspecified (Diaz-Benjumea and Garcia-Bellido, 1990) Egfr^E3/Egfr^E3 is a suppressor \| partially of wing vein phenotype of rho^unspecified, vn^unspecified (Diaz-Benjumea and Garcia-Bellido, 1990, Diaz-Benjumea and Garcia-Bellido, 1990) Egfr^E3 is a suppressor of axon & mechanosensory neuron & adult head \| conditional ts phenotype of Nrg^l10 (Garcia-Alonso et al., 2000) Egfr^E3 is a suppressor of axon & ocellus sensory structure \| conditional ts phenotype of Nrg^l10 (Garcia-Alonso et al., 2000) Egfr^E3 is a suppressor of phenotype of vn^ddd-13 (Schnepp et al., 1996) Egfr^E3 is a suppressor of phenotype of vn^L6 (Schnepp et al., 1996)
NOT Suppressor of
Statement Reference Egfr^E3/Egfr[+] is a non-suppressor of axon & mechanosensory neuron & adult head phenotype of Scer\GAL4^sca-537.4, htl^{DN.Scer\UAS.cMb} (Garcia-Alonso et al., 2000) Egfr^E3 is a non-suppressor of wing disc phenotype of ft^k07918 (Garoia et al., 2000)
Other
Statement Reference Egfr^E3, dac² has eye phenotype (Mardon et al., 1994) Egfr^E3, dac⁵ has eye phenotype (Mardon et al., 1994) Egfr^E3, dac⁶ has eye phenotype (Mardon et al., 1994) Egfr^E3, dac⁷ has eye phenotype (Mardon et al., 1994) Egfr^E3, dac⁸ has eye phenotype (Mardon et al., 1994) Egfr^E3, dac⁹ has eye phenotype (Mardon et al., 1994) Egfr^E3, stg^hs.PE3/stg^hs.PE3 has eye-antennal disc phenotype (Kylsten and Saint, 1997, Kylsten and Saint, 1997) Egfr^E3, stg^hs.PE3/stg^hs.PE3 has wing disc phenotype (Kylsten and Saint, 1997)
Additional Comments
Genetic Interactions
Statement Reference The small rough eye phenotype of Egfr[E3]/+ is suppressed by expression of the brm[K804R.T:Ivir\HA1] genomic construct. The small rough eye phenotype of Egfr[E3]/+ is suppressed by brm[2]/+. geminin[k03202b]/+ enhances the Egfr[E3]/+ small rough eye phenotype. (Herr et al., 2010) Egfr[E3]/+ adults have extra vein tissue at the distal end of L2. This phenotype is enhanced by ash2[S112411]/ash2[S112411] - the resulting wings are more reduced and have more ectopic veination than ash2[S112411]/ash2[S112411] animals. (Angulo et al., 2004) Egfr^E3/+, Cct1¹⁶⁹¹⁹/+ double mutants show reduced loss of photoreceptors in the eye compared to Egfr^E3/+ single mutants. Additionally, the eyes of the double mutants show a more regular arrangement of ommatidia. The extra crossvein phenotype seen in the wings of Egfr^E3/+ flies is partially suppressed in Cct1^EP831/+, Egfr^E3/+ double mutants, with the majority of these flies exhibiting two, rather than several, extra crossveins. This phenotype is further suppressed in Cct1¹⁶⁹¹⁹/+, Egfr^E3/+ double mutants, with the majority of these flies exhibiting no, or only one, extra crossvein in the wing. Further, the expression of Cct1^Ala.Scer\UAS under the control of Scer\GAL4^sd-SG29.1 also partially suppresses the Egfr^E3 wing phenotype. The Egfr^E3 allele dominantly enhances the notched wing phenotype seen in N^55e11/+ flies. (Weber et al., 2003) The number of ommatidia in the eyes of Egfr^E1/Egfr^E3 adults is not altered if the flies are also expressing BacA\p35^GMR.PH, but the number of pigment cells is increased in these animals. (Yu et al., 2002) The addition of SelD^k11320/+ to Egfr^E3/+ animals leads to a complete suppression of the ectopic wing phenotype in 66% of wings and a partial suppression in the rest. (Morey et al., 2001) Heterozygous mutants do not cause any defects in the ocellar sensory system (OSS) neurogenesis or axon guidance. (Garcia-Alonso et al., 2000) The eye and wing phenotypes are dominantly suppressed by Shc^BG or Shc^111-40. The Egfr^E3 phenotype is completely suppressed if the flies are also homozygous for Shc^BG or Shc^111-40 and the viability of these flies is restored. (Luschnig et al., 2000) Null alleles of ru interact dominantly with Egfr^E3. (Wasserman et al., 2000) The ectopic wing vein phenotype of Egfr^E3/+ flies is slightly enhanced by emc¹/emc¹¹ and slightly suppressed by emc^D/emc^D. (Baonza and Garcia-Bellido, 1999) argos^W11 enhances the extra wing vein phenotype of Egfr^E1/Egfr^E3 transheterozygotes but suppresses the eye phenotype. N^l1N-ts1 also suppresses the eye phenotype of Egfr^E1/Egfr^E3. (Lesokhin et al., 1999) Appearance of ectopic wing tissue in the adult wing is suppressed by loss of a functional copy of Jra (Jra¹ or Jra^IA109). (Kockel et al., 1997) 25 minutes of heat induced stg^hs.PE3 expression causes mitotic cell appearance in the eye and wing discs. Induction of mitosis in the eye discs leads to a marked reduction of pyknotic bodies that were normally present on the basal side of the discs. Cellular progression into and through apoptosis is disrupted by ectopic stg expression. Heat induced stg expression does not affect the mutant eye phenotype: adults exhibit small elliptical and rough eyes