FlyBase Allele Report: Dmel\Egfr[f11]

General Information

Symbol

Dmel\Egfr^f11

Species

D. melanogaster

Name

FlyBase ID

FBal0003539

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

Also Known As

top^3C81, flb^3C81, Egfr^3C81, Egfr^top3C81

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Brunner et al., 1994, Clifford and Schupbach, 1989, Schejter and Shilo, 1989)

Mutagen

ethyl methanesulfonate

(Clifford and Schupbach, 1989, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

antennal disc | larval stage | somatic clone

(Xu and Rubin, 1993)

anterior crossvein

(Casci et al., 1999)

anterior crossvein (with Egfr^t1)

(Angulo et al., 2004)

chaeta | cell non-autonomous | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

dorsal appendage

(Wasserman and Freeman, 1998)

egg

(Wasserman and Freeman, 1998)

eye

(Casci et al., 1999)

eye disc | larval stage | somatic clone

(Xu and Rubin, 1993)

head | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

leg | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

mesonotum | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

midline glial cell

(Scholz et al., 1997, Scholz et al., 1997)

ommatidium (with Egfr^t1)

(Weber et al., 2008)

photoreceptor neuron | larval stage | somatic clone

(Xu and Rubin, 1993)

wing | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

wing disc | larval stage | somatic clone

(Xu and Rubin, 1993)

wing vein L4

(Casci et al., 1999)

wing vein L4 (with Egfr^t1)

(Angulo et al., 2004)

Detailed Description

Statement

Reference

Egfr^f11/Egfr^t1 flies show mild planar cell polarity defects in the eye.

(Weber et al., 2008)

In Egfr^f11/Egfr^t1 adults, wings lack the anterior cross-vein and a segment of L4.

(Angulo et al., 2004)

Egfr^t1/Egfr^f11 flies have a rough eye phenotype, a gap in wing vein L4 and the anterior crossvein is missing.

(Casci et al., 1999)

Heterozygotes of Egfr^t1 with Egfr^f11 produce eggs with fused dorsal appendages. Larvae hatch from the eggs, with dorsal-ventral pattern unperturbed.

(Wasserman and Freeman, 1998)

Loss of Egfr function reduces the number of glial cells in stage 12 embryos and in later embryos these cells die.

(Scholz et al., 1997, Scholz et al., 1997)

Clonal analysis in eye, antenna, wing and leg discs suggests that Egfr^- cells do not proliferate as well as wild type. Egfr cells in the eye disc are unable to differentiate as photoreceptor cells, and cells lacking Egfr function can perturb the developmental fate of their neighbors.

(Xu and Rubin, 1993)

Suppresses the "Ellipse" phenotype.

(Baker and Rubin, 1992)

The viability of homozygous clones in the wing is very low. Homozygous clones in the legs, notum and head seem to be inviable. Homozygous clones in the abdominal tergites are viable. Wild-type chaetae are clustered immediately adjacent to or included within these clones and there is a depletion of chaetae around the clones for several cell diameters.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Homozygotes and hemizygotes display a severe 'flb' phenotype. Embryos produced from heteroallelic combination with Egfr^t1 have a severe ventralised phenotype, reduction in size of their dorsal appendage.

(Clifford and Schupbach, 1989)

severe allele

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Egfr^t1/Egfr^f11 has abnormal planar polarity phenotype, suppressible | partially by fz[+]/fz²¹

(Weber et al., 2008)

Egfr^t1/Egfr^f11 has abnormal planar polarity phenotype, suppressible | partially by fz²³/fz[+]

(Weber et al., 2008)

Egfr^t1/Egfr^f11 has visible phenotype, suppressible by sty[+]/sty^S73

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has visible phenotype, suppressible by sty[+]/sty^S88

(Casci et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Egfr^t1/Egfr^f11 has phenotype, enhanceable by Vno¹/Vno[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by rho^unspecified/rho^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by vn^unspecified/vn^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by ci^unspecified/ci^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by ast^unspecified/ast^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by H²/H[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by vvl^unspecified/vvl[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by N^Ax-M1/N[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

Suppressed by

Statement

Reference

Egfr^t1/Egfr^f11 has ommatidium phenotype, suppressible | partially by fz[+]/fz²¹

(Weber et al., 2008)

Egfr^t1/Egfr^f11 has ommatidium phenotype, suppressible | partially by fz²³/fz[+]

(Weber et al., 2008)

Egfr^t1/Egfr^f11 has anterior crossvein phenotype, suppressible | partially by ash2[+]/ash2^I1

(Angulo et al., 2004)

Egfr^t1/Egfr^f11 has wing vein L4 phenotype, suppressible | partially by ash2[+]/ash2^I1

(Angulo et al., 2004)

Egfr^t1/Egfr^f11 has wing vein L4 phenotype, suppressible by sty[+]/sty^S73

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has anterior crossvein phenotype, suppressible by sty[+]/sty^S73

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has eye phenotype, suppressible by sty[+]/sty^S73

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has wing vein L4 phenotype, suppressible by sty[+]/sty^S88

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has anterior crossvein phenotype, suppressible by sty[+]/sty^S88

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has eye phenotype, suppressible by sty[+]/sty^S88

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has phenotype, suppressible by kn¹/kn¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, suppressible by net^unspecified/net^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, suppressible by Delta^M1/Dl[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, suppressible by tkv^unspecified/tkv^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has wing vein phenotype, suppressible by kn¹/kn¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has wing vein phenotype, suppressible by net^unspecified/net^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Enhancer of

