|Feature type||allele||Associated gene||Dmel\Egfr|
|Also Known As||topCJ, egfrCJ|
|Map ( GBrowse )|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Nucleotide substitution: C406T. Amino acid replacement: S58F.
|Phenotype Manifest In|
Dsor1 mutant alleles do not suppress the eggshell dorso-ventral polarity defect of the Egfrt2 maternal mutation.
Transheterozygous females with Egfrf2 display egg chambers with gaps in the follicular epithelium that uncover the nurse cells. Eggs derived from these females display weak or intermediate ventralised phenotypes.
Expression of phlF22.hs in the anterior follicle cells of heterozygotes with Egfrt1 causes dorsalisation of the egg chamber.
Homozygous adult viable.
Weak ventralization of embryos. Filzkorper are normal. Only one dorsal appendage forms. 51% of laid eggs contain embryos. Mesoderm is wider than usual and cannot be enveloped by remaining epidermis. Two ventral furrows form.
Does not suppress the "Ellipse" phenotype. Hemizygotes die during pupariation, and have abnormally small dorsal imaginal discs.
Viable as a homozygote and hemizygote. Adults exhibit milder eye defects than would be expected from the severity of the wing and haltere defects.
|Phenotype Manifest In|
16% of Egfrt2 hup1 double homozygous egg chambers are dicephalic, and an additional 12.5% of double homozygous egg chambers (either dicephalic or with the oocyte normally localised) show degenerated nurse cells. 10% of double homozygous egg chambers have multiple layers of follicle cells at the posterior end. In some cases, these follicle cells try to migrate centripetally at the posterior, splitting the cytoplasm of the oocyte.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
Class I allele.
Mutation of Egfr that coordinately affects all gene activities, a class I lesion. The allelic series for class I lesions: Egfrt2 = Egfrt1 < Egfrtop-EC20 < Egfrf7 = Egfrf1 = Egfrflb-2E07 < Egfrtop-EE39 = Egfrtop-ED26 = Egfrf5 < Egfrf9 = Egfrf10 = Egfrf2 = Egfrtop-EE42 = Egfrf11 = Egfrf24 = Egfrf3 = Df(2R)Egfr3.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 6 )|
|Secondary FlyBase IDs|
|References ( 17 )|