FlyBase Allele Report: Dmel\Egfr[t1]

General Information

Symbol

Dmel\Egfr^t1

Species

D. melanogaster

Name

FlyBase ID

FBal0003572

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

Also Known As

top¹, top^QY1, EGFR^top1, egfr^QY1, EGFR^top, DER^top1, top, top^QY, Egfr¹, Egfr^top-1

Key Links

Genomic Maps

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Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Price et al., 1997, Roth et al., 1995, Diaz-Benjumea and Garcia-Bellido, 1990)

Mutagen

ethyl methanesulfonate

(Clifford and Schupbach, 1994, Schupbach and Wieschaus, 1991, Clifford and Schupbach, 1989, Schupbach, 1987)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point_mutation

2R:21,554,848..21,554,848 [+]

Nucleotide change:

C21554848T

Reported nucleotide change:

C406T

Amino acid change:

S58F | Egfr-PA; S107F | Egfr-PB

Reported amino acid change:

S58F

(Clifford and Schupbach, 1994)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Nucleotide substitution: C406T. Amino acid replacement: S58F.

(Clifford and Schupbach, 1994)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates colorectal cancer

modeled by Src42A^CA.UAS

(Cordero et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity

(Gaengel and Mlodzik, 2003)

abnormal cell polarity (with Egfr^top-EC20)

(Gaengel and Mlodzik, 2003)

abnormal planar polarity (with Egfr^f11)

(Weber et al., 2008)

abnormal wound healing

(Geiger et al., 2011)

female semi-sterile | recessive

(Dong et al., 1999)

female sterile

(Schupbach and Wieschaus, 1991, Diaz-Benjumea and Garcia-Bellido, 1990, Price et al., 1989)

female sterile | recessive

(Clifford and Schupbach, 1989)

lethal - all die during embryonic stage | maternal effect

(Roth and Schupbach, 1994)

some die during embryonic stage | maternal effect

(Roth and Schupbach, 1994)

viable

(Baker and Rubin, 1992, Diaz-Benjumea and Garcia-Bellido, 1990)

visible

(Price et al., 1997)

visible (with Df(2R)Egfr3)

(Rawlings et al., 2004)

visible (with Egfr^f24)

(Alvarado et al., 2004)

visible | heat sensitive

(Guichard et al., 1999)

visible | recessive

(Baonza and Garcia-Bellido, 1999, Casci et al., 1999, Dong et al., 1999, Roch et al., 1998)

Phenotype Manifest In

anterior crossvein

(Casci et al., 1999, Price et al., 1997)

anterior crossvein (with Df(2R)Egfr3)

(Rawlings et al., 2004)

anterior crossvein (with Egfr^f11)

(Angulo et al., 2004)

anterior crossvein (with Egfr^f24)

(Alvarado et al., 2004)

crossvein | increased number (with Egfr^E3)

(Weber et al., 2003)

dorsal appendage

(Papadia et al., 2005, Ghiglione et al., 2003, Ghiglione et al., 1999, Zhao and Bownes, 1999, Wasserman and Freeman, 1998, Deng and Bownes, 1997, Dobens et al., 1997, Hsu et al., 1996, Brand and Perrimon, 1994, Schupbach, 1987)

dorsal appendage | maternal effect

(Roth and Schupbach, 1994)

egg

(Papadia et al., 2005, Ghiglione et al., 2003, Ghiglione et al., 1999, Zhao and Bownes, 1999, Wasserman and Freeman, 1998, Forlani et al., 1993)

egg chamber

(Hsu et al., 1996, Gonzalez-Reyes et al., 1995)

egg chorion

(Papadia et al., 2005, Goff et al., 2001, Zhao and Bownes, 1999, Brand and Perrimon, 1994)

embryo

(Dong et al., 1999, Brand and Perrimon, 1994)

embryo | ventral

(Schupbach, 1987)

embryonic/first instar larval cuticle

(Goff et al., 2001, Morisato, 2001)

eye

(Gaengel and Mlodzik, 2003, Casci et al., 1999, Dong et al., 1999)

eye (with Df(2R)Egfr3)

(Alvarado et al., 2004)

eye (with Egfr^f24)

(Alvarado et al., 2004)

eye (with Egfr^flb-2E07)

(Alvarado et al., 2004)

follicle cell

(Hsu et al., 1996)

follicle cell (with Egfr^f3)

(Smith et al., 2002)

macrochaeta

(Dong et al., 1999, Diaz-Benjumea and Hafen, 1994)

ommatidium

(Gaengel and Mlodzik, 2003)

ommatidium (with Egfr^f11)

(Weber et al., 2008)

ommatidium (with Egfr^top-EC20)

(Gaengel and Mlodzik, 2003)

ventral furrow

(Schupbach, 1987)

ventral furrow | ectopic

(Morisato, 2001)

ventral furrow | increased number

(Morisato, 2001)

ventral furrow | maternal effect

(Roth and Schupbach, 1994)

wing disc

(Nagaraj et al., 1999)

wing vein

(Dong et al., 1999, Diaz-Benjumea and Hafen, 1994)

wing vein | ectopic

(Diaz-Benjumea and Hafen, 1994)

wing vein L4

(Baonza and Garcia-Bellido, 1999, Casci et al., 1999, Roch et al., 1998, Price et al., 1997)

wing vein L4 (with Df(2R)Egfr3)

(Rawlings et al., 2004)

wing vein L4 (with Egfr^f11)

(Angulo et al., 2004)

wing vein L4 (with Egfr^f24)

(Alvarado et al., 2004)

wing vein L4 | heat sensitive

(Guichard et al., 1999)

Detailed Description

Statement

Reference

Homozygous embryos show wound closure defects.