as seen in Egfr^E3 homozygotes. (Kylsten and Saint, 1997) Suppresses the viability of vn^ddd-13, the proliferation defects in vn^L6 and (partially) the small disc phenotype of vn^γ4. (Schnepp et al., 1996) The heterozygous extra wing vein phenotype is enhanced when transheterozygous with rl^Sem. Flies heterozygous for Egfr^E3 and rl^Sem have smaller eyes than Egfr^E3 heterozygotes alone. (Brunner et al., 1994) Reduction of the dose of spi causes some suppression of the Egfr^E3 phenotype; more ommatidia and increase in the size of the eye. S²¹⁸ Egfr^E3 double heterozygous adults exhibit severely reduced and rough eyes. Most ommatidia have a reduced number of photoreceptor cells, there are also defects in orientation, spacing and pigment cell and bristle numbers. This phenotype is more severe than a simple addition of the dominant effects of Egfr and S. Mutation has no effect on rho^hs.sev rough eye phenotype. (Freeman, 1994) Double mutant combinations of Egfr^E3/Egfr^E3 with net^unspecified/net^unspecified or px¹/px¹ have a superadditive phenotype. Egfr^E3/Egfr^E3 shows a negative interaction in combination with either rho^unspecified/rho^unspecified or kni^unspecified/kni^unspecified. Egfr^E3/+ shows a negative interaction in combination with either H²/+ or Vno^unspecified/+. Egfr^E3/Egfr^E3 shows a simple additive phenotype with tt¹/tt¹ and N^Ax-M1/+. Egfr^E3/+ shows a simple additive phenotype with N^55e11/+ and Dl^M1/+. E(spl)^rv1 gro^unspecified Egfr^E3/Egfr^E3 flies show a simple additive phenotype. The lack of vein phenotype of rho^unspecified vn^unspecified flies is partially rescued by Egfr^E3/Egfr^E3. (Diaz-Benjumea and Garcia-Bellido, 1990)
Xenogenetic Interactions
Statement Reference Expression of Hsap\CDKN1A^GMR.PH in homozygous Egfr^E3 mutants does not prevent the apoptosis of undifferentiated cells in the eye disc that is seen in the Egfr^E3 mutant background. (Baker and Yu, 2001)
Complementation & Rescue Data
Comments	Expression of Egfr^1.Scer\UAS under the control of Scer\GAL4^GMR.PF in Egfr^E3 flies results in mitosis in all cells in the eye disc. Expression of stg^hs.PE3 using heat shock in Egfr^E3 discs causes all G2-arrested cells to enter mitosis. This mitosis is abnormal, with the cells remaining in mitosis for 4 hours (mitosis normally lasts about 15 minutes). Extensive cell death occurs amongst the mitotically arrested cells from 2-4 hours, so that some of the disc epithelium is lost. (Baker and Yu, 2001)
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	No interaction with P{sev-svp1} or P{sev-svp2} exists. (Begemann et al., 1995) Clonal analysis shows that normal ommatidia are less likely to develop if precluster cells R2, R3, R4, R5 or R8 are Egfr^E3/Egfr^E3. (Baker and Rubin, 1992) Egfr protein expression in the eye imaginal discs of Egfr^E3 homozygous third instar larvae has been compared with wild-type expression. The pattern of cell divisions posterior to the morphogenetic furrow is altered in Egfr^E3 homozygotes. (Zak and Shilo, 1992)
External Crossreferences & Linkouts
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Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	DER^EB1 (Polaczyk et al., 1998) DER^elpB1 (Rintelen et al., 2003) DER<up>Elp B1</up> (Kylsten, 1994) DER^ElpB1 (Schnepp et al., 1996, Brunner et al., 1994) egfr^E3 (Yu et al., 2002) Egfr^E3 Egfr^EB1 (Freeman, 1994, Xu and Rubin, 1993) Egfr^ElpB1 (Weber et al., 2003, Begemann et al., 1995, Mirkovic and Mlodzik, 2006) EGFR^ElpB1 (Herr et al., 2010) Elp^1B (Schweitzer et al., 1995) Elp^B1 (Brumby et al., 2004, Morey et al., 2001, Ciapponi et al., 2001, Bai et al., 2001, Baker and Yu, 2001, Garcia-Alonso et al., 2000, Wasserman et al., 2000, Luschnig et al., 2000, Bai et al., 1999, Chen and Chien, 1999, Baonza and Garcia-Bellido, 1999, Lesokhin et al., 1999, Roch et al., 1998, Hsu et al., 1998, Stemerdink and Jacobs, 1997, Kockel et al., 1997, Lim et al., 1997, Jacobs et al., 1997, Verheyen et al., 1996, Baker and Zitron, 1995, Mardon et al., 1994, de Celis and Garcia-Bellido, 1994, Diaz-Benjumea and Hafen, 1994, Kunes et al., 1993, Baker et al., 1992, Zak and Shilo, 1992, Baker and Rubin, 1992, Baker et al., 1990, Diaz-Benjumea and Garcia-Bellido, 1990, Baker and Rubin, 1989, Friedman and Perrimon, 2006, Angulo et al., 2004, Vaccari et al., 2009, Almudi et al., 2009, Baonza and Freeman, 2005) ElpB1 (Herr et al., 2010) top^ElpB1 (Garoia et al., 2000)
Name Synonym	ellipse (Vaccari et al., 2009) ellipse^B1 (Jones et al., 2006)
Secondary FlyBase IDs

References ( 52 )

Generate a list of	All references relating to this allele ( 52 )

List References by type	Research paper ( 48 ) Abstract ( 4 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...

Allele Dmel\EgfrE3

Allele Dmel\Egfr^E3