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General Information
Symbol
Dmel\Egfrf37
Species
D. melanogaster
Name
FlyBase ID
FBal0003565
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
top4A
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T21556932A

Reported nucleotide change:

T2469A

Amino acid change:

C662S | Egfr-PA; C711S | Egfr-PB

Reported amino acid change:

C662S

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: T2469A. Amino acid replacement: C662S.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous somatic clones in the legs and wings have bractless mechanosensory bristles.

Egfrt1/Egfrf37 flies show loss of wing vein L4.

Egfrf37/Egfrt1 lack wing vein L4. Wing clones of Egfrf37 mutant cells are smaller, narrower amd more elongated than controls and are incapable of differentiating vein histotype except in L1.

In trans to Egfrt1, Egfrf37 shows unexpectedly severe wing vein abnormalities.

Clonal analysis reveals phenotypes in the adult including loss of wing vein, ectopic wing vein, reduced cell size, extra bristles, cell lethality and tergite bristle abnormalities. Phenotype is cell autonomous. rl1/Df(2R)rl10a strongly enhances the wing phenotype of Egfrt1/Egfrf37.

Strong hypomorph. The viability of homozygous clones in the wing is reduced, but higher than the viability of homozygous Egfrf24 or Egfrf11 clones in the wing. Cells in the Egfrf37 clone are 40-50% smaller than normal. A clone present on one wing surface causes the opposite wing surface to blister. Wing veins fail to differentiate where clones cross them, although the sensilla campaniformia of wing vein LIII are not removed by dorsal clones crossing this vein. The failure to differentiate wing vein is cell autonomous. Wild-type cells may differentiate into extra wing vein material abutting the clone border when the border is near the normal course of a vein. Homozygous clones in the notum contain small cells, with densely packed trichomes. Cell density is 40-50% higher than normal. Clones in the leg contain extra chaetae. Clones in the head contain small cells, with extra chaetae. Homozygous clones in the abdominal tergites are viable.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference

Egfrf37 has phenotype, suppressible by bs03267

Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

This loss of wing vein L4 seen in Egfrt1/Egfrf37 flies is suppressed by emc1/emc11. emcD enhances the loss of wing veins seen in Egfrt1/Egfrf37 flies.

Double mutant wing clones with Egfrf37 occupy vein territories like those for bs03267 but with a frequency and size similar to Egfrf37 controls. Double mutant cells differentiate autonomously into pigmented, corrugated and compacted cells characteristic of the vein histotype.

The extra chaetae found over the wing veins in heterozygous acHw-49c/+ females are removed or reduced in number from the dorsal veins LIII and LV, but not from the LII and LIV ventral veins, by homozygous Egfrf37 clones in these regions.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: Failure to complement the wing-vein defect of "Egfrt" alleles.

Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (11)