(Geiger et al., 2011)

Egfr^f11/Egfr^t1 flies show mild planar cell polarity defects in the eye.

(Weber et al., 2008)

Egfr^t1 mutant flies lay ventralised eggs with a central, very thin and short dorsal appendage, or very little dorsal appendage material.

(Papadia et al., 2005)

Egfr^t1/Egfr^flb-2E07, Egfr^t1/Egfr^flb-2E07 and Egfr^t1/Df(2R)Egfr3 animals have rough eyes.

(Alvarado et al., 2004)

Egfr^t1/Egfr^f24 animals show loss of the anterior crossvein (100% penetrance) and partial loss of vein L4 in the wing (169% penetrance).

(Alvarado et al., 2004)

In Egfr^f11/Egfr^t1 adults, wings lack the anterior cross-vein and a segment of L4.

(Angulo et al., 2004)

Egfr^t1/Df(2R)Egfr3 flies lack the anterior crossvein and the central portion of wing vein L4.

(Rawlings et al., 2004)

Mutant adults have rough eyes. A loss of photoreceptor cells is seen as well as many ommatidia with rotation defects. Egfr^t1/Egfr^top-EC20 animals display rotation defects in adult ommatidia.

(Gaengel and Mlodzik, 2003)

Eggs laid by Egfr^t1 homozygous females are strongly ventralised.

(Ghiglione et al., 2003)

In Egfr^E3/Egfr^t1 mutants, some flies exhibit an extra crossvein at the tip of L2 in the wing.

(Weber et al., 2003)

Homozygous females lay eggs with a ventralised eggshell and embryo.

(Goff et al., 2001)

A fraction of embryos derived from Egfr^t1 females gastrulate with two ventral furrows. Cuticles show an expansion of ventral structures.

(Morisato, 2001)

Egfr^t1/Egfr^f37 flies show loss of wing vein L4. Egfr^t1 homozygotes do not have a wing vein phenotype. Homozygous Egfr^t1 wings are 14-20% smaller than wild-type.

(Baonza and Garcia-Bellido, 1999)

Egfr^t1/Egfr^f11 flies have a rough eye phenotype, a gap in wing vein L4 and the anterior crossvein is missing.

(Casci et al., 1999)

Egfr^t1/Egfr^f2 phenotypes are similar to ebi^P7/ebi^E90 and partial female sterility resulting from partially ventralized eggs, wing vein defects, short bristles and rough eyes.

(Dong et al., 1999)

Eggs derived from Egfr^t1/Egfr^flb-2E07 females are ventralised and have no or only one dorsal appendage.

(Ghiglione et al., 1999)

When Egfr^f1/Egfr^t1 flies are raised at the non-permissive temperature (29^oC)a vein-loss phenotype is seen. There is a large truncation in wing vein L4 which is similar to the Egfr^t1/Deficiency phenotype. This phenotype is seen if heat shocking occurs from 6 to 18 hours APF (after puparium formation).

(Guichard et al., 1999)

The notum is significantly reduced in size in Egfr^tsla/Egfr^t1 wing discs raised at the non-permissive temperature.

(Nagaraj et al., 1999)

Eggs laid by Egfr^t1 mothers are ventralised, with either a fused single dorsal appendage, or two appendages closer together than seen in wild-type.

(Zhao and Bownes, 1999)

Egfr^f37/Egfr^t1 lack wing vein L4.

(Roch et al., 1998)

Homozygous females or heterozygotes of Egfr^t1 with Egfr^f11 produce eggs with fused dorsal appendages. Larvae hatch from the eggs, with dorsal-ventral pattern unperturbed.

(Wasserman and Freeman, 1998)

Females produce eggs with dorsally fused dorsal appendages.

(Deng and Bownes, 1997)

Dorsal appendages are reduced in size and fused, and are shifted slightly posteriorly in Egfr^t1/Df(2R)Pu-D17 eggs.

(Dobens et al., 1997)

Dsor1 mutant alleles do not suppress the eggshell dorso-ventral polarity defect of the Egfr^t1 maternal mutation.

(Lim et al., 1997)

Wings are often indistinguishable from wild-type but may show deletions of the anterior crossveins. Hemizygous flies display a more severe defect, typically missing a section of wing vein L4.

(Price et al., 1997)

Transheterozygous females with Egfr^f2, Egfr^f3 or Egfr^f8 display egg chambers with gaps in the follicular epithelium that uncover the nurse cells. Eggs derived from these females display weak or intermediate ventralised phenotypes.

(Goode et al., 1996)

Ventralised egg chambers. Egg chambers become elongated in shape, dorsal appendages fuse and shrink and the number of main body follicle cells increases. Overexpression of P{CF2-s} in heterozygotes generates more ventralised eggs.