Statement

Reference

Egfr^t1/Egfr^f11 is an enhancer of phenotype of vvl^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of ci^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of ast^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of N^Ax-M1

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of tt¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of H²

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of Vno¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of vn^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Suppressor of

Statement

Reference

Egfr^f11 is a suppressor of photoreceptor cell R1 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Egfr^f11 is a suppressor of photoreceptor cell R2 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Egfr^f11 is a suppressor of photoreceptor cell R3 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Egfr^f11 is a suppressor of photoreceptor cell R4 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Egfr^f11 is a suppressor of photoreceptor cell R5 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Egfr^f11 is a suppressor of photoreceptor cell R6 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Egfr^f11 is a suppressor of phenotype of svp^2.sev

(Begemann et al., 1995)

Egfr^f11 is a suppressor of phenotype of svp^1.sev

(Begemann et al., 1995)

Egfr^t1/Egfr^f11 is a suppressor of phenotype of Delta^M1

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is a suppressor of phenotype of kn¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is a suppressor of wing vein phenotype of kn¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is a suppressor of wing vein phenotype of net^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is a suppressor of phenotype of tkv^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

NOT Suppressor of

Statement

Reference

Egfr^f11 is a non-suppressor of photoreceptor cell R7 phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Other

Statement

Reference

BacA\p35^GMR.PH, Egfr^f11 has eye photoreceptor cell phenotype

(Baker and Yu, 2001)

Egfr^f11, rl¹ has wing vein L4 phenotype

(Brunner et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

The planar cell polarity defects seen in Egfr^f11/Egfr^t1 eyes are partially suppressed by fz²¹/+ or fz²³/+.

(Weber et al., 2008)

The loss of anterior cross-vein and L4 gap seen in Egfr^f11/Egfr^t1 wings are partially rescue by ash2^I1/+.

(Angulo et al., 2004)

Only R8 photoreceptor cells differentiate in Egfr^f11 clones which are also expressing BacA\p35^GMR.PH. Some mutant cells differentiate small photoreceptor rhabdomeres; most cells resemble pigment cells morphologically, but contain little pigment.

(Baker and Yu, 2001)

The Egfr^t1/Egfr^f11 phenotypes are dominantly suppressed by sty^S73 or sty^S88.

(Casci et al., 1999)

Egfr^f11 significantly suppresses the formation of extra outer photoreceptors caused by B-H1^sev.PH, although it does not affect the loss of R7 cell phenotype caused by B-H1^sev.PH.

(Hayashi et al., 1998)

Suppressor of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

Double mutants of rl¹ and Egfr^f11 show disruption of the longitudinal vein L4.

(Brunner et al., 1994)

Double mutant combinations of Egfr^t1/Egfr^f11 with rho^unspecified/rho^unspecified, vn^unspecified/vn^unspecified, ci^unspecified/ci^unspecified, ast^unspecified/ast^unspecified, tt¹/tt¹, Vno^unspecified/+, H²/+, vvl^unspecified/+ or N^Ax-M1/+ have a superadditive phenotype. Double mutant combinations of Egfr^t1/Egfr^f11 with kn¹/kn¹ or net^unspecified/net^unspecified show mutual suppression, with both the Egfr and vein phenotypes being normalised. Egfr^t1/Egfr^f11 shows a negative interaction in combination with either Dl^M1/+ or tkv^unspecified/tkv^unspecified. Egfr^t1/Egfr^f11 shows a simple additive phenotype with dpp^unspecified/dpp^unspecified, kni^unspecified/kni^unspecified, tg²/tg², cv-2^unspecified/cv-2^unspecified and N^55e11/+. E(spl)^rv1 gro^unspecified Egfr^t1/Egfr^f11 flies show a simple additive phenotype.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: Embryonic lethal.

Comments

Mutation of Egfr that coordinately affects all gene activities, a class I lesion. The allelic series for class I lesions: Egfr^t2 = Egfr^t1 < Egfr^top-EC20 < Egfr^f7 = Egfr^f1 = Egfr^flb-2E07 < Egfr^top-EE39 = Egfr^top-ED26 = Egfr^f5 < Egfr^f9 = Egfr^f10 = Egfr^f2 = Egfr^top-EE42 = Egfr^f11 = Egfr^f24 = Egfr^f3 = Df(2R)Egfr3.

(Clifford and Schupbach, 1989)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

DER^flb3C81

(Hayashi et al., 1998)

DER^top3C81

(Brunner et al., 1994)

Egfr^3C81

(Weber et al., 2008, Wasserman and Freeman, 1998, Ruohola-Baker et al., 1993)

Egfr^f11

Egfr^f3C81

(Xu and Rubin, 1993)

Egfr^flb3C81

(Begemann et al., 1995)

Egfr^top3C81

(Weber et al., 2008, Casci et al., 1999)

flb

flb^3C81

(Takahashi et al., 1996, Baker and Rubin, 1992, Raz et al., 1991, Schejter and Shilo, 1989)

flb^IIIC81

(Tearle and Nusslein-Volhard, 1987)

top^3C18

(Baker and Yu, 2001)

top^3C81

(Angulo et al., 2004, Scholz et al., 1997, Scholz et al., 1997, Diaz-Benjumea and Garcia-Bellido, 1990, Clifford and Schupbach, 1989)

top^3c81

(de Celis and Garcia-Bellido, 1994)

Name Synonyms

faint little ball

Secondary FlyBase IDs

References (21)

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