(Hsu et al., 1996)

Homozygotes have mutant egg chambers. Posterior follicle cells of Egfr^top-CA/Egfr^t1 transheterozygotes have an abnormal shape and behaviour.

(Gonzalez-Reyes et al., 1995)

Most Egfr^t1/Df(2R)Egfr18 heterozygous embryos have one fused dorsal appendage at the dorsal midline, few have a posterior micropyle and about half contain embryos.

(Roth et al., 1995)

Eggs laid by homozygous females are ventralised, fused and shortened dorsal appendages and the eggs are longer than wild type. Expression of phl^F22.hs causes females to lay ventralised eggs, expression in the anterior follicle cells of homozygotes or heterozygotes with Egfr^t2 causes dorsalisation of the egg chamber.

(Brand and Perrimon, 1994)

Weak and intermediate ventralised embryos.

(Christerson and McKearin, 1994)

Homozygous adult viable.

(Clifford and Schupbach, 1994)

Clonal analysis reveals phenotypes in the adult including loss of wing vein, ectopic wing vein, reduced cell size, extra bristles, cell lethality and tergite bristle abnormalities. Phenotype is cell autonomous. rl¹/Df(2R)rl10a strongly enhances the wing phenotype of Egfr^t1/Egfr^f37.

(Diaz-Benjumea and Hafen, 1994)

Weak ventralization of embryos. Filzkorper are normal. Only one dorsal appendage forms. 51% of laid eggs contain embryos. Mesoderm is wider than usual and cannot be enveloped by remaining epidermis. Two ventral furrows form.

(Roth and Schupbach, 1994)

Egfr^t1 homozygous females also heterozygous or homozygous for fs(1)K10¹³ or fs(1)K10¹ produce eggs with a ventralised phenotype.

(Forlani et al., 1993)

Embryos from double mutants with sqd^ix43 are strongly dorsalised.

(Kelley, 1993)

Heterozygous rho^ve-1 dominantly enhances the homozygous phenotype. Heterozygous rho^Mod suppresses the homozygous phenotype.

(Sturtevant et al., 1993)

Does not suppress the "Ellipse" phenotype. Ommatidia are missing photoreceptor cells, and photoreceptor cell morphology may be abnormal in hemizygotes.

(Baker and Rubin, 1992)

Reduction or absence of dorsal appendages (ventralization) with increase in main body egg shell. Micropyle at both ends of eggs, embryos ventralized.

(Schupbach and Wieschaus, 1991)

Viable.

(Clifford and Schupbach, 1989)

An enlarged mass of mesodermal cells invaginates on the ventral side of the embryo, the enlarged mesoderm is often organised into two ventral furrows. Organisation is lost in later stages of development and a mass of mesodermal cells fills the ventral half of the embryo. Respiratory appendages are fused and inserted directly on the dorsal midline.

(Schupbach, 1987)

maternal-effect lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Egfr^f37/Egfr^t1 has visible phenotype, enhanceable by emc^D

(Baonza and Garcia-Bellido, 1999)

Egfr^t1 has visible phenotype, enhanceable by E(Egfr)B56^B56

(Price et al., 1997)

Egfr^t1 has visible phenotype, enhanceable by E(Egfr)C12^C12

(Price et al., 1997)

Egfr^t1 has visible phenotype, enhanceable by E(Egfr)C22^C22

(Price et al., 1997)

Egfr^t1 has visible phenotype, enhanceable by gro^C105

(Price et al., 1997)

Egfr^t1 has visible phenotype, enhanceable by vn^C221

(Price et al., 1997)

Egfr^t1 has visible phenotype, enhanceable by H^C24

(Price et al., 1997)

Egfr^t1 has visible phenotype, enhanceable by H^C57

(Price et al., 1997)

Egfr^t1 has visible phenotype, enhanceable by H^C73

(Price et al., 1997)

Suppressed by

Statement

Reference

Egfr^t1/Egfr^f11 has abnormal planar polarity phenotype, suppressible | partially by fz[+]/fz²¹

(Weber et al., 2008)

Egfr^t1/Egfr^f11 has abnormal planar polarity phenotype, suppressible | partially by fz²³/fz[+]

(Weber et al., 2008)

Egfr^t1/Egfr^f24 has visible phenotype, suppressible by kek1^RA5/kek1^RM2

(Alvarado et al., 2004)

Egfr^f37/Egfr^t1 has visible phenotype, suppressible by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

Egfr^t1/Egfr^f11 has visible phenotype, suppressible by sty[+]/sty^S73

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has visible phenotype, suppressible by sty[+]/sty^S88

(Casci et al., 1999)

Enhancer of

Statement

Reference

Egfr[+]/Egfr^t1 is an enhancer of visible phenotype of CycE^JP

(Brumby et al., 2004)

Egfr^t1 is an enhancer of abnormal cell polarity phenotype of S^48-5

(Gaengel and Mlodzik, 2003)

Egfr[+]/Egfr^t1 is an enhancer of visible phenotype of rg^γ6

(Shamloula et al., 2002)

Egfr^t1 is an enhancer of visible phenotype of gro¹

(Price et al., 1997)

Egfr^t1 is an enhancer of visible phenotype of rl¹

(Price et al., 1997)

NOT Enhancer of

Statement

Reference

Egfr[+]/Egfr^t1 is a non-enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Suppressor of

Statement

Reference

Egfr[+]/Egfr^t1 is a suppressor | partially of hyperplasia phenotype of Scer\GAL4^NP5130, Src42A^CA.UAS

(Cordero et al., 2014)

Egfr[+]/Egfr^t1 is a suppressor of increased occurrence of cell division | adult stage phenotype of Burs^Z5569

(Scopelliti et al., 2014)

Egfr[+]/Egfr^t1 is a suppressor of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Egfr^t1 is a suppressor | partially of abnormal cell polarity phenotype of aos^rlt

(Gaengel and Mlodzik, 2003)

NOT Suppressor of

Statement

Reference

Egfr[+]/Egfr^t1 is a non-suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Other

Statement

Reference

Egfr^t1, emc^D has visible | recessive phenotype

(Baonza and Garcia-Bellido, 1999)

Egfr^t1, H^C21 has visible phenotype

(Price et al., 1997)

Df(3R)Espl22, Egfr^t1 has visible phenotype

(Price et al., 1997)

Egfr^t1, dac^P has visible phenotype

(Mardon et al., 1994)

Phenotype Manifest In

Enhanced by

Statement

Reference

Egfr^f3/Egfr^t1 has follicle cell phenotype, enhanceable by da[+]/da²

(Smith et al., 2002)

Egfr^f37/Egfr^t1 has wing vein phenotype, enhanceable by emc^D

(Baonza and Garcia-Bellido, 1999)

Egfr^t1 has phenotype, enhanceable by ebi^unspecified/ebi[+]

(Dong et al., 1999)

Egfr^t1 has wing vein L4 phenotype, enhanceable by H^C21

(Price et al., 1997)

Egfr^t1 has wing vein L2 phenotype, enhanceable by E(Egfr)B56^B56

(Price et al., 1997)

Egfr^t1 has wing vein L4 phenotype, enhanceable by E(Egfr)B56^B56

(Price et al., 1997)

Egfr^t1 has wing vein L5 phenotype, enhanceable by E(Egfr)B56^B56

(Price et al., 1997)

Egfr^t1 has wing vein L4 phenotype, enhanceable by E(Egfr)C12^C12

(Price et al., 1997)

Egfr^t1 has wing vein L4 phenotype, enhanceable by E(Egfr)C22^C22

(Price et al., 1997)

Egfr^t1 has anterior crossvein phenotype, enhanceable by E(Egfr)C22^C22

(Price et al., 1997)

Egfr^t1 has wing vein L4 phenotype, enhanceable by gro^C105

(Price et al., 1997)

Egfr^t1 has anterior crossvein phenotype, enhanceable by gro^C105

(Price et al., 1997)

Egfr^t1 has wing vein L4 phenotype, enhanceable by vn^C221

(Price et al., 1997)

Egfr^t1 has wing phenotype, enhanceable by H^C24

(Price et al., 1997)

Egfr^t1 has wing phenotype, enhanceable by H^C57

(Price et al., 1997)

Egfr^t1 has wing phenotype, enhanceable by H^C73

(Price et al., 1997)

Egfr^t1/Egfr^top-CA has phenotype, enhanceable by rl^10b

(Gonzalez-Reyes et al., 1995)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by rho^unspecified/rho^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by vn^unspecified/vn^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by ci^unspecified/ci^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by ast^unspecified/ast^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by Vno^unspecified/Vno[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by H²/H[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by vvl^unspecified/vvl[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by N^Ax-M1/N[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, enhanceable by Vno¹/Vno[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

NOT Enhanced by

Statement

Reference

Egfr^t1 has egg phenotype, non-enhanceable by Scer\GAL4^T155/Egfr::kek1^UAS.cGa

(Ghiglione et al., 2003)

Suppressed by

Statement

Reference

Egfr^t1/Egfr^f11 has ommatidium phenotype, suppressible | partially by fz[+]/fz²¹

(Weber et al., 2008)

Egfr^t1/Egfr^f11 has ommatidium phenotype, suppressible | partially by fz²³/fz[+]

(Weber et al., 2008)

Egfr^flb-2E07/Egfr^t1 has eye phenotype, suppressible by kek1^RA5/kek1^RM2

(Alvarado et al., 2004)

Df(2R)Egfr3/Egfr^t1 has eye phenotype, suppressible | partially by kek1^RA5/kek1[+]

(Alvarado et al., 2004)

Egfr^t1/Egfr^f24 has eye phenotype, suppressible | partially by kek1^RA5/kek1[+]

(Alvarado et al., 2004)

Egfr^flb-2E07/Egfr^t1 has eye phenotype, suppressible | partially by kek1^RA5/kek1[+]

(Alvarado et al., 2004)

Egfr^flb-2E07/Egfr^t1 has eye phenotype, suppressible | partially by kek1[+]/kek1^RM2

(Alvarado et al., 2004)

Egfr^t1/Egfr^f24 has wing vein L4 phenotype, suppressible by kek1^RA5/kek1^RM2

(Alvarado et al., 2004)

Egfr^t1/Egfr^f11 has anterior crossvein phenotype, suppressible | partially by ash2[+]/ash2^I1

(Angulo et al., 2004)

Egfr^t1/Egfr^f11 has wing vein L4 phenotype, suppressible | partially by ash2[+]/ash2^I1

(Angulo et al., 2004)

Egfr^t1 has embryonic/first instar larval cuticle phenotype, suppressible | partially by spz[+]/spz^unspecified

(Morisato, 2001)

Egfr^t1 has ventral furrow | ectopic phenotype, suppressible by spz[+]/spz^unspecified

(Morisato, 2001)

Egfr^t1 has ventral furrow | increased number phenotype, suppressible by spz[+]/spz^unspecified

(Morisato, 2001)

Egfr^f37/Egfr^t1 has wing vein L4 phenotype, suppressible by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

Egfr^t1/Egfr^f11 has wing vein L4 phenotype, suppressible by sty[+]/sty^S73

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has anterior crossvein phenotype, suppressible by sty[+]/sty^S73

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has eye phenotype, suppressible by sty[+]/sty^S73

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has wing vein L4 phenotype, suppressible by sty[+]/sty^S88

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has anterior crossvein phenotype, suppressible by sty[+]/sty^S88

(Casci et al., 1999)

Egfr^t1/Egfr^f11 has eye phenotype, suppressible by sty[+]/sty^S88

(Casci et al., 1999)

Egfr^flb-2E07/Egfr^t1 has egg phenotype, suppressible | partially by kek1^RA5/kek1^RM2

(Ghiglione et al., 1999)

Egfr^flb-2E07/Egfr^t1 has dorsal appendage phenotype, suppressible | partially by kek1^RA5/kek1^RM2

(Ghiglione et al., 1999)

Egfr^t1 has phenotype, suppressible by bs⁰³²⁶⁷

(Roch et al., 1998)

Egfr^t1/Egfr^f11 has phenotype, suppressible by tkv^unspecified/tkv^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, suppressible by kn¹/kn¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has wing vein phenotype, suppressible by kn¹/kn¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, suppressible by net^unspecified/net^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has wing vein phenotype, suppressible by net^unspecified/net^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 has phenotype, suppressible by Dl^M1/Dl[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

NOT suppressed by

Statement

Reference

Egfr^t1 has egg phenotype, non-suppressible by Scer\GAL4^T155/Egfr::kek1^UAS.cGa

(Ghiglione et al., 2003)

Enhancer of

Statement

Reference

Egfr[+]/Egfr^t1 is an enhancer of eye phenotype of CycE^JP

(Brumby et al., 2004)

Egfr^t1 is an enhancer of ommatidium phenotype of S^48-5

(Gaengel and Mlodzik, 2003)

Egfr[+]/Egfr^t1 is an enhancer of egg phenotype of Scer\GAL4^VP16.nos.UTR, kek1^UASp.cGa

(Ghiglione et al., 2003)

Egfr[+]/Egfr^t1 is an enhancer of crossvein | increased number phenotype of Pcyt1^Ala.UAS, Scer\GAL4^sd-SG29.1

(Weber et al., 2003)

Egfr[+]/Egfr^t1 is an enhancer of eye phenotype of rg^γ6

(Shamloula et al., 2002)

Egfr^t1/Egfr^f1 is an enhancer of wing vein phenotype of rho^ve-1

(Guichard et al., 1999)

Egfr^t1 is an enhancer of ocellus phenotype of gro¹

(Price et al., 1997)

Egfr^t1 is an enhancer of adult head & microchaeta phenotype of gro¹

(Price et al., 1997)

Egfr^t1 is an enhancer of ocellus phenotype of rl¹

(Price et al., 1997)

Egfr^t1 is an enhancer of adult head & microchaeta phenotype of rl¹

(Price et al., 1997)

Egfr^t1 is an enhancer of wing phenotype of rl¹

(Price et al., 1997)

Egfr^t1 is an enhancer of wing phenotype of gro¹

(Price et al., 1997)

Egfr^t1 is an enhancer of prothoracic leg phenotype of rl¹

(Price et al., 1997)

Egfr^t1 is an enhancer of prothoracic leg phenotype of gro¹

(Price et al., 1997)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of vn^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of ast^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of N^Ax-M1

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of Vno^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of tt¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of H²

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of vvl^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of Vno¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is an enhancer of phenotype of ci^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

NOT Enhancer of

Statement

Reference

Egfr[+]/Egfr^t1 is a non-enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Egfr[+]/Egfr^t1 is a non-enhancer of embryonic epidermis phenotype of cact^E10

(Wakabayashi-Ito et al., 2001)

Egfr^t1 is a non-enhancer of embryonic epidermis phenotype of fus¹

(Wakabayashi-Ito et al., 2001)

Suppressor of

Statement

Reference

Egfr[+]/Egfr^t1 is a suppressor | partially of intestinal stem cell of posterior adult midgut epithelium phenotype of Scer\GAL4^NP5130, Src42A^CA.UAS

(Cordero et al., 2014)

Egfr[+]/Egfr^t1 is a suppressor of adult midgut phenotype of Burs^Z5569

(Scopelliti et al., 2014)

Egfr[+]/Egfr^t1 is a suppressor of intestinal stem cell | adult stage phenotype of Burs^Z5569

(Scopelliti et al., 2014)

Egfr^t1, Scer\GAL4^Tub.PU is a suppressor of wing vein phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

Egfr^t1, Scer\GAL4^Tub.PU is a suppressor of eye phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

Egfr^t1, Scer\GAL4^Tub.PU is a suppressor of ommatidium phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

Egfr^t1, Scer\GAL4^Tub.PU is a suppressor of photoreceptor cell R7 | ectopic phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

Egfr[+]/Egfr^t1 is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Egfr[+]/Egfr^t1 is a suppressor of wing phenotype of Nrg^GPI.UAS, Nrg^l3, Scer\GAL4^MS1075

(Islam et al., 2004)

Egfr[+]/Egfr^t1 is a suppressor of wing phenotype of Nrg^GPI.UAS, Scer\GAL4^MS1075

(Islam et al., 2004)

Egfr^t1 is a suppressor of wing phenotype of Nrg^GPI.UAS, Scer\GAL4^MS1075

(Islam et al., 2004)

Egfr[+]/Egfr^t1 is a suppressor of wing phenotype of Nrg^167.UAS, Nrg^l3, Scer\GAL4^MS1075

(Islam et al., 2004)

Egfr[+]/Egfr^t1 is a suppressor of wing phenotype of Nrg^167.UAS, Scer\GAL4^MS1075

(Islam et al., 2004)

Egfr^t1 is a suppressor of wing phenotype of Nrg^167.UAS, Scer\GAL4^MS1075

(Islam et al., 2004)

Egfr^t1 is a suppressor | partially of ommatidium phenotype of aos^rlt

(Gaengel and Mlodzik, 2003)

Egfr^t1/Egfr^t1 is a suppressor of egg phenotype of Egfr::kek1^UAS.cGa, Scer\GAL4^T155

(Ghiglione et al., 2003)

Egfr^t1 is a suppressor of phenotype of svp^1.sev

(Begemann et al., 1995)

Egfr^t1 is a suppressor of phenotype of svp^2.sev

(Begemann et al., 1995)

Egfr^t1/Egfr^f11 is a suppressor of wing vein phenotype of net^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is a suppressor of phenotype of kn¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is a suppressor of wing vein phenotype of kn¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is a suppressor of phenotype of tkv^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^t1/Egfr^f11 is a suppressor of phenotype of Dl^M1

(Diaz-Benjumea and Garcia-Bellido, 1990)

NOT Suppressor of

Statement

Reference

Egfr[+]/Egfr^t1 is a non-suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Egfr^t1 is a non-suppressor of ommatidium phenotype of ec^spok

(Montrasio et al., 2007)

Egfr[+]/Egfr^t1 is a non-suppressor of egg chorion phenotype of Egfr::kek1^{KEΔCG.UAS.GFP}, Scer\GAL4^CY2

(Alvarado et al., 2004)

Other

Statement

Reference

Egfr^t1, cic^fet-T6/cic^fet-E11 has egg chorion phenotype

(Goff et al., 2001)

Egfr^t1, cic^fet-T6/cic^fet-E11 has embryonic/first instar larval cuticle phenotype

(Goff et al., 2001)

Egfr^t1, spz^unspecified has ventral furrow phenotype

(Morisato, 2001)

Egfr^t1, spz[+]/spz^unspecified has ventral furrow phenotype

(Morisato, 2001)

Egfr^t1, emc^D has wing vein phenotype

(Baonza and Garcia-Bellido, 1999)

Egfr^t1, H^C21 has adult head & macrochaeta phenotype

(Price et al., 1997)

Egfr^t1, H^C21 has adult thorax & macrochaeta phenotype

(Price et al., 1997)

Egfr^t1, H^C21 has adult head & microchaeta phenotype

(Price et al., 1997)

Egfr^t1, H^C21 has adult thorax & microchaeta phenotype

(Price et al., 1997)

Egfr^t1, H^C21 has ocellar bristle phenotype

(Price et al., 1997)

Egfr^t1, H^C21 has anterior orbital bristle phenotype

(Price et al., 1997)

Df(3R)Espl22, Egfr^t1 has wing vein L4 phenotype

(Price et al., 1997)

Egfr^f37/Egfr^t1, vvl^sep/vvl^sep has wing vein L2 phenotype

(de Celis et al., 1995)

Egfr^f37/Egfr^t1, vvl^sep/vvl^sep has wing vein L3 phenotype

(de Celis et al., 1995)

Df(2R)rl10a, Egfr^t1 has wing vein L4 phenotype

(Brunner et al., 1994)

Egfr^t1, dac^P has eye phenotype

(Mardon et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Egfr^t1/+ suppresses the intestinal stem cell hyperproliferation seen in Burs^Z5569/Burs^Z5569 mutants.

(Scopelliti et al., 2014)

The presence of a Egfr^t1 background significantly suppresses ectopic wing vein formation found in csw^{Y279C.Scer\UAS} (Scer\GAL4^tub) mutants.

A Egfr^t1 background suppresses the csw^{Y279C.Scer\UAS} (Scer\GAL4^tub) rough eye phenotype, normalizing the numbers of R7 and ommatidial rotation.

(Oishi et al., 2009)

The planar cell polarity defects seen in Egfr^f11/Egfr^t1 eyes are partially suppressed by fz²¹/+ or fz²³/+.

(Weber et al., 2008)

The ommatidial rotation defects observed in ec^spok hemizygous adult eyes are not suppressed by Egfr^t1/+.

(Montrasio et al., 2007)

Heterozygous kek1^RM2 or kek1^RA5 partially suppresses the rough eye phenotype seen Egfr^flb-2E07/Egfr^t1 animals. kek1^RM2/kek1^RA5 fully suppresses the phenotype. Heterozygous kek1^RA5 partially suppresses the rough eye phenotype seen Egfr^f24/Egfr^t1 animals. Heterozygous kek1^RA5 partially suppresses the rough eye phenotype seen Df(2R)Egfr3/Egfr^t1 animals.

(Alvarado et al., 2004)

The loss of wing vein L4 seen in Egfr^t1/Egfr^f24 animals is suppressed if they are also mutant for kek1 (kek1^RA5/kek1^RM2). The dorsalised chorion phenotype caused by expression of Egfr::kek1^{KEΔCG.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^CY2 is not suppressed if the flies are also heterozygous for Egfr^t1.

(Alvarado et al., 2004)

The loss of anterior cross-vein and L4 gap seem in Egfr^f11/Egfr^t1 wings are partially rescue by ash2^I1/+.

(Angulo et al., 2004)

The defective wing phenotype, seen in both Nrg^167.Scer\UAS and Nrg^GPI.Scer\UAS mutants expressed under the control of Scer\GAL4^MS1075, is partially suppressed in a Egfr^t1 or Egfr^t1/+ background. Egfr^t1 also suppresses the wing phenotype when either Nrg^167.Scer\UAS or Nrg^GPI.Scer\UAS is expressed in a Nrg^l3 background.

(Islam et al., 2004)

S^48-5/Egfr^t1 mutants show 41.52%+-7.24 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone.

(Gaengel and Mlodzik, 2003)

The ventralized phenotype of eggs laid by Egfr^t1 homozygous females is unaffected by Egfr::kek1^Scer\UAS.cGa; Scer\GAL4^T155. The penetrance and expressivity of the weak ventralization phenotype seen in eggs laid by kek1^{Scer\UAS.P\T.cGa}; Scer\GAL4^{nos.UTR.T:Hsim\VP16} females is strongly enhanced by heterozygosity for Egfr^t1 (64% of eggs are ventralized, 8% strongly ventralised).

(Ghiglione et al., 2003)

The extra crossvein wing phenotype of Cct1^Ala.Scer\UAS mutants is enhanced when Cct1^Ala.Scer\UAS is overexpressed (driven by Scer\GAL4^sd-SG29.1) in Egfr^t1/+ flies.

(Weber et al., 2003)

Egfr^t1/Egfr^t1 ; cic^fet-T6/cic^fet-E11 females lay eggs with a dorsalised embryo (like cic^fet-T6/cic^fet-E11 single mutant females) and an eggshell that shows a combination of cic and Egfr mutant phenotypes; the dorsal appendages are broadened (as in cic mutants) but are positioned closer to the dorsal midline (as in Egfr mutants).

(Goff et al., 2001)

Embryos derived from Egfr^t1 ; spz^unspecified/+ females fail to invaginate ventral furrows and their cuticles show a reduction in ventral fates as compared to embryos laid by Egfr^t1 single mutant females.

(Morisato, 2001)

This loss of wing vein L4 seen in Egfr^t1/Egfr^f37 flies is suppressed by emc¹/emc¹¹. emc^D enhances the loss of wing veins seen in Egfr^t1/Egfr^f37 flies. Egfr^t1 emc^D double homozygotes show loss of wing veins.

(Baonza and Garcia-Bellido, 1999)

The Egfr^t1/Egfr^f11 phenotypes are dominantly suppressed by sty^S73 or sty^S88.

(Casci et al., 1999)

The Egfr^t1/Egfr^flb-2E07 phenotype is partially suppressed by kek1^RA5/kek1^RM2.

(Ghiglione et al., 1999)

When Egfr^f1/Egfr^t1; rho^ve-1/rho^ve-1 flies are raised at the permissive temperature (18^oC) a wing vein phenotype is seen that is similar to (but slightly more severe than) rho^ve-1/rho^ve-1 alone; wing veins L4 and L5 have prominent distal truncations, L2 and L3 remain largely intact. When raised at the non-permissive temperature (29^oC) there is an enhancement of the wing vein phenotype with all wing veins showing major truncations. This phenotype is seen if heat shocking occurs from 0 to 24 hours APF (after puparium formation).

(Guichard et al., 1999)

Egfr^t1/Egfr^t1; H^C21/H⁺ flies exhibit reduced numbers of macrochaetae, most noticeably on the head. Egfr^t1/Df(2R)Egfr18; gro¹/gro¹ flies display a combination of Egfr and gro phenotypes. The L4 wing vein defect is restored and the ocellar bristles are present but disarrayed. In many cases supernumerary ocellar bristles and/or interocellar bristles are present producing a patch of bristles where the ocelli would normally have been. The ocelli are either reduced or eliminated. Most males display one or more ectopic eye structure dorso-medial to the normal eyes. These structures are small and contain discrete ommatidia but no interommatidial bristles. The lens material of these ectopic eyes is fused into a uniform glaze and they are recessed into the head cuticle.

(Price et al., 1997)

Weak suppression of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

rl^10b causes strong dominant enhancement of the Egfr^top-CA/Egfr^t1 transheterozygous phenotype.

(Gonzalez-Reyes et al., 1995)

Double mutants of Df(2R)rl10a and Egfr^t1 show disruption of the longitudinal vein L4.

(Brunner et al., 1994)

dac^P, Egfr^t1 double homozygotes have a reduced, rough eye phenotype that exceeds that of either mutant alone or the expected additive effects of the two mutants.

(Mardon et al., 1994)

Double mutant combinations of Egfr^t1/Egfr^f11 with rho^unspecified/rho^unspecified, vn^unspecified/vn^unspecified, ci^unspecified/ci^unspecified, ast^unspecified/ast^unspecified, tt¹/tt¹, Vno^unspecified/+, H²/+, vvl^unspecified/+ or N^Ax-M1/+ have a superadditive phenotype. Double mutant combinations of Egfr^t1/Egfr^f11 with kn¹/kn¹ or net^unspecified/net^unspecified show mutual suppression, with both the Egfr and vein phenotypes being normalised. Egfr^t1/Egfr^f11 shows a negative interaction in combination with either Dl^M1/+ or tkv^unspecified/tkv^unspecified. Egfr^t1/Egfr^f11 shows a simple additive phenotype with dpp^unspecified/dpp^unspecified, kni^unspecified/kni^unspecified, tg²/tg², cv-2^unspecified/cv-2^unspecified and N^55e11/+. E(spl)^rv1 gro^unspecified Egfr^t1/Egfr^f11 flies show a simple additive phenotype.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

2079

106659

Notes on Origin

Discoverer

Comments

Weak Egfr allele.

(Schupbach, 1987)

Mutation of Egfr that coordinately affects all gene activities, a class I lesion. The allelic series for class I lesions: Egfr^t2 = Egfr^t1 < Egfr^top-EC20 < Egfr^f7 = Egfr^f1 = Egfr^flb-2E07 < Egfr^top-EE39 = Egfr^top-ED26 = Egfr^f5 < Egfr^f9 = Egfr^f10 = Egfr^f2 = Egfr^top-EE42 = Egfr^f11 = Egfr^f24 = Egfr^f3 = Df(2R)Egfr3.

(Clifford and Schupbach, 1989)

Class I allele.

(Clifford and Schupbach, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

DER^top1

(Schnepp et al., 1996, Brunner et al., 1994, Diaz-Benjumea and Hafen, 1994)

DER^top

(Ghiglione et al., 2003)

EGFR^t1

(Geiger et al., 2011, Doronkin et al., 2002)

EGFR^top1

(Cordero et al., 2014, Scopelliti et al., 2014, Oishi et al., 2009, Weber et al., 2003, Nagaraj et al., 1999)

EGFR^top

(Montrasio et al., 2007, Flores et al., 2000)

Egf-r^top

(Sturtevant et al., 1993)

Egfr-top1

(Gaengel and Mlodzik, 2003)

Egfr/top^QY1

(Dequier et al., 2001)

Egfr¹

(Goff et al., 2001, Morisato, 2001)

Egfr^QY1

(Wasserman and Freeman, 1998, Neuman-Silberberg and Schupbach, 1996, Ruohola-Baker et al., 1993)

Egfr^t1

(Djiane and Mlodzik, 2010, Wang et al., 2008, Hannan et al., 2006)

Egfr^top-1

(Clifford and Schupbach, 1994, Schupbach and Wieschaus, 1991)

Egfr^top-QY1

Egfr^top1

(Thuveson et al., 2019, Weber et al., 2008, Oishi et al., 2006, Rawlings et al., 2004, Casci et al., 1999, Dong et al., 1999, Begemann et al., 1995)

Egfr^top

(Guichard et al., 1999)

egfr^QY1

(Alvarado et al., 2004, Alvarado et al., 2004, Ghiglione et al., 2003, Ghiglione et al., 1999)

egfr^t1

(Jeon and Zinn, 2009)

top

(Islam et al., 2004, Ghiglione et al., 2003, Moses et al., 1997)

top^QY1

(Duong et al., 2008, Papadia et al., 2005, Brumby et al., 2004, Zhao and Bownes, 1999, Deng and Bownes, 1997, Hsu et al., 1996, Morimoto et al., 1996, Gonzalez-Reyes et al., 1995, Brand and Perrimon, 1994, Costa et al., 1994, Forlani et al., 1993, Neuman-Silberberg and Schupbach, 1993, Tolias et al., 1993)

top^QY

(Pathirana et al., 2001, Newmark et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (87)

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